云克联合锶-89治疗乳腺癌骨痛及骨质疏松的疗效评价

目的探讨云克(99锝亚甲基二磷酸盐注射液,99Tc-MDP)联合锶-89治疗乳腺癌,骨质疏松及骨痛的临床效果。方法乳腺癌患者常规激素治疗5年后,应用骨密度测定及骨显像检查确诊为骨质疏松骨痛患者51例;使用云克联合锶-89治疗,同时加用钙剂和活性维生素D3,观察患者的症状、体征及治疗效果。结果经过云克联合锶-89治疗后总有效率为88.2%。结论云克联合锶-89能有效改善乳腺癌激素治疗后的骨质疏松及骨痛的临床症状,且副反应少。

治疗青少年Graves甲亢520例疗效观察

目的:探讨^(131)I治疗青少年Graves甲亢的疗效。方法:对采用^(131)I治疗的520例青少年Graves甲亢患者进行1～20年随访。结果:^(131)I治疗后6个月,治愈384例,好转110例,亚临床甲减18例,临床甲减4例。^(131)I治疗2次者70例。对^(131)I治疗后未达到治疗目的及亚临床和临床甲减采用中西药治疗,均恢复正常。经长期随访未发现生长发育及智力异常、甲状腺癌和白血病等。结论:青少年Graves甲亢患者治疗效果与成人相同,对长期服用中西药物治疗效果不佳者,采取以^(131)I治疗为主的综合治疗是安全有效的。发生甲减是暂时性的,经中西药物治疗一个时期基本恢复正常。至随访结束,晚发甲减发生率为0.76%。

非小细胞肺癌免疫治疗的影像学研究进展

非小细胞肺癌(NSCLC)免疫治疗是近年来的研究热点,传统的影像技术主要从宏观层面对肿瘤进行监测,已经无法完全满足临床诊断与治疗的需求。影像组学能从分子层面挖掘肿瘤生物学特性,为患者免疫治疗的疗效评价及预后预测提供了新的方法。笔者围绕影像学预测NSCLC免疫检查点标志物及疗效和预后进行综述。

第15届美国神经肿瘤会议简介

600余篇,本次会议包括教育日(Educational Day)、专题讲座(Lecture)、青年研究者圆桌会议(Young Investigator Roundtables)、墙报(Poster)及国际委员会议(International Committee Meeting)等部分。

胰腺癌影像学进展与思考

胰腺癌(PC)的发病率、病死率均在上升,但治疗效果几乎无改善,相关病死率接近其发生率。MSCT和高场磁共振已成为PC诊断的主要手段,并有一定贡献。随着肿瘤综合治疗理念的普及,多学科协作(MDT)优势整合,个体化诊疗日趋规范,新辅助治疗效果喜人,胰腺癌在治疗前后的影像评估也面临诸多机遇和挑战。本文就胰腺癌CT、MRI诊断的现状做一综述,旨在促进同行关注并协力研究,突破现有困境,最终改善患者预后。

中华医学会放射学分会第八届全国乳腺影像学术会议征文通知

中华医学会放射学分会第八届全国乳腺影像学术会议将于2017年7月21-23日在辽宁省大连市棒棰岛宾馆召开。本次会议主题为乳腺影像技术及诊断规范化和乳腺影像最新进展。届时将邀请国内外著名乳腺影像学界专家做专题讲座,同时就国际、国内乳腺影像学技术的最新进展进行广泛交流。参会者将获得国家继续医学教育Ⅰ类学分6分。1.征文内容乳腺各种影像学检查技术规范化;乳腺各种影像学诊断规范化;乳腺影像技术及诊断最新进展等。

2016年《肿瘤代谢与营养电子杂志》第3卷第2期主要内容预告

肿瘤生酮疗法终末期患者营养治疗临床路径营养治疗疗效评价与随访肿瘤溶解综合征肿瘤代谢与营养治疗科建设基本要求肿瘤细胞为什么选择有氧糖酵解?肿瘤患者身体组分的影像学评估和临床应用瘦体组织的维持与调控特别声明:本预告内容为杂志下一期的约稿内容,由于多种原因,最后的实际内容可能与预告内容有一些不同不便之处敬请谅解,请以杂志实际刊登内容为准。

