The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy ar...The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.展开更多
Nowadays, language has gained great importance due to mass media which allows men to interact with other people anytime and anywhere. Some issues arise： Do media change the way we communicate？ Are there any means in...Nowadays, language has gained great importance due to mass media which allows men to interact with other people anytime and anywhere. Some issues arise： Do media change the way we communicate？ Are there any means in particular that can help people to communicate better？ This paper finds the route for individuals to communicate better, understand each other, and promote values of both our society and culture demand. Three main issues are presented to reach this goal： Firstly, the platonic theory about names, if things are called by convention or by its nature. Secondly, three methods by which these names are used： the grammar, the rhetoric, and the dialectics. Lastly, how orality is a fundamental means for human communication. Each of these subjects will become arguments to support that dialogue is the most suitable and human way for men to communicate, because it gives the necessary tools to man to build himself according to his nature, that is to say, the search for the good and the rational perfection.展开更多
文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.
文摘Nowadays, language has gained great importance due to mass media which allows men to interact with other people anytime and anywhere. Some issues arise： Do media change the way we communicate？ Are there any means in particular that can help people to communicate better？ This paper finds the route for individuals to communicate better, understand each other, and promote values of both our society and culture demand. Three main issues are presented to reach this goal： Firstly, the platonic theory about names, if things are called by convention or by its nature. Secondly, three methods by which these names are used： the grammar, the rhetoric, and the dialectics. Lastly, how orality is a fundamental means for human communication. Each of these subjects will become arguments to support that dialogue is the most suitable and human way for men to communicate, because it gives the necessary tools to man to build himself according to his nature, that is to say, the search for the good and the rational perfection.
