针对电力设备载流故障与接触电阻、设备载流、外部环境温度及其结构尺寸之间的关系,研究建立了高压电气设备载流连接板温升故障的有限元计算方法,借助传热学理论,建立温升模型。并针对一起35 k V电流互感器载流连接板仿真发热故障进行了...针对电力设备载流故障与接触电阻、设备载流、外部环境温度及其结构尺寸之间的关系,研究建立了高压电气设备载流连接板温升故障的有限元计算方法,借助传热学理论,建立温升模型。并针对一起35 k V电流互感器载流连接板仿真发热故障进行了ANSYS计算分析,重点研究了载流连接板通过的电流大小、外部环境温度及连接板尺寸对其温度升高的影响。该分析结果可以用于对红外测温过程中电气设备电流型致热故障进行参考分析,并对实际设计中生产厂家选用高压电气设备一次电流连接板尺寸大小有一定的指导意义。展开更多
An aluminum extrusion process is mainly used to fabricate long tubes, beams and rods for various applications. However, this process has a high production cost due to the need for investment of high-pressure machinery...An aluminum extrusion process is mainly used to fabricate long tubes, beams and rods for various applications. However, this process has a high production cost due to the need for investment of high-pressure machinery. The objective of this work is to develop a new semi-solid extrusion process using semi-solid slurry at low solid fractions. A laboratory extrusion system was used to fabricate aluminum rods with the diameter of 12 ram. The semi-solid metal process used in this study was the gas induced semi-solid (GISS) technique. To study the feasibility of the GISS extrusion process, the effects of extrusion parameters such as plunger speed and solid fi-action on the extrudability, microstructure, and mechanical properties of extruded samples were investigated. The results show that the plunger speed and solid fraction of the semi-solid metal need to be carefully controlled to produce complete extruded parts.展开更多
Underwater cylindrical shell structures have been found a wide of application in many engineering fields, such as the element of marine, oil platforms, etc. The coupled vibration analysis is a hot issue for these unde...Underwater cylindrical shell structures have been found a wide of application in many engineering fields, such as the element of marine, oil platforms, etc. The coupled vibration analysis is a hot issue for these underwater structures. The vibration characteristics of underwater structures are influenced not only by hydrodynamic pressure but also by hydrostatic pressure corresponding to different water depths. In this study, an acoustic finite element method was used to evaluate the underwater structures. Taken the hydrostatic pressure into account in terms of initial stress stiffness, an acoustical fluid-structure coupled analysis of underwater cylindrical shells has been made to study the effect of hydrodynamic pressures on natural frequency and sound radiation. By comparing with the frequencies obtained by the acoustic finite element method and by the added mass method based on the Bessel function, the validity of present analysis was checked. Finally, test samples of the sound radiation of stiffened cylindrical shells were acquired by a harmonic acoustic analysis. The results showed that hydrostatic pressure plays an important role in determining a large submerged body motion, and the characteristics of sound radiation change with water depth. Furthermore, the analysis methods and the results are of significant reference value for studies of other complicated submarine structures.展开更多
A kind of low power connector used e.g. in household appliances was partly burned in routine experiment. The heat sources were four paralleled contacts constructed by springs (Sn/CuSn-alloy) in socket and a plug sheet...A kind of low power connector used e.g. in household appliances was partly burned in routine experiment. The heat sources were four paralleled contacts constructed by springs (Sn/CuSn-alloy) in socket and a plug sheet (Ni/Steel) while mating. The contact interfaces were detected by scanning electronic microscope (SEM) and X-ray energy dispersive spectros- copy (XEDS), obvious wear tracks and various contaminants, including element Si, Al, Na, K, S, Cl, O, etc., were found. The contamination degrees on the four paralleled contacts were different, so that the ratio of average contact resistance on the four contacts was about 5:8:3:1. The maximum contact resistance on contacts of the plug sheet reached 28 ?. The main failure rea- sons were fretting and contamination between the contact interfaces. Fretting simulation showed that connection resistance of connectors was raised up, even to ohms level. When the current increased to 5 A, the socket housing was heated and decom- posed. By the thermal analysis, it was estimated that the connector would be burned under the lower current if the current was not evenly distributed on the four paralleled contacts caused by uneven contamination. Improvement methods for connector failure are also discussed.展开更多
