中药治疡液对外伤性感染伤口作用的实验与临床研究

目的:观察中药治疡液在外伤性感染伤口的实验与临床研究。方法:选择外伤性感染伤口患者其中手80例、小腿45例、足背40例,随机分为治疗组与对照组,治疗组局外敷30 ml中药治疡液,而对照组采用呋喃西林30 ml湿敷治疗,观察治疗后创面的治愈率及有效率。另将中药治疡液在实验室进行抑菌环实验,动物实验则将感染小鼠随机分组,对照组给予呋喃西林液30 ml湿敷,治疗组给予治疡液30 ml湿敷,在治疗前和治疗后取伤口分泌物进行细菌培养,以观察中药治疡液杀菌抑菌、抗炎作用。结果:手部治疗组的总有效率为95.1%,治愈率为84.6%,对照组总有效率72.6%,治愈率37.2%;小腿部治疗组的有效率为94.3%,治愈率为85.7%,对照组的有效率为76.0%,治愈率为48%;足背部治疗组的总有效率为95.6%,治愈率为85.3%,对照组总有效率74.5%,治愈率34.1%。各部两组相比均有显著性差异(P<0.001),治疗组明显优于对照组。实验室检验结果表明中药治疡液对金黄色葡萄球菌有抑菌作用。动物实验结果显示中药治疡液有杀菌抑菌、抗炎的作用,对金黄色葡萄球菌有明显的抑菌作用。结论:中药治疡液具有清热解毒、祛腐生肌作用,能够促进外伤性创面的愈合,同时也有杀菌抑菌、抗炎的作用,对金黄色葡萄球菌有明显的抑菌作用。结果显示中药治疡液能清热解毒、活血化瘀、祛腐生肌,特别是对外伤性感染伤口创面有促进愈合作用,对局部炎症有明显的抗炎作用,从而提高了临床疗效。

治疡液治疗慢性溃疡35例疗效观察

目的:观察治疡液局部外敷创面治疗慢性溃疡的临床疗效。方法:选择慢性溃疡患者60例,随机分为2组。治疗组35例创面用生理盐水清洗后,局部外敷治疡液(组成:黄连、黄柏、黄芩、大黄、虎杖、连翘)。对照组25例创面用生理盐水清洗后,采用呋喃西林湿敷。结果:总有效率、治愈率治疗组分别为94.29%、85.71%,对照组分别为76.00%、48.00%,2组比较,差异均有非常显著性意义(P<0.01)。结论:治疡液具有清热解毒、祛腐生肌作用,能够促进慢性溃疡创面的愈合。

Epinephrine injection therapy versus a combination of epinepnrine injection and endoscopic hemoclip in the treatment of bleeding ulcers

AIM: To assess the efficacy of hemoclip application in combination with epinephrine injection in the treatment of bleeding peptic ulcers and to compare the clinical outcomes between patients treated with such a combination therapy and those treated with epinephrine injection alone.METHODS: A total of 293 patients (211 males, 82females) underwent endoscopic therapy for bleeding peptic ulcers. Of these, 202 patients (152 males, 50females) received epinephrine injection therapy while 91patients (59 males, 32 females) received combination therapy. The choice of endoscopic therapy was made by the endoscopist. Hemostatic rates, rebleeding rates, need for emergency surgery and 30-d mortality were the outcome measures studied.RESULTS: Patients who received combination therapy were significantly older (mean age 66±16 years, range24-90 years) and more suffered from chronic renal failure compared to those who received epinephrine injection therapy alone (mean age 61±17 years, range 21-89 years).Failure to achieve permanent hemostasis was 4% in the group who received epinephrine injection alone and 11%in the group who received combination therapy. When the differences in age and renal function between the two treatment groups were taken into account by multivariate analysis, the rates of initial hemostasis,rebleeding rates, need for surgery and 30-d mortality for both treatment options were not significantly different.CONCLUSION: Combination therapy of epinephrine injection with endoscopic hemoclip application is an effective method of achieving hemostasis in bleeding peptic ulcer diseases. However, superiority of combination therapy over epinephrine injection alone, could not be demonstrated.