AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion ...AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion （THVE） using a porcine model. METHODS： Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly： the DHP-PMX group （n = 5） underwent DHP-PMX at a flow rate of 80 mL/min for 220 min （beginning 10 rain before reperfusion）, while the control group did not （n = 6）. The rate pressure product （RPP）： heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow （HTBF）, portal vein blood flow （PVBF）, and serum aspartate aminotransferase （AST） levels were compared between the two groups. RESULTS： RPP and HTBF were significantly （P 〈 0.05） higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly （P 〈 0.05） compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly （P 〈 0.05） lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION： DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.展开更多
Three acceptor-donor-acceptor （A-D-A） small molecules DCAODTBDT, DRDTBDT and DTBDTBDT using dithieno[2,3-d：2＇,3＇-d＇]benzo[1,2-b：4,5-b＇]dithiophene as the central building block, octyl cyanoacetate, 3-octylrhod...Three acceptor-donor-acceptor （A-D-A） small molecules DCAODTBDT, DRDTBDT and DTBDTBDT using dithieno[2,3-d：2＇,3＇-d＇]benzo[1,2-b：4,5-b＇]dithiophene as the central building block, octyl cyanoacetate, 3-octylrhodanine and thiobarbituric acid as the end groups were designed and synthesized as donor materials in solution-processed photovoltaic cells （OPVs）. The impacts of these different electron withdrawing end groups on the photophysical properties, energy levels, charge carrier mobility, morphologies of blend films, and their photovoltaic properties have been systematically investigated. OPVs device based on DRDTBDT gave the best power conversion efficiency （PCE） of 8.34%, which was significantly higher than that based on DCAODTBDT （4.83%） or DTBDTBDT （3.39%）. These results indicate that rather dedicated and balanced consideration of absorption, energy levels, morphology, mobility, etc. for the design of small-molecule-based OPVs （SM-OPVs） and systematic investigations are highly needed to achieve high performance for SM-OPVs.展开更多
文摘AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion （THVE） using a porcine model. METHODS： Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly： the DHP-PMX group （n = 5） underwent DHP-PMX at a flow rate of 80 mL/min for 220 min （beginning 10 rain before reperfusion）, while the control group did not （n = 6）. The rate pressure product （RPP）： heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow （HTBF）, portal vein blood flow （PVBF）, and serum aspartate aminotransferase （AST） levels were compared between the two groups. RESULTS： RPP and HTBF were significantly （P 〈 0.05） higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly （P 〈 0.05） compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly （P 〈 0.05） lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION： DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.
基金supported by the Ministry of Science and Technology(2014CB643502,2016YFA0200200)the Natural Science Foundation of China(21404060,51422304,91433101)
文摘Three acceptor-donor-acceptor （A-D-A） small molecules DCAODTBDT, DRDTBDT and DTBDTBDT using dithieno[2,3-d：2＇,3＇-d＇]benzo[1,2-b：4,5-b＇]dithiophene as the central building block, octyl cyanoacetate, 3-octylrhodanine and thiobarbituric acid as the end groups were designed and synthesized as donor materials in solution-processed photovoltaic cells （OPVs）. The impacts of these different electron withdrawing end groups on the photophysical properties, energy levels, charge carrier mobility, morphologies of blend films, and their photovoltaic properties have been systematically investigated. OPVs device based on DRDTBDT gave the best power conversion efficiency （PCE） of 8.34%, which was significantly higher than that based on DCAODTBDT （4.83%） or DTBDTBDT （3.39%）. These results indicate that rather dedicated and balanced consideration of absorption, energy levels, morphology, mobility, etc. for the design of small-molecule-based OPVs （SM-OPVs） and systematic investigations are highly needed to achieve high performance for SM-OPVs.
