期刊文献+
共找到82篇文章
< 1 2 5 >
每页显示 20 50 100
论税源联动管理的法制机理
1
作者 陈方淑 《政法学刊》 2009年第3期69-73,共5页
税源联动管理机制源于税收流失,是税收实践不断试炼的产物。税源联动管理机制有其独特的联动谱系——横向联动和纵向联动。信息不对称作为一种"客观存在",是税收征管实践的"常态",为征管过程中的税收风险提供了滋... 税源联动管理机制源于税收流失,是税收实践不断试炼的产物。税源联动管理机制有其独特的联动谱系——横向联动和纵向联动。信息不对称作为一种"客观存在",是税收征管实践的"常态",为征管过程中的税收风险提供了滋生的土壤。税源联动管理的法制机理在于:通过"税源联动"突破信息瓶颈,优化税收风险控制,从而实现税收征管方式的现代性嬗变。 展开更多
关键词 税源联动管理机制 联动谱系 法制机理
原文传递
Formation mechanism and criterion of linear segregation in ZL205A alloy 被引量:10
2
作者 王晔 吴士平 +3 位作者 薛祥 陈瑞润 张建兵 肖文峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第11期3632-3638,共7页
The experiments and numerical simulation were conducted for ZL205A aluminum alloy cylindrical shell casting. The formation mechanism of the linear segregation produced by the low pressure die casting (LPDC) process wa... The experiments and numerical simulation were conducted for ZL205A aluminum alloy cylindrical shell casting. The formation mechanism of the linear segregation produced by the low pressure die casting (LPDC) process was investigated. And the heat transfer of the casting during solidification process was analyzed by simulation technique, resulting from the information of linear segregation obtained by plenty of experiments. The new linear segregation criterion was proposed through the simulation and experimental results. It was found that the melting metal with high Cu contents was feeding the crack shrinkage formed by the tearing under the effect of feeding pressure during the later solidification, which led to the formation of linear segregation. The control methods for the linear segregation were suggested based on the proposed mechanism. Finally, the criterion of linear segregation was confirmed by the production of the actual castings. 展开更多
关键词 cylindrical shell casting linear segregation formation mechanism CRITERION control method
下载PDF
民营企业信用缺失问题的法律思考
3
作者 牛珊珊 钱富新 《现代商业》 2011年第6期162-162,共1页
民营企业诚信问题最突出的表现为企业信用缺失,这已严重阻碍了我国民营经济的健康发展。本文分析我国民营企业信用建设现状,在此基础上深刻剖析产生民营企业信用缺失的法律机理,最后提出了民营企业信用建设的法律对策。
关键词 民营企业 信用缺失 法制机理 法律措施
下载PDF
Replication-selective Oncolytic Adenovirus CNHK300 in the Treatment of Breast Cancer Cell Lines in vitro
4
作者 李月敏 宋三泰 +3 位作者 江泽飞 徐建明 张琪 钱其军 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第6期334-337,共4页
Objective: To evaluate the tumor selectivity and therapeutic efficiency of replication-competent adenovirus CNHK300 on human breast cancer cells. Methods: RT-PCR was used to detect the hTERT mRNA activity in various... Objective: To evaluate the tumor selectivity and therapeutic efficiency of replication-competent adenovirus CNHK300 on human breast cancer cells. Methods: RT-PCR was used to detect the hTERT mRNA activity in various breast cancer and normal fibroblast cell lines. Virus proliferation assay, cell viability assay and Western blot were applied to evaluate the proliferation and cytolysis selectivity of CNHK300. Results: The telomerase activity of MCF-7, BT-549 and SK-BR-3 was positive, while telomerase in MRC-5 and BJ was negative. The progeny virus titers in MCF-7, BT-549 and SK-BR-3 after 48 h of CNHK300 exposure was 40 625, 1 265 and 20 000 fold higher than those of 0 h, even slightly higher than those of wtAd5 (except in SK-BR-3). ONYX-015 virus proliferation ability was weaker than that of CNHK300 in cancer cells. However, CNHK300 exhibited attenuated replicative ability as compared with wtAd5 in MRC-5 and BJ. The CNHK300 replicatative multiple was 63 and 192 fold at 48 h respectively, while the wtAd5 still multiplied 3 160-4 846 fold. CNHK300 could cause about half of breast cancer cells to die within 7 days at MOI 10 pfu/cell and below, whereas the IC50 in BJ and MRC-5 was as high as MOI 100 pfu/cell. CNHK300 E1A protein could be detected in breast cancer cells and 293 cells but not in normal fibroblast cells. Conclusion: hTERT promoter can successfully modulate the CNHK300 to be selectively replicated in breast cancer cells positive for telomerase, which may be a potential treatment strategy in breast cancer. 展开更多
关键词 gene therapy VIROTHERAPY replicative adenovirus breast cancer
下载PDF
Studies on the Mechanism of Arsenic Trioxide-Induced Apoptosis in HepG_2 Human Hepatocellular Carcinoma Cells
5
作者 李航宇 鞠培新 钟鑫平 《Chinese Journal of Clinical Oncology》 CSCD 2008年第1期22-25,共4页
