Anesthesia Management in Hereditary Pheochromocytoma and Paraganglioma:Updated Insights into Clinical Features and Perioperative Care

Approximately 40%of pheochromocytoma and paraganglioma(PPGL)cases are familial,typically presenting earlier with more complex symptoms.This paper synthesizes literature and guidelines to inform on clinical characteristics and perioperative care for PPGL.Pheochromocytoma in von Hippel-Lindau(VHL)disease exhibits heightened secretion activity without significant perioperative hemodynamic changes.Tumors in multiple endocrine neoplasia type 2(MEN2)have a stronger endocrine function,which may induce hemodynamic fluctuations during surgery Therefore,pheochromocytoma screening is essential at all stages of MEN2.Neurofibromatosis type 1(NF1)often presents multisystem lesions and can result in dificult airway.Pheochromocytoma should be evaluated when NF1 patients present hypertension.Pheochromocytoma and paraganglioma type 5 may present multiple lesions of pheochromocytoma or paraganglioma.In summary,hereditary PPGLs may present with severe lesions in other systems,beyond tumor function.A multi-disciplinary team(MDT)approach is often invaluable in perioperative management.

0D-1D coupling model and 3D fluid-structure interaction model based on coronary CT angiography for displaying hemodynamic characteristics of coronary artery stenosis

Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,respectively.Then hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(i.e.sampling point 1—5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient r s.Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,respectively.Both models showed basically distribution of the pressure,flow velocity and WSS of the stenosed LAD.For more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed segment.Compared with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity.For sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(r s=0.730,0.807,both P<0.05).The consistencies of pressure,flow velocity and WSS between 2 models at the proximal and distal segment of stenosis,i.e.1,3—5 sampling points were week to moderate(r s=0.237—0.669,all P<0.05).Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis.

A hybrid ventilation scheme applied to bidirectional excavation tunnel construction with a long inclined shaft

The breakage and bending of ducts result in a difficulty to cope with ventilation issues in bidirectional excavation tunnels with a long inclined shaft using a single ventilation method based on ducts.To discuss the hybrid ventilation system applied in bidirectional excavation tunnels with a long inclined shaft,this study has established a full-scale computational fluid dynamics model based on field tests,the Poly-Hexcore method,and the sliding mesh technique.The distribution of wind speed,temperature field,and CO in the tunnel are taken as indices to compare the ventilation efficiency of three ventilation systems(duct,duct-ventilation shaft,duct–ventilated shaft-axial fan).The results show that the hybrid ventilation scheme based on duct-ventilation shaft–axial fan performs the best among the three ventilation systems.Compared to the duct,the wind speed and cooling rate in the tunnel are enhanced by 7.5%–30.6%and 14.1%–17.7%,respectively,for the duct-vent shaft-axial fan condition,and the volume fractions of CO are reduced by 26.9%–73.9%.This contributes to the effective design of combined ventilation for bidirectional excavation tunnels with an inclined shaft,ultimately improving the air quality within the tunnel.

Rate Law for Photoelectrochemical Water Splitting Over CuO

Photocatalytic splitting of water over p-type semiconductors is a promising strategy for production of hydrogen.However,the determination of rate law is rarely reported.To this purpose,copper oxide(CuO)is selected as a model photocathode in this study,and the photogenerated surface charge density,interfacial charge transfer rate constant and their relation to the water reduction rate(in terms of photocurrent)were investigated by a combination of(photo)electrochemical techniques.The results showed that the charge transfer rate constant is exponential-dependent on the surface charge density,and that the photocurrent equals to the product of the charge transfer rate constant and surface charge density.The reaction is first-order in terms of surface charge density.Such an unconventional rate law contrasts with the reports in literature.The charge density-dependent rate constant results from the Fermi level pinning(i.e.,Galvani potential is the main driving force for the reaction)due to accumulation of charge in the surface states and/or Frumkin behavior(i.e.,chemical potential is the main driving force).This study,therefore,may be helpful for further investigation on the mechanism of hydrogen evolution over a CuO photocathode and for designing more efficient CuO-based photocatalysts.

