Objective: To describe the visual field defects in retinobl- astoma survivors and relate those defects to characteristics such as tumor siz e, tumor location, and treatment modality. Methods: Thirty-one patients treat...Objective: To describe the visual field defects in retinobl- astoma survivors and relate those defects to characteristics such as tumor siz e, tumor location, and treatment modality. Methods: Thirty-one patients treated for retinoblastoma were included in this study. Humphrey visual fields were det ermined in 33 eyes. Results: Twenty-seven patients (29 eyes, 68 tumors) had suf ficient diagnosis and treatment data available for further analysis. Twenty-six of the 27 patients had both absolute and relative visual field defects. Four ty pes of visual field defects were observed and correlated with location of the tu mor and therapy to the individual tumors: (1) no residual defect, (2) absolute s cotoma, (3) arcuate and sector scotoma, and (4) "pseudo"-visual field defects caused by relative enophthalmos resulting from radiation. Conclusions: Patients with retinoblastoma demonstrate a variety of long-term visual field defects af ter treatment for their intraocular disease. Characteristics that determine the size and type of defects are tumor size, tumor location, and treatment method.展开更多
Background: Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate fr om Western countries. There is only one report from Africa...Background: Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate fr om Western countries. There is only one report from Africa, conducted in Dakar i n 1979. The aim of our study was to provide information about this condition in our country. Patients and methods: Our study was retrospective, dealing with 80 erythrodermic adults, examined between January 1981 and December 2000. Patient i nformation included clinical, laboratory, histopathologic and therapeutic data. We also noted patientsoutcomes within an average follow-up period of 30 month s. Thus,we calculated the mortality rate and estimated the probability of surviv al without relapses according to the Kaplan-Meier method. Results: The frequenc y of erythroderma in our dermatology department was 0.3%. The sex ratio (male/f emale) was 2.2. The average age of our patients was 53.78 ±18 years. Previous h istory of skin disease was found in 49/80 patients (61.2%) and 32 of them were suffering from psoriasis. Hyperthermia was significantly associated with drug re actions (P=0.013). Hypereosinophilia was not a specific finding. The mortality r ate was higher than that of an age-matched population. Conclusion: Adult erythr oderma is a rare condition. Its most common cause in our study was psoriasis. No cases of atopic dermatitis were found. Prognosis was adversely affected by the presence of erythroderma.展开更多
Objective(s): Description of mothers “ characteristics, obstetricians” practices, and PPROM-linked mortality in all 81 maternity hospitals in the Rhone-Alpes Region, over a period of 2 years. Study design: Prospecti...Objective(s): Description of mothers “ characteristics, obstetricians” practices, and PPROM-linked mortality in all 81 maternity hospitals in the Rhone-Alpes Region, over a period of 2 years. Study design: Prospective cohort study of 598 women with PPROM between 24 and 34 weeks’gestation, leading to 680 births. At time of PPROM, collection of mothers’ socioeconomic characteristics, medical and obstetric histories and PPROM circumstances. Collection of perinatal management, neonates’ medical status and postnatal referral. Results: The birth rate after PPROM between 24 and 34 weeks’ gestation was 0.47% (95% CI: 0.42- 0.48). Sixty percent of PPROM occurred before 32 weeks’ gestation and 98% of births before 37 weeks. The incidence of previous PPROM was 14.3% . Antibiotics, corticosteroids, and tocolytics were given to 82, 78, and 52% of women, respectively. The rate of antibiotics and antenatal corticosteroids varied with gestational age (lower rates for antibiotics just after the limit of viability (23- 24 weeks) and after 32 weeks, higher rates of corticosteroids between 26 and 30 weeks). The PPROM- birth interval became shorter as gestation advanced. The incidence of C- section was 58.7% (n = 270), C- section before labour being the most frequent mode of delivery. Sixty-seven percent of neonates were born in Level- 3 hospitals. The overall neonatal mortality rate at 28 days decreased with gestational age at PPROM, and was 17.2% (16/93), 3% (6/200), and 0.41% (1/241) at 24- 27, 28- 31 and 32- 33 weeks of PPROM, respectively. Conclusion(s): After PPROM, antibiotics and antenatal corticosteroids were widely used in our cohort, and C- section rates were elevated. With that up-to-date management, the perinatal mortality rate was less than 3% following PPROM after 28 weeks’ gestation.展开更多
文摘Objective: To describe the visual field defects in retinobl- astoma survivors and relate those defects to characteristics such as tumor siz e, tumor location, and treatment modality. Methods: Thirty-one patients treated for retinoblastoma were included in this study. Humphrey visual fields were det ermined in 33 eyes. Results: Twenty-seven patients (29 eyes, 68 tumors) had suf ficient diagnosis and treatment data available for further analysis. Twenty-six of the 27 patients had both absolute and relative visual field defects. Four ty pes of visual field defects were observed and correlated with location of the tu mor and therapy to the individual tumors: (1) no residual defect, (2) absolute s cotoma, (3) arcuate and sector scotoma, and (4) "pseudo"-visual field defects caused by relative enophthalmos resulting from radiation. Conclusions: Patients with retinoblastoma demonstrate a variety of long-term visual field defects af ter treatment for their intraocular disease. Characteristics that determine the size and type of defects are tumor size, tumor location, and treatment method.
