麻烦事

郭炳江锒铛入狱2014年12月23日,卷入了香港"世纪贪腐案"的新鸿基地产前联席主席郭炳江,被裁定串谋公职人员行为失当罪成立,被判监禁五年,以及罚款50万港元,五年内不能再担任任何公司董事。摩根大通报告称,新鸿基地产卷入前政务司司长许仕仁涉贪案,目前的结果比市场预期要好,但如今现任主席郭炳联无罪释放,并会继续管理公司,相信对集团正面的发展会好于预期。

Impact of a Pharmacist Implemented Protocol on Overall Use of Alvimopan （Entereg） and Length of Stay in Laparoscopic Colorectal Surgeries

The primary objective of this study is to assess the impact of a pharmacist-implemented protocol on number of post-operative alvimopan doses. The secondary objective of this study is to assess LOS （length of stay）, in days, before and after protocol implementation. A retrospective chart review was conducted from October 2015 through March 2016 for all laparoscopic colorectal surgeries. Number of post-operative alvimopan doses received and LOS was recorded for each patient that received at least one dose of alvimopan. Comparative data, before protocol implementation, from November 2014 through June 2015 were analyzed against the study data. Number of post-operative alvimopan doses and LOS were recorded. The mean number of doses was 6.41 in the comparator group and 4.25 in the study group （probability size P 〈 0.001）, which did meet statistical significance. Although the secondary objective was not statistically significant, LOS slightly decreased as the mean LOS was 5.01 days in the comparator group versus 4.49 days in the study group （P = 0.256）. At the current price of $120 per capsule, close to $30,000 was saved during the study period, projecting an annual cost savings of approximately $68,000. Results from this study show that pharmacists can play a vital role in cost savings and ensuring appropriate use of certain high-risk medications, like alvimopan, without increasing overall length of stay.

A Statistical Power Comparison of the Kolmogorov-Smirnov Two-Sample Test and the Wald Wolfowitz Test in Terms of Fixed Skewness and Fixed Kurtosis in Large Sample Sizes

In this study, the statistical powers of Kolmogorov-Smimov two-sample （KS-2） and Wald Wolfowitz （WW） tests, non-parametric tests used in testing data from two independent samples, have been compared in terms of fixed skewness and fixed kurtosis by means of Monte Carlo simulation. This comparison has been made when the ratio of variance is two as well as with equal and different sample sizes for large sample volumes. The sample used in the study is： （25, 25）, （25, 50）, （25, 75）, （25, 100）, （50, 25）, （50, 50）, （50, 75）, （50, 100）, （75, 25）, （75, 50）, （75, 75）, （75, 100）, （100, 25）, （100, 50）, （100, 75）, and （100, 100）. According to the results of the study, it has been observed that the statistical power of both tests decreases when the coefficient of kurtosis is held fixed and the coefficient of skewness is reduced while it increases when the coefficient of skewness is held fixed and the coefficient of kurtosis is reduced. When the ratio of skewness is reduced in the case of fixed kurtosis, the WW test is stronger in sample volumes （25, 25）, （25, 50）, （25, 75）, （25, 100）, （50, 75）, and （50, 100） while KS-2 test is stronger in other sample volumes. When the ratio of kurtosis is reduced in the case of fixed skewness, the statistical power of WW test is stronger in volume samples （25, 25）, （25, 75）, （25, 100）, and （75, 25） while KS-2 test is stronger in other sample volumes.

The psychological tale of Lord Jim

The present thesis takes Joseph Conrad＇s best-known novel, Lord Jim as a text of analysis to explore its themes that are the ambiguous nature of good and evil, the importance and fragility of ideals, the isolation of the individual, and the threat of disaster and failure that looms behind the calm surface of every day. It focuses on the psychological process of the protagonist, Jim, by employing Freud＇s psychoanalysis to solve the puzzle surrounding Jim.

The Image of an Addressee in Translational Discourse： Exemplified by the Texts Translated From Slovenian Language

Translational discourse requires at least three participants, therefore it is suggested to consider the universal model of the picture of the world, according to which it is much easier for a translator to combine the pictures of the world of an addressee and an author. An addressee is a mental image existing in the mind of an addresser during the creative process. Having defined its parameters, a translator has an opportunity to deliver the thought of an addresser to an addressee as accurately as possible and to select the means of expression that are clear to an addressee. The type of an addressee correlates with ＂the relation to the new＂.

