The statistical properties of a homogeneously broadened ring laser with an injected signal are investigated and the normalized two-mode intensity auto- and cross-correlation functions are calculated by a full saturati...The statistical properties of a homogeneously broadened ring laser with an injected signal are investigated and the normalized two-mode intensity auto- and cross-correlation functions are calculated by a full saturation laser theory with backscattering. The theoretical predictions are in good agreement with the experimental measurements.Further investigation reveals that the backscattering can reduce the fluctuations in the system while the full saturation effect plays a major role when the laser is operated above threshold. It is also quite important to notice that the injected signal can drive the weak mode from incoherent light to coherent light.展开更多
Background The benefit of statin use after acute ST-segment elevation myocardial infarction （STEMI） has been well established, however, the influence of the timing of statin administration has not been elucidated. T...Background The benefit of statin use after acute ST-segment elevation myocardial infarction （STEMI） has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention （PCI）. Methods This analysis of the Korea Working Group on Myocardial Infarction registry （KorMI） study included 3,584 STEMI patients （mean age, 63 ±13 years;male, 2,684, 74.9%） undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events （MACE：all-cause death, recurrent MI, and target lesion revascularization） were compared among patients grouped according to statin therapy timing：I, both during and after hospitalization （n=2,653, 74%）;II, only during hospita-lization （n=309, 8.6%）;III, only after discharge （n=157, 4.4%）;and IV, no statin therapy （n=465, 13%）. Mean follow-up duration was 234 ± 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups Ⅲ and Ⅳ had the highest MACE rates （2.3%, 3.9%, 5.1%, and 4.9%for groups I-IV, respectively, P=0.004）. After adjusting for confounders, groups Ⅱ-Ⅳ had a higher MACE risk than group Ⅰ [hazard ratio （HR）：3.20, 95%confidence interval （95%CI）：1.31-7.86, P=0.011;HR：3.84, 95%CI：1.47-10.02, P=0.006;and HR：3.17, 95%CI：1.59-6.40, P=0.001;respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical prac-tice.展开更多
Based on the low energy effective Hamiltonian with naive factorization, we calculate the branching ratios （BRs） and CP asymmetries （CPAs） for the twenty three double charm decays B/B8 → D（＊）D（＊） in both the...Based on the low energy effective Hamiltonian with naive factorization, we calculate the branching ratios （BRs） and CP asymmetries （CPAs） for the twenty three double charm decays B/B8 → D（＊）D（＊） in both the standard （s） （s） model （SM） and the minimal supergravity （mSUGRA） model. Within the considered parameter space, we find that （a） the theoretical predictions for the BRs, CPAs and the polarization fractions in the SM and the mSUGRA model are all consistent with the currently available data within ±2σ errors; （b） For all the considered decays, the supersymmetric contributions in the mSUGRA model are very small, less than 7% numerically. It may be difficult to observe so small SUSY contributions even at LHC.展开更多
Objective To investigate the role of Astragali and Angelica (A&A) of Chinese herbs in acute renal ischemia/reperfusion injury, and the related intracellular signal transduction mechanism. Methods Acute ischemic ...Objective To investigate the role of Astragali and Angelica (A&A) of Chinese herbs in acute renal ischemia/reperfusion injury, and the related intracellular signal transduction mechanism. Methods Acute ischemic renal injury in rats was induced by clamping in renal pedicel for 45 minutes. Rats in therapy group were given a single dose (2 ml/day) of A&A for 3 days before clamping, and then continued for another 3 days. Forty-five minutes after clamping and at different reperfusion time, serum creatinine (Scr) and renal pathological changes were taken and compared in both groups. The proliferating cell nuclear antigen (PCNA) positive cells were detected by immunohistochemistry. Extracelluar regulating kinase (ERK) and c-Jun N-terminal kinase (JNK) activity was assayed by specific substrate phosphorylation with immunoprecipitation. Results At the 24th hour of reperfusion, Scr was lower in A&A group than that in the control. Much less necrotic tubular cells， casts， and more PCNA-positive cells were found in A&A group. ERK activity decreased after clamping, and recovered at 5 minutes of reperfusion. There was no difference between the two groups. JNK activity did not change after ischemia, but increased at 5 minutes and peaked at 20 minutes of reperfusion. JNK activity was significantly higher in A&A group than that in the control group. Conclusion A&A protected kidney against ischemic insult and accelerated both functional and histological recovery after acute renal ischemia/reperfusion injury, which may associate with the change of JNK signaling pathway.展开更多
