Multiple Kalman filters model with shaping filter GPS real-time deformation analysis

In order to detect the deformation in real-time of the GPS time series and improve its reliability, the multiple Kalman filters model with shaping filter was proposed. Two problems were solved: firstly, because the GPS real-time deformation series with a high sampling rate contain coloured noise, the multiple Kalman filter model requires the white noise, and the multiple Kalman filters model is augmented by a shaping filter in order to reduce the colored noise; secondly, the multiple Kalman filters model with shaping filter can detect the deformation epoch in real-time and improve the quality of GPS measurements for the real-time deformation applications. Based on the comparisons of the applications in different GPS time series with different models, the advantages of the proposed model were illustrated. The proposed model can reduce the colored noise, detect the smaller changes, and improve the precision of the detected deformation epoch.

幕墙玻璃影像失真问题及解决方案

为了控制和改善幕墙玻璃的表面变形,减少玻璃影像失真现象发生,本文通过大量的幕墙案例,分析了幕墙玻璃变形的各种原因,提出了玻璃主要由表面的弓形变形导致的影像失真的观点。采用提高浮法玻璃质量等级以及降低钢化玻璃弓形变形等措施来控制和改善幕墙玻璃影像失真。

水体视觉效果模拟与实现

本文简要描述基于波形函数变形、法线纹理贴图2种水体视觉模拟技术,并基于Tiled Directional Flow的算法实现河流水体视觉模拟,基于波形叠加的方法实现海洋水体视觉模拟,结合GPU渲染管线实现组合条件绘制,最后比较2种不同模拟技术所适用模拟的情景。本文所采用的水体视觉模拟技术及实现方法对于研究水体视觉模拟有一定助益,水体视觉模拟效果良好。

Relationship between epithelial to mesenchymaltransition and chemoresistance of lung cancer

Objective： The aim of this study was to explore the correlation between epithelial to mesenchymal transition （EMT） and chemoresistance of non-small-cell lung cancer （NSCLC）. Methods： In vitro, the drug resistance index of cisplatin resistant lung adenocarcinoma cell line （A549/DDP） was detected by CCK-8 assay; the morphological change between A549/ DDP cells and lung adenocarcinoma cells （A549） was observed by phase contrast microscope; expression of EMT markers （including E-cadherin and vimentin） and resistance protein, excision repair cross-complementing 1 （ERCC1） was detected by immunocytochemistry. The expression of E-cadherin, vimentin and ERCC1 was investigated by immunohistochemistry in 120 cases of NSCLC, half of that were treated with pre-operative neoadjuvant chemotherapy （neoadjuvant chemotherapy group）, and the other underwent surgery alone （simple surgery group）. Results： There was a significant difference between the ICso （half maximal inhibitory concentration） of A549/DDP cells （5.20） and A549 cells （1.88） （P 〈 0.05）, and the drug resistance index of A549/DDP cells was 2.77. Compared with A549 cells, A549/DDP cells increased expression of ERCC1 （P 〈 0.05）. Moreover, A549/DDP cells showed morphological and phenotypic changes consistent with EMT： with spindle-shaped morphology, and decreased expression of E-cadherin and increased expression of vimentin. Immunohistochemistry showed significant positive correlation between the expression of ERCCI and vimentin （r = 0.496, 0.332, P 〈 0.05）, and significant negative correlation between the ERCCI and E-cadherin （r = -0.403, -0.295, P 〈 0.05） in neoadjuvant chemotherapy group and simple surgery group. In addition, compared with simple surgery group, the expression of ERCC1 （P = 0.003） and vimentin （P = 0.004） was significantly increased, and the expression of E-cadherin was decreased in neoadjuvant chemotherapy group （P = 0.032）. Cenclusion： A549/DDP cells acquired cisplatin-resistance and occurred EMT simultaneously; the phenomenon of chemoresistance and EMT was caused more easily in neoadjuvant chemotherapy group. As such, we further confirmed the close correlation between chemoresistance and EMT of NSCLC, and provided theoretical basis for the targeting therapy with EMT regulatory factor for chemoresistant NSCLC patients.

音响的组织及其隐含的曲式意味——音响型电子音乐实例解析

本文以一首音响型电子音乐作品为对象，在逐一分析其音响材料和组织手法的基础上，整体地揭示出全曲的隐含曲式性质。