Aim To establish a sensitive and specific liquid chromatography-massspeetrometry method for determination of scutellarin in rabbit plasma after oral administration.Methods For the quantitative analysis, rutin was used...Aim To establish a sensitive and specific liquid chromatography-massspeetrometry method for determination of scutellarin in rabbit plasma after oral administration.Methods For the quantitative analysis, rutin was used as an internal standard and solid-phaseextraction (SPE) was performed by using a Phenomenex C_8 cartridge. HPLC was carried out using aZorbax Extend-C_(18) column (150 mm x 2.1 mm ID, 5 μm) with a guard cartridge (Phenomenex) .Gradient elution was selected with the mobile phase of methanol 10 mmol·L^(-1) ammonium acetatesolution (pH adjusted to 8.0 with ammonia solution). The flow rate of mobile phase was 0.4mL·min^(-1) and the column temperature was 35 ℃ . Both scutellarin and the internal standard rutinin rabbit plasma extracts were detected by mass spectrometry using an ESI interface in the negativeion mode. Results The linear range was from 2 to 200 ng· mL^(-1), with acceptable accuracy andprecision (RSD) . Conclusion A sensitive, reliable and accurate method for the quantitation ofscutellarin in rabbit plasma has been established.展开更多
Due to the diversified demands of quality of service（QoS） in volume multimedia application, QoS routings for multiservice are becoming a research hotspot in low earth orbit（LEO） satellite networks. A novel QoS sat...Due to the diversified demands of quality of service（QoS） in volume multimedia application, QoS routings for multiservice are becoming a research hotspot in low earth orbit（LEO） satellite networks. A novel QoS satellite routing algorithm for multi-class traffic is proposed. The goal of the routing algorithm is to provide the distinct QoS for different traffic classes and improve the utilization of network resources. Traffic is classified into three classes and allocated priorities based on their QoS requirements, respectively. A priority queuing mechanism guarantees the algorithm to work better for high-priority classes. In order to control the congestion, a blocking probability analysis model is built up based on the Markov process theory. Finally, according to the classification link-cost metrics, routings for different classes are calculated with the distinct QoS requirments and the status of network resource. Simulations verify the performance of the routing algorithm at different time and in different regions, and results demonstrate that the algorithm has great advantages in terms of the average delay and the blocking probability. Meanwhile, the robustness issue is also discussed.展开更多
Considering that the vehicle routing problem （VRP） with many extended features is widely used in actual life, such as multi-depot, heterogeneous types of vehicles, customer service priority and time windows etc., a ...Considering that the vehicle routing problem （VRP） with many extended features is widely used in actual life, such as multi-depot, heterogeneous types of vehicles, customer service priority and time windows etc., a mathematical model for multi-depot heterogeneous vehicle routing problem with soft time windows （MDHVRPSTW） is established. An improved ant colony optimization （IACO） is proposed for solving this model. First, MDHVRPSTW is transferred into different groups according to the nearest principle, and then the initial route is constructed by the scanning algorithm （SA）. Secondly, genetic operators are introduced, and crossover probability and mutation probability are adaptively adjusted in order to improve the global search ability of the algorithm. Moreover, the smooth mechanism is used to improve the performance of the ant colony optimization （ACO）. Finally, the 3-opt strategy is used to improve the local search ability. The proposed IACO was tested on three new instances that were generated randomly. The experimental results show that IACO is superior to the other three existing algorithms in terms of convergence speed and solution quality. Thus, the proposed method is effective and feasible, and the proposed model is meaningful.展开更多
The self-organization mapping （SOM） neural network algorithm is a new method used to identify the ecosystem service zones at regional extent. According to the ecosystem assessment framework of Millennium Ecosystem A...The self-organization mapping （SOM） neural network algorithm is a new method used to identify the ecosystem service zones at regional extent. According to the ecosystem assessment framework of Millennium Ecosystem Assessment （ MA）, this paper develops an indicator system and conducts a spatial cluster analysis at the 1km by I km grid pixel scale with the SOM neural network algorithm to sort the core ecosystem services over the vertical and horizontal dimensions. A case study was carried out in Xilingol League. The ecosystem services in Xilingol League could be divided to six different ecological zones. The SOM neural network algorithm was capable of identifying the similarities among the input data automatically. The research provides both spatially and temporally valuable information targeted sustainable ecosystem management for decision-makers.展开更多
At evaluating the combat effectiveness of the defense system, target′s probability to penetrate the defended area is a primary care taking index. In this paper, stochastic model to compete the probability that targe...At evaluating the combat effectiveness of the defense system, target′s probability to penetrate the defended area is a primary care taking index. In this paper, stochastic model to compete the probability that target penetrates the defended area along any flight path is established by the state analysis and statistical equilibrium analysis of stochastic service system theory. The simulated annealing algorithm is an enlightening random search method based on Monte Carlo recursion, and it can find global optimal solution by simulating annealing process. Combining stochastic model to compete the probability and simulated annealing algorithm, this paper establishes the method to solve problem quantitatively about combat configuration optimization of weapon systems. The calculated result shows that the perfect configuration for fire cells of the weapon is fast found by using this method, and this quantificational method for combat configuration is faster and more scientific than previous one based on principle via map fire field.展开更多
