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“流动生”心理健康水平研究 被引量:1
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作者 王殿春 梁栋 《教育探索》 CSSCI 北大核心 2010年第10期124-126,共3页
"流动生"在学习焦虑、自责倾向、过敏倾向等方面存在明显的心理问题,初中"流动生"和小学"流动生"在自责倾向和过敏倾向两个方面差异明显,男生和女生则在自责倾向、身体症状和恐怖倾向等方面存在显著性差... "流动生"在学习焦虑、自责倾向、过敏倾向等方面存在明显的心理问题,初中"流动生"和小学"流动生"在自责倾向和过敏倾向两个方面差异明显,男生和女生则在自责倾向、身体症状和恐怖倾向等方面存在显著性差异。从总体上看,女"流动生"的心理健康状况显著低于男"流动生"。解决"流动生"心理问题的对策包括观念的转变、家长的重视、学校和老师的共同努力和政策的关注等。 展开更多
关键词 流动生心理健康 问题 影响因素 对策
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他变坏了——一个流动生的个案分析
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作者 朱红 《新课程》 2017年第7期236-237,共2页
曾有一位伟人说过这样一句话:"除了没出生的和已经逝世的,人人都会犯错误。"任何人物(包括伟人)都会犯错误,何况孩子!但每当向办公室同事诉说自己班里一个名叫马××的孩子所犯的错误时,对方总会先问道是本地生还是外地生... 曾有一位伟人说过这样一句话:"除了没出生的和已经逝世的,人人都会犯错误。"任何人物(包括伟人)都会犯错误,何况孩子!但每当向办公室同事诉说自己班里一个名叫马××的孩子所犯的错误时,对方总会先问道是本地生还是外地生。这令人十分不解,这难道有区别吗?为什么在老师的心里外地生的犯错几率一定高于本地生呢?为什么会觉得外地生天生就是会犯错呢?这些现象到底是什么原因造成的呢? 展开更多
关键词 流动生 行为习惯 根源 反思
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针对流动生进行有效数学教学的策略
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作者 陆金华 《小学教学参考(综合版)》 2017年第5期47-47,共1页
流动生的数学素养参差不齐,是数学教学的老大难问题。教师应针对流动生的学习特点和教育环境多动脑筋、多想办法,寻找出行之有效的教学方法,促进流动生数学素养的提高。
关键词 小学数学 流动生 数学素养 教学策略
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教育公平视野下“流动借读生”教育研究 被引量:2
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作者 徐红 《教育研究与实验》 CSSCI 北大核心 2008年第6期24-28,共5页
流动借读生的义务教育挑战教育公平的底线。影响流动借读生享受公平教育的根源主要有:义务教育政策疲软、义务教育体制滞后、城乡教育质量悬殊、教师公平意识薄弱;保障他们享受公平教育的主要对策为:加强义务教育政策刚性、改革现行义... 流动借读生的义务教育挑战教育公平的底线。影响流动借读生享受公平教育的根源主要有:义务教育政策疲软、义务教育体制滞后、城乡教育质量悬殊、教师公平意识薄弱;保障他们享受公平教育的主要对策为:加强义务教育政策刚性、改革现行义务教育体制、缩小城乡义务教育差距以及提升教师教育公平意识。 展开更多
关键词 教育公平 流动借读 义务教育 教育券
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班级归属感对初中“流动边缘生”教育复原力的影响
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作者 吴丽兰 《中小学心理健康教育》 2019年第22期60-62,共3页
社会发展大潮中,有一个特殊的群体——处于青春期的流动初中生引起了社会各界的关注,其中有小部分成了流动初中生中的“边缘生”,他们往往容易被忽视在学生教育之外,引发各种不良行为,学习上失去取得成功的能力,即教育复原力低下,主要... 社会发展大潮中,有一个特殊的群体——处于青春期的流动初中生引起了社会各界的关注,其中有小部分成了流动初中生中的“边缘生”,他们往往容易被忽视在学生教育之外,引发各种不良行为,学习上失去取得成功的能力,即教育复原力低下,主要原因在于班级归属感缺失。通过培养班级归属感发现,他们的各方面行为都有良好趋势,学习成绩逐步提高,获得了教育复原力。可见,归属感对于“流动边缘生”的成长和社会性发展具有非常的意义。营造班级归属感,是学生作为个体实现自身价值的必由之路,也是我们创建和谐班级最有效的门路,更是体现了发展学生核心素养的需要,在此将提出相应的教育措施和建议。 展开更多
关键词 班级归属感 初中 流动生 教育复原力
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Rate Law for Photoelectrochemical Water Splitting Over CuO
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作者 Bo-Yuan Gao Wen-HuaLeng 《电化学(中英文)》 CAS 北大核心 2024年第8期17-27,共11页
Photocatalytic splitting of water over p-type semiconductors is a promising strategy for production of hydrogen.However,the determination of rate law is rarely reported.To this purpose,copper oxide(CuO)is selected as ... Photocatalytic splitting of water over p-type semiconductors is a promising strategy for production of hydrogen.However,the determination of rate law is rarely reported.To this purpose,copper oxide(CuO)is selected as a model photocathode in this study,and the photogenerated surface charge density,interfacial charge transfer rate constant and their relation to the water reduction rate(in terms of photocurrent)were investigated by a combination of(photo)electrochemical techniques.The results showed that the charge transfer rate constant is exponential-dependent on the surface charge density,and that the photocurrent equals to the product of the charge transfer rate constant and surface charge density.The reaction is first-order in terms of surface charge density.Such an unconventional rate law contrasts with the reports in literature.The charge density-dependent rate constant results from the Fermi level pinning(i.e.,Galvani potential is the main driving force for the reaction)due to accumulation of charge in the surface states and/or Frumkin behavior(i.e.,chemical potential is the main driving force).This study,therefore,may be helpful for further investigation on the mechanism of hydrogen evolution over a CuO photocathode and for designing more efficient CuO-based photocatalysts. 展开更多
关键词 CUO Photoelectrochemical water splitting Electrochemical impedance spectroscopy Rate law Kinetics of photogenerated carriers
