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关于中国是否需要建立沉默权缺席的思考
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作者 冯治明 薛东生 《犯罪研究》 2000年第4期16-17,12,共3页
作者长期工作于基层公安机关执法了线,认为《公民权利和政治权利国际公约》所要求的默示式沉默权中国实际存在,但尚通过修改刑事诉讼法加以完善美国式的沉默权缺席不适合中国国情,沉默权制度不是解决刑讯逼供问题的治本之策,中国刑事司... 作者长期工作于基层公安机关执法了线,认为《公民权利和政治权利国际公约》所要求的默示式沉默权中国实际存在,但尚通过修改刑事诉讼法加以完善美国式的沉默权缺席不适合中国国情,沉默权制度不是解决刑讯逼供问题的治本之策,中国刑事司法制度改革的成败应以“三个有利于”为标准,建设具有中国特色的社会主义法治国家,对于美英等发达国家的,司法制度借鉴是必要的,照搬是愚蠢的,全盘西化是危险的。 展开更多
关键词 中国 沉默 刑事诉讼 刑讯逼供 刑事司法
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Epigenetics and neural stem cell commitment 被引量:1
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作者 汤海亮 朱剑虹 《Neuroscience Bulletin》 SCIE CAS CSCD 2007年第4期241-248,共8页
Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refe... Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate. 展开更多
关键词 stem cells EPIGENESIS neuron restrictive silencer element genomic imprinting H19 non-coding RNA
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Biochemical mechanisms of the RNA-induced silencing complex 被引量:5
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作者 Zain Paroo Qinghua Liu Xiaodong Wang 《Cell Research》 SCIE CAS CSCD 2007年第3期187-194,共8页
In less than 10 years since its inception, RNA interference (RNAi) has had extraordinary impact on biomedical science. RNAi has been demonstrated to influence numerous biological and disease pathways. Development an... In less than 10 years since its inception, RNA interference (RNAi) has had extraordinary impact on biomedical science. RNAi has been demonstrated to influence numerous biological and disease pathways. Development and adoption of RNAi technologies have been prolific ranging from basic loss-of-function tools, genome-wide screening libraries to pharmaceutical target validation and therapeutic development. However, understanding of the molecular mechanisms of RNAi is far from complete. The purpose of this brief review is to highlight key achievements in elucidating the bio- chemical mechanisms of the RNA-induced silencing complex and to outline major challenges for the field. 展开更多
关键词 ARGONAUTE DICER dsRBP RISC RNA interference
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Effect of siRNAs on HSV-1 Plaque Formation and Relative Expression Levels of RR mRNA 被引量:3
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作者 Zhe Ren Shen Li +7 位作者 Qiao-li Wang Yang-fei Xiang Yun-xia Cui Yi-fei Wang Ren-bin Qi Da-xiang Lu Shu-min Zhang Pei-zhuo Zhang 《Virologica Sinica》 SCIE CAS CSCD 2011年第1期40-46,共7页
RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed ... RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40,respectively. In this study,we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication. 展开更多
关键词 Small interfering RNA (siRNA) Herpes simplex virus type 1 (HSV-1) Ribonucleotide reductase(RR) GENE
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Progress of research in miR-218 and cervical cancer
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作者 Kangkang Zeng Wei Zhang Xiaoxia Hu 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第8期399-402,共4页
MicroRNAs (miRNAs) are small endogenous non-coding RNAs which can specifically silence gene expression, and thereby alter cell and organism phenotype. Deregulation of miRNA expression has been discovered in a variet... MicroRNAs (miRNAs) are small endogenous non-coding RNAs which can specifically silence gene expression, and thereby alter cell and organism phenotype. Deregulation of miRNA expression has been discovered in a variety of tumors and it is now clear that they contribute to cancer development and progression. Previous studies have indicated that miRNAs are involved in developmental timing, cell proliferation, apoptosis, morphogenesis [1], antiviral defense 121, and tumorigenesis [3]. In cancer pathways, altered expression of tumor suppressive or oncogenic miRNAs can disrupt regulatory mechanisms normal. Altered miRNAs expression patterns have been observed in a variety of diseased tissues. Cervical cancer is the most common malignant tumor in female reproductive tract. Recently more and more study showed a large number of miRNAs were down-regulated or up-regulated in cervical cancer. Recent data revealed that miRNA-218 (miR-218) played important roles in tumor initiation and development. This review focuses on analysis of miR-218 and will provide some insight into the progress of cervical cancer. 展开更多
关键词 MIR-218 cervical cancer RELATIONSHIP PROGRESS
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A TOM1 homologue is required for multiplication of Tobacco mosaic virus in Nicotiana benthamiana
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作者 CHEN Bing JIANG Jin-hua ZHOU Xue-ping 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第4期256-259,共4页
The AtTOM1 gene of Arabidopsis thaliana had been shown to be essential for the efficient multiplication of Tobacco mosaic virus(TMV) in A.thaliana.In this study,we cloned an AtTOM1-like gene from Nicotiana benthamiana... The AtTOM1 gene of Arabidopsis thaliana had been shown to be essential for the efficient multiplication of Tobacco mosaic virus(TMV) in A.thaliana.In this study,we cloned an AtTOM1-like gene from Nicotiana benthamiana named as NbTOM1.Sequence alignment showed that NbTOM1 is closely related to AtTOM1 homologues of N.tabacum and Lycopersicon esculentum with 97.2% and 92.6% nucleotide sequence identities,respectively.Silencing of NbTOM1 by a modified viral satellite DNA-based vector resulted in complete inhibition of the multiplication of TMV in N.benthamiana.The result suggests that inhibition of NbTOM1 via RNA silencing is a potentially useful method for generating TMV-resistant plants. 展开更多
关键词 Tobacco mosaic virus NbTOM1 Virus induced gene silencing Nicotiana benthamiana
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罪犯改造实质性的突破与制度化:19世纪美国监狱发展的回顾 被引量:1
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作者 翟中东 《中国监狱学刊》 2015年第2期156-164,共9页
18、19世纪罪犯改造从精神诉求走向实践。独居制、沉默制在美国先后出现。1870年10月在辛辛那提的“国家监管工作会议”(The National Congress of Penitentiary and Reformatory Discipline)总结了独居制与沉默制的探索,明确了罪犯... 18、19世纪罪犯改造从精神诉求走向实践。独居制、沉默制在美国先后出现。1870年10月在辛辛那提的“国家监管工作会议”(The National Congress of Penitentiary and Reformatory Discipline)总结了独居制与沉默制的探索,明确了罪犯改造的地位。这次会议所确定的原则为现代监狱发展规划了路线图,现代监狱由此诞生。 展开更多
关键词 罪犯改造 独居 沉默制 累进处遇
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以小见大写美文——读贾平凹《我的老师》的启示 被引量:1
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作者 李弗不 《初中生之友(快乐号)(上)》 2007年第5期19-20,共2页
贾平凹的文章非常好读,无论是他的长篇大作,像《废都》、《商州》、《秦腔》等等,还是他的随笔小文,像《冬景》、
关键词 《废都》 语言特色 小文 沉默制 大快朵颐 令人 生活材料 随手拈来 《师说》 优良品德
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