Objective. To investigate the characteristics of urotensin II (U II) receptor in the rat airway smooth muscle and the effect and signal transduction pathway of U II on the proliferation of airway smooth muscle cells. ...Objective. To investigate the characteristics of urotensin II (U II) receptor in the rat airway smooth muscle and the effect and signal transduction pathway of U II on the proliferation of airway smooth muscle cells. Methods. Using 125I UII binding assay to measure the Bmax and Kd of U II receptor. Using the 3H TdR incorporation to determine the effect of U II on the proliferation of airway smooth muscle cells and its signal transduction pathway. Using Fura 2/AM to measure the effect of U II on the cytosolic free calcium concentration. Results. 1. 125I UII binding increased with the time and reached saturation at 45min. The Bmax was (11.36±0.37)fmol/mg pr and Kd was (4.46±0.61)nmol/L. 2. U II increased 3H TdR incorporation of the airway smooth muscle cells in a dose dependent manner. 3. H7, PD98059 and nicardipine, inhibitors of PKC, MAPK, calcium channel, respectively, significantly inhibited U II stimulated 3H TdR incorporation of airway smooth muscle cells. W7, inhibitor of CaM PK, had no effect. 4. Cyclosporin A, inhibitor of CaN, inhibited 3H TdR incorporation of the airway smooth muscle cells induced by U II in a dose dependent manner. 5. U II promoted cytosolic free calcium concentration increase by 18%. Conclusions. 1. There was U II receptor in the rat airway smooth muscle. 2. The effect of U II stimulated 3H TdR incorporation of airway smooth muscle cells was mediated by such signal transduction pathway as Ca2+, PKC, MAPK and CaN, etc.展开更多
Objective Recently it has been suggested that, in patients with large patent foramen ovale （PFO） and atrial septal aneurysms （ASA）, a certain amount of left atrial （LA） dysfunction may be active as an alternate ...Objective Recently it has been suggested that, in patients with large patent foramen ovale （PFO） and atrial septal aneurysms （ASA）, a certain amount of left atrial （LA） dysfunction may be active as an alternate mechanism promoting arterial embolism. Following this hypothesis, elderly patients, being more susceptible to atrial chambers stiffness, should present a more severe LA dysfunction profile. We sought to evaluate the grade of LA dysfunction in elderly patients submitted to transcatheter PFO closure. Methods We retrospectively enrolled 28 consecutive patients with previous stroke （mean age 674-12.5 years, 18 females） referred to our centre for catheter-based PFO closure after recurrent stroke. Baseline values of LA passive and active emptying, LA conduit function, LA ejection fraction, and spontaneous echocontrast （SEC） in the LA and LA appendage were compared with those of 50 atrial fibrillation patients, as well as a sex/age/cardiac risk matched population of 70 healthy controls. Results Pre-closure elderly subjects demonstrated significantly greater reservoir function as well as passive and active emptying, with reduced conduit function and LA ejection fraction, when compared to healthy and younger patients. After closure in elderly patients, LAparameters did not return completely to the levels of healthy patients, whereas LA dysfunction in younger subjects returned normal. Conclusions This study suggests that elderly patients have more severe LA dysfunction than younger patients, which affects the LA remodelling after closure.展开更多
Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptio...Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptions were employed during the derivation： 1） principal strains by M-C model and D-P model are equal, and 2） the material is under plane strain condition. Based on the analysis of the surface on rt plane, it is found that the proposed D-P type criterion is better than the D-P criterion with M-C circumscribed circle or M-C inscribed circle, and is applicable for stress Lode angle less than zero. By comparing the predicted results with the test data of sand under plane strain condition and other D-P criteria, the proposed criterion is verified and agrees well with the test data, which is further proved to be better than other D--P type criteria in certain range of Lode angle. The criterion was compiled into a finite difference package FLAC3D by user-subroutine, and was used to analyze the stability of a slope by strength reduction method. The predicted slope safety factor from the proposed criterion agrees well with that by Spencer method, and it is more accurate than that from classic D-P criteria.展开更多