OBJECTIVE:To observe the regulation of electroacupuncture on gene expression at calcium signaling pathways in mice with cerebral ischemia reperfusion.METHODS:Sixty male, inbred Kunming mice were randomly assigned to t...OBJECTIVE:To observe the regulation of electroacupuncture on gene expression at calcium signaling pathways in mice with cerebral ischemia reperfusion.METHODS:Sixty male, inbred Kunming mice were randomly assigned to three groups:repeated cerebral ischemia reperfusion group(RG, n = 24),sham-operated group(SG, n = 12), and electroacupuncture group(EG, n = 24).Mice in RG and EGgroups were modeled by repeated cerebral ischemia reperfusion surgery, and EG mice were treated with electroacupuncture for 30 min after recovery from anesthesia.Changes in gene expression profile of mice hippocampi were analyzed by global expression profile microarray.Genes that were up-regulated or down-regulated greater than 1.5folds were considered to be biologically meaningful.Real-time quantitative polymerase chain reaction(q-PCR) method was used to verify the expression of selected genes based on the algorithm [2^(ΔΔCt)].RESULTS:Compared with SG mice, 242 genes showed different in expressions in RG mice:107down-regulated and 135 up-regulated.Compared with RG mice, 609 genes showed a difference of expression in EG mice:315 down-regulated and 375up-regulated.Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated two pathways:calcium signaling and long-term potentiation in which 11 differentially expressed genes selected.Six of the 11 genes in the calcium signaling pathway were verified after real-time q-PCR testing.CONCLUSION:Electroacupuncture treatment of cerebral ischemia reperfusion appears to regulate Atp2a2, Cacna1 e, Camk2 a, Gnas, Grm1, Rapgef3 genes in the calcium signaling pathway.展开更多
Objective:To explore the network control mechanism of the calcium signaling pathway in cerebral ischemic injury after intervention by the main components of Qingkailing(清开灵),i.e.Baicalin,Jasminoidin and their combi...Objective:To explore the network control mechanism of the calcium signaling pathway in cerebral ischemic injury after intervention by the main components of Qingkailing(清开灵),i.e.Baicalin,Jasminoidin and their combination.Methods:Thirty mice were randomly divided into 5 groups,a baicalin group,a Jasminoidin group,a baicalin plus Jasminoidin group,a nimodipine group,and a model group(n=6).The global cerebral ischemia-reperfusion mouse model was established.The mice were administrated respectively by injection of baicalin,Jasminoidin,mixture of baicalin and Jasminoidin,and nimodipine into the caudal vein,with the model group given no any drug.Three hours after operation,the brain was removed and sectioned.After calculation of cerebral ischemic area by 2,3,5-triphenyltetrazolium staining,the percentage of infarct volume was calculated.The total RNA of the mouse brain tissue was extracted to obtain the whole genome expression profile,and the differentially expressed genes related to the calcium signaling pathway was analyzed with Bayesian network structures.Results:Compared with the model group,the ischemic area was significantly reduced in the baicalin group,the Jasminoidin group,the Baicalin plus Jasminoidin group(all P<0.05).The ischemic area in the baicalin plus Jasminoidin group was smaller than the other three groups(all P<0.01).In the gene regulatory network structures of calcium signaling pathway,the average length and equitability were the highest in the baicalin plus Jasminoidin group,followed by the nimodipine group.Conclusion:Compared with a single component,combination of Baicalin and Jasminoidin can more obviously intervene in the overall expression of calcium signaling pathway,and the mechanism is related with the aggregation characteristic of the gene expression network.展开更多
In this paper we systematically investigate the influence of control parameters on the competition results between spiral waves and target waves. Driving frequency f , amplitude A and injection area n of the input sig...In this paper we systematically investigate the influence of control parameters on the competition results between spiral waves and target waves. Driving frequency f , amplitude A and injection area n of the input signals are three important parameters and the competition results between spiral waves and target waves are influenced by these three parameters remarkably. Based on these understandings we can control spiral waves effectively by suitable combination these parameters to generate faster target waves. And the effective controllable parameter regions are also studied.展开更多
文摘The statistical properties of a homogeneously broadened ring laser with an injected signal are investigated and the normalized two-mode intensity auto- and cross-correlation functions are calculated by a full saturation laser theory with backscattering. The theoretical predictions are in good agreement with the experimental measurements.Further investigation reveals that the backscattering can reduce the fluctuations in the system while the full saturation effect plays a major role when the laser is operated above threshold. It is also quite important to notice that the injected signal can drive the weak mode from incoherent light to coherent light.
