校本开发课程:沙球运动特点及内容方案

一、沙球运动的由来沙球运动是浙江省教育规划课题《6~8岁儿童“视-动协调”能力的诊断与干预》衍生出来的科研成果。研究初期使用的是普通沙包,在练习传(抛)接的过程中发现沙包会渗出细沙飘落到学生的眼睛里。团队成员想办法改进制作了正十二边形的沙包。改进后的球体融合了垒球和沙包的优点,具有大小重量适中、不易破损、抓握感强、安全实用的特点,后来将之命名为“沙球”(图1)。

沙球是螃蟹的便便吗

海边沙滩上的螃蟹洞口，常常可以看到一粒粒的小沙球，这些沙球是螃蟹的便便吗？

A generalized viscoelastic Biot/squirt model for clay-bearing sandstones in a wide range of permeabilities

To simultaneously take into account the Biot-flow mechanism, the squirt-flow mechanism, and the frame-viscoelasticity mechanism, a generalized viscoelastic BISQ （Biot/squirt） model is developed for wave propagation in clay-bearing sandstones based on Dvorkin＇s elastic BISQ model. The present model is extended to a wide range of permeabilities （k 〉 0.05 mD） by introducing a dimensionless correction factor for viscoelastic parameters, defined as a function of the permeability and the clay content. We describe the frame＇s stress-strain relationship of the clay-bearing sandstones by the differential constitutive equations of generalized viscoelasticity and then derive the viscoelastic-wave dynamic equations. With the assumption of a plane-wave solution, we finally yield the phase velocities and the attenuation coefficients by solving the dynamic wave equations in the frequency and wave number domain. The comparison of numerical results and experimental data shows that the generalized viscoelastic BISQ model is applicable for modeling the wave propagation in most of the sandstones mainly bearing kaolinite clay.

Preparation, Characterization and in Vitro Release of Ciprofloxacin Polylactic Acid Microspheres

Aim Ciprofloxacin polylactic acid microspheres (CFX-PLA-MS) were preparedusing solvent evaporation method from a solid-in-oil-in-water emulsion system. Methods Orthogonalexperiment was used to optimize the method of CFX-PLA-MS preparation. Microspheres werecharacterized in terms of morphology, size, encapsulation efficiency, drug loading and in vitro drugrelease. Results The physical state of CFX-PLA-MS was determined by scanning electron microscopy(SEM) and differential scanning calorimetry (DSC) . Microspheres formed were spherical with smoothsurfaces. Drug was enveloped in microspheres without mixing physically with PLA. The averageparticle size was 280.80 ± 0.15 μm, with over 90% of microspheres falling in the range of 250 -390 μm. The encapsulation efficiency was 65.8% ± 0.58% and the drug loading was 34.1% ± 0.51% .In vitro release study revealed a profile of sustained release of Ciprofloxacin from CFX-PLA-MS. Theaccumulated release percentage and half-life (T_(1/2) of Ciprofloxacin microspheres were 84.0% in53.2 h, and 31.9 h, respectively. Higuchi equation was Q= -0.0043 + 0.003 9 t^(1/2), r = 0.9941.Conclusion Ciprofloxacin microspheres have been successfully prepared and sustained release of CFXfrom microspheres is achieved.

让美的语言沐浴儿童心灵

要儿童学会学习,只有通过学生本身的积极主动参与、内化、吸收才能实现。儿童是学习的主人,教学中应充分发挥儿童的主体作用。初入学的儿童,其思维特征往往是一种无意注意,我根据儿童的这一思维特征,自编一些趣味性强的儿歌,让儿童在课间10分钟或午休时间一边诵读,一边做游戏,如“大沙滩,金灿灿,沙蟹在这打地道战,滚沙球,打连洞。

谜语六则

原始森林里, 茫茫大海上。 有我灵巧小手, 指点前进方向。 (指南针)

Case Report:A case of chylothorax treated curatively with Sapylin, a streptococcus preparation

Chylothorax is an uncommon disease where fatty fluid accumulates within the chest cavity. Conservative manage- ment, including repeated thoracentesis or pleurodesis, seems to be suitable to most cases. Herein, we present a case of efficacious pleurodesis by intrapleural injection of Sapylin, a streptococcus preparation, for the treatment of chylothorax. A 52-year-old non-smoking female farmer was diagnosed as idiopathic chylothorax after we ruled out possible causes including chest trauma, lymphoma, lung cancer, filariasis, tuberculosis, and etc. Two-time intra-thoracic injection of 3 Klinische Einheit (KE) Sapylin achieved rapid and effective control of chylothorax with no severe side effects. Sapylin may facilitate pleurodesis by producing a strong inflammatory response.