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VAR模型中流动性风险的度量及对我国的启示
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作者 刘昕婷 吴循 《商场现代化》 北大核心 2006年第12X期43-43,共1页
传统的VAR模型虽已经被广泛应用于度量价格风险和信用风险,但对流动性风险的度量考虑不多。本文归纳总结了关于如何把流动性风险度量纳入VAR模型已有的研究成果,并提出该模型在我国证券市场上应用存在的难题。
关键词 风险价值(VAR) 流动风险 证券市场
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黑龙江省农民工子女接受义务教育情况调查研究
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作者 刘万宇 《黑龙江教育学院学报》 2008年第7期18-19,共2页
通过调查,黑龙江省农民工子女接受义务教育存在的主要问题是,相关部门对农民工子女教育问题不重视,教师编制、经费没有得到解决,城市学校在接收、安置农民工子女就学方面存在困难和压力。对此,全社会都应引起高度重视,政府、学校要加强... 通过调查,黑龙江省农民工子女接受义务教育存在的主要问题是,相关部门对农民工子女教育问题不重视,教师编制、经费没有得到解决,城市学校在接收、安置农民工子女就学方面存在困难和压力。对此,全社会都应引起高度重视,政府、学校要加强管理,增加教育投入,特别是加强农村教育投入,缩小农村教育与城市教育差距。 展开更多
关键词 义务教育 农民工子女 流动生 留守
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挑战全球化:COVID-19大流行和教育国际化 被引量:6
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作者 莫家豪 谢心怡(译) 《北京大学教育评论》 CSSCI 北大核心 2020年第4期34-46,185,186,共15页
写作本文时,世界正面临COVID-19大流行之后前所未有的全球健康危机。早在全球健康危机爆发之前,人们就开始批评全球化所带来的负面影响,在高等教育领域质疑国际教育的价值。在过去几年中,反全球化和“民族主义”的复兴在全球不同地区出... 写作本文时,世界正面临COVID-19大流行之后前所未有的全球健康危机。早在全球健康危机爆发之前,人们就开始批评全球化所带来的负面影响,在高等教育领域质疑国际教育的价值。在过去几年中,反全球化和“民族主义”的复兴在全球不同地区出现,全球正义、替代全球化、反全球化表达以及反公司批评或者对新自由主义全球化的广泛批评等各种形式的反全球化运动已经出现。有着多种定义的“全球化”无疑在经济、社会、政治及文化等多重维度影响了国家的发展,COVID-19的流行进一步强化了复兴中的民族主义,本文从更广泛的政治经济背景出发,探讨关于全球化与反全球化的争论。有鉴于目前对国际高等教育价值的反思,本文讨论了亚洲的特定国家如何通过调整其政策和战略促进高等教育的国际化,从而在民族主义复兴和反全球化日渐高涨的浪潮中做出认真的尝试。 展开更多
关键词 新冠肺炎 教育国际化 全球化挑战 国际流动
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关注中小学教育中的“短板”和“漏洞”
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作者 许佳 《黑龙江教育(理论与实践)》 2003年第1期30-31,共2页
在质量管理上有个著名的“木桶理论”:一只木桶盛水量的多少,并不取决于最长的那块木板,而取决于最短的那块木板.而且还不能让这只木桶出现一点漏洞,因为即使有很小的漏洞.桶里的水也会跑掉。由此,我们可以得到这样的启示:学生个体(教... 在质量管理上有个著名的“木桶理论”:一只木桶盛水量的多少,并不取决于最长的那块木板,而取决于最短的那块木板.而且还不能让这只木桶出现一点漏洞,因为即使有很小的漏洞.桶里的水也会跑掉。由此,我们可以得到这样的启示:学生个体(教育对象)的发展水平,制约着学校教育整体的质量;欲使基础教育改革有所突破,就必须重视对学生个体的研究,尤其要重视对各种特殊教育对象的研究.这也恰恰是当前中小学教育中的“短板”和“漏洞”。 展开更多
关键词 中小学 子女教育 流动生教育 教育观念 干部子女教育 教育质量
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Phase-field modeling of dendritic growth under forced flow based on adaptive finite element method 被引量:2
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作者 朱昶胜 雷鹏 +1 位作者 肖荣振 冯力 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第1期241-248,共8页
A mathematical model combined projection algorithm with phase-field method was applied. The adaptive finite element method was adopted to solve the model based on the non-uniform grid, and the behavior of dendritic gr... A mathematical model combined projection algorithm with phase-field method was applied. The adaptive finite element method was adopted to solve the model based on the non-uniform grid, and the behavior of dendritic growth was simulated from undercooled nickel melt under the forced flow. The simulation results show that the asymmetry behavior of the dendritic growth is caused by the forced flow. When the flow velocity is less than the critical value, the asymmetry of dendrite is little influenced by the forced flow. Once the flow velocity reaches or exceeds the critical value, the controlling factor of dendrite growth gradually changes from thermal diffusion to convection. With the increase of the flow velocity, the deflection angle towards upstream direction of the primary dendrite stem becomes larger. The effect of the dendrite growth on the flow field of the melt is apparent. With the increase of the dendrite size, the vortex is present in the downstream regions, and the vortex region is gradually enlarged. Dendrite tips appear to remelt. In addition, the adaptive finite element method can reduce CPU running time by one order of magnitude compared with uniform grid method, and the speed-up ratio is proportional to the size of computational domain. 展开更多
关键词 dendritic growth phase-field model forced flow adaptive finite element method
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Physiology of bile secretion 被引量:19
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作者 Alejandro Esteller 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第37期5641-5649,共9页