Comparison of Beer Quality Produced Using Malt from Kosovo and Other Countries

Aiming to optimize the beer production process by improving the properties of beer and reducing production costs at the J.S.C. ＂Birra Peja＂ brewery, Peja, Kosovo, this study did an evaluation of beer produced using six different malts. Four of the six studied malts were produced in four European countries： Ukraine, Croatia, Serbia and Kosovo; and, the other two malts were obtained from two （2） 30：70 proportion mixtures： one from Kosovo and Ukraine and another one from Kosovo and Croatia. Chemical, microbiological, sensory and tasting analyses were carried on beers produced by these malts. The study included three working groups from： ＂Birra Peja＂; the Agricultural University of Tirana, Albania and ＂Union Brewery＂, Ljubljana, Slovenia. Chemical and microbiological tests were based on methods under the EBC （European Beer Convention） and MEBAK （Mitteleurop^iische Brautechnische Analysenkommision e.V.） guidelines. The analyses and assessments made for the quality of beer have come to the conclusion that beer produced by Croatian origin malt corresponds to a better quality beer.

An ecological perspective on Joseph Rock’s(1884-1962)plant collection activities in China

In the early 20th century,numerous western botanists,often referred to as‘plant hunters’,embarked on ambitious expeditions to China,playing a crucial role in the study of botany and botanical diversity.Despite their contributions,comprehensive assessments of their explorations are lacking.To bridge this gap,this article focuses on the work of Joseph Charles Francis Rock,a notable figure in that era.Our work revisits Rock’s botanical expeditions within the broader context of botanical diversity conservation.It outlines his historical experiences in collecting plants in China and enumerates the species composition and phenotypic traits of the plants he collected.Additionally,it also analyzes the spatial distribution of the species,the completeness of his collection and the α-and β-diversity of the plants he collected.Our findings reveal that Rock led four major botanical expeditions in China between 1922 and 1933,amassing a total of 28184 sheets and 16608 numbers across 204 families,1081 genera and 4231 species.His focus was predominantly on ornamental species,which exhibit a variety of flower colors and inflorescences.His collection work spanned 5 provinces,35 cities and 72 counties,with a notable concentration in the Hengduan Mountains,a current biodiversity hotspot.This study not only reconstructs Rock’s botanical legacy but also offers valuable historical data and fresh analytical insights for understanding contemporary plant diversity.It contributes to the ongoing discourse on the importance of preserving plant diversity as a cornerstone of environmental sustainability.

日语复合词的简略形式

复合词的简略形式称省略语。日语里称为“略语”(りゃくで)。省略词语的一部分,使该词语简明易记是世界上许多语言都有的共同现象。象汉语中把全国人民代表大会.说成“人大”,把联合国教育科学文化组织说成“教科文”都是词组的简略。汉语的缩略方式是抽出代表性的语素加以组和而成。那么日语是如何缩略的呢?也就是说日语的缩略语是怎么省略的呢?日语的词汇分为和语、汉语、外来语和混种语,一般认为和语的省略语很少见,日语中汉语词汇和外来语的省略语居多,笔者根据日本新星出版社的《早れかり新略语辞典》的统计,日语的省略语有如下一些省略形式。

诗探索(理论卷)

李建春的《新观念写作:对当代诗的一种观察》提出了当下诗歌的一种新的走势,并把其概括为"新观念写作",呢喃的《新叙事主义诗歌刍议》

编者的话

在本辑的"诗坛态势剖析"栏目中,我们编发了诗人李建春和呢喃的文章。李建春的《新观念写作:对当代诗的一种观察》提出了当下诗歌的一种新的走势,并把其概括为"新观念写作"。

禁闭岛金牌搭档再续前缘

片名:禁闭岛Shutter Island导演:马丁·斯科塞斯演员:莱昂纳多·迪卡普里奥马克·鲁弗洛本·金斯利出品:2010年2月19日美国推荐指数:9精彩看点1马丁·斯科塞斯——奥斯卡对马丁·斯科塞斯的吝啬绝不会降低他在众多影迷和专家心目中的地位。在好莱坞,斯科塞斯享有"电影社会学家"的称号,他的作品往往具有深刻的洞察力,这次转型拍摄悬疑惊悚片也值得期待。

妖媚舞男裘德·洛

裘德·洛是一个"冷酷"的家伙,以至于朋友们叫他"冰箱"。事实上,我们最终总会发现那其实足他最可爱的地方:就像个孩子,永远不失孩子的固执与纯真。他是天使孩子气与成熟男人味最完美的结合体。

Cost-utility of erlotinib combined with bevacizumab versus bevacizumab alone after completion of chemotherapy with bevacizumab for first-line treatment of advanced non-small-cell lung cancer

