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奥美拉唑联合西沙必利治疗反流性食管炎的临床研究 被引量:1
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作者 石翠娥 《中国社区医师(医学专业)》 2011年第13期64-64,66,共2页
目的:探讨奥美拉唑联合西沙必利治疗反流性食管炎的临床疗效。方法:将47例确诊为反流性食管炎的患者,按随机数字表法分为治疗组24例和对照组23例。治疗组患者服用奥美拉唑和西沙必利,对照组服用西咪替丁和西沙必利,两组疗程均为8周。治... 目的:探讨奥美拉唑联合西沙必利治疗反流性食管炎的临床疗效。方法:将47例确诊为反流性食管炎的患者,按随机数字表法分为治疗组24例和对照组23例。治疗组患者服用奥美拉唑和西沙必利,对照组服用西咪替丁和西沙必利,两组疗程均为8周。治疗前后对烧心、反酸等症状各记录1次,治疗后均行胃镜复查,记录病变的大小和范围。结果:治疗8周后,治疗组的临床总有效率(91.66%)明显高于对照组(73.91%),治疗组胃镜下食管炎愈合有效率(95.83%)优于对照组(69.57%),两组比较差异均有统计学意义(P<0.05)。结论:奥美拉唑和西沙必利联合应用治疗反流性食管炎是一种安全可靠疗效显著的治疗方法,值得临床进一步推广应用。 展开更多
关键词 奥美拉唑西 沙必利 食管炎 反流性
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枳术宽中胶囊联合莫沙必利治疗胃癌术后功能性排空障碍临床观察 被引量:3
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作者 高洁 马婧婧 《湖北中医药大学学报》 2021年第5期74-76,共3页
目的观察枳术宽中胶囊联合莫沙必利治疗胃癌术后功能性排空障碍(FED)临床疗效。方法将我院70例胃癌术后FED患者随机分为观察组与对照组各35例。对照组采用莫沙必利治疗,观察组采用枳术宽中胶囊联合莫沙必利治疗,比较两组患者治疗后的临... 目的观察枳术宽中胶囊联合莫沙必利治疗胃癌术后功能性排空障碍(FED)临床疗效。方法将我院70例胃癌术后FED患者随机分为观察组与对照组各35例。对照组采用莫沙必利治疗,观察组采用枳术宽中胶囊联合莫沙必利治疗,比较两组患者治疗后的临床疗效、治疗前后的中医证候评分、治疗后的症状改善时间和治疗前后的血清学指标的含量。结果治疗后,观察组总有效率优于对照组(P<0.05);两组中医症候评分较治疗前下降,且观察组低于对照组(P<0.05);观察组术后症状改善时间均低于对照组(P<0.05);两组血清一氧化氮(NO)、P物质(SP)、乙酰胆碱酯酶(AchE)水平较治疗前下降且观察组上述指标水平低于对照组(P<0.05)。结论枳术宽中胶囊、莫沙必利联合口服治疗胃癌术后FED患者疗效满意,能显著改善临床症状,增强胃肠道平滑肌的兴奋程度,降低对胃肠道运动的抑制程度。 展开更多
关键词 胃癌 术后 功能性排空障碍 枳术宽中胶囊 沙必利
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腹部术后早期炎性肠梗阻26例诊治体会
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作者 郑达武 姚振秀 《右江医学》 2004年第6期582-582,共1页
关键词 术后 早期炎性肠梗阻 腹部手术 并发症 沙必利 大承气汤 斯的明
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Dissolution Improvement of Cisapride by Solid Dispersion with HPMC
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作者 魏振平 毛世瑞 +1 位作者 毕殿洲 李勇 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第4期254-258,共5页
To prepare a solid dispersion of cisapride with hydroxypropylmethyl cellulose(HPMC E5 LV) as carrier for the purpose of accelerating the in vitro drug release by means ofimproving the solubility of the model drug. Met... To prepare a solid dispersion of cisapride with hydroxypropylmethyl cellulose(HPMC E5 LV) as carrier for the purpose of accelerating the in vitro drug release by means ofimproving the solubility of the model drug. Methods Alcohol and simulated gastric fluid (SGF) wereused to dissolve cisapride and HPMC in order to make the model drug dispersed homogeneously in thecarrier. The HPMC-cisapride solid dispersion was then obtained by conventional solvent evaporationmethod. Powder X-ray diffraction (XRD) was used to measure the diffraction peaks of pure carrier,pure cisapride, physical mixture of HPMC with cisapride (4:1), and HPMC-cisapride solid dispersion(4:1) to confirm the crystal existence. The solubility of pure drug and HPMC-cisapride soliddispersion was measured with water, SGF and simulated intestinal fluid (SIF) . The in vitro drugreleases of the sustained release tablet prepared with pure cisapride or HPMC-cisapride soliddispersion were investigated with water and SGF as media, respectively. Results No diffraction peakswere found by X-ray diffraction in the HPMC-cisapride solid dispersion (4:1), indicating that thedrug existed in an amorphous form at that drug-carrier ratio. Compared with the pure drug, thesolubilities of HPMC-cisapride solid dispersion are increased by 239.4% in SGF, 132.6% in water, and117.9% in SIF. According to the in vitro drug release, the sustained release tablet prepared withHPMC-cisapride solid dispersion had a faster drug release than did that prepared with pure drug. Thein vitro drug release profiles were found to comply with Higuchi's rule. Conclusion The in vitrodrug release of the sustained release tablet made by HPMC-cisapride solid dispersion is improvedowing to the increased drug solubility. 展开更多
关键词 CISAPRIDE HPMC E5 LV solid dispersion
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(R)-乙基-6-[2-(叠氮甲基)吗啉基]己酸酯的合成工艺
