Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchym...Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites.展开更多
The cobalt phosphate-/cobalt borate-based oxygen-evolving catalysts （OECs） are the important class of earth-abundant electrocatalysts that can operate with high activity for water splitting under benign conditions. ...The cobalt phosphate-/cobalt borate-based oxygen-evolving catalysts （OECs） are the important class of earth-abundant electrocatalysts that can operate with high activity for water splitting under benign conditions. This article reports the integration of cobalt phosphate （Co- Pi） and cobalt borate （Co-Bi） OECs with three-dimensional （3D） graphene foam （GF） for the electrocatalytic water oxidation reaction. The GF showed a unique advantage to serve as a highly conductive 3D support with large capacity for anchoring and loading Co-OECs, thereby facilitating mass and charge transfer due to the large amount of active sites provided by the 3D graphene scaffold. As a result, this integrated system of GF and Co-OECs exhibits synergistically enhanced catalytic activity. The overpotential （η） of Co-Pi and Co-Bi/graphene catalysts is about 0.390 and 0.315 V in neutral solutions, respectively. Besides, the integrated Co-OECs/graphene catalysts have also exhibited improved and stable oxygen evolution catalytic ability in alkaline solution.展开更多
Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinf...Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-Co V-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-Co V-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-Co V-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.展开更多
基金Supported by the Program for New Century Excellent in University of China(30740061)the National Natural Science Foundation of China(30672001)
文摘Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites.
基金supported by the National Natural Science Foundation of China(21322304,11290161)the National Basic Research Program of China(2012CB933003,2013CB932603)
文摘The cobalt phosphate-/cobalt borate-based oxygen-evolving catalysts （OECs） are the important class of earth-abundant electrocatalysts that can operate with high activity for water splitting under benign conditions. This article reports the integration of cobalt phosphate （Co- Pi） and cobalt borate （Co-Bi） OECs with three-dimensional （3D） graphene foam （GF） for the electrocatalytic water oxidation reaction. The GF showed a unique advantage to serve as a highly conductive 3D support with large capacity for anchoring and loading Co-OECs, thereby facilitating mass and charge transfer due to the large amount of active sites provided by the 3D graphene scaffold. As a result, this integrated system of GF and Co-OECs exhibits synergistically enhanced catalytic activity. The overpotential （η） of Co-Pi and Co-Bi/graphene catalysts is about 0.390 and 0.315 V in neutral solutions, respectively. Besides, the integrated Co-OECs/graphene catalysts have also exhibited improved and stable oxygen evolution catalytic ability in alkaline solution.
基金supported by the National Natural Science Foundation of China(21890753,21988101 to Dehui Deng,91853101 to Fangjun Wang,and 91845106 to Liang Yu)the Strategic PriorityResearch Program of the Chinese Academy of Sciences(XDB36030200 to Dehui Deng)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y201936 to Dehui Deng,Y201750 to Yangbo Hu)。
文摘Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-Co V-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-Co V-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-Co V-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.
