OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodula...OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodulatory effects on transforming growth factor （TGF）-131 and procollagen type III peptide （PIIIP） were investigated. METHODS： Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy （Group A） and intravenous Xuebijing administra- tion plus conventional therapy （Group 13）. Twenty volunteers served as controls （Group C）. Blood sam- ples were collected upon admission （day O） and at post-treatment days 5, 10, and 14. TGF-β1 and PIIIP concentrations were determined by ELISA and ana- lyzed for intra- and inter-group differences over time. One-month follow-up was conducted for de- termining the mortality rate. RESULTS： TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time （Groups A and B vs C, P〈0.01）. However, the TGF-β1 and PIIIP levels were consistently significant- ly lower in Group B compared with those of Group A （P〈0.01）. The 1-month mortality rate was also lower in Group B compared with that of Group A （P〈0.05）. PQ poisoning patients showed remark- ably high levels of TGF-β1 and PIIIP, which increased as PQ-induced pulmonary fibrosis progressed. CONCLUSION： Treatment with intravenous Xuebi- jing plus conventional therapy significantly low- ered TGF-β1 and PIIIP levels, which indicates thera- peutic efficacy in the treatment of PQ poisoning pa- tients.展开更多
文摘OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodulatory effects on transforming growth factor （TGF）-131 and procollagen type III peptide （PIIIP） were investigated. METHODS： Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy （Group A） and intravenous Xuebijing administra- tion plus conventional therapy （Group 13）. Twenty volunteers served as controls （Group C）. Blood sam- ples were collected upon admission （day O） and at post-treatment days 5, 10, and 14. TGF-β1 and PIIIP concentrations were determined by ELISA and ana- lyzed for intra- and inter-group differences over time. One-month follow-up was conducted for de- termining the mortality rate. RESULTS： TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time （Groups A and B vs C, P〈0.01）. However, the TGF-β1 and PIIIP levels were consistently significant- ly lower in Group B compared with those of Group A （P〈0.01）. The 1-month mortality rate was also lower in Group B compared with that of Group A （P〈0.05）. PQ poisoning patients showed remark- ably high levels of TGF-β1 and PIIIP, which increased as PQ-induced pulmonary fibrosis progressed. CONCLUSION： Treatment with intravenous Xuebi- jing plus conventional therapy significantly low- ered TGF-β1 and PIIIP levels, which indicates thera- peutic efficacy in the treatment of PQ poisoning pa- tients.