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作者 陈冉章 《科技风》 2011年第23期94-94,共1页
以R-苄基缩水甘油醚、6-溴己酸乙酯为原料,经环合、氨基保护、催化氢化、酰化、叠氮取代、脱保护、烃化反应,成功得到了(R)-乙基-6-[2-(叠氮甲基)吗啉基]己酸酯。反应条件温和,操作简单。产物经过核磁共振、质谱确认。
关键词 盐酸奎沙必利 (R)-乙基-6-[2-(叠氮甲基)吗啉基]己酸酯 合成
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Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation 被引量:23
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作者 Masahiro Tajika Yasumasa Niwa +12 位作者 Vikram Bhatia Hiroki Kawai Shinya Kondo Akira Sawaki Nobumasa Mizuno Kazuo Hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi Akira Saeki Asana Akabane Koji Komori Kenji Yamao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第20期2517-2525,共9页
AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to ... AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte solution.Of 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation process.The efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's criteria.The primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the analysis.In the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation. 展开更多
关键词 Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution COLONOSCOPY PROKINETICS
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Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia 被引量:11
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作者 Hyun Chul Lim Sang In Lee +1 位作者 Jiande DZ Chen Hyojin Park 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第41期5948-5956,共9页
AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively... AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010.We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment.We also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment.RESULTS:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug treatment.Patients who had normal gastric slow waves showed symptom improvement group after treatment.Postprandial DF showed a downward trend in the symptom improvement group,especially in the itopride group.Post-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride group.Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment.The EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride groups.CONCLUSION:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics. 展开更多
关键词 ELECTROGASTROGRAPHY Functional dyspepsia ITOPRIDE MOSAPRIDE Levosulpiride
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Effect of herbal formula Xiao Pi-II on functional dyspepsia 被引量:3
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作者 Baohai Liu Xuehua Piao Lianyi Guo 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2013年第3期298-302,共5页
OBJECTIVE: To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dysepsia (FD). METHODS: A total of 180 FD patients were divided ran... OBJECTIVE: To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dysepsia (FD). METHODS: A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II (100 mL, t.d.s., ante cibum) and mosapride (5 mg, t. d.s., ante cibum) for 2 weeks. Before treatment and 3 days after all medication was stopped, patients responded to a questionnaire evaluating gastrointestinal symptoms and were assessed with abdominal three dimensional ultrasonography (3D-US) for gastric motility. RESULTS: Gastrointestinal symptoms (especially bloating, post-prandial fullness and eructation) were improved significantly in FD patients treated with Xiao Pi-II (P<0.05, P<0.05, and P<0.05), but no significant difference was found in the mosapride group (P>0.05). The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, respectively (P<0.05). The gastric liquid emptyingrate (GLER) in the Xiao Pi-II group showed a significant increase (P<0.01) after 2 weeks of treatment but there was no significant change (P>0.05) of GLER in the mosapride group. CONCLUSION: Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying. 展开更多
关键词 DYSPEPSIA Strengthening spleen Gas-tric liquid emptying rate
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