OBJECTIVE To study the anti-tumor effect of arsenic trioxide on the HepG2 human hepatocellular carcinoma cell line, and to explore its mechanism of action. METHODS The MTT assay was used to determine the inhibitory ef... OBJECTIVE To study the anti-tumor effect of arsenic trioxide on the HepG2 human hepatocellular carcinoma cell line, and to explore its mechanism of action. METHODS The MTT assay was used to determine the inhibitory effect of As2O3 on HepG2 cells at various As2O3 concentrations. The expression of p-JNK, caspase-3 and PARP was detected by Western blots. RESULTS As2O3 markedly inhibited the growth of the HepG2 cells and induced apoptosis. The results of Western blot analysis showed that the As2O3-induced apoptosis was accompanied by caspase-3 and PARP activation. p-JNK was detected at 10 min following As2O3 treatment, and preceded to peak at 20 min, and decreased by 30 min. The total protein content did not obviously change. The activation of JNK occurred prior to cell apoptosis. SP600125, a JNK inhibitor, suppressed the As2O3-induced activation of caspase-3 and PARP cleavage. CONCLUSION As2O3 inhibits the proliferation of human HepG2 hepatocellular carcinoma cells by inducing apoptosis in vitro. As2O3-induced apoptosis is accessed through the caspase-3 pathway. The JNK signal-transduction pathway and caspase-3 are involved upstream in the As2O3 induced HepG2 apoptotic response. 展开更多
关键词 arsenic trioxide hepatic cancer MTT assay Western blot.
下载PDF
Efficacy Study on Six Antibiotic Methods for Treating Non-Gonococcal Urethritis and Cervicitis
6
作者 齐蔓莉 张楠 刘全忠 《Chinese Journal of Sexually Transmitted Infections》 2005年第1期46-49,共4页
Objective: To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods: Retrospective analysis of 878 nongonococcal urethritis ... Objective: To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods: Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results: The mean cure rate of six methods for Chlamydia trachamatis (Ct) was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum (Uu) was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion: The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study. 展开更多
关键词 Non-gonococcal urethritis / cervicitis Antibiotic TREATMENT
下载PDF
Therapeutic Effects of Stereotactic Radiotherapy on 389 Cases of Brain Glioma 被引量:1
7
作者 牛道立 何中 胡慧玲 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第4期221-224,共4页
Objective: To investigate the treatment effectiveness and side effects of stereotactic radiotherapy for brain glioma. Methods: From Jun. 1995 to Dec. 1998, 389 cases of brain gliomas were treated by stereotactic rad... Objective: To investigate the treatment effectiveness and side effects of stereotactic radiotherapy for brain glioma. Methods: From Jun. 1995 to Dec. 1998, 389 cases of brain gliomas were treated by stereotactic radiotherapy, among which 151 cases were treated by stereotactic radiosurgery (SRS) and the other 238 cases, by fractionated stereotactic radiotherapy (FSRT). In the SRS group, the marginal tumor dose was 20 to 30 Gy (median, 2.6 Gy). One to 6 isocenters (median, 2.48) and 5 to 21 irradiation arcs (median, 8.45) were applied. In the FSRT group, the per-fraction marginal tumor dose was 8 to 12 Gy with 1 to 6 isocenters (median, 2.53), 6 to 20 irradiation arcs (median, 8.25) and 2-5 fractions delivered everyday or every other day. Results: Three months after treatment, the complete and partial response rates were 13.9% and 45.7% in SRS group respectively. The stable disease rate was 17.2%. The total effective rate was 76.8%. In FSRT group, the complete and partial remission rates were 19.7% and 47.9% respectively. The stable disease rate was 20.6%. The total effective rate was 88.2%. The total effective rate of FSRT group was higher than that in SRS group (X^2=9.874, P=0.020). The 1-year, 3-year and 5-year survival rate of all patients was 54.3%, 29.3%, 16.5% respectively. The 1-year, 3-year and 5-year survival rate in SRS group and FSRT group was 52.3% vs 26.5%, 11.9% vs 55.5%, and 31.1 vs 19.3% respectively. There was no significant difference between the two groups (X^2=2.16, P=0.1417). The brain edema caused by the main radiation was more severe in the SRS group than in FSRT group (X^2=4.916, P=0.027). Conclusion: It is effective for brain glioma to be treated by stereotactic radiotherapy. Compared with SRS, the FSRT has the advantage of good effect and less side response. 展开更多
