China has achieved economic growth while great carbon emissions reduction in recent years. Amid China＇s effort to reduce emissions, the Five-Year Plans have guided and motivated local and foreign forces from the gove...China has achieved economic growth while great carbon emissions reduction in recent years. Amid China＇s effort to reduce emissions, the Five-Year Plans have guided and motivated local and foreign forces from the government, industries, and society to work together. This paper showed that a mediumehigh economic growth gate, industry structure adjustment, and energy structure adjustment, which are guaranteed under the Five-Year Plan, all contribute to energy saving in China. The economy entered a stable growing phase during the 12 th Five-Year Plan, while the economic growth rate declined to 7.8% from 11.2% in the 11 th Five-Year Plan. Simultaneously, the CO2 emissions growth rate declined from8.32%（2009-2012 mean） to 1.82%（2012-2014 mean）. Industrial structure adjustment canceled out nearly one-third of the CO2 emissions caused by economic growth. Under the 13 th Five-Year Plan, China will continue its energy saving efforts on the green development path, with greener quotas, a stricter implementation process, and more key projects.展开更多
Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and ther...Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.展开更多
Transcatheter aortic valve replacement （TAVR） has revolutionised the treatment of patients with aortic stenosis （AS） over the last 15 years.TAVR is a well-established procedure for the treatment of patients consid...Transcatheter aortic valve replacement （TAVR） has revolutionised the treatment of patients with aortic stenosis （AS） over the last 15 years.TAVR is a well-established procedure for the treatment of patients considered high risk for open surgery. Results from the PARTNER （Placement of AoRTic traNscathetER） trial showed that inoperable patients randomly assigned to TAVR, had a 20% reduction in all-cause mortality, as well as hospitalisation, at one year compared to best medical management.展开更多
This paper focuses on how the implementation of a single regional political instrument is perceived, understood and communicated. Designed as a regional political instrument, the Norwegian Ministry of Transport and Co...This paper focuses on how the implementation of a single regional political instrument is perceived, understood and communicated. Designed as a regional political instrument, the Norwegian Ministry of Transport and Communications started a pilot project： ＂Driver education as a part of upper secondary school in district Norway＂. The focal point in this paper is to explore how the professional participants understand and interpret the project as a regional political instrument in order to maintain the local community, identity and local belonging. The theoretical approach is based on Giddens＇s actor/structure theory, while the analysis based on discourse analysis, in the analysis we separated the arguments used in the professional discourse. We detected different categories of argument in the discourses among the professionals. In addition to the professional discourse, we became aware of a personal discourse. In both discourses the political instrument was perceived to be important in order to maintain the local community, create equality and maintain local identity and a sense of belonging.展开更多
Abdominal aortic aneurysm is a common vascular disease that affects elderly population.Open surgical repair is regarded as the gold standard technique for treatment of abdominal aortic aneurysm,however,endovaseular an...Abdominal aortic aneurysm is a common vascular disease that affects elderly population.Open surgical repair is regarded as the gold standard technique for treatment of abdominal aortic aneurysm,however,endovaseular aneurysm repair has rapidly expanded since its first introduction in 1990s.As a less invasive technique,endovascular aneurysm repair has been confirmed to be an effective alternative to open surgical repair,especially in patients with co-morbid conditions.Computed tomography （CT） angiography is currently the preferred imaging modality for both preoperative planning and post-operative follow-up.2D CT images are complemented by a number of 3D reconstructions which enhance the diagnostic applications of CT angiography in both planning and follow-up of endovascular repair.CT has the disadvantage of high cummulative radiation dose,of particular concern in younger patients,since patients require regular imaging follow-ups after endovascular repair,thus,exposing patients to repeated radiation exposure for life.There is a trend to change from CT to ultrasound surveillance of endovascular aneurysm repair.Medical image visualizations demonstrate excellent morphological assessment of aneurysm and stent-grafts,but fail to provide hemodynamic changes caused by the complex stent-graft device that is implanted into the aorta.This article reviews the treatment options of abdominal aortic aneurysm,various image visualization tools,and follow-up procedures with use of different modalities including both imaging and computational fluid dynamics methods.Future directions to improve treatment outcomes in the follow-up of endovascular aneurysm repair are outlined.展开更多