珠江三角洲的第四纪地层

珠江三角洲总面积8601.1平方公里,其中平原面积6932.5平方公里,占80.6%,其余为突起在平原上的岛丘,计160余座。关于珠江三角洲平原的第四纪地层,前人曾分为三段,即:下段为 Q41河流相沉积层和三角洲相沉积层,中段为Q:42风化层;上段为Q43三角洲相沉积层[1]。或者下段为Q41—Q42的陆相层;中段为Q42—Q43的滨海相层;上段为Q43的河海混合相层[2]。这些划分,因当时C14年代数据不足,多属推论。

关于闽南——台湾浅滩渔场上升流的研究

我们分析了闽南渔场水温、盐度、密度的分布规律,得出:自6月至翌年3月,闽南渔场存在着上升流。6月至9月上升流最强盛的位置在厦门——汕头海岸与台湾浅滩之间的海域(即图1加斜线的区域);10月至翌年3月则移至台湾浅滩西南外斜一带(即图8加斜线的区域)。这两支上升流的来源有所不同,前者来自南海下层水,后者可能来自黑潮下层水。我们还分析了闽南渔场底层常流,表层风生海流的规律。并从底层海流的爬升作用以及风生海流引起的海水涌升运动等动力学方面的因素出发,对闽南渔场上升流形成的可能机制及位置变动的原因作了进一步的阐述。最后,我们计算了上升流的速度,其量级为10-5米/秒。

Optimum design of flow distribution in quenching tank for heat treatment of A357 aluminum alloy large complicated thin-wall workpieces by CFD simulation and ANN approach

Based on the computational fluid dynamics （CFD） method, a quenching tank with two agitator systems and two flow-equilibrating devices was selected to simulate flow distribution using Fluent software. A numerical example was used to testify the validity of the quenching tank model. In order to take tank parameters （agitation speed, position of directional flow baffle and coordinate position in quench zone） into account, an approach that combines the artificial neural network （ANN） with CFD method was developed to study the flow distribution in the quenching tank. The flow rate of the quenching medium shows a very good agreement between the ANN predicted results and the Fluent simulated data. Methods for the optimal design of the quenching tank can be used as technical support for industrial production.

Numerical simulation of flow regions in red mud separation thickener's feedwell by analysis of residence-time distribution

The residence-time distribution （RTD） and the compartment model were applied to characterizing the flow regions in red mud separation thickener’s feedwells. Combined with the experimental work, validated mathematical model as well as three-dimensional computational fluid dynamics （CFD） model was established to analyze the flow regions of feedwells on an industrial scale. The concept of RTD, although a well-known method for the characterization of mixing behavior in conventional mixers and reactors, is still a novel measure for the characterization of mixing in feedwells. Numerical simulation results show that the inlet feed rate and the aspect ratio of feedwells are the most critical parameters which affect the RTD of feedwell. Further simulation experiments were then carried out. Under the optimal operation conditions, the volume fraction of dead zone can reduce by10.8% and an increasement of mixing flow volume fraction by 6.5% is also observed. There is an optimum feed inlet rate depending on the feedwell design. The CFD model in conjunction with the RTD analysis then can be used as an effective tool in the design, evaluation and optimization of thickener feedwell in the red mud separation.

台湾海峡西部沿岸上升流的研究

本文分析了台湾浅滩至闽江口南近海海水的温度、盐度和密度等要素的分布特征,获知夏季海峡西部沿岸存在着上升流。上升流最强的位置有两处:其一在平潭岛附近海域,另一处位于台湾浅滩西北侧东山岛以东海域。文中从底层海流逆坡爬升及风生海流引起的海水涌升等动力学因素方面,对台湾海峡西北部沿岸上升流形成的可能机制进行了探讨,并用等密度线位移估算了平潭岛附近海域上升流的速度为1.6×10^(-3)cm/s。

Simulation of mould filling process using smoothed particle hydrodynamics

The implementation of high pressure die casting （HPDC） filling process modeling based on smoothed particle hydrodynamics （SPH） was discussed. A new treatment of inlet boundary was established by discriminating fluid particles from inlet particles. The roles of artificial viscosity and moving least squares method in the present model were compared in the handling pressure oscillation. The final model was substantiated by simulating filling process in HPDC in both two and three dimensions. The simulated results from SPH and finite difference method （FDM） were compared with the experiments. The results show the former is in a better agreement with experiments. It demonstrates the efficiency and precision of this SPH model in describing flow pattern in filling process.

