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西酞普兰对小鼠角膜上皮细胞和泪膜功能的影响 被引量:2
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作者 闵幼兰 刘佳祥 +8 位作者 贺赢 马明洋 徐晓玮 姜楠 刘康成 袁晴 朱佩文 叶蕾 邵毅 《中国现代医学杂志》 CAS 2019年第1期1-6,共6页
目的研究西酞普兰对小鼠泪膜功能和角膜上皮细胞的影响。方法选取36只BABL/c雄性小鼠随机分为A、B、C 3组,A组:空白对照组(不进行任何处理);B组:生理盐水组,以10 mg/kg腹腔注射生理盐水;C组:西酞普兰组,以10 mg/kg腹腔注射西酞普兰。分... 目的研究西酞普兰对小鼠泪膜功能和角膜上皮细胞的影响。方法选取36只BABL/c雄性小鼠随机分为A、B、C 3组,A组:空白对照组(不进行任何处理);B组:生理盐水组,以10 mg/kg腹腔注射生理盐水;C组:西酞普兰组,以10 mg/kg腹腔注射西酞普兰。分别在实验第1、4和7天时行泪液分泌试验(SIT)、泪膜破裂时间(BUT)检测,同时于实验第7天进行角膜荧光素染色(FL),取眼球做扫描电镜及HE染色观察角膜上皮损伤情况。结果 (1) 3组不同时间点的SIT、BUT、FL有差异(F=9.749、10.427和6.752,P=0.008、0.019和0.032);(2) 3组的SIT、BUT、FL有差异(F=11.234、14.842和5.337,P=0.002、0.012和0.029);(3) 3组的SIT、BUT、FL变化趋势有差异(F=16.438、11.753和16.431,P=0.000、0.001和0.002)。干预后第7天,3组上皮空泡细胞数比较,差异有统计学意义(F=7.749,P=0.013)。3组微绒毛数量比较差异无统计学意义(F=0.917,P=0.092)。结论西酞普兰会损伤小鼠泪膜功能的稳定性,但对角膜上皮细胞无影响。 展开更多
关键词 泪膜/眼 西酞普兰 小鼠 上皮 角膜
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Effects of dry eye syndrome and tear film mucin treated with acupuncture 被引量:8
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作者 赖满英 《World Journal of Acupuncture-Moxibustion》 2011年第4期26-28,共3页
Objective To explore the therapeutic effects and mechanism of dry eye syndrome treated with acupuncture therapy. Methods Thirty cases (60 eyes) of dry eye syndrome were treated with both local and distal acupuncture... Objective To explore the therapeutic effects and mechanism of dry eye syndrome treated with acupuncture therapy. Methods Thirty cases (60 eyes) of dry eye syndrome were treated with both local and distal acupuncture. Jingrning (睛明 BL 1), Cuanzhu (攒竹 BL 2), Tatiyang (太阳 EX-HN 5) and Quchi (曲池 LI 11) were selected; tear secretion quantity, break up time of tear film (BUT) and expression of tear film mucin were observed before and after treatment. Results Tear secretion quantity was increased and break up time of tear film was prolonged after acupuncture therapy, indicating the significant differences (both P〈0.05); meanwhile, the expression of tear film mucin was increased [(0.67 ± 0.1) ng vs (0.89 ± 0.23) ng, P〈0.05]. Conclusion Acupuncture can promote the expression of tear film mucin, enhance the stability of tear film and remarkably improve the symptoms of dry eye. 展开更多
关键词 Dry Eye Syndrome Acupuncture Therapy Tear Film Muein
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