The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was inv...The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.展开更多
Coccophagus scutellaris (Dalman) is one of the specific parasitoids that attack soft scale insects in Egypt. In the present study, C. scutellaris was reared from 6 species of soft scale insects. These are Cero...Coccophagus scutellaris (Dalman) is one of the specific parasitoids that attack soft scale insects in Egypt. In the present study, C. scutellaris was reared from 6 species of soft scale insects. These are Ceroplastes floridensis Comstock, Coccus hesperidum L., Pulvinaria floccifera (Westwood), P. psidii Maskell, Saissetia coffeae (Walker) and S. oleae (Oliver).The abundance of C. scutellaris was monitored from July to Nov. 1999-2000 in five localities in Egypt, the Beni Suef, Cairo, Giza, Gharbiya and the Northern coast. C. scutellaris is considered an effective parasitoid of S. coffeae and S. oleae with maximum parasitism rates reaching 26% and 22% in Nov. and Aug. 1999, respectively.展开更多
基金supported by the Bill & Melinda Gates Foundation(Grant No.1024516)
文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.
文摘Coccophagus scutellaris (Dalman) is one of the specific parasitoids that attack soft scale insects in Egypt. In the present study, C. scutellaris was reared from 6 species of soft scale insects. These are Ceroplastes floridensis Comstock, Coccus hesperidum L., Pulvinaria floccifera (Westwood), P. psidii Maskell, Saissetia coffeae (Walker) and S. oleae (Oliver).The abundance of C. scutellaris was monitored from July to Nov. 1999-2000 in five localities in Egypt, the Beni Suef, Cairo, Giza, Gharbiya and the Northern coast. C. scutellaris is considered an effective parasitoid of S. coffeae and S. oleae with maximum parasitism rates reaching 26% and 22% in Nov. and Aug. 1999, respectively.