In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenom...In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenomena is considered. Based on the theory of fuzzy recognition and fault diagnosis, this method only depends on experience and statistical data to set up fuzzy query relationship between the outside phenomena (fault characters) and the fault sources (fault patterns). From this relationship the most probable fault sources can be obtained, to attain the goal of quick diagnosis. Based on the above approach, the standard fuzzy relationship matrix is stored in the computer as a system database. And experiment data are given to show the fault diagnosis results. The important parameters can be on line sampled and analyzed, and when faults occur, faults can be found, the alarm is given and the controller output is regulated.展开更多
This paper introduced an integrated allocation model for distribution centers (DCs). The facility cost, inventory cost, transportation cost and service quality were considered in the model. An improved genetic algorit...This paper introduced an integrated allocation model for distribution centers (DCs). The facility cost, inventory cost, transportation cost and service quality were considered in the model. An improved genetic algorithm (IGA) was proposed to solve the problem. The improvement of IGA is based on the idea of adjusting crossover probability and mutation probability. The IGA is supplied by heuristic rules too. The simulation results show that the IGA is better than the standard GA(SGA) in search efficiency and equality.展开更多
With the increasing popularity of cloud computing,privacy has become one of the key problem in cloud security.When data is outsourced to the cloud,for data owners,they need to ensure the security of their privacy;for ...With the increasing popularity of cloud computing,privacy has become one of the key problem in cloud security.When data is outsourced to the cloud,for data owners,they need to ensure the security of their privacy;for cloud service providers,they need some information of the data to provide high QoS services;and for authorized users,they need to access to the true value of data.The existing privacy-preserving methods can't meet all the needs of the three parties at the same time.To address this issue,we propose a retrievable data perturbation method and use it in the privacy-preserving in data outsourcing in cloud computing.Our scheme comes in four steps.Firstly,an improved random generator is proposed to generate an accurate "noise".Next,a perturbation algorithm is introduced to add noise to the original data.By doing this,the privacy information is hidden,but the mean and covariance of data which the service providers may need remain unchanged.Then,a retrieval algorithm is proposed to get the original data back from the perturbed data.Finally,we combine the retrievable perturbation with the access control process to ensure only the authorized users can retrieve the original data.The experiments show that our scheme perturbs date correctly,efficiently,and securely.展开更多
文摘Aim To establish a sensitive and specific liquid chromatography-massspeetrometry method for determination of scutellarin in rabbit plasma after oral administration.Methods For the quantitative analysis, rutin was used as an internal standard and solid-phaseextraction (SPE) was performed by using a Phenomenex C_8 cartridge. HPLC was carried out using aZorbax Extend-C_(18) column (150 mm x 2.1 mm ID, 5 μm) with a guard cartridge (Phenomenex) .Gradient elution was selected with the mobile phase of methanol 10 mmol·L^(-1) ammonium acetatesolution (pH adjusted to 8.0 with ammonia solution). The flow rate of mobile phase was 0.4mL·min^(-1) and the column temperature was 35 ℃ . Both scutellarin and the internal standard rutinin rabbit plasma extracts were detected by mass spectrometry using an ESI interface in the negativeion mode. Results The linear range was from 2 to 200 ng· mL^(-1), with acceptable accuracy andprecision (RSD) . Conclusion A sensitive, reliable and accurate method for the quantitation ofscutellarin in rabbit plasma has been established.
基金Supported by the National High Technology Research and Development Program of China(″863″Program)(2010AAxxx404)~~
文摘Due to the diversified demands of quality of service（QoS） in volume multimedia application, QoS routings for multiservice are becoming a research hotspot in low earth orbit（LEO） satellite networks. A novel QoS satellite routing algorithm for multi-class traffic is proposed. The goal of the routing algorithm is to provide the distinct QoS for different traffic classes and improve the utilization of network resources. Traffic is classified into three classes and allocated priorities based on their QoS requirements, respectively. A priority queuing mechanism guarantees the algorithm to work better for high-priority classes. In order to control the congestion, a blocking probability analysis model is built up based on the Markov process theory. Finally, according to the classification link-cost metrics, routings for different classes are calculated with the distinct QoS requirments and the status of network resource. Simulations verify the performance of the routing algorithm at different time and in different regions, and results demonstrate that the algorithm has great advantages in terms of the average delay and the blocking probability. Meanwhile, the robustness issue is also discussed.