Aluminium phosphide is a rodenticide widely used in agriculture to protect grains and foods. Poisoning with this product represents a real problem in developing countries, as an interested young people and it causes h...Aluminium phosphide is a rodenticide widely used in agriculture to protect grains and foods. Poisoning with this product represents a real problem in developing countries, as an interested young people and it causes high mortality. Aims of this study are to analysis epidemiological aspects, clinics, therapeutic, outcome of this acute poisoning and determine the factors of mortality. It is a retrospective study, concerned 47 patients intoxicated by the Aluminium phosphide between January 2009 and December 2012. It represents 23.4% of all poisonings. The mean age was 24.5 years with a female predominance （63.8%）. The poisoning was in a suicidal goal in 95.7% of cases. The mean ingested quantity was 3 grams. The initial clinical picture was dominated by vomiting, abdominal pain, shock and disorders of consciousness in 57.4%, 48.9%, 31.9% and 21.3%, respectively. Electrocardiogram abnormalities were observed in 38.3% of cases. Increase of Troponin was observed in 27.7% of cases. 36.2% of patients were intubated and ventilated and 40.4% have been placed under vasoactive drugs. The mortality rate was 38.3%. The prognostic factors were： delay of management, potassium disorders, elevated of Troponin, hypotension, tachycardia, need for mechanical ventilation, vasoactive drugs and shock. To improve the prognosis, the management should be rapid and the governement should focus more on prevention, so the aluminium phosphide will not be avaible to general population.展开更多
The group G of general coordinate transformations on the thermodynamic configuration space ε spanned by all the extensive variables keeps the first law of thermodynamics invariant. One can introduce a metric with Lor...The group G of general coordinate transformations on the thermodynamic configuration space ε spanned by all the extensive variables keeps the first law of thermodynamics invariant. One can introduce a metric with Lorentzian signature on the space ε, with the corresponding line element also being invariant under the action of G. This line element is identi6ed as the square of the proper entropy. Thus the second law of thermodynamics is also formulated invariantly and this lays down the foundation for the principle of thermal relativity.展开更多
An epidemiological survey of anisakid nematodes was conducted on 205 specimens of horse mackerel （Trachurus trachurus） and 183 of axillary seabream （Pagellus acarne） captured in the zone between Tangier and Larach...An epidemiological survey of anisakid nematodes was conducted on 205 specimens of horse mackerel （Trachurus trachurus） and 183 of axillary seabream （Pagellus acarne） captured in the zone between Tangier and Larache in the north Atlantic Moroccan＇s coasts. Three species of nematodes were morphologically identified： Anisakis simplex s.l., Hysterothylacium sp., Pseudotarranova sp. According to the season, the nematode most observed in T. trachurus was .4. simplex s.1. （the highest values of prevalence （100%）, the mean intensity （48.6）. Hysterothylacium sp. was the most frequent anisakid in P. acarne with 100% of prevalence and 34.46 of the mean intensity. The infestation parameters were also analyzed according to the host species length, noting a maximum of infected fish by Anisakis simplex s.1. （96%） in samples of horse mackerel larger than 28 cm, while in axiliary seabream, the highest prevalence of infestation by Hysterothylacium sp. （100%） was found in fish more than 29 cm.展开更多
To compare the pharmacokinetics properties of enalapril-felodipine sustained-release tablet with enalapril and felodipine in the two reference formulations in Chinese healthy volunteers, the study was designed to a ra...To compare the pharmacokinetics properties of enalapril-felodipine sustained-release tablet with enalapril and felodipine in the two reference formulations in Chinese healthy volunteers, the study was designed to a randomized, open label, crossover and two treatment pharmacokinetic study using enalapril-felodipine sustatined-release tablet as the test formulation. A total of 12 individuals were randomly assigned to 2 gorups （6 individuals in each group）. The wash-out period was 14 d. Compared with the reference formulations, felodipine in the sustained-release tablet showed significantly sustained-release characteristics, while the pharmacokinetics processes of enalapril and its active metabolite enalaprilat were basically similar in Chinese healthy volunteers.展开更多