Objective： The aim of our study was to investigate the feasibility and safety of thoracoscopic internal mammary lymphadenectomy as a method to refine and thereby improve nodal staging in breast cancer. Methods： Duri...Objective： The aim of our study was to investigate the feasibility and safety of thoracoscopic internal mammary lymphadenectomy as a method to refine and thereby improve nodal staging in breast cancer. Methods： During the period from June 2004 to May 2007, 50 patients with operable breast cancer underwent modified radical mastectomy （MRM） or breast conserving surgery （BCS）, followed by thoracoscopic internal mammary lymphadenectomy, using 3 ports through the skin incision of the MRM or the BCS. Metal clips were used to mark precise site of lymphadenectomy. Results： of total number of 50 patients, the mean age of patients was 44 years （range, 27-60 years）. 40 （80%） had medio-central tumor, 10 （20%） had lateral tumor. 35 （70%） had clinically involved axillary nodes. 16 out of 50 patients received neo-adjuvant CTH. 44 patients underwent MRM and 6 patients underwent BCS. No intra-operative complications occurred. Atelectasis was the only postoperative complication that was encountered, which occurred in 12 cases, and was treated conservatively. The average chest drainage period was 1.2 day （range, 1-2 days）. The total number of IMN metastasis was 18 patients （36%）. The risk of IMN metastasis was higher; in younger patients （P = 0.03）, in medio-central tumors （P = 0.03）, in bigger tumors （P = 0.05）, with heavier metastasis of axillary LNs （P = 0.001）. But a correlation with the histological pattern of the lry tumor didn＇t exist （P = 1）. Knowing the IMN status helped in proper staging of patients, 7 patients showed evident stage migration after adding the IMN analysis to that of primary tumor and axillary LN. During the follow up period （the median, 22 months; range, 7 to 42 months）, no patient had pleural dissemination or port-site metastasis. Conclusion： Thoracoscopic IMN lymphadenectomy is a safe procedure, which can be done serious additional complications or cosmetic compromise. And allow proper nodal staging, which allow proper treatment planning.展开更多
This paper is devoted to intercultural dialogue from the point of view of Pope Benedict XVI （pontificate between 2005 and 2013）. It presents pontifical documents, statements, and speeches dedicated to this issue as ...This paper is devoted to intercultural dialogue from the point of view of Pope Benedict XVI （pontificate between 2005 and 2013）. It presents pontifical documents, statements, and speeches dedicated to this issue as well as the conclusions resulting from them. The aim of the paper is to prove that intercultural dialogue and interreligious dialogue are within the context of a new scientific discipline--political science of religion--which deals with the issues of relations between the sphere of religion and the sphere of politics. Intercultural dialogue is tightly connected to interreligious dialogue. Interreligious and intercultural dialogue allows to create the world based on brotherhood and reconciliation. They are the foundation of the future, an effective tool to build a civilization of love and they are born out of God＇s mercy.展开更多
Incomplete contract theory （GHM-model）, namely, GHM model, Grossman-Hart-Moore model, GHM model or called ownership - control model by Grossman and Hart （Grossman ＆ Hart, 1986）, it is established by Hart and Moo...Incomplete contract theory （GHM-model）, namely, GHM model, Grossman-Hart-Moore model, GHM model or called ownership - control model by Grossman and Hart （Grossman ＆ Hart, 1986）, it is established by Hart and Moore （Hart ＆ Moore, 1990） and other cofounder, so this theory is also known as GHM theory or GHM model. Domestic scholars generally call their theory incomplete contract theory or incomplete contract theory, because the theory is ba^ed on the following analytical framework： They use the incompleteness of contracts for research as starting point to property or （ residual ） optimal control with Ge for research purposes. It is the most important analytical tool for analyze business theory and corporate governance structures with Ge control incentives to obtain the information. GHM model directly inherit the transaction cost theory by Coase, and Williamson, and it is a critical development. Among them, the 1986 model is mainly to solve the integration problem of assets, in 1990, the model evolved into a general model of asset ownership.展开更多