The sources and transport of iron in the North Paci?c and its impact on marine ecosystems

The limitation of iron(Fe)makes the North Pacific a typically high-nitrate,low-chlorophyll(HNLC)region in comparison with other oceanic regions of the world.Iron inputs from land via river discharge and atmospheric dust deposition are the primary processes introducing Fe into the ocean.Also,subsequent physical processes are crucial in transporting biologically available Fe into the upper ocean.As anthropogenic dust increases,the Fe from anthropogenic activities is expected to become more important in terms of impacting marine ecosystems.To investigate the Fe cycle and its impact on ecosystems,a project entitled‘The sources and transport of Fe in the North Pacific and its impact on marine ecosystems’has been funded by the National Natural Science Foundation of China.The project will focus on three major scientific questions:(1)What are the major sources of Fe in the North Pacific?(2)What is the influence of the Fe-binding ligand cycle on marine ecosystems?(3)What is the likely influence of global change in the future?The distribution of Fe and its corresponding impact on the marine ecosystem in current and future environmental conditions will be investigated.The results of the project are expected to improve our understanding of the marine ecosystem in the North Pacific.

Isolation and identification of symbiotic bacteria from the skin, mouth, and rectum of wild and captive tree shrews

Endosymbionts influence many aspects of their hosts’ health conditions, including physiology, development, immunity, metabolism, etc. Tree shrews(Tupaia belangeri chinensis) have attracted increasing attention in modeling human diseases and therapeutic responses due to their close relationship with primates. To clarify the situation of symbiotic bacteria from their body surface, oral cavity, and anus, 12 wild and 12 the third generation of captive tree shrews were examined. Based on morphological and cultural characteristics, physiological and biochemical tests, as well as the 16 S rDNA full sequence analysis, 12 bacteria strains were isolated and identified from the wild tree shrews: body surface: Bacillus subtilis(detection rate 42%), Pseudomonas aeruginosa(25%), Staphlococcus aureus(33%), S. Epidermidis(75%), Micrococcus luteus(25%), Kurthia gibsonii(17%); oral cavity: Neisseria mucosa(58%), Streptococcus pneumonia(17%); anus: Enterococcus faecalis(17%), Lactococus lactis(33%), Escherichia coli(92%), Salmonella typhosa(17%); whereas, four were indentified from the third generation captive tree shrews: body surface: S. epidermidis(75%); oral cavity: N.mucosa(67%); anus: L. lactis(33%), E. coli(100%). These results indicate that S. epidermidis, N. mucosa, L. lactis and E. coli were major bacteria in tree shrews, whereas, S. aureus, M. luteus, K. gibsonii, E. faecalis and S. typhosa were species-specific flora. This study facilitates the future use of tree shrews as a standard experimental animal and improves our understanding of the relationship between endosymbionts and their hosts.

Geotechnical Evaluation of Sedimentary Rocks and Karstification Phenomena of Carbonates Exposed along New Upper Egypt-Red Sea Road, Eastern Desert, Egypt

Geotechnical properties of sedimentary rocks exposed along upper Egypt-Red Sea road were investigated to evaluate their geotechnical behavior. One of the most important aims of this work was to determine the engineering problems affected on the road due to the geotechnical behavior of the studied sedimentary rocks and to suggest the suitable solution. Specific weight, unconfined compressive strength, slaking durability and free swelling were measured. The results showed that the studied crystalline limestone, marly limestone and Issawia limestone had higher unconfined compressive strength values ranging from 34,184.00 kN/m2 to 42,602.00 kN/m2 and the studied shale, siltstone and coral reef had lower values ranging from 3,689.00 kN/m2 to 6,933.00 kN/m2. The results showed also that the studied shale, siltstone and mudstone had fast to very fast slaking rate and their slaking amount described as low to medium after Gamble＇s slake durability classification. Replacement and/or chemical stabilization （using lime and/or cement kiln dust） of the expansive sedimentary rocks （shale and mudstone） were recommended to reduce the swelling. Geophysical investigations including shallow seismic, microgravity and GPR （ground penetrating radar） were recommended to scan the sub-grade of the road at El Maaza plateau to determine possible other caves and large voids under the road to avoid its collapse.

Application of Sediment Traps in Global Change Research in Mountain Lakes

Representativity of biota in the biosphere also have similar significance in the lithosphere after their death. Recently, taphonomic representation of biota in the lithosphere has been widely used for minimizing the biases in palaeo-environmental reconstructions including global climate change. In September 2001, a sediment trap was installed at the central area of the Loch Coire Fionnaraich （LCFR）, a small, oligotrophic mountain loch in northwest Scotland for a taphonomic study of cladoceran zooplankton. The trap was emptied on a seasonal basis, where an average 0.14 g dry material was recovered in each season, January, May and August 2002 respectively. A sediment core was also taken from near the sediment trap location. The top 0.5 cm section, the ＇core＇ was used for a comparative study with the trap sediment samples. The planktonic Cladocera consisted of Bosmina coregoni and appeared to have excellent preservation in the trap assemblages. Moreover, some common littoral Cladocera such as Alonella excisa and Aloha guttata appear to be less well preserved in the fossil assemblages. Large littoral taxa such as Eurycercus lamellatus and Aloha quadrangularis were rare in the trap but relatively common and well preserved in the sediment-water interface. It is suggested that taphonomic processes play a dominant role on deposition of fossil remains of Cladocera and caution should be taken while inferring the past environmental changes whilst using fossil assemblages recovered from the lake centre as a representation of the entire cladoceran community in the lake.