基金The National Natural Science Foundation of China(No.61074147)the Natural Science Foundation of Guangdong Province(No.S2011010005059)+2 种基金the Foundation of Enterprise-University-Research Institute Cooperation from Guangdong Province and Ministry of Education of China(No.2012B091000171,2011B090400460)the Science and Technology Program of Guangdong Province(No.2012B050600028)the Science and Technology Program of Huadu District,Guangzhou(No.HD14ZD001)
文摘Considering that the vehicle routing problem （VRP） with many extended features is widely used in actual life, such as multi-depot, heterogeneous types of vehicles, customer service priority and time windows etc., a mathematical model for multi-depot heterogeneous vehicle routing problem with soft time windows （MDHVRPSTW） is established. An improved ant colony optimization （IACO） is proposed for solving this model. First, MDHVRPSTW is transferred into different groups according to the nearest principle, and then the initial route is constructed by the scanning algorithm （SA）. Secondly, genetic operators are introduced, and crossover probability and mutation probability are adaptively adjusted in order to improve the global search ability of the algorithm. Moreover, the smooth mechanism is used to improve the performance of the ant colony optimization （ACO）. Finally, the 3-opt strategy is used to improve the local search ability. The proposed IACO was tested on three new instances that were generated randomly. The experimental results show that IACO is superior to the other three existing algorithms in terms of convergence speed and solution quality. Thus, the proposed method is effective and feasible, and the proposed model is meaningful.
基金Supported by the National Scientific Foundation of China(4080123170873118)+6 种基金the Chinese Academy of Sciences(KZCX2-YW-305-2KSCX2-YW-N-039KZCX2-YW-326-1)the Ministry of Science and Technology of China(2006DFB91912012006BAC08B032006BAC08B062008BAK47B02)~~
文摘The self-organization mapping （SOM） neural network algorithm is a new method used to identify the ecosystem service zones at regional extent. According to the ecosystem assessment framework of Millennium Ecosystem Assessment （ MA）, this paper develops an indicator system and conducts a spatial cluster analysis at the 1km by I km grid pixel scale with the SOM neural network algorithm to sort the core ecosystem services over the vertical and horizontal dimensions. A case study was carried out in Xilingol League. The ecosystem services in Xilingol League could be divided to six different ecological zones. The SOM neural network algorithm was capable of identifying the similarities among the input data automatically. The research provides both spatially and temporally valuable information targeted sustainable ecosystem management for decision-makers.
文摘At evaluating the combat effectiveness of the defense system, target′s probability to penetrate the defended area is a primary care taking index. In this paper, stochastic model to compete the probability that target penetrates the defended area along any flight path is established by the state analysis and statistical equilibrium analysis of stochastic service system theory. The simulated annealing algorithm is an enlightening random search method based on Monte Carlo recursion, and it can find global optimal solution by simulating annealing process. Combining stochastic model to compete the probability and simulated annealing algorithm, this paper establishes the method to solve problem quantitatively about combat configuration optimization of weapon systems. The calculated result shows that the perfect configuration for fire cells of the weapon is fast found by using this method, and this quantificational method for combat configuration is faster and more scientific than previous one based on principle via map fire field.
文摘In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenomena is considered. Based on the theory of fuzzy recognition and fault diagnosis, this method only depends on experience and statistical data to set up fuzzy query relationship between the outside phenomena (fault characters) and the fault sources (fault patterns). From this relationship the most probable fault sources can be obtained, to attain the goal of quick diagnosis. Based on the above approach, the standard fuzzy relationship matrix is stored in the computer as a system database. And experiment data are given to show the fault diagnosis results. The important parameters can be on line sampled and analyzed, and when faults occur, faults can be found, the alarm is given and the controller output is regulated.
文摘This paper introduced an integrated allocation model for distribution centers (DCs). The facility cost, inventory cost, transportation cost and service quality were considered in the model. An improved genetic algorithm (IGA) was proposed to solve the problem. The improvement of IGA is based on the idea of adjusting crossover probability and mutation probability. The IGA is supplied by heuristic rules too. The simulation results show that the IGA is better than the standard GA(SGA) in search efficiency and equality.
基金supported in part by NSFC under Grant No.61172090National Science and Technology Major Project under Grant 2012ZX03002001+3 种基金Research Fund for the Doctoral Program of Higher Education of China under Grant No.20120201110013Scientific and Technological Project in Shaanxi Province under Grant(No.2012K06-30, No.2014JQ8322)Basic Science Research Fund in Xi'an Jiaotong University(No. XJJ2014049,No.XKJC2014008)Shaanxi Science and Technology Innovation Project (2013SZS16-Z01/P01/K01)
文摘With the increasing popularity of cloud computing,privacy has become one of the key problem in cloud security.When data is outsourced to the cloud,for data owners,they need to ensure the security of their privacy;for cloud service providers,they need some information of the data to provide high QoS services;and for authorized users,they need to access to the true value of data.The existing privacy-preserving methods can't meet all the needs of the three parties at the same time.To address this issue,we propose a retrievable data perturbation method and use it in the privacy-preserving in data outsourcing in cloud computing.Our scheme comes in four steps.Firstly,an improved random generator is proposed to generate an accurate "noise".Next,a perturbation algorithm is introduced to add noise to the original data.By doing this,the privacy information is hidden,but the mean and covariance of data which the service providers may need remain unchanged.Then,a retrieval algorithm is proposed to get the original data back from the perturbed data.Finally,we combine the retrievable perturbation with the access control process to ensure only the authorized users can retrieve the original data.The experiments show that our scheme perturbs date correctly,efficiently,and securely.