文摘Background The benefit of statin use after acute ST-segment elevation myocardial infarction （STEMI） has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention （PCI）. Methods This analysis of the Korea Working Group on Myocardial Infarction registry （KorMI） study included 3,584 STEMI patients （mean age, 63 ±13 years;male, 2,684, 74.9%） undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events （MACE：all-cause death, recurrent MI, and target lesion revascularization） were compared among patients grouped according to statin therapy timing：I, both during and after hospitalization （n=2,653, 74%）;II, only during hospita-lization （n=309, 8.6%）;III, only after discharge （n=157, 4.4%）;and IV, no statin therapy （n=465, 13%）. Mean follow-up duration was 234 ± 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups Ⅲ and Ⅳ had the highest MACE rates （2.3%, 3.9%, 5.1%, and 4.9%for groups I-IV, respectively, P=0.004）. After adjusting for confounders, groups Ⅱ-Ⅳ had a higher MACE risk than group Ⅰ [hazard ratio （HR）：3.20, 95%confidence interval （95%CI）：1.31-7.86, P=0.011;HR：3.84, 95%CI：1.47-10.02, P=0.006;and HR：3.17, 95%CI：1.59-6.40, P=0.001;respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical prac-tice.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10947020 and 11005033Foundation of Henan Educational Committee for Youth Backbone Scholars in Colleges and Universities+1 种基金the Natural Science Foundation of the Eduction Department of Henan Province under Grant No. 2010A140012Natural Science Foundation of Henan Province under Grant No. 102300410210
文摘Based on the low energy effective Hamiltonian with naive factorization, we calculate the branching ratios （BRs） and CP asymmetries （CPAs） for the twenty three double charm decays B/B8 → D（＊）D（＊） in both the standard （s） （s） model （SM） and the minimal supergravity （mSUGRA） model. Within the considered parameter space, we find that （a） the theoretical predictions for the BRs, CPAs and the polarization fractions in the SM and the mSUGRA model are all consistent with the currently available data within ±2σ errors; （b） For all the considered decays, the supersymmetric contributions in the mSUGRA model are very small, less than 7% numerically. It may be difficult to observe so small SUSY contributions even at LHC.
文摘Objective To investigate the role of Astragali and Angelica (A&A) of Chinese herbs in acute renal ischemia/reperfusion injury, and the related intracellular signal transduction mechanism. Methods Acute ischemic renal injury in rats was induced by clamping in renal pedicel for 45 minutes. Rats in therapy group were given a single dose (2 ml/day) of A&A for 3 days before clamping, and then continued for another 3 days. Forty-five minutes after clamping and at different reperfusion time, serum creatinine (Scr) and renal pathological changes were taken and compared in both groups. The proliferating cell nuclear antigen (PCNA) positive cells were detected by immunohistochemistry. Extracelluar regulating kinase (ERK) and c-Jun N-terminal kinase (JNK) activity was assayed by specific substrate phosphorylation with immunoprecipitation. Results At the 24th hour of reperfusion, Scr was lower in A&A group than that in the control. Much less necrotic tubular cells， casts， and more PCNA-positive cells were found in A&A group. ERK activity decreased after clamping, and recovered at 5 minutes of reperfusion. There was no difference between the two groups. JNK activity did not change after ischemia, but increased at 5 minutes and peaked at 20 minutes of reperfusion. JNK activity was significantly higher in A&A group than that in the control group. Conclusion A&A protected kidney against ischemic insult and accelerated both functional and histological recovery after acute renal ischemia/reperfusion injury, which may associate with the change of JNK signaling pathway.