Mine rocky desertification： Another type of rocky desertification coexisting with Karst rocky desertification in Karst region

Mine rocky desertification is another type of rocky desertification which coexists with Karst rocky desertification, suggested firstly by professor SONG Jian-bo, Guizhou University. Mine rocky desertification is a process and result that the earth＇s surface is similar to desert landscapes after rock is exposed gradually, owing to mine wastes discharged at will which consist of waste residue, waste liquid and waste gas. On the basis of introducing Karst rocky desertification simply, we clarify the concept of Mine rocky desertification systemically, analyze its danger and compare the differences between Mine rocky desertification and Karst rocky desertification. Finally, we make preliminary discussion on the study significance of comprehensive treatment of Mine rocky desertification

Antibacterial Screening of Fifteen Cameroonian Medicinal Plants against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi

Multi-drug resistant microbial infections caused by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi represent a critical public health issue worldwide. Plant-derived agents are credible sources for search and development of alternative antimicrobials to fight these infections. This study describes the in-vitro antibacterial activity of plants extracts from 15 medicinal plants of the Cameroonian pharmacopeia against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. Plants selected based on their ethnopharmacological uses were extracted by either maceration or decoction using distilled water, ethanol, methanol and ethylacetate. The afforded extracts were phytochemically screened for bioactive secondary metabolites. The microdilution method was used to assess the antibacterial activity. The two promising extracts were tested in combination using the cbeckboard technique. Eighty one extracts showed antibacterial activity with eight having minimum inhibitory concentrations below 2.5 mg/mL. Results from combination assays with extracts from Terminalia catappa and Gnidia glauca leaves showed synergistic effect against Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi and additive effect against Staphylococcus aureus. These extracts mainly contained saponins, tannins, glucosides, phenols, triterpenes and anthraquinones. These results support the ethnobotanical claims and indicate further directions for the investigation of plants extracts to develop alternative drugs against multi-resistant bacteria.

Use of Cladophora glomerata Extract against Multidrug Resistant Bacterial Pathogens

The antibacterial effect of the crude methanol extracts and purified fractions of Ctadophora glomerata （Linnaeus） Kutzing （Cladophoraceae） against multidrug resistant human pathogen were investigated. The test bacterial strains were Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus faecalis, Escherichia coli and S. typhimurium. Ethanol extract （0.5 mg/mL） of Cladophora glomerata inhibited growth of all the test organisms. Primary detection of active compounds showed that maeroalgae （Cladophora glomerata） containing flavonoids, alkaloids, phenols and tannins. Gas Chromatography-Mass Spectrometry was used to know the compounds which responsible of antibacterial activity and they were g-Pentadecanone that was found to be a major compound （42.67%） followed by 8-Octadecanone （22.43%） and Salicylic acid （20.04%） in addition to 10-hexadecaden （8.01%）. These findings suggest the possibility of using the Cladophora glomerata as a novel source of natural antimicrobial agents in pharmaceutical industries.

Chemical Composition and in Vitro Antibacterial Activity of the Leaf Essential Oil of Mentha officinalis from Rwanda

The search for new prototype drugs to combat infection is an absolute necessity and in this regard plant essential oils may offer great potential and hope. In this investigation, the essential oil of the leaves ofMentha officinalis grown in Rwanda was extracted by hydrodistillation method and analyzed by gas chromatography （GC） and gas chromatography coupled with mass spectrometry （GC-MS）. The disc diffusion method was used to evaluate in vitro the zone of bacterial growth inhibition at various concentrations of the oil for five bacterial strains： Escherichia coli, Bacillus aureus, Streptococcus lactis, Staphylococcus aureus and Salmonella typhimurium. The results of this study revealed many components among which the major components were menthol （80.79%）, menthone （4.906%）, isomenthone （3.5%）, piperitone （2.56%）, and methyl acetate （2.2%）. After 7 days of incubation on PCA medium, the growth of Escherichia coli, Bacillus aureus, Streptococcus lactis and Staphylococcus aureus was totally inhibited at an average diameter of 19 mm, 32 mm, 50 mm and 30 mm respectively by a medium concentration of 30 μm/disc ofM. officinalis oil. Quite the reverse, this investigation by a bioassay showed that the essential oil ofM. officinalis has no effect on Salmonella typhimurium. The obtained results in the present study indicate the possibility of exploiting the essential oil ofM. officinalis to combat so many infectious human diseases in Rwanda. However, further investigations are required to make the medical exploitation of this plant successful.

生活中最好的“玩具”(下)

废旧日用品 别急着将家中的废旧日用品扔掉,它们都可以给宝宝当玩具.家中废旧的收音机、电话机、梳子、钟表、毛巾等,都是宝宝玩"过家家"的理想玩具.还可以帮助宝宝利用家中的工具将一些可拆卸的废旧日用品拆开,然后再重新组装,锻炼宝宝的动手、动脑能力.