The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis. The structural bases that p... The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis. The structural bases that permit bile secretion as well as various aspects related with its composition and flow rate in physiological conditions will first be reviewed. Canalicular bile is produced by polarized hepatocytes that hold transporters in their basolateral (sinusoidal) and apical (canalicular) plasma membrane. This review summarizes recent data on the molecular determinants of this primary bile formation. The major function of the biliary tree is modification of canalicular bile by secretory and reabsorptive processes in bileduct epithelial cells (cholangiocytes) as bile passes through bile ducts. The mechanisms of fluid and solute transport in cholangiocytes will also be discussed. In contrast to hepatocytes where secretion is constant and poorly controlled, cholangiocyte secretion is regulated by hormones and nerves. A short section dedicated to these regulatory mechanisms of bile secretion has been included. The aim of this revision was to set the bases for other reviews in this series that will be devoted to specific issues related with biliary physiology and pathology. 展开更多
关键词 HEPATOCYTES CHOLANGIOCYTES Bile flow Bile acid TRANSPORT
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Changes in functions,forms,and locations of lead during its anthropogenic flows to provide services
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作者 毛建素 马兰 梁静 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第1期233-242,共10页
Knowledge of the changes in a material’s function, form, and location during the transfer and transformation of materials to generate human services will improve our understanding of how humanity interacts with the e... Knowledge of the changes in a material’s function, form, and location during the transfer and transformation of materials to generate human services will improve our understanding of how humanity interacts with the environment and of how services are formed by human activities. We compared lead’s anthropogenic and biogeochemical cycles and found that the services, pathways, and changes in form requiring the most attention. We traced lead through its life cycle and identified the changes in its functions, forms, and locations by examining technology and engineering information. Lead ore and scrap were the two main anthropogenic sources of lead. When lead provides human services, its main functions included the storage and delivery of electricity, anti-corrosion treatments, and radiation protection; the main forms of lead in these products were Pb, PbO2 and PbSO4, and the main location changed from lithosphere in central China to regions in eastern China. 展开更多
关键词 service economy material flow analysis anthropogenic cycle human activity life cycle transformation
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Swimming of motile gyrotactic microorganisms and suspension of nanoparticles in a rheological Jeffery fluid with Newtonian heating along elastic surface 被引量:2
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作者 Siddra RANA Rashid MEHMOOD +1 位作者 M.M.BHATTI Mohsan HASSAN 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第11期3279-3296,共18页
Bioconvection plays an inevitable role in introducing sustainable and environment-friendly fuel cell technologies.Bio-mathematical modelling of such designs needs continuous refinements to achieve strong agreements in... Bioconvection plays an inevitable role in introducing sustainable and environment-friendly fuel cell technologies.Bio-mathematical modelling of such designs needs continuous refinements to achieve strong agreements in experimental and computational results.Actually,microorganisms transport a miscellaneous palette of ingredients in manufacturing industrial goods particularly in fertilizer industries.Heat transfer characteristics of molecular structure are measured by a physical phenomenon which is