关键词 fractionated stereotactic radiotherapy stereotactic radiosurgery brain glioma PROGNOSIS
下载PDF
Local Recurrence of Low-Grade Myofibroblastic Sarcoma of the Chest Wall:Report of a Case and Literatures Review
8
作者 吴捷 陈奇勋 朱慧能 《Chinese Journal of Clinical Oncology》 CSCD 2008年第1期72-74,共3页
Myofibroblastic sarcoma, composed primarily of myofibroblast, is a rare malignant tumor. Low-grade myofibroblastic sarcoma (LGMS) has been defined properly as a distinct entity in the 2002 WHO classification of soft... Myofibroblastic sarcoma, composed primarily of myofibroblast, is a rare malignant tumor. Low-grade myofibroblastic sarcoma (LGMS) has been defined properly as a distinct entity in the 2002 WHO classification of soft tissue tumors. Primary sarcoma of the chest wall is also a rare disease. This article describes a case of locally recurrent LGMS of the chest wall. 展开更多
关键词 myofibroblastic sarcoma chest wall recurrence.
下载PDF
OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease 被引量:20
9
作者 Mei Li Xiang Gao +3 位作者 Chang-Cun Guo Kai-Chun Wu Xin Zhang Pin-Jin Hu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第31期4923-4927,共5页
AIM: To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672CFT and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD). METHODS: A to... AIM: To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672CFT and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD). METHODS: A total of 61 patients with Crohn's disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specific primer polymerase chain reaction (PCR-SSP) or by restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 (0/61 with CD) and 1.3% (2/151 with UC). CONCLUSION: Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients. 展开更多
关键词 Inflammatory bowel disease Ulcerative colitis Crohn's disease CARD15 Carnitine/organic cation transporter gene
下载PDF
Programmed death-1 expression is associated with the disease status in hepatitis B virus infection 被引量:25
10
作者 Plan Ye Zhi-Hong Weng +6 位作者 Shu-Ling Zhang Jian-Ao Zhang Lei Zhao Ji-Hua Dong Sheng-Hua Jie Ran Pang Rong-Hua Wei 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第28期4551-4557,共7页
AIM: TO define the potential role of programmed death-i/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined the expression of PD-1 on antigen spe... AIM: TO define the potential role of programmed death-i/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined the expression of PD-1 on antigen specific CD8+T cells in peripheral blood of patients with chronic hepatitis B (CriB) and acute exacerbation of hepatitis B (AEHB) infection. METHODS: The PD-1 level on CD8+ T lymphocytes and the number of HBV specific CD8+ T lymphocytes in patients and healthy controls (HCs) were analyzed by staining with pentameric peptide-human leukocyte antigen2 (HLA2) complexes combined with flow cytometry. Real-time quantitative polymerase chain reaction (PCR) was used to measure the serum HBV- DNA levels. RESULTS: The level of PD-1 expression on total CD8+ T cells in CHB patients (13.86% ± 3.38%) was significantly higher than that in AEHB patients (6.80%± 2.19%, P 〈 0.01) and healthy individuals (4.63% ± 1.23%, P 〈 0.01). Compared to AEHB patients (0.81% ± 0.73%), lower frequency of HBV-specific CD8+ T cells was detected in chronic hepatitis B patients (0.37% ± 0.43%, P 〈 0.05). There was an inverse correlation between the strength of HBV-specific CD8+ T-cell response and the level of PD-1 expression. Besides, there was a significant positive correlation between HBV viral load and the percentage of PD-1 expression on CD8+ T cells in CriB and AEHB subjects (R = 0.541, P 〈 0.01). However, PD-1 expression was not associated with disease flare-ups as indicated by alanine aminotransferase (ALT) levels (R = 0.066, P 〉 0.05). CONCLUSION: Our results confirm previous reports that HBV specific CD8+T-cell response in the peripheral blood is more intense in patients with AEHB than in chronic hepatitis B wlth persistent viral infection. Moreover, there is a negative correlation between the level of PD-1 and the intensity of virus specific CD8+ T cell response. 展开更多
关键词 Chronic hepatitis B Acute exacerbation of hepatitis B Programmed death-1 Programmed deathligand 1 PENTAMER Serum viral load BLOCKADE
下载PDF
