时尚健身的“交谊”

流行易学的Salsa “Salsa（萨尔萨舞）是什么？”如果您经常跳舞还要向社区里的年轻人问这样的问题，一定会被笑话。别着急，这可不是您的舞蹈知识面不宽。Salsa是最近几年才开始流行的一种拉丁风味十足的社交舞蹈。并且抢占了很多场所，倍受年轻人们的青睐。

p53 codon 72 polymorphism and liver cancer susceptibility: A meta-analysis of epidemiologic studies

AIM:To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis. METHODS:Two investigators independently searched the Medline,Embase and Chinese Biomedicine databases.Summary odds ratios and 95%CI for p53 codon 72 polymorphism and liver cancer were calculated in fixedeffects model(Mantel-Haenszel method)and randomeffects model(DerSimonian and Laird method)when appropriate. RESULTS:This meta-analysis included 1115 liver cancer cases and 1778 controls.The combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer,but not between Arg/Arg or Pro/Arg genotype and liver cancer.When stratifying for race,similar results were obtained,i.e.patients with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among Asians.After stratifying thevarious studies by control source,gender,family history of liver cancer and chronic hepatitis virus infection,we found that(1)patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer;(2)female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer;(3)subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development;and(4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer. CONCLUSION:This meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.

Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.

AN EPIDEMIOLOGY AND MOLECULAR GENETIC STUDY ON BREAST CANCER SUSCEPTIBILITY

Objectives. To investigate the genetic susceptibility for breast cancer of Chinese, a hospital-based case-control study, pedigree survey and molecular genetic study were conducted. Methods. Logistic regression model and stratification methods were used in the risk factors analysis. Li-Mantel-Gart and Falconer methods were used to analyze the segregation ratio and heritability. Polymerase chain reaction(PCR) and polyacrylamide gel electrophoresis were used to detect AI, G-banding technique was used to detect the chromosome aberration of peripheral blood lymphocyte. Results. Family history of breast cancer is related to enhanced breast cancer risk significantly, OR is 3905(95%CI=1079～1413), and it widely interacts with other risk factors. Accumulative incidence of breast cancer in first degree relatives is 999%, which is larger than that in second, third degree and non-blood relatives. Segregation ratio is 0021, heritability among first degree relatives is 356±58%. Frequencies of LOH at BRCA1 and BRCA2 loci in sporadic breast cancer are 612% and 577% respectively. In the sibs, both of them show LOH at D13S173 locus, and high frequencies of chromosome aberrations were observed. Conclusions. Genetic susceptibility contributes to breast cancer occurrence of Chinese, and its racial variation may be one of the important reasons for the large difference of incidence between western and eastern countries.

Physico-mechanical performance of debris-flow deposits with particular reference to characterization and recognition of debris flow-related sediments

To characterize and recognize the debris flow-related deposits,the physico-mechanical performance of four deposits from the Dongyuege(DYG),Shawa(SW),Jiangjia Gully(JJG),and Gengdi(GD)debris flows in southwest China is investigated through laboratory analyses and tests.The four debris-flow materials can all be remolded into coherent,homogeneous cylinders with high densification and strength–porosity of 25%-36%,mean pore-throat radius of 0.46-5.89μm,median pore-throat radius of 0.43-4.28μm,P-wave velocity of 800-1200 m/s,modulus of elasticity of 28-103 MPa,unconfined compressive strength(UCS)of 220-760 kPa,and cohesion of 65-281 kPa.Based on the comparison in slurryability and formability among debris-flow deposits,granular flow deposits,fluvial deposits,residual lateritic clay and loess,whether a sediment can be cast into competent cylinders for physico-mechanical tests can be regarded as a diagnostic evidence of old debris-flow deposits.The discrepancy in physico-mechanical properties among the four debris-flow deposits suggests that the combination of foregoing physico-mechanical parameters can characterize assembling characteristics of debris flow-related sediments including grain size distribution,mineralogy,and accidental detritus.Four deposited sediments above can be surprisingly classified as hard soil-soft rocks according to UCS,and the hard soil-soft rock behaviors can advance the further understanding of debris flows.

Acupuncture and Irritable Bowel Syndrome： A Population-based Epidemiological and Clinical Study

Objective： To explore the prevalence of irritable bowel syndrome （IBS） based on a community population of Shanghai and the treatment of IBS by acupuncture therapy. Methods： A population of 1 685 subjects aged between 18-80 years were randomly selected by clustered sampling from the inhabitants in Changqiao Community of Shanghai to receive a questionnaire, for understanding the symptomatology and prevalence of IBS according to modified Manning and Rome Ⅱ criteria, and the voluntary IBS patients were treated by acupuncture therapy. Results： The community- based prevalence of IBS was 11.45 % and 5.04% respectively according to modified Manning criteria and Rome Ⅱ criteria. The ratio of male and female was 0.77：1 in IBS patients and the proportion was 10.62% and 12.19% respectively. But there were no significant difference in prevalence between different age groups （ P〉0.05 ） . IBS is more common in subjects aged between 45-65 years （38.86%）. Regarding the 62 IBS patients treated by electroacupuncture （EA）, the total effective rate in Tianshu （ST 25） group （n=32） was 84.38%, and it was 56.67% in Daheng （SP 15） group （n=30）, which showed a significant difference. （P〈0.05）. Conclusion： IBS is a commonly encountered disorder in Changqiao Community of Shanghai and should be taken into consideration for human welfare, disease prevention and further epidemical investigation. Acupuncture treatment is recommended for treating IBS due to its satisfactory therapeutic effect.

GLOBAL DYNAMICS OF A DIFFERENTIAL SUSCEPTIBILITY MODEL

An SIS epidemiological model in a population of varying size with two dissimilar groups of susceptible individuals has been analyzed. We prove that all the solutions tend to the equilibria of the system. Then we use the Poincar~ Index theorem to determine the number of the rest points and their stability properties. It has been shown that bistability occurs for suitable values of the involved parameters. We use the perturbations of the pitchfork bifurcation points to give examples of all possible dynamics of the system. Some numerical examples of bistability and hysteresis behavior of the systeIn has been also provided.