CFD-supported optimization of flow distribution in quench tank for heat treatment of A357 alloy large complicated components

The flow distribution in quench tank for heat treatment of A357 alloy large complicated components was simulated using FLUENT computational fluid dynamics（CFD） software.The flow velocity and the uniformity of flow field in two types of quench tanks（with or without agitation system） were calculated.The results show that the flow field in the quench tank without agitation system has not evident regularity.While as for the quench tank with agitation system,the flow fields in different parameters have certain regularity.The agitation tanks have a distinct advantage over the system without agitation.Proper process parameters were also obtained.Finally,the tank model established in this work was testified by an example from publication.This model with high accuracy is able to optimize the tank structures and can be helpful for industrial production and theoretical investigation in the fields of heat treatment of large complicated components.

MULTI-BODY AEROELASTIC STABILITY ANALYSIS OF TILTROTOR AIRCRAFT IN HELICOPTER MODE

The muhi-body analysis of the aeroelastic stability of the tiltrotor aircraft is presented. Muhi-body dynamic differential equations are combined with the equations of the unsteady dynamic inflow model to establish the complete unsteadily aeroelastic coupling analytical model of the tiltrotor. The stability of the tiltrotor in the helicopter mode is analyzed aiming at a semi span soft-inplane tihrotor model with an elastic wing. Parametric effects of the lag stiffness of blades and the flight speed are analyzed. Numerical simulations demonstrate that the multibody analytical model can analyze the aeroelastic stability of the tiltrotor aircraft in the helicopter mode.

Size dependent flow behaviors of particles in hydrocyclone based on multiphase simulation

To investigate the flow behaviors of different size particles in hydrocyclone,a designed process was numerically simulated by the transient solver,where the quartz particles possessing a size distribution were injected into a 100 mm diameter hydrocyclone with the steady water field and air core inside.A lab experimental work has validated the chosen models in simulation by comparing the classification efficiency results.The simulated process shows that the 25 μm quartz particles,close to the cut size,need much more time than the finer and coarser particles to reach the steady flow rate on the outlets of hydrocyclone.For the particles in the inner swirl,with the quartz size increasing from 5 to 25 μm,the particles take more time to enter the vortex finder.The 25 μm quartz particles move outward in the radial direction when they go up to the vortex finder,which is contrary to the quartz particles of 5 μm and 15 μm as they are closely surrounding the air core.The studies reveal that the flow behaviors of particles inside the hydrocyclone depend on the particle size.

Smoothed particle hydrodynamics modeling and simulation of foundry filling process

A numerical model of foundry filling process was established based on the smoothed particle hydrodynamics（SPH）method.To mimic the constraints that the solid mold prescribes on the filling fluid,a composite treatment to the solid boundaries is elaborately designed.On solid boundary surfaces,boundary particles were set,which exert Lennard-Jones force on approaching fluid particles;inside the solid mold,ghost particles were arranged to complete the compact domain of near-boundary fluid particles.Water analog experiments were conducted in parallel with the model simulations.Very good agreement between experimental and simulation results demonstrates the success of model development.

Air interaction around outdoor air-cooled condensers

In order to increase cooling or heating efficiency,a porous computational fluid dynamics（CFD）model is employed to predict the thermo-fluid status and optimize the placement of outdoor units.A full scale model is established to validate the accuracy of CFD simulation in terms of velocity and temperature distributions.The comparison between the measurement and the simulation shows a good agreement.By evaluating the condensers＇ sucked air temperature with CFD for three units installed in a row,it is found that the minimum separation distance among neighboring units is 0.2 m;a vertical wall should be apart from the unit line by at least 0.8 m;and large different operating pressures among units do not impact the flow rate and the heat transfer of the other units meaningfully.