Value of gastrografin in adhesive small bowel obstruction after unsuccessful conservative treatment: A prospective evaluation 被引量:8
11
作者 Hok-Kwok Choi Wai-Lun Law +1 位作者 Judy Wai-Chu Ho Kin-Wah Chu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第24期3742-3745,共4页
AIM: Gastrografin is a hyperosmolar water-soluble contrast medium. Besides its predictive value for the need for operative treatment, a potential therapeutic role of this agent in adhesive small bowel obstruction has ... AIM: Gastrografin is a hyperosmolar water-soluble contrast medium. Besides its predictive value for the need for operative treatment, a potential therapeutic role of this agent in adhesive small bowel obstruction has been suggested. This study aimed at evaluating the effectiveness of gastrografin in adhesive small bowel obstruction when conservative treatment failed. METHODS: Patients with adhesive small bowel obstruction were given trial conservative treatment unless there was fear of bowel strangulation. Those responded in the initial 48 h had conservative treatment continued. Patients who showed no improvement in the initial 48 h were given 100 mL of gastrografin through nasogastric tube followed by serial abdominal radiographs. Patients with the contrast appeared in large bowel within 24 h were regarded as having partial obstruction and conservative treatment was continued. Patients in which the contrast failed to reach large bowel within 24 h were considered to have complete obstruction and laparotomy was performed. RESULTS: Two hundred and twelve patients with 245 episodes of adhesive obstruction were included. Fifteen patients were operated on soon after admission due to fear of strangulation. One hundred and eighty-six episodes of obstruction showed improvement in the initial 48 h and conservative treatment was continued. Two patients had subsequent operations because of persistent obstruction. Forty-four episodes of obstruction showed no improvement within 48 h and gastrografin was administered. Seven patients underwent complete obstruction surgery. Partial obstruction was demonstrated in 37 other cases, obstruction resolved subsequently in all of them except one patient who required laparotomy because of persistent obstruction. The overall operative rate in this study was 10%. There was no complication that could be attributed to the use of gastrografin. CONCLUSION: The use of gastrografin in adhesive small bowel obstruction after unsuccessful conservative treatment is safe and reduces the need for suraical intervention 展开更多
关键词 GASTROGRAFIN ADHESIONS Intestinal obstruction
下载PDF
Expression and Significance of LRIG1 Gene in Human Astrocytomas 被引量:1
12
作者 易伟 叶飞 +2 位作者 郭东升 薛德麟 雷霆 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第4期225-228,共4页
Objective: LRIG1 gene is a newly found human gene that displays homologies to the Drosophila Kek-1 gene. Previous researches have shown that the LRIG1 gene almost expressed in all human tissues. However, its function... Objective: LRIG1 gene is a newly found human gene that displays homologies to the Drosophila Kek-1 gene. Previous researches have shown that the LRIG1 gene almost expressed in all human tissues. However, its functions, particularly its functions in human tumors, are still unknown. The goals of the present study are to magnify the expression spectrum of the LRIG1 gene and determine their roles in the oncogenesis. Methods: A triphasic oligonucleotide probe was designed and used to detect the expression level of the LRIG1 gene in 16 astrocytomas and the corresponding tissues around the tumors by in situ hybridization. 11 primary astrocytoma cells were cultured. Among these, the expression level of the LRIG1 gene was checked by in situ hybridization and the expression of the Proliferating Cell Nuclear Antigen (PCNA) protein was detected by immunohistochemistry. Results: The expression of LRIG1 protein was detected in different degree in all the tumors and the surrounding tissues. Compared to the surrounding tissues, the expression of the tumors was lower. The decrease extends from the surrounding tissues to the tumors were correlation to the tumors' grades. The primary cultured cells also expressed LRIG1 to various extent and the expression of LRIG1 in the cultures was negatively correlated with the intensity of the PCNA staining. Conclusion: The LRIG1 protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor. 展开更多
