目的:探讨阻生智齿手术患者同期美观治疗倾向及其相关影响因素分析。方法:纳入2022年1月-2023年2月于笔者医院拟行阻生智齿手术治疗的323例患者为研究对象,入院时采用牙科审美社会心理影响量表(Psychosocial impact of dental aesthetic...目的:探讨阻生智齿手术患者同期美观治疗倾向及其相关影响因素分析。方法:纳入2022年1月-2023年2月于笔者医院拟行阻生智齿手术治疗的323例患者为研究对象,入院时采用牙科审美社会心理影响量表(Psychosocial impact of dental aesthetics questionnaire,PIDAQ)评估患者同期美观治疗倾向;同时收集患者人口学资料及临床资料,分析阻生智齿手术患者同期美观治疗倾向的相关影响因素。结果:323例患者中,165例(51.08%)患者PIDAQ评分为0~23分,平均得分为(16.35±4.07)分,为低倾向组;158例(48.92%)患者PIDAQ评分为24~92分,平均得分为(68.24±10.26)分,为高倾向组。两组患者年龄、家庭经济状况、同期美观治疗预估费用、疼痛及牙齿健康因素(Dental health component,DHC)、美观因素(Aesthetic component,AC)、牙牙合美观程度自我评价(Self-perceivedaesthetic component,SAC)评分比较差异有统计学意义(P<0.05),性别、体重指数、居住地、受教育程度、职业等资料比较,差异无统计学意义(P>0.05)。Logistic回归分析结果显示家庭经济状况<5 000(元/月)(OR=1.875)、AC评分高(OR=3.560)、SAC评分高(OR=3.171)是阻生智齿手术患者同期美观治疗倾向的危险因素,同期美观治疗预估费用低(OR=0.196)是阻生智齿手术患者同期美观治疗倾向保护因素。ROC曲线分析显示,同期美观治疗预估费用、AC评分及SAC评分的截值点分别为1.03、5.00、5.00。结论:阻生智齿手术患者低同期美观治疗倾向的患者占比51.08%,高同期美观治疗倾向的患者占比48.92%;其中家庭经济状况、同期美观治疗预估费用及牙颌美观度是阻生智齿手术患者同期美观治疗倾向的影响因素。展开更多
This paper discusses a neglected theme in Wittgenstein＇s writings on meaning and psychology from the early 1930s until 1949. Throughout this period Wittgenstein deals with aspects of meaning of words and pictures tha...This paper discusses a neglected theme in Wittgenstein＇s writings on meaning and psychology from the early 1930s until 1949. Throughout this period Wittgenstein deals with aspects of meaning of words and pictures that cannot be accounted for in dispositional terms but have to be related to experience and perception. Wittgenstein＇s reading of William James, I argue, has sharpened his eye for the many pitfalls in coming to terms with this experiential notion of meaning. James＇s treatment of experiences of meaning succumbs to the temptation to postulate ~~meaning-bodies,＂ bearers of meaning apart from the way and context in which we use the particular words. I argue that the conflation of what Wittgenstein calls the transitive and intransitive use of words is at the root of postulating meaning-bodies. I also argue that contemporary treatments of experiences of meaning are similarly vulnerable to James＇s confusion.展开更多
Clinical guidelines recommend a steady-state vancomycin(VCM)trough concentration(SVTC)of 10–15 mg/L for regular infections and 15–20 mg/L for severe infections.However,clinical trials have shown that increasing SVTC...Clinical guidelines recommend a steady-state vancomycin(VCM)trough concentration(SVTC)of 10–15 mg/L for regular infections and 15–20 mg/L for severe infections.However,clinical trials have shown that increasing SVTC is not beneficial for efficacy,and instead it leads to nephrotoxicity.To verify whether increasing the SVTC results in improved clinical outcomes with sustainable adverse effects,we prospectively determined its correlation with clinical efficacy and safety.The participants included patients hospitalized with Gram-positive bacterial infections from March 2017 through October 2018.The patients were classified into group I(SVTC<10 mg/L),II(10≤SVTC≤20 mg/L),or III(SVTC>20 mg/L).Clinical,microbiological,and laboratory data were collected.Clinical outcomes between group I and II were matched after propensity score matching(PSM).A total of 331 patients were included in this study.Clinical failure occurred in 59(29%)of 204 patients on day 14,with no significant difference between groups I and II(P=0.535).Infection recurred at 28 d in 62(30%)of 204 patients,and no significant difference in infection recurrence was observed between both the groups(log-rank,P=0.674).Except for a significant increase in the incidence of acute kidney injury in group II,no significant difference was observed between two groups for any clinical results.The incidence of adverse events in groups I and II was significantly lower than that in group III(P<0.001).SVTC had an applicable cut-off point at 14.55 mg/L.SVTC was not correlated with VCM clinical efficacy,while it was a good indicator of nephrotoxicity.展开更多
文摘This paper discusses a neglected theme in Wittgenstein＇s writings on meaning and psychology from the early 1930s until 1949. Throughout this period Wittgenstein deals with aspects of meaning of words and pictures that cannot be accounted for in dispositional terms but have to be related to experience and perception. Wittgenstein＇s reading of William James, I argue, has sharpened his eye for the many pitfalls in coming to terms with this experiential notion of meaning. James＇s treatment of experiences of meaning succumbs to the temptation to postulate ~~meaning-bodies,＂ bearers of meaning apart from the way and context in which we use the particular words. I argue that the conflation of what Wittgenstein calls the transitive and intransitive use of words is at the root of postulating meaning-bodies. I also argue that contemporary treatments of experiences of meaning are similarly vulnerable to James＇s confusion.
基金Fujian Medical Innovation Project(Grant No.2017-CX-31)Guidance Project of Fujian Science and Technology Department(Grant No.2017Y0033).
文摘Clinical guidelines recommend a steady-state vancomycin(VCM)trough concentration(SVTC)of 10–15 mg/L for regular infections and 15–20 mg/L for severe infections.However,clinical trials have shown that increasing SVTC is not beneficial for efficacy,and instead it leads to nephrotoxicity.To verify whether increasing the SVTC results in improved clinical outcomes with sustainable adverse effects,we prospectively determined its correlation with clinical efficacy and safety.The participants included patients hospitalized with Gram-positive bacterial infections from March 2017 through October 2018.The patients were classified into group I(SVTC<10 mg/L),II(10≤SVTC≤20 mg/L),or III(SVTC>20 mg/L).Clinical,microbiological,and laboratory data were collected.Clinical outcomes between group I and II were matched after propensity score matching(PSM).A total of 331 patients were included in this study.Clinical failure occurred in 59(29%)of 204 patients on day 14,with no significant difference between groups I and II(P=0.535).Infection recurred at 28 d in 62(30%)of 204 patients,and no significant difference in infection recurrence was observed between both the groups(log-rank,P=0.674).Except for a significant increase in the incidence of acute kidney injury in group II,no significant difference was observed between two groups for any clinical results.The incidence of adverse events in groups I and II was significantly lower than that in group III(P<0.001).SVTC had an applicable cut-off point at 14.55 mg/L.SVTC was not correlated with VCM clinical efficacy,while it was a good indicator of nephrotoxicity.
