Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milie...Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These include nutrient uptake, signaling from cell- surface receptors, and many other processes essential for cell and tissue functioning in metazoans. It is also central to the maintenance of PM lipid and protein homeostasis. There are multiple means of internalization that operate concurrently, at the cell surface. With advancement in high-resolution visualization techniques, it is now possible to track multiple endocytic cargo at the same time, revealing a remarkable diversity of endocytic processes in a single cell. A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular players in these mechanisms of internalization. Here we provide an account of various endocytic routes, their mechanisms of operation and occurrence across phyla.展开更多
With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have ...With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have the ability to provide the personalized recommendations and the implementation of differentiated business strategy. This text aims to make enterprises understand the customers＇ personalized requirement by using the data processed though questionnaire and rough set theory. And enterprises can provide production and marketing auxiliary decision-making effectively. The feasibility and practicality of rough set theory is verified through the personalized recommendationseases.展开更多
文摘Endocytosis occurs at the cell surface and involves internalization of the plasma membrane （PM） along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These include nutrient uptake, signaling from cell- surface receptors, and many other processes essential for cell and tissue functioning in metazoans. It is also central to the maintenance of PM lipid and protein homeostasis. There are multiple means of internalization that operate concurrently, at the cell surface. With advancement in high-resolution visualization techniques, it is now possible to track multiple endocytic cargo at the same time, revealing a remarkable diversity of endocytic processes in a single cell. A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular players in these mechanisms of internalization. Here we provide an account of various endocytic routes, their mechanisms of operation and occurrence across phyla.
基金This work is supported by the National Natural Science Foundation of China （No. 71301100）, Innovation Program of Shanghai Municipal Education Commission（No. 14YZ140 and No. ZZGJD12036）, Innovation Program of ShanghaiUniversity of Engineering Science （NO. E1-0903-15-01143, Title： 15KY0354Research on personalizedrecommendafionof clothing based on Data Mining） and Doctorate Foundation of Shanghai（No. 11692191400）.
文摘With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have the ability to provide the personalized recommendations and the implementation of differentiated business strategy. This text aims to make enterprises understand the customers＇ personalized requirement by using the data processed though questionnaire and rough set theory. And enterprises can provide production and marketing auxiliary decision-making effectively. The feasibility and practicality of rough set theory is verified through the personalized recommendationseases.