Value of MR perfusion imaging after intervention treatment of hepatic cancer

Objective： To investigate the value of MR perfusion imaging in evaluating the curative effect of intervention treatment of hepatic cancer. Methods： 36 patients underwent MR perfusion imaging after intervention treatment. The quantization results were differed between carcinoma residue and benign tissue. And the diagnosis accuracy was judged, Results： There was a significant difference in mean MSI between residue tumor after surgery and the benign enhancement area. The timeintension curve of residue tumor was observed to ascend rapidly to reach the peak, whereas that of the enhancement tissue ascended slowly to reach the peak. The sensitivity and specificity of PWl on detection of residuary or recurrent tumor were 0.89 and 0.73 respectively. Conclusion： PWl is a very sensitive imaging technique that can be used to distinguish liver tissue condition after surgery. PWI contributed to early stage diagnosis and dynamic monitoring following HCC surgery.

Evaluation of cilazapril in vasovagal syncope treatment

Objective: to evaluate cilazapril in vasovagal syncope treatment. Method: eighty\|six cases of VVS patients found positive in TTT tilt were medicated with 2.5 mg cilazapril daily for three months and followed up by TTT. Results: seven cases quit due to cough or unexplained reason; 79 VVS patients had no more fainting spells; 75.95% of TTT results of patients changed to negative after 3 months therapy. The before and after cilazapril treatment average blood pressures (taken in lying position) were 121/73 mm Hg (1 mm Hg= 0.133kPa) and 120/76 mm Hg respectively ( P > 0.05); and mean heart rates were 68.63±12.37/min and 70.13±13.15/min respectively with no significant changes ( P > 0.05). Conclusion: Cilazapril was effective in treatment of VVS; did not affect normal blood pressure and heart rate; was safe; and had little side effect.

The value of radionuclide bone imaging on monitoring chemotherapeutic effects of multiple myeloma

Objective： To investigate the value of radionuclide whole-body bone imaging on monitoring chemotherapeutic ~ffects for multiple myeloma （MM）. Methods： Sixty patients were included. Twenty nine cases received CTD （thalidomide 100-200 rag/d; cyclophosphamide 200-300 mg/m2od, 1-4 days, every 4 weeks; and dexamethasone 20-40 rag/d, 1-4 days, every 4 weeks）; Thirty cases received VAD （vincristine 0.4 mg/d, 1-4 days, every 4 weeks; adriamycin 10 mg/d, 1-4 days, every 4 weeks; dexamethasone 40 rag/d, 1-4 days, every 4 weeks）. Radionuclide bone imagings were performed in all patients before chemotherapy, six months, twelve months and eighteen months after chemotherapy. The correlation of chemothera- peutic effects between CTD and VAD were analyzed. Results： One hundred and seventy nine bone lesions were visualized by bone scintigraphy before CTD treatment. Eighteen months after CTD chemotherapy, it was observed by bone scintigraphy that 39/179 （21.78%） lesions disappeared, 112/179 （62.57%） improved, and 281179 （15.64%） had no change. One hundred and ninety one bone lesions were showed by bone imaging before VAD treatment, 361191 （18.84%） lesions disappeared, eighteen months after chemotherapy, 103/191 （53.92%） improved, and 52/191 （27.22%） had no change. The significant dif- ference was observed in locations of MM induced bone lesions treated with CTD （H = 8.23, P 〈 0.05） and VAD （H = 11.18, P 〈 0.05）. A significant chemotherapeutic sensitivity in detecting MM induced lesions in ribs was found compared with other bone lesions. The chemotherapeutic effect of CTD was statistically significant than that of VAD （U = 2.17, P 〈 0.05）. Conclusion： Radionuclide whole-body bone imaging has great value in monitoring chemotherapeutic effects for MM.