In this paper, a sample including 68 blazars (18 BL Lacs and 50 FSRQs) with known Doppler factors and superluminal velocity from our previous papers is presented. Both the Lorentz factors (/') and viewing angles (...In this paper, a sample including 68 blazars (18 BL Lacs and 50 FSRQs) with known Doppler factors and superluminal velocity from our previous papers is presented. Both the Lorentz factors (/') and viewing angles (0) are estimated for the 68 sources The relationship between BL Lacs and FSRQs is also revisited using the two variables off'and 0. The Lorenz factors are in the range of 2.33 to 64.07. The viewing angles are in the range of 0.04 to 24.56. The averaged value of the viewing angle for BL Lacs is slightly larger than that for FSRQs, while the averaged value of the Lorentz factor for BL Lacs is smaller than that for FSRQs.展开更多
By making use of the weak gravitational field approximation, we obtain a linearized solution of the gravitational vacuum field equation in an anisotropic spacetime. The plane-wave solution and dispersion relation of g...By making use of the weak gravitational field approximation, we obtain a linearized solution of the gravitational vacuum field equation in an anisotropic spacetime. The plane-wave solution and dispersion relation of gravitationaJ wave is presented explicitly. There is possibility that the speed of gravitational wave is larger than the speed of light and the easuality still holds. We show that the energy-momentum of gravitational wave in the ansiotropic spacetime is still well defined and conserved.展开更多
We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The avera...We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The average lifetime of the metastable state was observed to increase with the magnitude of the gradient of applied field. In the high gradient regime, the system was observed to show two distinct region of up and down spins. The interface or the domain wall was observed to move as one increases the gradient. The displacement of the mean position of the interface was observed to increase with the gradient as hyperbolic tangent function. The roughness of the interface was observed to decay exponentially as the gradient increases. The number of spin flip per site was observed to show a discontinuity in the vicinity of the domain wall. The amount of the discontinuity was found to diverge with the system size as a power law fashion with an exponent 5/3.展开更多
The equilibrium problem for the infinite elastic plane consisting of two different media is considered, in which the interface is a broken line, there is a straight crack touching the vertex of the broken line with ...The equilibrium problem for the infinite elastic plane consisting of two different media is considered, in which the interface is a broken line, there is a straight crack touching the vertex of the broken line with some symmetry and the same uniform pressures are applied to both of its sides. The problem is reduced to a uniquely solvable singular integral equation on the interface and the crack. The order of singularity at the vertex is considered, which may be determined by a transcendental equation.展开更多
文摘Objective. To investigate the characteristics of urotensin II (U II) receptor in the rat airway smooth muscle and the effect and signal transduction pathway of U II on the proliferation of airway smooth muscle cells. Methods. Using 125I UII binding assay to measure the Bmax and Kd of U II receptor. Using the 3H TdR incorporation to determine the effect of U II on the proliferation of airway smooth muscle cells and its signal transduction pathway. Using Fura 2/AM to measure the effect of U II on the cytosolic free calcium concentration. Results. 1. 125I UII binding increased with the time and reached saturation at 45min. The Bmax was (11.36±0.37)fmol/mg pr and Kd was (4.46±0.61)nmol/L. 2. U II increased 3H TdR incorporation of the airway smooth muscle cells in a dose dependent manner. 3. H7, PD98059 and nicardipine, inhibitors of PKC, MAPK, calcium channel, respectively, significantly inhibited U II stimulated 3H TdR incorporation of airway smooth muscle cells. W7, inhibitor of CaM PK, had no effect. 4. Cyclosporin A, inhibitor of CaN, inhibited 3H TdR incorporation of the airway smooth muscle cells induced by U II in a dose dependent manner. 5. U II promoted cytosolic free calcium concentration increase by 18%. Conclusions. 1. There was U II receptor in the rat airway smooth muscle. 2. The effect of U II stimulated 3H TdR incorporation of airway smooth muscle cells was mediated by such signal transduction pathway as Ca2+, PKC, MAPK and CaN, etc.