Ultrafast Carrier Dynamics in CdSe/CdS/ZnS Quantum Dots

The intra- and inter-band relaxation dynamics of CdSe/CdS/ZnS core/shell/shell quantum dots are investigated with the aid of time-resolved nonlinear transmission spectra which are obtained using femtosecond pump-probe technique. By selectively exciting the core and shell carrier, the dynamics are studied in detail. Carrier relaxation is found faster in the conduction band of the CdS shell （about 130 fs） than that in the conduction band of the CdSe core （about 400 fs）. From the experiments it is distinctly demonstrated the existence of the defect states in the interface between the CdSe core and the CdS shell, indicating that ultrafast spectroscopy might be a suitable tool in studying interface and surface morphology properties in nanosystems.

UPWIND SCHEME FOR IDEAL 2-D MHD FLOWS BASED ON UNSTRUCTURED MESH

An upwind scheme based on the unstructured mesh is developed to solve ideal 2-D magnetohydrodynamics （MHD） equations. The inviscid fluxes are approximated by using the modified advection upstream splitting method （AUSM） scheme, and a 5-stage explicit Runge-Kutta scheme is adopted in the time integration. To avoid the influence of the magnetic field divergence created during the simulation, the hyperbolic divergence cleaning method is introduced. The shock-capturing properties of the method are verified by solving the MHD shock-tube problem. Then the 2-D nozzle flow with the magnetic field is numerically simulated on the unstructured mesh. Computational results demonstrate the effects of the magnetic field and agree well with those from references.

NUMERICAL SIMULATION OF SUPERSONIC AXISYMMETRIC FLOW OVER MISSILE AFTERBODY WITH JET EXHAUST USING POSITIVE SCHEMES

Supersonic axisymmetric jet flow over a missile afterbody containing exhaust jet is simulated using the second order accurate positive schemes method developed for solving the axisymmetric Euler equations based on the 2-D conservation laws.Comparisons between the numerical results and the experimental measurements show excellent agreements.The computed results are in good agreement with the numerical solutions obtained by using third order accurate RKDG finite element method.The results show larger gradient at discontinuous points compared with those obtained by second order accurate TVD schemes.It indicates that the presented method is efficient and reliable for solving the axisymmetric jet with external freestream flows,and shows that the method captures shocks well without numerical noise.

Numerical simulation of two-phase flow field in underwater sealing device based on dynamic mesh

In order to speed underwater launch of minor-caliber weapons,a sealing device can be set in front of underwater muzzle to separate water,preventing the muzzle from water immersion.By establishing and simplifying the model of underwater weapon sealing device and unstructured mesh computing domain model based on computational fluid dynamics（CFD）,dynamic mesh and user defined function（UDF）,the N-S equation is solved and the numerical analysis and calculation of the complex two-phase flow inside the sealing device are carried out.The results show that the gas discharged from the sealing device is conducive to the formation of the projectile supercavity.When the projectile is launched at 5munder water,the shock wave before and after the projectile has impact on the box body up to 100 MPa,therefore the sealing device must be strong enough.The research results have the vital significance to the design of underwater weapon sealing device and the formation of the projectile supercavitation.

Kinetics of cerium(Ⅳ) and fluoride extraction from sulfuric solutions using bifunctional ionic liquid extractant(Bif-ILE)[A336][P204]

The extraction kinetics of Ce（Ⅳ） and Ce（Ⅳ）-F^- mixture systems from sulfuric solutions to n-heptane solution containing Bif-ILE[A336][P204]（[trialkylmethylammonium][di-2-ethylhewanxylphosphinate]） with a constant interfacial area cell with laminar flow were studied,just to elucidate the extraction mechanism and the mass transfer models.The data were analyzed in terms of pseudo-first-order constants.The effects of stirring speed,specific interfacial area and temperature on the extraction rate in both systems were discussed,suggesting that the extractions were mixed bulk phases-interfacial control process.Supported by the experimental data,the corresponding rate equations for Ce（Ⅳ） extraction system and Ce（Ⅳ）-F^- mixture extraction system were obtained.The experimental results indicated the rate-controlling step.The kinetics model was deduced from the rate-controlling step and consistent with the rate equation.