基金Supported by the 2013 National Natural Science Foundation of China:The Effect of Electro-acupuncture for Mediating Jnk Mitochondrial Pathway in Bax-gene Knockout Mice With the Cerebral Ischemia Reperfusion(No.81373731)
文摘OBJECTIVE:To observe the regulation of electroacupuncture on gene expression at calcium signaling pathways in mice with cerebral ischemia reperfusion.METHODS:Sixty male, inbred Kunming mice were randomly assigned to three groups:repeated cerebral ischemia reperfusion group(RG, n = 24),sham-operated group(SG, n = 12), and electroacupuncture group(EG, n = 24).Mice in RG and EGgroups were modeled by repeated cerebral ischemia reperfusion surgery, and EG mice were treated with electroacupuncture for 30 min after recovery from anesthesia.Changes in gene expression profile of mice hippocampi were analyzed by global expression profile microarray.Genes that were up-regulated or down-regulated greater than 1.5folds were considered to be biologically meaningful.Real-time quantitative polymerase chain reaction(q-PCR) method was used to verify the expression of selected genes based on the algorithm [2^(ΔΔCt)].RESULTS:Compared with SG mice, 242 genes showed different in expressions in RG mice:107down-regulated and 135 up-regulated.Compared with RG mice, 609 genes showed a difference of expression in EG mice:315 down-regulated and 375up-regulated.Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated two pathways:calcium signaling and long-term potentiation in which 11 differentially expressed genes selected.Six of the 11 genes in the calcium signaling pathway were verified after real-time q-PCR testing.CONCLUSION:Electroacupuncture treatment of cerebral ischemia reperfusion appears to regulate Atp2a2, Cacna1 e, Camk2 a, Gnas, Grm1, Rapgef3 genes in the calcium signaling pathway.
基金supported by the 47th Postdoctoral Fund in China (No. 20100470521)the Independent Selection Project of China Academy of Chinese Medical Sciences (No. Z02154)by China National Scientific Fundation (No. 81001596)
文摘Objective:To explore the network control mechanism of the calcium signaling pathway in cerebral ischemic injury after intervention by the main components of Qingkailing(清开灵),i.e.Baicalin,Jasminoidin and their combination.Methods:Thirty mice were randomly divided into 5 groups,a baicalin group,a Jasminoidin group,a baicalin plus Jasminoidin group,a nimodipine group,and a model group(n=6).The global cerebral ischemia-reperfusion mouse model was established.The mice were administrated respectively by injection of baicalin,Jasminoidin,mixture of baicalin and Jasminoidin,and nimodipine into the caudal vein,with the model group given no any drug.Three hours after operation,the brain was removed and sectioned.After calculation of cerebral ischemic area by 2,3,5-triphenyltetrazolium staining,the percentage of infarct volume was calculated.The total RNA of the mouse brain tissue was extracted to obtain the whole genome expression profile,and the differentially expressed genes related to the calcium signaling pathway was analyzed with Bayesian network structures.Results:Compared with the model group,the ischemic area was significantly reduced in the baicalin group,the Jasminoidin group,the Baicalin plus Jasminoidin group(all P<0.05).The ischemic area in the baicalin plus Jasminoidin group was smaller than the other three groups(all P<0.01).In the gene regulatory network structures of calcium signaling pathway,the average length and equitability were the highest in the baicalin plus Jasminoidin group,followed by the nimodipine group.Conclusion:Compared with a single component,combination of Baicalin and Jasminoidin can more obviously intervene in the overall expression of calcium signaling pathway,and the mechanism is related with the aggregation characteristic of the gene expression network.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11105003,11005075the Science Foundation of the Education Bureau of Shaanxi Province of China under Grant No.11JK0544the Fundamental Research Funds for the Central Universities under Grant No.2012ZB0019
文摘In this paper we systematically investigate the influence of control parameters on the competition results between spiral waves and target waves. Driving frequency f , amplitude A and injection area n of the input signals are three important parameters and the competition results between spiral waves and target waves are influenced by these three parameters remarkably. Based on these understandings we can control spiral waves effectively by suitable combination these parameters to generate faster target waves. And the effective controllable parameter regions are also studied.