allied with the transpiration of heat within matter.Motivated by bioinspired fuel cells involved in near-surface flow phenomena,in the present article,we examine the transverse swimming of motile gyrotactic microorganisms numerically in a rheological Jeffery fluid near a stretching wall.The leading physical model is converted in a nonlinear system of ODEs through proper similarity alterations.A numerical technique called shooting method with R-K Fehlberg is applied via mathematical software and graphical presentations are obtained.The influence of all relative physical constraints on velocity,temperature,concentration,and volume fraction of gyrotactic microorganisms is expressed geometrically.It is found that heat and mass flux at the surface as well as density of motile microorganism’s declines for Brownian motion and thermophoresis parameter.Comparison in tabular form is made with existing literature to validate the results for limiting cases with convective boundary conditions. 展开更多
关键词 oblique stagnation point flow Jeffery fluid BIOCONVECTION swimming of motile gyrotactic NANOPARTICLES
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Impact of fecal incontinence on quality of life 被引量:11
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作者 Lynne Bartlett Madeleine Nowak Yik-Hong Ho 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第26期3276-3282,共7页
AIM:To explore the impact of fecal incontinence (FI) on quality of life (QOL) of patients attending urogynecology and colorectal clinics (CCs).METHODS:Cross-sectional study of 154 patients (27 male) with FI,who attend... AIM:To explore the impact of fecal incontinence (FI) on quality of life (QOL) of patients attending urogynecology and colorectal clinics (CCs).METHODS:Cross-sectional study of 154 patients (27 male) with FI,who attended the clinics at a regional hospital in North Queensland,Australia in 2003 and 2004,and completed the Fecal Incontinence Quality of Life Scale (FIQL:1=very affected;4=not affected).RESULTS:More than 22% of patients had their QOL affected severely by FI.Patients reported that they had not previously been asked about FI by a medical practitioner nor did they voluntarily disclose its presence.The median FIQL scores for all participants were:lifestyle=3.24;coping=2.23;depression=2.42;and embarrassment=2.33.Increasing frequency of soiling had a negative effect on all four FIQL scales (P < 0.001) as did the quantity of soiling (P < 0.01).Female CC patients had poorer FIQL scores than urogynecology clinic patients for lifestyle (P=0.015),coping (P=0.004) and embarrassment (P=0.009),but not depression (P=0.062),despite having experienced FI for a shorter period.CONCLUSION:Failure to seek treatment for FI degrades the quality of patients' lives over time.FI assessment tools should incorporate the quantity of fecal loss. 展开更多
关键词 Quality of life Fecal incontinence Rural health Colorectal cancer UROGYNECOLOGY
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Clinical applications of fractional flow reserve in bifurcation lesions 被引量:2
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作者 Sang Hyun Park Bon-Kwon Koo 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2012年第3期278-284,共7页
Pereutaneous coronary intervention (PCI) for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiograph... Pereutaneous coronary intervention (PCI) for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiographic evaluation alone is sometimes inaccurate and does not reflect the fimctional significance of bifurcation lesions. The fractional flow reserve (FFR) is an easily obtainable, reliable, and reproducible physiologic parameter. This parameter is epicardial lesion specific and reflects both degree of stenosis and the myocardial territory supplied by the specific artery. Recent studies have shown that FFR-guided provisional side branch intervention strategy for bifurcation lesions is feasible and effective and can reduce unnecessary complex interventions and related complications. However, an adequate understanding of coronary physiology and the pitfalls of FFR is essential to properly use FFR for PCI of complex bifurcation lesions. 展开更多