Clinical Analysis of 30 Cases of Deep Lamellar Keratoplasty for the Treatment of Corneal Disease

purpose： to analyze clinical therapeutic effect of deep lamellar keratoplasty on treatment of corneal disease. Method： select 30 cases of corneal disease patients with a total of sick eyes, from 2012 January to 2013 January; all patients underwent deep lamellar keratoplasty, then observe and analyze visual acuity, corneal and occurrence of complications, to comprehensively assess the clinical therapeutic effect. Result： after receiving treatment of deep lamellar keratoplasty, of the 30 patients and 40 eyes, 31 corneal grafts are transparent; 9 corneal grafts are translucent; postoperative visual acuity： I0 eyes are 0.01-0.04; 13 eyes are 0.05~0.1; 14 eyes are 0.1-0.4; 3 eyes are above 0.5; 10 eyes have descemet micro-perforation or small perforation; 7 eyes have complications; these conditions are all controlled after active treatment. Conclusion： for patients with corneal disease, deep lamellar keratoplasty can not only achieve the similar transparency and visual rehabilitation as penetrating keratoplasty, but also reduce the incidence of adverse reactions and reject reaction after operation, to achieve the purpose of treatment and vision improvement; it has significant clinical effect, and greatly improve the quality of patients＇ life, so it is worthy of clinical application.

TAS-102可显著改善转移性结直肠癌患者生存

来自Dana-Farber癌症研究所的Mayer博士等发表在5月14日的《新英格兰医学》杂志上的研究显示,曲氟胸苷(TAS-102)可显著提高转移性结直肠癌患者生存。先前日本的RECOURSE研究显示,口服药核苷类抗肿瘤药物TAS-102(由曲三氟胸苷和盐酸硫脲嘧啶组成)用于不可切除的转移性结直肠癌日本患者表现出良好的生存优势。研究者在全球范围内开展了一项双盲、III期随机对照研究用以评估TAS-102的疗效和安全性。

Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study

OBJECTIVE: To evaluate the self-efficacy and satisfaction of asthma patients subjected to summer acupoint application treatment(SAAT).METHODS: A two-year follow-up clinical study was conducted. Patients with asthma were treated by applying a herbal paste onto the Feishu(BL 13) and Fengmen(BL 12) acupoints on the three hottest days of summer, according to the traditional Chinese calendar, from 2008 to 2010. During a two-year follow-up, these patients were asked tofill out a questionnaire evaluating asthma degree,exacerbation frequency, concomitant medications and self-satisfaction. The self-rate and doctor-report outcomes obtained in parallel were evaluated to assess the efficacy of SAAT.RESULTS: A total of 527 asthma patients were initially enrolled in this study, of which 97 elderly patients and those with more severe cases of asthma were lost to follow-up. Thus, a total of 430 patients were valid for analysis using self-rate data. Nevertheless, occasional negative returns were obtained;almost all of the outcomes were rated as "No change", "Moderate effective", or "Very effective". In addition, 80% of the patients were satisfied with this treatment. Moreover, 391(91.4%) patients were somewhat improved after SAAT in 2009, and further improvement was observed in 2010. After SAAT, the average asthma-degree score decreased from 5.3 in 2008 to 4 in 2009 and, subsequently to3.5 in 2010.CONCLUSION: With pronounced patient satisfaction, SAAT can reduce the exacerbation severity and frequency, concomitant medications and asthma degree. Prolonging the treatment course might enhance the efficacy of SAAT.

Therapeutic evaluation of lumbar tender point deep massage for chronic non-specific low back pain

OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intensity as indices.METHODS:We randomly divided 64 patients into a treatment group(32 cases) and a control group(32 cases).Two drop-outs occurred in each group.Patients in the treatment group received tender point deep tissue massage plus lumbar traction and patients in the control group received lumbar traction,alone.We used a tissue hardness meter/algometer and visual analog scale(VAS) to assess the pressure pain threshold,muscle hardness and pain intensity.RESULTS:Following treatment,we obtained the following results in the treatment and control groups,respectively:the pressure pain threshold difference was 1.5±0.8 and 1.1±0.7;the muscle hardness difference was 4.2±1.6 and 3.5±1.3;and the VAS score difference was 1.9±0.9 and 1.4±0.8.Compared to the control group,the treatment group had higher pressure pain threshold(t=2.09,P<0.05),and lower muscle hardness(t=2.05,P<0.05) and pain intensity(t=2.46,P<0.05).CONCLUSION:Lumbar tender point deep tissue massage combined with lumbar traction produced better improvement in pressure pain threshold,muscle hardness and pain intensity in patients with chronic non-specific low back pain than with lumbar traction alone.