文摘Objective Recently it has been suggested that, in patients with large patent foramen ovale （PFO） and atrial septal aneurysms （ASA）, a certain amount of left atrial （LA） dysfunction may be active as an alternate mechanism promoting arterial embolism. Following this hypothesis, elderly patients, being more susceptible to atrial chambers stiffness, should present a more severe LA dysfunction profile. We sought to evaluate the grade of LA dysfunction in elderly patients submitted to transcatheter PFO closure. Methods We retrospectively enrolled 28 consecutive patients with previous stroke （mean age 674-12.5 years, 18 females） referred to our centre for catheter-based PFO closure after recurrent stroke. Baseline values of LA passive and active emptying, LA conduit function, LA ejection fraction, and spontaneous echocontrast （SEC） in the LA and LA appendage were compared with those of 50 atrial fibrillation patients, as well as a sex/age/cardiac risk matched population of 70 healthy controls. Results Pre-closure elderly subjects demonstrated significantly greater reservoir function as well as passive and active emptying, with reduced conduit function and LA ejection fraction, when compared to healthy and younger patients. After closure in elderly patients, LAparameters did not return completely to the levels of healthy patients, whereas LA dysfunction in younger subjects returned normal. Conclusions This study suggests that elderly patients have more severe LA dysfunction than younger patients, which affects the LA remodelling after closure.
基金Project(2010B14814) supported by the Fundamental Research Funds for the Central Universities of ChinaProject(200801133) supported by the Ministry of Water Resources of China for Public Welfare ProfessionProject(50809023) supported by the National Natural Science Foundation of China
文摘Based on Mohr-Coulomb （M-C） criterion, the parameters of Druker-Prager （D-P） criterion for geomaterial were determined under non-associated flow rule, and thus a new D-P type criterion was presented. Two assumptions were employed during the derivation： 1） principal strains by M-C model and D-P model are equal, and 2） the material is under plane strain condition. Based on the analysis of the surface on rt plane, it is found that the proposed D-P type criterion is better than the D-P criterion with M-C circumscribed circle or M-C inscribed circle, and is applicable for stress Lode angle less than zero. By comparing the predicted results with the test data of sand under plane strain condition and other D-P criteria, the proposed criterion is verified and agrees well with the test data, which is further proved to be better than other D--P type criteria in certain range of Lode angle. The criterion was compiled into a finite difference package FLAC3D by user-subroutine, and was used to analyze the stability of a slope by strength reduction method. The predicted slope safety factor from the proposed criterion agrees well with that by Spencer method, and it is more accurate than that from classic D-P criteria.
文摘Aluminium phosphide is a rodenticide widely used in agriculture to protect grains and foods. Poisoning with this product represents a real problem in developing countries, as an interested young people and it causes high mortality. Aims of this study are to analysis epidemiological aspects, clinics, therapeutic, outcome of this acute poisoning and determine the factors of mortality. It is a retrospective study, concerned 47 patients intoxicated by the Aluminium phosphide between January 2009 and December 2012. It represents 23.4% of all poisonings. The mean age was 24.5 years with a female predominance （63.8%）. The poisoning was in a suicidal goal in 95.7% of cases. The mean ingested quantity was 3 grams. The initial clinical picture was dominated by vomiting, abdominal pain, shock and disorders of consciousness in 57.4%, 48.9%, 31.9% and 21.3%, respectively. Electrocardiogram abnormalities were observed in 38.3% of cases. Increase of Troponin was observed in 27.7% of cases. 36.2% of patients were intubated and ventilated and 40.4% have been placed under vasoactive drugs. The mortality rate was 38.3%. The prognostic factors were： delay of management, potassium disorders, elevated of Troponin, hypotension, tachycardia, need for mechanical ventilation, vasoactive drugs and shock. To improve the prognosis, the management should be rapid and the governement should focus more on prevention, so the aluminium phosphide will not be avaible to general population.
基金Supported by the National Natural Science Foundation of China under Grant No.10875059
文摘The group G of general coordinate transformations on the thermodynamic configuration space ε spanned by all the extensive variables keeps the first law of thermodynamics invariant. One can introduce a metric with Lorentzian signature on the space ε, with the corresponding line element also being invariant under the action of G. This line element is identi6ed as the square of the proper entropy. Thus the second law of thermodynamics is also formulated invariantly and this lays down the foundation for the principle of thermal relativity.
