Objective: To evaluate the heterogeneity of keratic precipitates (KP) in varyi ng subtypes of uveitis by in vivo confocal microscopy (IVCM). Methods: The KP we re viewed with a scanning confocal microscope in patients...Objective: To evaluate the heterogeneity of keratic precipitates (KP) in varyi ng subtypes of uveitis by in vivo confocal microscopy (IVCM). Methods: The KP we re viewed with a scanning confocal microscope in patients (m=33) who sought care at a tertiary referral uveitis service for immune-mediated and infectious form s of uveitis, including HLA-B27-associ-ated uveitis, sarcoidosis, Vogt-Koyan - agi-Harada syndrome, juvenile chronic arthritis, Fuchs heterochromic iridocyc litis, cytomegalovirus retinitis, herpes zoster ophthalmicus, ocular toxoplasmos is, and idiopathic uveitis. Images were captured and digitalized in real time. R esults: Forty-two eyes of 33 patients were examined in this study. Patient age ranged from 22 to 84 years, with a mean age of 49.4 years. Seventeen (52%) of t he patients were women, and 16 patients (48%) were men. The KP ranged in diamet er from 10 to 350 μm. We observed the following absolute and speculative outcom es: KP are markedly heterogeneous and variable as documented by IVCM; KP in indi vidual patients are consistent throughout the cornea; the morphologic features o f KP change across time; infectious vs noninfectious causes of uveitis seem to b e readily distinguishable by using IVCM; and KP may have consistency for specifi c disease states and therefore may have diagnostic importance. Conclusions: To o ur knowledge, this is the first time that IVCM has been used to describe the arc hitecture and heterogeneity of KP in uveitis. Such observations reveal a heterog eneity that could not be appreciated by conventional slitlamp microscopy and may have diagnostic relevance.展开更多
文摘Objective: To evaluate the heterogeneity of keratic precipitates (KP) in varyi ng subtypes of uveitis by in vivo confocal microscopy (IVCM). Methods: The KP we re viewed with a scanning confocal microscope in patients (m=33) who sought care at a tertiary referral uveitis service for immune-mediated and infectious form s of uveitis, including HLA-B27-associ-ated uveitis, sarcoidosis, Vogt-Koyan - agi-Harada syndrome, juvenile chronic arthritis, Fuchs heterochromic iridocyc litis, cytomegalovirus retinitis, herpes zoster ophthalmicus, ocular toxoplasmos is, and idiopathic uveitis. Images were captured and digitalized in real time. R esults: Forty-two eyes of 33 patients were examined in this study. Patient age ranged from 22 to 84 years, with a mean age of 49.4 years. Seventeen (52%) of t he patients were women, and 16 patients (48%) were men. The KP ranged in diamet er from 10 to 350 μm. We observed the following absolute and speculative outcom es: KP are markedly heterogeneous and variable as documented by IVCM; KP in indi vidual patients are consistent throughout the cornea; the morphologic features o f KP change across time; infectious vs noninfectious causes of uveitis seem to b e readily distinguishable by using IVCM; and KP may have consistency for specifi c disease states and therefore may have diagnostic importance. Conclusions: To o ur knowledge, this is the first time that IVCM has been used to describe the arc hitecture and heterogeneity of KP in uveitis. Such observations reveal a heterog eneity that could not be appreciated by conventional slitlamp microscopy and may have diagnostic relevance.
