Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the resul...Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.展开更多
Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis...Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.展开更多
基金supported by the National Natural Science Foundation of China (31123005)the Chinese Academy of Sciences (Y002731071)the National Basic Research Program of China (2009CB941300)
文摘Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.
文摘Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.