关键词 LRIG1 ASTROCYTOMA in situ hybridization primary cell culture proliferating cell nuclear antigen (PCNA)
下载PDF
Quantitative evaluation of long-term liver repopulation and the reconstitution of bile ductules after hepatocellular transplantation 被引量:9
13
作者 Yun-Wen Zheng Nobuhiro Ohkohchi Hideki Taniguchi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第39期6176-6181,共6页
AIM: The treatment of liver disease is severely limited by a shortage of donor livers. In trying to address this growing problem, hepatocellular transplantation (HTx) has received much attention as an alternative t... AIM: The treatment of liver disease is severely limited by a shortage of donor livers. In trying to address this growing problem, hepatocellular transplantation (HTx) has received much attention as an alternative to whole organ transplant. However, the expansion of transplanted cells is at low level, and the reconstitution of functional liver tissue is limited by this cellular property. We set up an animal model to better understand cell dose effect and the kinetics of liver repopulation following HTx. METHODS: Dipeptidyl peptidase Ⅳ (DPPⅣ)-deficient rats treated with retrorsine and subjected to partial hepatectomy were infused with DPPⅣ-positive hepatocytes. Rats were injected with varying numbers of donor hepatocytes down to 100 cells low, and liver repopulation was examined at different time points up to 20 mo long. Repopulation was assessed by computer-aided quantitative detection. RESULTS: Transplanted hepatocytes underwent multiple rounds of proliferation and stably repopulated the injured livers after 20 mo and at all cell doses. Transplanted cells divided 14 times within the 3-mo time period following infusion, and the liver repopulation reached a plateau between 3 and 20 too. Approximately 90% replacement occurred. Donor-derived cells also reconstituted the bile ductules of the recipients. CONCLUSION: The ability of transplanted hepatocytes to fully reconstitute injured livers strongly supports further investigation into the clinical potential of HTx. Additionally, the observation that transplanted hepatocytes also form components of the biliary system suggests that these cells may have bi-potential property of the stem cells. 展开更多
关键词 Hepatocellular transplantation Hepatic stem cell Kinetics Cell dose Long-term repopulation Bile ductules Quantification In viva Therapeutic potential
下载PDF
A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction:A hint for early diagnosis of gallbladder carcinoma 被引量:6
14
作者 Masafumi Suyama Yoshihiro Kubokawa 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第28期4593-4595,共3页
A 62-year-old man with progressive thickening of the gallbladder wall visited our outpatient clinic. The biliary amylase level in the common bile duct was 19900 IU/L and that of the gallbladder was 127000 IU/L, althou... A 62-year-old man with progressive thickening of the gallbladder wall visited our outpatient clinic. The biliary amylase level in the common bile duct was 19900 IU/L and that of the gallbladder was 127000 IU/L, although endoscopic retrograde cholangiopancreatography revealed no pancreaticobiliary maljunction. Histology demonstrated a moderately differentiated adenocarcinoma of the gallbladder. Pancreatobiliary reflux and associated gallbladder carcinoma were confirmed in the present case, in the absence of a pancreaticobiliary maljunction. Earlier detection of the pancreatobiliary reflux and progressive thickening of the gallbladder wall might have led to an earlier resection of the gallbladder and improved this patient's poor prognosis. 展开更多
关键词 AMYLASE BILE Gallbladder carcinoma Pancreatobiliary reflux Pancreaticobiliary maljunction Diagnosis
下载PDF
A left-sided periappendiceal abscess in an adult with intestinal malrotation 被引量:4
15
作者 Min Ro Lee Jong Hun Kim +1 位作者 Yong Hwang Young Kon Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第33期5399-5400,共2页
Left-sided periappendiceal abscesses occur in association with two types of congenital anomaly: intestinal malrotation and situs inversus. It is diffi cult to obtain an accurate preoperative diagnosis of these abscess... Left-sided periappendiceal abscesses occur in association with two types of congenital anomaly: intestinal malrotation and situs inversus. It is diffi cult to obtain an accurate preoperative diagnosis of these abscesses due to the abnormal position of the appendix. We present an unusual case of a left-sided periappendiceal abscess in an adult with intestinal malrotation, the diagnosis of which was a challenge. 展开更多
