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bHLH因子对大脑神经前体细胞的增殖分化与命运决定的调节
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作者 付志猛 芦国珍 赵湘辉 《生理科学进展》 CAS CSCD 北大核心 2017年第5期321-327,共7页
神经前体细胞(neural progenitor cells,NPCs)是具有自我更新能力和多向分化潜能的细胞,它的增殖和分化受到多种内源或者外源因子,以及邻近或远程细胞信号通路的调控。多项研究表明,碱性螺旋——环——螺旋(basic helix-loop-helix,b H... 神经前体细胞(neural progenitor cells,NPCs)是具有自我更新能力和多向分化潜能的细胞,它的增殖和分化受到多种内源或者外源因子,以及邻近或远程细胞信号通路的调控。多项研究表明,碱性螺旋——环——螺旋(basic helix-loop-helix,b HLH)家族转录因子之间相互联系,相互竞争,广泛参与调控端脑的发育过程,在NPCs向神经元和神经胶质细胞分化过程中起着重要的调控作用。而b HLH家族分子的不同的表达状态,即持续表达或波动表达,又与NPCs增殖或者分化的最终结局有着重要的关系。本文主要对在端脑发育中有重要代表性作用的b HLH转录因子,以及它们之间的表达调控关系的研究进展进行综述。 展开更多
关键词 bHLH因子 神经前体细胞 持续表达 波动表达
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Solution of Travelling Wave for Nonlinear Disturbed Long-Wave System 被引量:33
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作者 MO Jia-Qi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第3期387-390,共4页
The approximate expressions of the travelling wave solutions for a class of nonlinear disturbed long-wave system are constructed using the generalized variational iteration method.
关键词 nonlinear long-wave equation travelling wave approximate analytic solution
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Effects of Periodical Salinity Fluctuation on the Growth, Molting, Energy Homeostasis and Molting-Related Gene Expression of Litopenaeus vannamei 被引量:1
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作者 ZHANG Dan GUO Xiantao +1 位作者 WANG Fang DONG Shuanglin 《Journal of Ocean University of China》 SCIE CAS 2016年第5期911-917,共7页
To determine the response of Litopenaeus vannamei to periodical salinity fluctuation, a 30-day experiment was conducted in laboratory. In this experiment, two salinity fluctuation amplitudes of 4(group S4) and 10(grou... To determine the response of Litopenaeus vannamei to periodical salinity fluctuation, a 30-day experiment was conducted in laboratory. In this experiment, two salinity fluctuation amplitudes of 4(group S4) and 10(group S10) were designed. The constant salinity of 30(group S0) was used as the control. Levels of shrimp growth, molting frequency(MF), cellular energy status(ATP, ADP and AMP), as well as the expression of genes encoding molt-inhibiting hormone(MIH), crustacean hyperglycemic hormone(CHH), ecdysteroid-regulated protein(ERP), and energy-related AMP-activated protein kinase(AMPK) were determined. The results showed that periodical salinity fluctuation significantly influenced all indicators except MF which ranged from 13.3% in group S10 to15.4% in group S4. In comparison with shrimps cultured at the constant salinity of 30, those in group S4 showed a significant elevation in growth rate, food conversion efficiency, cellular energy status, ERP and MIH gene transcript abundance, and a significant reduction in CHH and AMPK transcript abundance(P < 0.05). However, salinity fluctuation of 10 only resulted in a significant variation in MIH and CHH gene expression when compared to the control(P < 0.05). According to our findings, L. vannamei may be highly capable of tolerating salinity fluctuation. When ambient salinity fluctuated at approx. 4, the increased MF and energy stores in organisms may aid to promoting shrimp growth. 展开更多
关键词 salinity shrimp fluctuation transcript periodical AMPK ranged Molting abundance Periodical
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Recurrence and Polya Number of General One-Dimensional Random Walks
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作者 张晓琨 万晶 +1 位作者 陆静菊 徐新平 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第8期293-296,共4页
The recurrence properties of random walks can be characterized by P61ya number, i.e., the probability that the walker has returned to the origin at least once. In this paper, we consider recurrence properties for a ge... The recurrence properties of random walks can be characterized by P61ya number, i.e., the probability that the walker has returned to the origin at least once. In this paper, we consider recurrence properties for a general 1D random walk on a line, in which at each time step the walker can move to the left or right with probabilities l and r, or remain at the same position with probability o (l + r + o = 1). We calculate Polya number P of this model and find a simple expression for P as, P = 1 - △, where △ is the absolute difference of l and r (△= |l - r|). We prove this rigorous expression by the method of creative telescoping, and our result suggests that the walk is recurrent if and only if the left-moving probability l equals to the right-moving probability r. 展开更多
关键词 random walk return probability Polya number
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