OBJECTIVE To discuss the pathologic characteristics and theprognosis of neuroendocrine carcinoma of the bladder(NECB)in order to assist in making a precise diagnosis and to effectivelytreat the disease.METHODS Clinico...OBJECTIVE To discuss the pathologic characteristics and theprognosis of neuroendocrine carcinoma of the bladder(NECB)in order to assist in making a precise diagnosis and to effectivelytreat the disease.METHODS Clinicopathologic features of the 6 cases with NECBwere analyzed retrospectively.The personal data of the patientsand the pathologic and immunohistochemical characteristics ofthe tumor were investigated.The follow-up of these patients wasconducted over a time period ranging from 3 months to 9 years.RESULTS Transurethral resection of the bladder tumorwas performed in all 6 patients.Based on the results of thepathologic examination,4 of the cases were diagnosed as smallcell neuroendocrine carcinoma and the other 2 were diagnosedas atypical carcinoid tumor.On immunohistochemical stainingall tumors expressed neuroendocrine markers includingneuronspecific enolase(CD56),synaptophysin(Syn)andchromogranin(CgA).In patients receiving partial cystectomyfollowed by postoperative chemotherapy,relapse was found in 4of the 6 cases on follow up.CONCLUSION NECB is a rare entity and a tumor with highmalignant potential and characteristic pathologic features.Hematuria is the cardinal symptom of NECB.Metastasis mayoccur at an early stage and the prognosis of the disease is poor.Final diagnosis of NECB depends on histopathologic examinationand immunohistochemical assays.Surgical excision combinedwith radiotherapy and chemotherapy is considered an effectivetreatment.展开更多
To predict the soil-water characteristic curve(i.e.SWCC)of natural and remoulded Malan loess from soil physical properties,one-point methods for determining the SWCC that are much simpler than experimental methods are...To predict the soil-water characteristic curve(i.e.SWCC)of natural and remoulded Malan loess from soil physical properties,one-point methods for determining the SWCC that are much simpler than experimental methods are proposed.The predicted SWCC is presented in the form of the BRUTSAERT equation,in which the four model parameters can be estimated from soil physical properties using the best correlations obtained in the present study along with one measured data point.The proposed one-point methods are validated using the measured SWCC data reported in the literature.The results of validation studies suggest that the proposed one-point methods can provide reasonable prediction of the SWCC for natural and remoulded Malan loess.The measured data point should be within the transition zone;the measured suction is suggested between25to100kPa for natural loess,while between100to500kPa for remoulded loess.展开更多
The use of literature, logical reasoning and other research methods are used in this thesis, classification and analysis of the definition of incentive methods, motivation methods are also stated in this paper, and th...The use of literature, logical reasoning and other research methods are used in this thesis, classification and analysis of the definition of incentive methods, motivation methods are also stated in this paper, and this article also combine with students＇ psychological characteristics, different teaching content, teaching methods together, discussed how to stimulate students＇ interest in sports and mobilize students＇ enthusiasm, initiative by motivation methods in the sports teaching, thus promoting teaching effectiveness, improve teaching quality, provide some theoretical reference for improving the quality of teaching physical education. The results showed that： we have already made some researches in the stimulation methods in teaching sports, but few are studied combining with the psychological characteristics of students展开更多
In this paper, the authors prove the existence of solutions for degenerate elliptic equations of the form-div(a(x)▽_p u(x)) = g(λ, x, |u|^(p-2)u) in R^N, where ▽_pu =|▽u|^(p-2)▽u and a(x) is a degenerate nonnegat...In this paper, the authors prove the existence of solutions for degenerate elliptic equations of the form-div(a(x)▽_p u(x)) = g(λ, x, |u|^(p-2)u) in R^N, where ▽_pu =|▽u|^(p-2)▽u and a(x) is a degenerate nonnegative weight. The authors also investigate a related nonlinear eigenvalue problem obtaining an existence result which contains information about the location and multiplicity of eigensolutions. The proofs of the main results are obtained by using the critical point theory in Sobolev weighted spaces combined with a Caffarelli-Kohn-Nirenberg-type inequality and by using a specific minimax method, but without making use of the Palais-Smale condition.展开更多
文摘OBJECTIVE To discuss the pathologic characteristics and theprognosis of neuroendocrine carcinoma of the bladder(NECB)in order to assist in making a precise diagnosis and to effectivelytreat the disease.METHODS Clinicopathologic features of the 6 cases with NECBwere analyzed retrospectively.The personal data of the patientsand the pathologic and immunohistochemical characteristics ofthe tumor were investigated.The follow-up of these patients wasconducted over a time period ranging from 3 months to 9 years.RESULTS Transurethral resection of the bladder tumorwas performed in all 6 patients.Based on the results of thepathologic examination,4 of the cases were diagnosed as smallcell neuroendocrine carcinoma and the other 2 were diagnosedas atypical carcinoid tumor.On immunohistochemical stainingall tumors expressed neuroendocrine markers includingneuronspecific enolase(CD56),synaptophysin(Syn)andchromogranin(CgA).In patients receiving partial cystectomyfollowed by postoperative chemotherapy,relapse was found in 4of the 6 cases on follow up.CONCLUSION NECB is a rare entity and a tumor with highmalignant potential and characteristic pathologic features.Hematuria is the cardinal symptom of NECB.Metastasis mayoccur at an early stage and the prognosis of the disease is poor.Final diagnosis of NECB depends on histopathologic examinationand immunohistochemical assays.Surgical excision combinedwith radiotherapy and chemotherapy is considered an effectivetreatment.
基金Project(41372329) supported by the National Natural Science Foundation of ChinaProject(2014CB744701) supported by the National Basic Research Program of China
文摘To predict the soil-water characteristic curve(i.e.SWCC)of natural and remoulded Malan loess from soil physical properties,one-point methods for determining the SWCC that are much simpler than experimental methods are proposed.The predicted SWCC is presented in the form of the BRUTSAERT equation,in which the four model parameters can be estimated from soil physical properties using the best correlations obtained in the present study along with one measured data point.The proposed one-point methods are validated using the measured SWCC data reported in the literature.The results of validation studies suggest that the proposed one-point methods can provide reasonable prediction of the SWCC for natural and remoulded Malan loess.The measured data point should be within the transition zone;the measured suction is suggested between25to100kPa for natural loess,while between100to500kPa for remoulded loess.
文摘The use of literature, logical reasoning and other research methods are used in this thesis, classification and analysis of the definition of incentive methods, motivation methods are also stated in this paper, and this article also combine with students＇ psychological characteristics, different teaching content, teaching methods together, discussed how to stimulate students＇ interest in sports and mobilize students＇ enthusiasm, initiative by motivation methods in the sports teaching, thus promoting teaching effectiveness, improve teaching quality, provide some theoretical reference for improving the quality of teaching physical education. The results showed that： we have already made some researches in the stimulation methods in teaching sports, but few are studied combining with the psychological characteristics of students
文摘In this paper, the authors prove the existence of solutions for degenerate elliptic equations of the form-div(a(x)▽_p u(x)) = g(λ, x, |u|^(p-2)u) in R^N, where ▽_pu =|▽u|^(p-2)▽u and a(x) is a degenerate nonnegative weight. The authors also investigate a related nonlinear eigenvalue problem obtaining an existence result which contains information about the location and multiplicity of eigensolutions. The proofs of the main results are obtained by using the critical point theory in Sobolev weighted spaces combined with a Caffarelli-Kohn-Nirenberg-type inequality and by using a specific minimax method, but without making use of the Palais-Smale condition.