文摘An epidemiological survey of anisakid nematodes was conducted on 205 specimens of horse mackerel （Trachurus trachurus） and 183 of axillary seabream （Pagellus acarne） captured in the zone between Tangier and Larache in the north Atlantic Moroccan＇s coasts. Three species of nematodes were morphologically identified： Anisakis simplex s.l., Hysterothylacium sp., Pseudotarranova sp. According to the season, the nematode most observed in T. trachurus was .4. simplex s.1. （the highest values of prevalence （100%）, the mean intensity （48.6）. Hysterothylacium sp. was the most frequent anisakid in P. acarne with 100% of prevalence and 34.46 of the mean intensity. The infestation parameters were also analyzed according to the host species length, noting a maximum of infected fish by Anisakis simplex s.1. （96%） in samples of horse mackerel larger than 28 cm, while in axiliary seabream, the highest prevalence of infestation by Hysterothylacium sp. （100%） was found in fish more than 29 cm.
基金National Natural Science Foundation of China(Grant No.81102499)supported by Hunan Science and Technology Project(Grant No.2011SK3261,Changsha,China)
文摘To compare the pharmacokinetics properties of enalapril-felodipine sustained-release tablet with enalapril and felodipine in the two reference formulations in Chinese healthy volunteers, the study was designed to a randomized, open label, crossover and two treatment pharmacokinetic study using enalapril-felodipine sustatined-release tablet as the test formulation. A total of 12 individuals were randomly assigned to 2 gorups （6 individuals in each group）. The wash-out period was 14 d. Compared with the reference formulations, felodipine in the sustained-release tablet showed significantly sustained-release characteristics, while the pharmacokinetics processes of enalapril and its active metabolite enalaprilat were basically similar in Chinese healthy volunteers.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10633010 and 11173009)the National Basic Research Program of China (Grant No. 2007CB 815405)+4 种基金the Bureau of Education of Guangzhou Municipality (Grant No. 11 Sui-Jiao-Ke[2009])Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(GDUPS) (2009), Yangcheng Scholar Funded Scheme (Grant No.10A027S)Hunan Provincial Natural Science Foundation of China (Grant No. 10JJ3020)the Fund of the 11th Five-year Plan for Key Construction Academic Subject (Optics) of Hunan Provincethe research fund of Hunan University of Arts and Science (Grant No. JJZD201101)
文摘In this paper, a sample including 68 blazars (18 BL Lacs and 50 FSRQs) with known Doppler factors and superluminal velocity from our previous papers is presented. Both the Lorentz factors (/') and viewing angles (0) are estimated for the 68 sources The relationship between BL Lacs and FSRQs is also revisited using the two variables off'and 0. The Lorenz factors are in the range of 2.33 to 64.07. The viewing angles are in the range of 0.04 to 24.56. The averaged value of the viewing angle for BL Lacs is slightly larger than that for FSRQs, while the averaged value of the Lorentz factor for BL Lacs is smaller than that for FSRQs.
基金Supported by the National Natural Science Foundation of China under Grant Nos.1087512911075166and 11147176
文摘By making use of the weak gravitational field approximation, we obtain a linearized solution of the gravitational vacuum field equation in an anisotropic spacetime. The plane-wave solution and dispersion relation of gravitationaJ wave is presented explicitly. There is possibility that the speed of gravitational wave is larger than the speed of light and the easuality still holds. We show that the energy-momentum of gravitational wave in the ansiotropic spacetime is still well defined and conserved.
文摘We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The average lifetime of the metastable state was observed to increase with the magnitude of the gradient of applied field. In the high gradient regime, the system was observed to show two distinct region of up and down spins. The interface or the domain wall was observed to move as one increases the gradient. The displacement of the mean position of the interface was observed to increase with the gradient as hyperbolic tangent function. The roughness of the interface was observed to decay exponentially as the gradient increases. The number of spin flip per site was observed to show a discontinuity in the vicinity of the domain wall. The amount of the discontinuity was found to diverge with the system size as a power law fashion with an exponent 5/3.
文摘The equilibrium problem for the infinite elastic plane consisting of two different media is considered, in which the interface is a broken line, there is a straight crack touching the vertex of the broken line with some symmetry and the same uniform pressures are applied to both of its sides. The problem is reduced to a uniquely solvable singular integral equation on the interface and the crack. The order of singularity at the vertex is considered, which may be determined by a transcendental equation.