Efficacy and safety of Traditional Chinese Medicine for the treatment of acquired immunodeficiency syndrome:a systematic review

OBJECTIVE:To systematically review the efficacy and safety ofTraditional Chinese Medicine(TCM)interventions,compared with control interventions(placebo or conventional Western medical therapy),in the treatment of acquired immunodeficiency syndrome(AIDS).METHODS:Electronic databases including PubMed,the Cochrane Library,China National Knowledge Infrastructure(CNKI),and Wanfang Data were searched to identify relevant randomized controlled trials(RCTs)published as of May 2012.Studies were selected according to the specified inclusion and exclusion criteria and then subjected to methodological quality assessment,data extraction,and meta-analysis according to the Cochrane Handbook for Systematic Reviews of Interventions.RESULTS:Twelve RCTs involving 881 patients with AIDS were included.Methodological quality assessment showed that two were high-quality,two were moderate-quality,and eight were low-quality.Meta-analysis showed that TCM interventions were associated with significantly reduced plasma viral load compared with placebo[odds ratio OR=2.46,95%confidence interval CI(1.02,5.94);P=0.04].However,the reductions in plasma viral load significantly favored conventional Western medical therapy alone over integrated traditional Chinese and Western medical therapy[OR=0.16,95%CI(0.05,0.55);P=0.004].Patients receiving TCM interventions had significantly higher CD4+T lymphocyte counts compared with those on placebo[OR=2.54,95%CI(1.40,4.60);P=0.002].In addition,TCM interventions were significantly more likely to have improved clinical symptoms[OR=2.82,95%CI(1.85,4.31);P<0.00001].TCM interventions conferred a similar risk of adverse events(AEs)compared with control interventions[OR=1.87,95%CI(0.58,6.01);P=0.29].CONCLUSION:Current evidence suggests that TCM interventions are significantly more effective than placebo in reducing plasma viral load and increasing CD4+T lymphocyte count in patients with AIDS.When compared with conventional Western medical therapy,TCM interventions were significantly less effective in reducing plasma viral load,although they were associated with a higher percentage of patients with improved symptoms.Patients receiving TCM interventions did not seem to be at an increased risk of AEs.

Clinical Research Progress of Acupuncture-moxibustion for Chronic Urticaria

To learn the current research status of acupuncture-moxibustion in treating chronic urticaria, the relevant clinical reports indexed by CNKI and VlP databases during 2000 and 2012 were retrieved, and then summarized and analyzed from the aspects of treatment method, acupoint selection, medicine, treatment frequency, and criteria of therapeutic efficacy, for guiding the treatment of chronic urticaria with acupuncture-moxibustion. The results show that acupuncture-moxibustion therapy has stable therapeutic efficacy in treating chronic urticaria with low adverse reaction rate, but the current evaluation criteria are too subiective to cluantifv.

Safety and efficacy of Danqipiantan capsule for treatment of stroke: a systematic review

OBJECTIVE： To evaluate the efficacy and safety of Danqipiantan capsule （DPC） for the treatment of stroke. METHODS： PubMed, China Science And Technolo- gy Journal Database, Wanfang Database, Chinese periodicals in the China National Knowledge Infra- structure, and the General Hospital of Tianjin Medi- cal University＇s Library were searched until July 2012. Randomized controlled trials （RCTs） and ob- servational studies that reported the use of DPC for treatment of stroke were selected. RESULTS： Eleven articles that included 12 RCTs, and 2 articles that included 3 observational studies were identified. A total of 2590 patients participat- ed in the studies. We found that there was a signifi-cant statistical difference between DPC treatment groups and the control groups in terms of the effec- tive rate [risk ratio （RR）, 1.14; 95% confidence inter- vals （CI）, 1.04, 1.25; P=0.01], FugI-Meyer Assessment Scale [weighted mean difference （WMD）, 9.77; 95% CI （4.84, 14.70）; P=0.00], Barthel Index [WMD=6.40; 95% CI （3.15, 9.65）], and mean flow velocity [WMD= 5.79; 95% CI （1.64, 9.94）]. There were no significant differences for The National Institutes of Health Stroke Scale [WMD=0.60; 95% CI （ - 1.09, 2.29）], vi- sual field defects [left visual field： WMD= - 203.10; 95% CI （ - 424.41, 18.21）; right visual field： WMD= - 172.60; 95% CI （ - 409.29, 64.09）] or the functional independence measure [WMD= - 7.90; 95% CI （ - 16.64, 0.84）]. Seven articles that included eight RCTs reported the safety of DPC treatment. Two ar- ticles that included three observational studies also reported beneficial effects for DPC. Because the Chinese studies were of poor methodological quali- ty, and most of the sample sizes were small, our analysis was likely affected by bias. CONCLUSION： DPC has a beneficial effect and is relatively safe when used for the treatment of stroke.

