Aim: To describe the management practices of newly diagnosed childhood idiopathic thrombocytopenic purpura (ITP) in the Nordic countries. Methods: A prospective registration was done from 1998 to 2000, including all c...Aim: To describe the management practices of newly diagnosed childhood idiopathic thrombocytopenic purpura (ITP) in the Nordic countries. Methods: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 years. Results: 506 children from 98 departments were registered.A diagnostic bone marrow aspiration was obtained within 14 days in 33%. Platelet and/or red blood cell transfusion was given in 11%. 287 children (57%) received platelet-enhancing therapy with intravenous immune globulin (IVIG) or corticosteroids within 14 days of diagnosis, IVIG being the first line choice in over 90%of the cases. There were noticeable national differences in the management. The decision to start drug treatment within two days of diagnosis was influenced mainly by the platelet count. Neither early treatment nor response to treatment changed the risk of chronic disease. Conclusion: This study has shown a great variation in the management practices of children with newly diagnosed ITP. Prospective studies are required to produce evidence-based recommendations for this patient group.展开更多
1文献来源Planchard D,Jänne PA,Cheng Y,et al.Osimertinib with or without chemotherapy in EGFR⁃mutated advanced NSCLC[J].N Engl J Med,2023,389(21):1935-1948.2证据水平1b。
2023年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)年会于2023年10月20日~24日在西班牙马德里隆重召开。本次大会报道多项食管癌领域的最新前沿研究。本文将从食管癌围手术期治疗和晚期食管癌药物治疗方面整理并解...2023年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)年会于2023年10月20日~24日在西班牙马德里隆重召开。本次大会报道多项食管癌领域的最新前沿研究。本文将从食管癌围手术期治疗和晚期食管癌药物治疗方面整理并解读此次会议中食管癌的重要进展。展开更多
文摘Aim: To describe the management practices of newly diagnosed childhood idiopathic thrombocytopenic purpura (ITP) in the Nordic countries. Methods: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 years. Results: 506 children from 98 departments were registered.A diagnostic bone marrow aspiration was obtained within 14 days in 33%. Platelet and/or red blood cell transfusion was given in 11%. 287 children (57%) received platelet-enhancing therapy with intravenous immune globulin (IVIG) or corticosteroids within 14 days of diagnosis, IVIG being the first line choice in over 90%of the cases. There were noticeable national differences in the management. The decision to start drug treatment within two days of diagnosis was influenced mainly by the platelet count. Neither early treatment nor response to treatment changed the risk of chronic disease. Conclusion: This study has shown a great variation in the management practices of children with newly diagnosed ITP. Prospective studies are required to produce evidence-based recommendations for this patient group.
文摘1文献来源Planchard D,Jänne PA,Cheng Y,et al.Osimertinib with or without chemotherapy in EGFR⁃mutated advanced NSCLC[J].N Engl J Med,2023,389(21):1935-1948.2证据水平1b。
文摘2023年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)年会于2023年10月20日~24日在西班牙马德里隆重召开。本次大会报道多项食管癌领域的最新前沿研究。本文将从食管癌围手术期治疗和晚期食管癌药物治疗方面整理并解读此次会议中食管癌的重要进展。
