Background-Dataon the possible association between depressive disorders and inflammatory markers are scarce and inconsistent. We investigated whether subjects with depressive mood had higher levels of a wide range of ...Background-Dataon the possible association between depressive disorders and inflammatory markers are scarce and inconsistent. We investigated whether subjects with depressive mood had higher levels of a wide range of inflammatory markers involved in coronary heart disease(CHD) incidence and examined the contribution of these inflammatory markers and depressive mood to CHD outcome. Methods and Results-We built a nested case-referent study within the Prospective Epidemiological Study of Myocardial Infarction(PRIME) study of healthy middle-aged men from Belfast and France. We considered the baseline plasma sample from 335 future cases(angina pectoris, nonfatal myocardial infarction, coronary death) and 670 matched controls(2 controls per case). Depressive mood characterized men whose baseline depression score(13-item modification of the Welsh depression subscale) was in the fourth quartile(mean score, 5.75; range, 4 to 12). On average, men with depressive mood had 46% , 16% , and 10% higher C-reactive protein, interleukin- 6, and intercellular adhesion molecule- 1 levels, respectively, independently of case-control status, social characteristics, and classic cardiovascular risk factors; no statistical difference was found for fibrinogen. The odds ratios of depressive mood for CHD were 1.35(95% CI, 1.05 to 1.73) in univariate analysis and 1.50(95% CI, 1.04 to 2.15) after adjustment for social characteristics and classic cardiovascular risk factors. The latter odds ratio remained unchanged when each inflammatory marker was added separately, and in this analysis, each inflammatory marker contributed significantly to CHD event risk. Conclusions-These data support an association of depressive mood with inflammatory markers and suggest that depressive mood is related to CHD even after adjustment for these inflammatory markers.展开更多
文摘Background-Dataon the possible association between depressive disorders and inflammatory markers are scarce and inconsistent. We investigated whether subjects with depressive mood had higher levels of a wide range of inflammatory markers involved in coronary heart disease(CHD) incidence and examined the contribution of these inflammatory markers and depressive mood to CHD outcome. Methods and Results-We built a nested case-referent study within the Prospective Epidemiological Study of Myocardial Infarction(PRIME) study of healthy middle-aged men from Belfast and France. We considered the baseline plasma sample from 335 future cases(angina pectoris, nonfatal myocardial infarction, coronary death) and 670 matched controls(2 controls per case). Depressive mood characterized men whose baseline depression score(13-item modification of the Welsh depression subscale) was in the fourth quartile(mean score, 5.75; range, 4 to 12). On average, men with depressive mood had 46% , 16% , and 10% higher C-reactive protein, interleukin- 6, and intercellular adhesion molecule- 1 levels, respectively, independently of case-control status, social characteristics, and classic cardiovascular risk factors; no statistical difference was found for fibrinogen. The odds ratios of depressive mood for CHD were 1.35(95% CI, 1.05 to 1.73) in univariate analysis and 1.50(95% CI, 1.04 to 2.15) after adjustment for social characteristics and classic cardiovascular risk factors. The latter odds ratio remained unchanged when each inflammatory marker was added separately, and in this analysis, each inflammatory marker contributed significantly to CHD event risk. Conclusions-These data support an association of depressive mood with inflammatory markers and suggest that depressive mood is related to CHD even after adjustment for these inflammatory markers.
文摘随着国家教育改革的有序进行,中小学义务教育中,尤其中学生潜在的心理与行为问题大量暴露出来,尽管我们的教师、学校、家庭、社会、国家在潜心研究应对措施,并有了些许成效,但是,对于各方面发展不平衡的青少年来说,其心理和行为随年龄的增长在逐渐发展,并滋生出新的心理与行为问题,来势汹汹,应接不暇。而且,多数青少年心理咨询意识薄弱,甚至拒绝接受心理咨询和治疗,同时其经济有限,导致不少青少年心理问题化为抑郁症状,又因为自我不会调节,得不到他人及时的帮助,直至深入严重,酿成极端后果。文中使用ZUNG氏抑郁自评量表对200位校内和校外的青少年进行测量,由此评判出这些青少年是否身患抑郁疾病,并进行抑郁症分级,同时运用SPSS软件和统计法进行统计分析。通过分析研究得知:第一,女性青少年比男性青少年更易患抑郁症,且女性青少年患抑郁程度比男性青少年患抑郁程度深;第二,不同学习情况的青少年,患抑郁程度不同,抑郁症状也不尽相同;第三,ZUNG氏抑郁自评量表测评得分与青少年性别(r = 0.395, p.