Invasive nonfunctional pituitary adenomas （NFPAs） are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFP...Invasive nonfunctional pituitary adenomas （NFPAs） are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy （BNCT） is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor （FR）-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs ceils for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors.展开更多
OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Si...OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool(PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.RESULTS: Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group(12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group(12.9 ± 2.6 vs 10.3 ± 1.6, P <0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group(8.6 ± 3.2 vs10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs(12.9 ± 2.2) mm, P =0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.CONCLUSION: These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule,and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE.展开更多
OBJECTIVES： To explore the distribution of TCM patterns in ketamine users and the inter-rater reli- ability of TCM diagnosis among TCM practitioners. METHODS： Eighty-four subjects recruited from sub- stance abuse cl...OBJECTIVES： To explore the distribution of TCM patterns in ketamine users and the inter-rater reli- ability of TCM diagnosis among TCM practitioners. METHODS： Eighty-four subjects recruited from sub- stance abuse clinics and non-governmental coun- seling services catering for ketamine abusers were examined by one or two TCM practitioners. The dis- tribution and inter-rater reliability of the TCM diag- noses between the two TCM practitioners were de- scribed and measured. RESULTS： Seven TCM patterns were differentiated. The four most common patterns were the Heart Yin deficiency （29.8%）, Kidney Yang deficiency （26.2%）, Kidney Yin deficiency （19.0%）, and Spleen Yang defi-ciency （14.3%）. The agreement between the two TCM practitioners was 59%, the kappa for the three most common patterns was 0.472 （P=O.O03）. The proportion of men was lower in the Kidney Yin defi- ciency group （18.8%）, in comparison to the Heart Yin deficiency （60.0%, P=0.009） and Kidney Yang de- ficiency group （59.1%, P=0.013）. CONCLUSION： The differences between the TCM groups in terms of the source of referral and num- ber of drug uses other than ketamine were of bor- derline significance. Further research should focus on validating diagnostic tools and improving in- ter-rater reliability in TCM to enhance the quality of clinical trials of TCM treatments for ketamine abuse.展开更多
Environmental pollution caused by rapid economic development like that seen in China over the past twenty years poses various threats to human health. People have started to place much more of an emphasis on environme...Environmental pollution caused by rapid economic development like that seen in China over the past twenty years poses various threats to human health. People have started to place much more of an emphasis on environmental security, working to find a balance between sustainability and economic growth. In recent years, air pollution has emerged as a highly discussed topic of social and environmental relevance in China, due in part to persistent smog that affects everyday life and causes serious harm to human health. Although air pollution is normally associated with human activity, is can be caused by natural processes such as eruptions and forest fires, but is always characterized by the release of certain substances into the atmosphere which, when present in certain concentrations or for given durations, can harm human health, daily life, productivity, and other aspects. In humans, it mainly affects the respiratory system, notably the lungs, as well as the immune system. A series of studies both in China and overseas have shown, in certain cases, even low concentrations of air pollution can pose a great threat to human health. In this study, we conducted an analysis of air quality policies, focusing on the 2018 revision of the People’s Republic of China’s Law on the Prevention and Control of Air Pollution(LPCAP). We utilized the content analysis method and Strauss and Corbin’s grounded theory to construct a policy framework, demarcate analysis units, code and classify policy texts, determine descriptive statistics, and analyze dimensional interactions. We used two dimensions(basic policy instruments classified as demand-, supply-, and environment-side;and air carrying capacity) to quantify and analyze the LPCAP, which enabled us to analyze the deficiencies and conflicts within policy instruments. The results show a higher utilization frequency of environment-side policy instruments, particularly regulation management and strategic measures. This reflects efforts by the government to create a favorable environment for improving air quality. Additionally, supply-side policy instruments are used far less frequently than environment-side policy instruments. Air quality legal policies and pollution control measures mainly consist of environment-side policy instruments;ecological thinking and air quality policies that are based mainly on supply-side and environment-side policy instruments;and social coordination policies that mainly use environment-side policy instruments. Based on the results of this study, we recommend an increase in the number of supply-and demand-side policy instruments, particularly the latter which includes promoting ecological thinking amongst citizens, to optimize and improve air pollution prevention and control policies.展开更多