Bevacizumab plus erlotinib prolonged patients＇ progression-free survive （PFS） versus bevacizumab alone for the maintenance treatment of none-small cell lung cancer （NSCLC） in phase III clinical trial ATLAS （ClinicalTrials. gov identifier NCT00257608）, which repealed a benefit outcome and acceptable side-effects, but whether its cost performance would be accepted by patients is blurry. The aim of our research is to figure out which strategy is the best option in clinic and would spread broadly. Markov Model was used to calculate incremental cost-utility radios （ICURs） and 10-year quality-adjusted life years （QALY） of both strategies. The clinical data were collected from phase III clinical trial ATLAS （ClinicalTrials. gov identifier NCT00257608）. The cost data were obtained from Chinese health care system. In the research, one-way sensitivity analysis, probabilistic sensitivity analysis （PSA） and Monte-Carlo analysis were performed to test the stability of the results. The better strategy was bevacizumab alone strategy, and the cumulative costs of both strategies were $178 648.47 and $46 445.28, respectively, and the QALY was 12.506 and 10.643, respectively. The ICUR of combined application was $70 962.53/QALY, which was much higher than 3 times of mean gross domestic product （GDP） in China, suggesting that this strategy was no economical at all. In one-way analysis, the change of willingness-to-pay could not influence the consequence. In addition, in Monte-Carlo analysis, the probability distribution of cost, effectiveness and ICUR was in normal distribution. Taken together, bevacizumab alone strategy was the better strategy in terms of cost-effectiveness.

Applications of the representative points in statistical simulations

The paper gives a new approach to statistical simulation and resampling by the use of numbertheoretic methods and representative points. Resempling techniques take samples from an approximate population. The bootstrap suggests to use a random sample to form an approximate population. We propose to construct some approximate population distribution by the use of two kinds of representative points, and samples are taken from these approximate distributions. The statistical inference is based on those samples. The statistical inference in this paper involves estimation of mean, variance, skewness, kurtosis, quantile and density of the population distribution. Our results show that the new method can significantly improve the results by the use of Monte Carlo methods.

Ridge-Forward Quadratic Discriminant Analysis in High-Dimensional Situations

Quadratic discriminant analysis is a classical and popular classification tool,but it fails to work in high-dimensional situations where the dimension p is larger than the sample size n.To address this issue,the authors propose a ridge-forward quadratic discriminant(RFQD) analysis method via screening relevant predictors in a successive manner to reduce misclassification rate.The authors use extended Bayesian information criterion to determine the final model and prove that RFQD is selection consistent.Monte Carlo simulations are conducted to examine its performance.

Checking for normality in linear mixed models

Linear mixed models are popularly used to fit continuous longitudinal data, and the random effects are commonly assumed to have normal distribution. However, this assumption needs to be tested so that further analysis can be proceeded well. In this paper, we consider the Baringhaus-Henze-Epps-Pulley （BHEP） tests, which are based on an empirical characteristic function. Differing from their case, we consider the normality checking for the random effects which are unobservable and the test should be based on their predictors. The test is consistent against global alternatives, and is sensitive to the local alternatives converging to the null at a certain rate arbitrarily close to 1/V~ where n is sample size. ^-hlrthermore, to overcome the problem that the limiting null distribution of the test is not tractable, we suggest a new method： use a conditional Monte Carlo test （CMCT） to approximate the null distribution, and then to simulate p-values. The test is compared with existing methods, the power is examined, and several examples are applied to illustrate the usefulness of our test in the analysis of longitudinal data.

A new sample preparation method for the determination of acyclovir by RP-HPLC:application to a drug-drug interaction study between gefitinib and acyclovir in rats

The assay of acyclovir in plasma seems to be a challenge because of its high hydrophily.In our present study,a reversed-phase high-performance liquid chromatography(RP-HPLC)method for the determination of acyclovir in rat plasma was described and validated in drug-drug interaction(DDI)between gefitinib and acyclovir in rats.The analytes were separated with gradient elution on C18 column(4.6 mm×250 mm,5μm),and the peaks were recorded using ultraviolet detector at a wavelength of 254 nm.Protein precipitation followed by methyl tertiary butyl ether extraction was used for sample preparation.The calibration curve was established between 0.2 and 40μg/mL(r^(2)=0.9999).The intra-and inter-day precisions were all less than 8%,and all the biases were not more than 10%.This new method was successfully applied to a DDI study between gefitinib and acyclovir in rats.Gefitinib up-regulated the absorption of acyclovir by about three times,and our findings guided the clinical co-administration of epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)with acyclovir.

A maximum a posteriori super resolution algorithm based on multidimensional Lorentzian distribution

This paper presents a threshold-free maximum a posteriori (MAP) super resolution (SR) algorithm to reconstruct high resolution (HR) images with sharp edges. The joint distribution of directional edge images is modeled as a multidimensional Lorentzian (MDL) function and regarded as a new image prior. This model makes full use of gradient information to restrict the solution space and yields an edge-preserving SR algorithm. The Lorentzian parameters in the cost function are replaced with a tunable variable, and graduated nonconvexity (GNC) optimization is used to guarantee that the proposed multidimensional Lorentzian SR (MDLSR) algorithm converges to the global minimum. Simulation results show the effectiveness of the MDLSR algorithm as well as its superiority over conventional SR methods.