关键词 Coronary stenosis Bifurcation lesion PHYSIOLOGY Fractional flow reserve
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The Contribution of Opal-Associated Phosphorus to Bioavailable Phosphorus in Surface and Core Sediments in the East China Sea 被引量:2
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作者 LI Huanxin HE Huijun +4 位作者 YANG Shifeng LIU Yanli CHE Hong LI Mujian ZHANG Jing 《Journal of Ocean University of China》 SCIE CAS CSCD 2018年第3期571-580,共10页
To improve the burial flux calculations of bioavailable phosphorus (P) and study opal-associated P (Opal-P) in the East China Sea (ECS), surface and core sediments were collected in the Changjiang Estuary (CE)... To improve the burial flux calculations of bioavailable phosphorus (P) and study opal-associated P (Opal-P) in the East China Sea (ECS), surface and core sediments were collected in the Changjiang Estuary (CE) and the south of the Cheju Island. In this study, sedimentary P was operationally divided into seven different forms using modified sedimentary extraction (SEDEX) technique: LSor-P (exchangeable or loosely sorbed P), Fe-P (easily reducible or reactive ferric Fe-bound P), CFA-P (authigenic carbonate fluorapatite and biogenic apatite and CaCO3-bound P), Detr-P (detrital apatite), Org-P (organic P), Opal-P and Ref-P (refractory P). The data revealed that the concentrations of the seven different P forms rank as Detr-P 〉 CFA-P 〉 Org-P 〉 Ref-P 〉 Opal-P 〉 Fe-P 〉 LSor-P in surface sediments and CFA-P 〉 Detr-P 〉 Org-P 〉 Ref-P 〉 Fe-P 〉 Opal-P 〉 LSor-P in core sediments. The distributions of the total phosphorus (TP), TIP, CFA-P, Detr-P are similar and decrease from the CE to the south of the Cheju Island. Meanwhile, Org-P and Opal-P exhibit different distribution trends; this may be affected by the grain size and TOM. The concentrations of potentially bioavailable P are 9.6-13.0 μmol g^-1 and 10.0-13.6 μmol g^-1, representing 61%-70% and 41%?64% of the TP in surface and core sediments, respectively. The concentrations of Opal-P are 0.6-2.3 μmol g^-1 and 0.6-1.4 μmol g^-1 in surface and core sediments, ac-counting for 5.3%?19.8% and 4.2%?10.6% of bioavailable P, respectively. The total burial fluxes of Opal-P and bioavailable P are 1.4×10^9 mol y^-1 and 1.1×10^10 mol yr^-1 in the ECS, respectively. Opal-P represents about 12.7% of potentially bioavailable P, which should be recognized when studying P cycling in marine ecosystems. 展开更多
关键词 phosphorus speciation opal-associated P burial flux SEDIMENTS East China Sea
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Quantifying growth and breakage of agglomerates in fluid-particle flow using discrete particle method 被引量:1
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作者 Lingfeng Zhou Junwu Wang +11 位作者 Wei Ge Shiwen Liu Jianhua Chen Ji xu Limin Wang Feiguo Chen Ning Yang Rongtao Zhou Lin Zhang Qi Chang Philippe Ricoux Alvaro Fernandez 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第5期914-921,共8页
The cohesive solids in liquid flows are featured by the dynamic growth and breakage of agglomerates, and the difficulties in the development, design and optimization of these systems are related to this significant fe... The cohesive solids in liquid flows are featured by the dynamic growth and breakage of agglomerates, and the difficulties in the development, design and optimization of these systems are related to this significant feature.In this paper, discrete particle method is used to simulate a solid–liquid flow system including millions of cohesive particles, the growth rate and breakage rate of agglomerates are then systematically investigated. It was found that the most probable size of the agglomerates is determined by the balance of growth and breakage of the agglomerates the cross point of the lines of growth rate and breakage rate as a function of the particle numbers in an agglomerate, marks the most stable agglomerate size. The finding here provides a feasible way to quantify the dynamic behaviors of growth and breakage of agglomerates, and therefore offers the possibility of quantifying the effects of agglomerates on the hydrodynamics of fluid flows with cohesive particles. 展开更多