基金supported by the "study of Green space management system and protection" of mechanism Economic Development Research Center of State Forestry Administration (ZDWT-2014-3)
文摘China has achieved economic growth while great carbon emissions reduction in recent years. Amid China＇s effort to reduce emissions, the Five-Year Plans have guided and motivated local and foreign forces from the government, industries, and society to work together. This paper showed that a mediumehigh economic growth gate, industry structure adjustment, and energy structure adjustment, which are guaranteed under the Five-Year Plan, all contribute to energy saving in China. The economy entered a stable growing phase during the 12 th Five-Year Plan, while the economic growth rate declined to 7.8% from 11.2% in the 11 th Five-Year Plan. Simultaneously, the CO2 emissions growth rate declined from8.32%（2009-2012 mean） to 1.82%（2012-2014 mean）. Industrial structure adjustment canceled out nearly one-third of the CO2 emissions caused by economic growth. Under the 13 th Five-Year Plan, China will continue its energy saving efforts on the green development path, with greener quotas, a stricter implementation process, and more key projects.
文摘Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.
文摘Transcatheter aortic valve replacement （TAVR） has revolutionised the treatment of patients with aortic stenosis （AS） over the last 15 years.TAVR is a well-established procedure for the treatment of patients considered high risk for open surgery. Results from the PARTNER （Placement of AoRTic traNscathetER） trial showed that inoperable patients randomly assigned to TAVR, had a 20% reduction in all-cause mortality, as well as hospitalisation, at one year compared to best medical management.
文摘This paper focuses on how the implementation of a single regional political instrument is perceived, understood and communicated. Designed as a regional political instrument, the Norwegian Ministry of Transport and Communications started a pilot project： ＂Driver education as a part of upper secondary school in district Norway＂. The focal point in this paper is to explore how the professional participants understand and interpret the project as a regional political instrument in order to maintain the local community, identity and local belonging. The theoretical approach is based on Giddens＇s actor/structure theory, while the analysis based on discourse analysis, in the analysis we separated the arguments used in the professional discourse. We detected different categories of argument in the discourses among the professionals. In addition to the professional discourse, we became aware of a personal discourse. In both discourses the political instrument was perceived to be important in order to maintain the local community, create equality and maintain local identity and a sense of belonging.
文摘Abdominal aortic aneurysm is a common vascular disease that affects elderly population.Open surgical repair is regarded as the gold standard technique for treatment of abdominal aortic aneurysm,however,endovaseular aneurysm repair has rapidly expanded since its first introduction in 1990s.As a less invasive technique,endovascular aneurysm repair has been confirmed to be an effective alternative to open surgical repair,especially in patients with co-morbid conditions.Computed tomography （CT） angiography is currently the preferred imaging modality for both preoperative planning and post-operative follow-up.2D CT images are complemented by a number of 3D reconstructions which enhance the diagnostic applications of CT angiography in both planning and follow-up of endovascular repair.CT has the disadvantage of high cummulative radiation dose,of particular concern in younger patients,since patients require regular imaging follow-ups after endovascular repair,thus,exposing patients to repeated radiation exposure for life.There is a trend to change from CT to ultrasound surveillance of endovascular aneurysm repair.Medical image visualizations demonstrate excellent morphological assessment of aneurysm and stent-grafts,but fail to provide hemodynamic changes caused by the complex stent-graft device that is implanted into the aorta.This article reviews the treatment options of abdominal aortic aneurysm,various image visualization tools,and follow-up procedures with use of different modalities including both imaging and computational fluid dynamics methods.Future directions to improve treatment outcomes in the follow-up of endovascular aneurysm repair are outlined.
