三阴性乳腺癌(TNBC)因其侵袭性、有限的治疗选择和与其他乳腺癌亚型相比更差的预后,在肿瘤学中带来了重大挑战。这篇全面的综述探讨了TNBC的治疗和诊断前景,重点介绍了当前的策略、新兴疗法和未来方向。精准医疗方法为基于肿瘤生物学的...三阴性乳腺癌(TNBC)因其侵袭性、有限的治疗选择和与其他乳腺癌亚型相比更差的预后,在肿瘤学中带来了重大挑战。这篇全面的综述探讨了TNBC的治疗和诊断前景,重点介绍了当前的策略、新兴疗法和未来方向。精准医疗方法为基于肿瘤生物学的定制治疗提供了机会,但多组学数据的整合和临床实施带来了挑战,需要创新的解决方案。尽管存在这些挑战,但正在进行的研究工作和合作计划为改善TNBC的结果和推进治疗策略带来了希望。通过解决TNBC生物学的复杂性并开发有效的治疗方法,可以实现个性化治疗,最终改善TNBC患者的生活。持续的研究、临床试验和跨学科合作对于实现这一愿景和在TNBC管理方面取得有意义的进展至关重要。Triple-negative breast cancer (TNBC) poses a major challenge in oncology because of its invasiveness, limited treatment options and worse prognosis compared with other breast cancer subtypes. This comprehensive review explores the therapeutic and diagnostic prospects of TNBC, with a focus on current strategies, emerging therapies, and future directions. Precision medical methods provide opportunities for customized treatments based on tumor biology, but the integration of multi-omics data and clinical implementation pose challenges that require innovative solutions. Despite these challenges, ongoing research and collaborative plans bring hope for improving the outcomes of TNBC and advancing treatment strategies. By addressing the complexity of TNBC biology and developing effective treatment methods, personalized treatment can be achieved, ultimately improving the lives of TNBC patients. Continuous research, clinical trials, and interdisciplinary collaboration are crucial for achieving this vision and making meaningful progress in TNBC management.展开更多
文摘三阴性乳腺癌(TNBC)因其侵袭性、有限的治疗选择和与其他乳腺癌亚型相比更差的预后,在肿瘤学中带来了重大挑战。这篇全面的综述探讨了TNBC的治疗和诊断前景,重点介绍了当前的策略、新兴疗法和未来方向。精准医疗方法为基于肿瘤生物学的定制治疗提供了机会,但多组学数据的整合和临床实施带来了挑战,需要创新的解决方案。尽管存在这些挑战,但正在进行的研究工作和合作计划为改善TNBC的结果和推进治疗策略带来了希望。通过解决TNBC生物学的复杂性并开发有效的治疗方法,可以实现个性化治疗,最终改善TNBC患者的生活。持续的研究、临床试验和跨学科合作对于实现这一愿景和在TNBC管理方面取得有意义的进展至关重要。Triple-negative breast cancer (TNBC) poses a major challenge in oncology because of its invasiveness, limited treatment options and worse prognosis compared with other breast cancer subtypes. This comprehensive review explores the therapeutic and diagnostic prospects of TNBC, with a focus on current strategies, emerging therapies, and future directions. Precision medical methods provide opportunities for customized treatments based on tumor biology, but the integration of multi-omics data and clinical implementation pose challenges that require innovative solutions. Despite these challenges, ongoing research and collaborative plans bring hope for improving the outcomes of TNBC and advancing treatment strategies. By addressing the complexity of TNBC biology and developing effective treatment methods, personalized treatment can be achieved, ultimately improving the lives of TNBC patients. Continuous research, clinical trials, and interdisciplinary collaboration are crucial for achieving this vision and making meaningful progress in TNBC management.