关键词 Left-sided periappendiceal abscess intestinalmalrotation DIAGNOSIS
下载PDF
He Jie Tang in the treatment of chronic hepatitis B patients 被引量:5
16
作者 Ze-Xiong Chen Shi-Jun Zhang +4 位作者 Shao-Xian Lao Hong-Tao Hu Cui-YiZhang Shi-He Guan Yan-Li Gu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第42期6638-6643,共6页
AIM: To explore the effect of He .lie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients. METHODS: Eighty-five patients with chr... AIM: To explore the effect of He .lie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients. METHODS: Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He .lie Tang (HIT) and 35 patients in group II were treated with combined medication. The levels of T-lymphocyte subsets (CD^3+, CD^4+, CD^8+), NK cell activity, cytokines (TNF-α, IL-8, sIL-2R) were observed before and after the treatment. Another 20 normal persons served as group 3. RESULTS: The level of CD^4+ cells and NK cell activity were lower, whereas the level of CD^8+ cells in patients was higher than that in normal persons (t = 2.685, 3.172, and 2.754 respectively; P〈0.01). The levels of TNF-α, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526, 3.170, and 2.876 respectively; P〈0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857 respectively; P〈0.01). The level of CD^4+ cells and NK cell activity were increased whereas the level of CD^8+ cells decreased (t = 2.179, 2.423, and 2.677 respectively; P〈0.05) in group I. The levels of TNF-α, IL-8, and sIL- 2R in group I were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively; P〈0.05) but had no significant difference in groupII after the treatment (t = 1.906, 1.833, and 2.029 respectively; P〉0.05). The total effective rate had no significant difference between the two groups (X^2 = 2.882, P〉0.05) but the markedly effective rate was significantly different between the two groups (X^2 = 5.340, P〈0.05). CONCLUSION: HIT is effective in treating chronic hepatitis B. HIT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients. The function of HIT in protecting liver function in the process of eliminating virus needs to be further studied. 展开更多
关键词 He Jie Tang Lymphocyte subsets NK cell CYTOKINES Chronic hepatitis B
下载PDF
Ten mg dexrabeprazole daily is as effective as 20 mg dexrabeprazole daily 被引量:6
17
作者 Rajendra Kanakia Suresh Jain 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第28期4586-4587,共2页
Ten mg dexrabeprazole daily has been shown to be more effective than 20 mg rabeprazole daily against gastroesophageal reflux disease (GERD). This report shows that the efficacy of 10 mg dexrabeprazole daily is equival... Ten mg dexrabeprazole daily has been shown to be more effective than 20 mg rabeprazole daily against gastroesophageal reflux disease (GERD). This report shows that the efficacy of 10 mg dexrabeprazole daily is equivalent to that of 20 mg dexrabeprazole daily against GERD. This implies that a dose of 10 mg dexra- beprazole is sufficient to block the maximum amount of proton pumps without any need to double the dose as suggested with rabeprazole. 展开更多
关键词 Dexrabeprazole RABEPRAZOLE Gastroesophageal reflux disease
下载PDF
An herbal formula,CGX,exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats 被引量:5
18
作者 Jang-Woo Shin Jin-Young Son +9 位作者 Se-Mi Oh Seung-Hyun Han Jing-Hua Wang Jung-Hyo Cho Chong-Kwan Cho Hwa-Seung Yoo Yeon-Weol Lee Myong-Min Lee Xiao Ping Hu Chang-Gue Son 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第38期6142-6148,共7页
AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats. METHODS: L... AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats. METHODS: Liver injuries were induced in Wistar rats by injection of DMN (ip, 10 mg/mL per kg) for 3 consecutive days per week for 4 wk. The rats were administered with CGX Coo, 100 or 200 mg/kg per day) or distilled water as a control daily for 4 wk starting from the 15^th d of the DMN treatment. Biochemical parameters (serum albumin, bilirubin, ALP, AST and ALT), lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis, were analyzed using real-time PCR. RESULTS: CGX administration restored the spleen weight to normal alter having been increased by DMN treatment. Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP (P 〈 0.05), ALT (P 〈 0.02), and AST (P 〈 0.02) that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β,TIMP-1, TIMP-2, PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration. CONCLUSION: CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis. 展开更多