文摘Objective： The aim of our study was to investigate the feasibility and safety of thoracoscopic internal mammary lymphadenectomy as a method to refine and thereby improve nodal staging in breast cancer. Methods： During the period from June 2004 to May 2007, 50 patients with operable breast cancer underwent modified radical mastectomy （MRM） or breast conserving surgery （BCS）, followed by thoracoscopic internal mammary lymphadenectomy, using 3 ports through the skin incision of the MRM or the BCS. Metal clips were used to mark precise site of lymphadenectomy. Results： of total number of 50 patients, the mean age of patients was 44 years （range, 27-60 years）. 40 （80%） had medio-central tumor, 10 （20%） had lateral tumor. 35 （70%） had clinically involved axillary nodes. 16 out of 50 patients received neo-adjuvant CTH. 44 patients underwent MRM and 6 patients underwent BCS. No intra-operative complications occurred. Atelectasis was the only postoperative complication that was encountered, which occurred in 12 cases, and was treated conservatively. The average chest drainage period was 1.2 day （range, 1-2 days）. The total number of IMN metastasis was 18 patients （36%）. The risk of IMN metastasis was higher; in younger patients （P = 0.03）, in medio-central tumors （P = 0.03）, in bigger tumors （P = 0.05）, with heavier metastasis of axillary LNs （P = 0.001）. But a correlation with the histological pattern of the lry tumor didn＇t exist （P = 1）. Knowing the IMN status helped in proper staging of patients, 7 patients showed evident stage migration after adding the IMN analysis to that of primary tumor and axillary LN. During the follow up period （the median, 22 months; range, 7 to 42 months）, no patient had pleural dissemination or port-site metastasis. Conclusion： Thoracoscopic IMN lymphadenectomy is a safe procedure, which can be done serious additional complications or cosmetic compromise. And allow proper nodal staging, which allow proper treatment planning.
文摘This paper is devoted to intercultural dialogue from the point of view of Pope Benedict XVI （pontificate between 2005 and 2013）. It presents pontifical documents, statements, and speeches dedicated to this issue as well as the conclusions resulting from them. The aim of the paper is to prove that intercultural dialogue and interreligious dialogue are within the context of a new scientific discipline--political science of religion--which deals with the issues of relations between the sphere of religion and the sphere of politics. Intercultural dialogue is tightly connected to interreligious dialogue. Interreligious and intercultural dialogue allows to create the world based on brotherhood and reconciliation. They are the foundation of the future, an effective tool to build a civilization of love and they are born out of God＇s mercy.
文摘Incomplete contract theory （GHM-model）, namely, GHM model, Grossman-Hart-Moore model, GHM model or called ownership - control model by Grossman and Hart （Grossman ＆ Hart, 1986）, it is established by Hart and Moore （Hart ＆ Moore, 1990） and other cofounder, so this theory is also known as GHM theory or GHM model. Domestic scholars generally call their theory incomplete contract theory or incomplete contract theory, because the theory is ba^ed on the following analytical framework： They use the incompleteness of contracts for research as starting point to property or （ residual ） optimal control with Ge for research purposes. It is the most important analytical tool for analyze business theory and corporate governance structures with Ge control incentives to obtain the information. GHM model directly inherit the transaction cost theory by Coase, and Williamson, and it is a critical development. Among them, the 1986 model is mainly to solve the integration problem of assets, in 1990, the model evolved into a general model of asset ownership.
基金supported by the National Natural Science Foundation of China (81072084)
文摘Invasive nonfunctional pituitary adenomas （NFPAs） are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy （BNCT） is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor （FR）-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs ceils for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors.