Economic Evaluation of Treating Herpes Zoster with Various Methods of Acupuncture and Moxibustion

OBJECTIVE:To analyze the cost effect of surrounding acupuncture plus electric acupuncture,cotton-sheet moxibustion,puncturing with red-hot needles,tapping plus cupping on herpes zoster.METHODS:Five hundred patients with herpes zoster were randomly divided into group A(surrounding acupuncture plus electric acupuncture),group B(cotton-sheet moxibustion),group C(puncturing with red-hot needles),group D(tapping plus cupping),and group E(Western medicine).The treatment was carried out twice a day in group E and once a day in the other four groups.The curative effect was observed on the 10th day of treatment;the cost was calculated for the five therapies,and the cost-effect ratio(C/E) and increment ratio(△ C/△ E) were analyzed.RESULTS:After the 10-day treatment,there was no statistical difference(P>0.05) in the curative effect among the five groups.Pain being alleviated one day faster than in group E amounted to a saving of RMB 21.90 yuan in group A,a saving of RMB 21.87 yuan in group B,a saving of RMB 26.00 yuan in group C,and a saving of RMB 20.23 yuan in group D.Compared with group C,the values of △ C/△ E were RMB 1.55,2.81,and 0.21 yuan in groups A,B,and D,respectively.CONCLUSIONS:The curative effect in groups A,B,C,and D was similar to that in group E,but the C/E was better than in group E.

Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis

Objective： To observe the effectiveness and safety of a therapy combining disease with syndrome on rheumatoid arthritis. Methods： Eighty patients with rheumatoid arthritis belonging to syndrome of damp-heat obstruction were randomly divided into a treatment group and a control group according to stratified blocked randomization method.Forty cases in the control group orally took Loxoprofen Sodium Tablet and Leifumite Tablet and the other 40 cases in the treatment group orally took a Chinese medicine for 12 weeks as a course of treatment. ACR therapeutic effect was used as the standard for evaluating the total therapeutic effect. Results： After l 2 weeks of treatment, there was a statistical difference （P〈0.01） in the improvement of VAS score, morning stiffness time, number of swelling joints, index of swelling joints, number of joints with tenderness, index of joints with tenderness, average grip strength of both hands, DSA28 score, HAQ, patient＇s assessment, physician＇s assessment, ESR, CRP and RF in both groups. The improvement of morning stiffness time, number of swelling joints, index of swelling joints, grip strength, HAQ and patient＇s assessment in the treatment group was much better than that in the control groups with statistical difference （P〈0.05）. ACR20, ACR50 and ACR70 was 27.5% （11/40）, 37.5% （15/40） and 22.5% （9/40） respectively in the treatment group and 40% （16/40）, 27.5% （11/42） and 10.0% （4/40） respectively in the control group with statistical difference （P〈0.05） in the superiority of the treatment group over the control group. The incidence of adverse reaction in the control group was higher than that in the treatment group （P〈0.05）. Conclusion： Definite therapeutic effect and high safety can be achieved in using the therapy combining disease with syndrome to treat rheumatoid arthritis belonging to syndrome of damp-heat obstruction.

The Qi-regulating Massotherapy for Treatment of Tonic Headache in 150 Cases

Objective: To observe the therapeutic effects of the qi-regulating massotherapy (通脉调气推拿法) for treatment of tonic headache. Methods: According to different clinical types, 150 cases of tonic headache were treated by the qi-regulating massotherapy. Evaluations were done according to the scores for physiology, behavior, intensity of pain, and the therapeutic effects. Results: After treatment, the total score in the 150 cases significantly decreased as compared with that before treatment (P<0.01). The total effective rate was 93.3%, and the effective rates for all the types were over 90%. Conclusion: The qi-regulating massotherapy is indicated for all types of tonic headache with obvious therapeutic effects.