关键词 DIMETHYLNITROSAMINE Hepatotherapeutic Herbal medicine PDGF-β Chunggan extract
下载PDF
The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients 被引量:16
19
作者 Peter Schemmer Frank Decker +4 位作者 Genevieve Dei-Anane Volkmar Henschel Klaus Buhl Christian Herfarth Stefan Riedl 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第22期3597-3601,共5页
AIM: To analyze the importance in predicting patients risk of mortality due to upper gastrointestinal (UGI) bleeding under today's therapeutic regimen. METHODS: From 1998 to 2001, 121 patients with the diagnosis ... AIM: To analyze the importance in predicting patients risk of mortality due to upper gastrointestinal (UGI) bleeding under today's therapeutic regimen. METHODS: From 1998 to 2001, 121 patients with the diagnosis of UGI bleeding were treated in our hospital. Based on the patients' data, a retrospective multivariate data analysis with initially more than 270 single factors was performed. Subsequently, the following potential risk factors underwent a logistic regression analysis: age, gender, initial hemoglobin, coumarines, liver cirrhosis, prothrombin time (PT), gastric ulcer (small curvature), duodenal ulcer (bulbus back wall), Forrest classification, vascular stump, variceal bleeding, MalloryWeiss syndrome, RBC substitution, recurrent bleeding, conservative and surgical therapy. RESULTS: Seventy male (58%) and 51 female (42%) patients with a median age of 70 (range: 21-96) years were treated. Their in-hospital mortality was 14%. While 12% (11/91) of the patients died after conservative therapy, 20% (6/30) died after undergoing surgical therapy. UGI bleeding occurred due to duodenal ulcer (n = 36; 30%), gastric ulcer (n = 35; 29%), esophageal varicosis (n = 12; 10%), Mallory-Weiss syndrome (n = 8, 7%), erosive lesions of the mucosa (n = 20; 17%), cancer (n = 5; 4%), coagulopathy (n = 4; 3%), lymphoma (n = 2; 2%), benign tumor (n = 2; 2%) and unknown reason (n = 1, 1%). A logistic regression analysis of all aforementioned factors revealed that liver cirrhosis and duodenal ulcer (bulbus back wall) were associated risk factors for a fatal course after UGI bleeding. Prior to endoscopy, only liver cirrhosis was an assessable risk factor. Thereafter, liver cirrhosis, the location of a bleeding ulcer (bulbus back wall) andpatients' gender (male) were of prognostic importance for the clinical outcome (mortality) of patients with a bleeding ulcer.CONCLUSION: Most prognostic parameters used in clinical routine today are not reliable enough in predicting a patient's vital threat posed by an UGI bleeding.Liver cirrhosis, on the other hand, is significantly more frequently associated with an increased risk to die after bleeding of an ulcer located at the posterior duodenal wall. 展开更多
关键词 UGT bleeding MORTALITY Risk factors
下载PDF
Colonic duplication in adults: Report of two cases presenting with rectal bleeding 被引量:7
20
作者 C Fotiadis M Genetzakis +3 位作者 I Papandreou EP Misiakos E Agapitos GC Zografos 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第32期5072-5074,共3页
Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a ra... Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a rather unusual clinical entity that remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults only in a few cases. This study reports two cases of colonic duplication in adults. Both cases presented with rectal bleeding on admission. The study was focused on clinical, imaging,histological, and therapeutical aspects of the presenting cases. Gastrografin enema established the diagnosis in both cases. The cystic structure and the adjacent part of the colon were excised en-block. The study implies that colonic duplication, though uncommon, should be included in the differential diagnosis of rectal bleeding. 展开更多
关键词 Colonic duplication Gastrointestinal bleeding
下载PDF
上一页 1 2 5 下一页 到第
使用帮助 返回顶部