基金Supported by a Grant from the National Key Basic Research Program of China(No.2013CB945204)a Research and Development Project for Young Doctors in Reproductive Medicine from the Chinese Medical Association Specialized Fund for Clinical Medical Research(No.16020380654)
文摘OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool(PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.RESULTS: Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group(12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group(12.9 ± 2.6 vs 10.3 ± 1.6, P <0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group(8.6 ± 3.2 vs10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs(12.9 ± 2.2) mm, P =0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.CONCLUSION: These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule,and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE.
基金Supported by a Research Grant (No. 8011013315) from the Hospital Authority,Hong Kong SAR
文摘OBJECTIVES： To explore the distribution of TCM patterns in ketamine users and the inter-rater reli- ability of TCM diagnosis among TCM practitioners. METHODS： Eighty-four subjects recruited from sub- stance abuse clinics and non-governmental coun- seling services catering for ketamine abusers were examined by one or two TCM practitioners. The dis- tribution and inter-rater reliability of the TCM diag- noses between the two TCM practitioners were de- scribed and measured. RESULTS： Seven TCM patterns were differentiated. The four most common patterns were the Heart Yin deficiency （29.8%）, Kidney Yang deficiency （26.2%）, Kidney Yin deficiency （19.0%）, and Spleen Yang defi-ciency （14.3%）. The agreement between the two TCM practitioners was 59%, the kappa for the three most common patterns was 0.472 （P=O.O03）. The proportion of men was lower in the Kidney Yin defi- ciency group （18.8%）, in comparison to the Heart Yin deficiency （60.0%, P=0.009） and Kidney Yang de- ficiency group （59.1%, P=0.013）. CONCLUSION： The differences between the TCM groups in terms of the source of referral and num- ber of drug uses other than ketamine were of bor- derline significance. Further research should focus on validating diagnostic tools and improving in- ter-rater reliability in TCM to enhance the quality of clinical trials of TCM treatments for ketamine abuse.
基金The National Social Science Foundation Major Project of China(18AFX023).
文摘Environmental pollution caused by rapid economic development like that seen in China over the past twenty years poses various threats to human health. People have started to place much more of an emphasis on environmental security, working to find a balance between sustainability and economic growth. In recent years, air pollution has emerged as a highly discussed topic of social and environmental relevance in China, due in part to persistent smog that affects everyday life and causes serious harm to human health. Although air pollution is normally associated with human activity, is can be caused by natural processes such as eruptions and forest fires, but is always characterized by the release of certain substances into the atmosphere which, when present in certain concentrations or for given durations, can harm human health, daily life, productivity, and other aspects. In humans, it mainly affects the respiratory system, notably the lungs, as well as the immune system. A series of studies both in China and overseas have shown, in certain cases, even low concentrations of air pollution can pose a great threat to human health. In this study, we conducted an analysis of air quality policies, focusing on the 2018 revision of the People’s Republic of China’s Law on the Prevention and Control of Air Pollution(LPCAP). We utilized the content analysis method and Strauss and Corbin’s grounded theory to construct a policy framework, demarcate analysis units, code and classify policy texts, determine descriptive statistics, and analyze dimensional interactions. We used two dimensions(basic policy instruments classified as demand-, supply-, and environment-side;and air carrying capacity) to quantify and analyze the LPCAP, which enabled us to analyze the deficiencies and conflicts within policy instruments. The results show a higher utilization frequency of environment-side policy instruments, particularly regulation management and strategic measures. This reflects efforts by the government to create a favorable environment for improving air quality. Additionally, supply-side policy instruments are used far less frequently than environment-side policy instruments. Air quality legal policies and pollution control measures mainly consist of environment-side policy instruments;ecological thinking and air quality policies that are based mainly on supply-side and environment-side policy instruments;and social coordination policies that mainly use environment-side policy instruments. Based on the results of this study, we recommend an increase in the number of supply-and demand-side policy instruments, particularly the latter which includes promoting ecological thinking amongst citizens, to optimize and improve air pollution prevention and control policies.