文摘Background: Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate fr om Western countries. There is only one report from Africa, conducted in Dakar i n 1979. The aim of our study was to provide information about this condition in our country. Patients and methods: Our study was retrospective, dealing with 80 erythrodermic adults, examined between January 1981 and December 2000. Patient i nformation included clinical, laboratory, histopathologic and therapeutic data. We also noted patientsoutcomes within an average follow-up period of 30 month s. Thus,we calculated the mortality rate and estimated the probability of surviv al without relapses according to the Kaplan-Meier method. Results: The frequenc y of erythroderma in our dermatology department was 0.3%. The sex ratio (male/f emale) was 2.2. The average age of our patients was 53.78 ±18 years. Previous h istory of skin disease was found in 49/80 patients (61.2%) and 32 of them were suffering from psoriasis. Hyperthermia was significantly associated with drug re actions (P=0.013). Hypereosinophilia was not a specific finding. The mortality r ate was higher than that of an age-matched population. Conclusion: Adult erythr oderma is a rare condition. Its most common cause in our study was psoriasis. No cases of atopic dermatitis were found. Prognosis was adversely affected by the presence of erythroderma.
文摘Objective(s): Description of mothers “ characteristics, obstetricians” practices, and PPROM-linked mortality in all 81 maternity hospitals in the Rhone-Alpes Region, over a period of 2 years. Study design: Prospective cohort study of 598 women with PPROM between 24 and 34 weeks’gestation, leading to 680 births. At time of PPROM, collection of mothers’ socioeconomic characteristics, medical and obstetric histories and PPROM circumstances. Collection of perinatal management, neonates’ medical status and postnatal referral. Results: The birth rate after PPROM between 24 and 34 weeks’ gestation was 0.47% (95% CI: 0.42- 0.48). Sixty percent of PPROM occurred before 32 weeks’ gestation and 98% of births before 37 weeks. The incidence of previous PPROM was 14.3% . Antibiotics, corticosteroids, and tocolytics were given to 82, 78, and 52% of women, respectively. The rate of antibiotics and antenatal corticosteroids varied with gestational age (lower rates for antibiotics just after the limit of viability (23- 24 weeks) and after 32 weeks, higher rates of corticosteroids between 26 and 30 weeks). The PPROM- birth interval became shorter as gestation advanced. The incidence of C- section was 58.7% (n = 270), C- section before labour being the most frequent mode of delivery. Sixty-seven percent of neonates were born in Level- 3 hospitals. The overall neonatal mortality rate at 28 days decreased with gestational age at PPROM, and was 17.2% (16/93), 3% (6/200), and 0.41% (1/241) at 24- 27, 28- 31 and 32- 33 weeks of PPROM, respectively. Conclusion(s): After PPROM, antibiotics and antenatal corticosteroids were widely used in our cohort, and C- section rates were elevated. With that up-to-date management, the perinatal mortality rate was less than 3% following PPROM after 28 weeks’ gestation.