关键词 AGGLOMERATE Growth and breakage Quantification Discrete particle method
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Research on Nitrogen Removal and Microorganism in a Subsurface Flow Constructed Wetland System in Sihong County 被引量:4
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作者 XIA Ning LIU Han-hu +2 位作者 GUO Ru-mei ZHANG Hong-zhen YANG Kun 《Journal of China University of Mining and Technology》 EI 2006年第4期505-508,共4页
Experiments in monitoring the removal of organic material and nitrogen and determining the amounts of mi- croorganism at different sites in the subsurface flow constructed wetland in Sihong county were performed. The ... Experiments in monitoring the removal of organic material and nitrogen and determining the amounts of mi- croorganism at different sites in the subsurface flow constructed wetland in Sihong county were performed. The results show that the removal of CODCr agrees with the kinetic equation of a first order reaction. The removal of pollutants varies with different seasons. The removal rates of CODCr, NH3-N, TN in the spring are 15%–23% higher than those in the autumn. The amount of ammonifier is larger than that of denitrifying bacteria and the amount of denitrifying bacte- ria is larger than that of nitrosomonas. The amount of bacteria around the plant roots is larger than that on the surface of the packing medium. No apparent change is observed for the amount of denitrifying bacteria and nitrosomonas between spring and autumn. 展开更多
关键词 subsurface flow constructed wetland (SFCW) Sihong county nitrogen removal MICROORGANISM
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Inducible nitric oxide synthase expression is related to angiogenesis,bcl—2 and cell proliferation in hepatocellular carcinoma 被引量:13
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作者 彭佳萍 郑树 +1 位作者 孝作祥 张苏展 《Journal of Zhejiang University Science》 EI CSCD 2003年第2期221-227,共7页
In this study, we examined the expression of inducible nitric oxide s ynthase (iNOS) and vascular endothelial growth factor (VEGF) by immunohistoc hemi cal staining in 76 tissue sections collected from hepatocellula... In this study, we examined the expression of inducible nitric oxide s ynthase (iNOS) and vascular endothelial growth factor (VEGF) by immunohistoc hemi cal staining in 76 tissue sections collected from hepatocellular carcinoma (HCC) patients undergoing hepatectomy. Microvascular density (MVD) was determined by counting endothelial cells immunostained using anti-CD34 antibody. We performe d DNA-flow cytometric analyses to elucidate the impact of iNOS and VEGF expressi o n on the cell cycle of HCC. Most of the HCC cells that invaded stroma were mark edly immunostained by iNOS antibody. The iNOS stain intensity of the liver tissu e close to the tumor edge was stronger than that of HCC tissue, and the stronges t was the hepatocytes closer to the tumor tissue. However, iNOS expression in 10 normal hepatic samples was undetectable. VEGF positive expression ratio was 84. 8% in iNOS positive expression cases, and the ratio was 35.3% in negative cases. There was significant correlation (P=0.000) between iNOS and VEGF expressi on. Moreover, iNOS expression was significantly associated with bcl-2 and MVD, but w ithout p53 expression. DNA-flow cytometric analyses showed that combined expres s ion of iNOS and VEGF had significant impact on the cell cycle in HCC. PI (Proli ferating Index) and SPF (S-phase fraction) in the combined positive expression o f iNOS and VEGF group was significantly higher than that in the combined negativ e group. The present findings suggested that iNOS expression was significantly a ssociated with angiogenesis, bcl-2 and cell proliferation of HCC. 展开更多
关键词 Hepatocellular carcinoma Nitric oxide synthase Angiog enesis BCL-2 Flow cytometric analyse
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