This study investigated the connection between the Australian summer monsoon(ASM) and summer precipitation over central China. It was found that,following a weaker-than-normal ASM, the East Asian summer monsoon and we...This study investigated the connection between the Australian summer monsoon(ASM) and summer precipitation over central China. It was found that,following a weaker-than-normal ASM, the East Asian summer monsoon and western North Pacific subtropical high tend to be stronger, yielding anomalous northward moisture to be transported from the western Pacific to central China. Besides, anomalous upwelling motion emerges over 30–37.5°N, along 110°E. Consequently,significant positive summer precipitation anomalies are located over central China. Further analysis indicated that the boreal winter sea surface temperature(SST) in the Indian Ocean and South China Sea shows positive anomalies in association with a weaker-than-normal ASM. The Indian Ocean warming in boreal winter could persist into the following summer because of its own long memory, emanating a baroclinic Kelvin wave into the Pacific that triggers suppressed convection and an anomalous anticyclone. Besides, the abnormal SST signal in the South China Sea develops eastward with time because of local air-sea interaction, causing summer SST warming in the western Pacific. The SST warming can further affect East Asian atmospheric circulation and precipitation through its impact on convection.展开更多
AIM: To investigate the correlation between the expression levels of interleukin (IL)-6 and proteins in tight junctions (TJs) in the esophageal mucosa of rats modeling different types of reflux esophagitis (RE)...AIM: To investigate the correlation between the expression levels of interleukin (IL)-6 and proteins in tight junctions (TJs) in the esophageal mucosa of rats modeling different types of reflux esophagitis (RE), and the ability of aluminum phosphate to protect against RE-induced mucosal damage via these proteins. METHODS: Male SPF Wistar rats aged 56 d were divided randomly into acid RE, alkaline RE, mixed RE, and control groups. Various surgical procedures were performed to establish rat models of acid RE. At 14 d after the procedure, some of the rats started aluminum phosphate treatment. Transmission electron microscopy (TEM) was used to observe the morphological features of TJs and desmosomes in the esophageal epithelium. Immunohistochemical methods and Western blotting were used to measure expression of claudin 1, occludin, ZO-1, JAM-l, DSG-1 and IL-6; reverse transcription polymerase chain reaction (RT- PCR) was used to measure expression of mRNA of claudin 1, occludin, ZO-1, JAM-1, DSG-1 and IL-6. RESULTS: At day 14 alter the procedures, an RE model was established in all subsequently sacrificed rats of groups A, B and C. By both gross and microscopic observation, the mucosa was damaged and thickened as the disease progressed. With TEM observation, a widened intercellular space was noticed, with significantly fewer desmosomes. Immunohistochemistry showed significantly higher levels of all proteins in all RE models compared to control rats at 3 d after operation (65.5% ± 25.6% vs 20.5% ± 2.1%, P 〈 0.05, respectively). At 14 d after operation, along with continuing hyperplasia in the basal layer, the expression of TJ proteins in individual cells gradually decreased (12.4% ± 2.1% vs 20.5% ± 2.1%, P 〈 0.05, respectively). Western blottings and RT-PCR showed a directly proportional increase in IL-6 levels in relation to TJ proteins, as compared to controls (0.878 ± 0.024 vs 0.205 ± 0.021 and 0.898±0.022 vs 0.205 ± 0.021, P 〈 0.05, respectively). Upon treatment with aluminum phosphate, however, these protein levels were restored to normal gradually over 30-60 d in rats with acid RE (30.4% ± 2.1% vs 20.5% ± 2.1%, P 〉 0.05, treated vs untreated, respectively). These levels increased in the rat with alkaline RE, and this increase was accompanied by continued hyperplasia in comparison with controls (85.5% ± 25.6% vs 20.5% ± 2.1%, P 〈 0.05, respectively). Furthermore, the expression of TJ proteins was not correlated significantly with that of IL-6 in this group. CONCLUSION: These findings indicate that TJ proteins are highly expressed as an early molecular event involved in RE development, and that IL-6 is an inflammatory factor in this process,展开更多
A system of m (≥2) linear convection-diffusion two-point boundary value problems is examined,where the diffusion term in each equation is multiplied by a small parameterεand the equations are coupled through their c...A system of m (≥2) linear convection-diffusion two-point boundary value problems is examined,where the diffusion term in each equation is multiplied by a small parameterεand the equations are coupled through their convective and reactive terms via matrices B and A respectively.This system is in general singularly perturbed. Unlike the case of a single equation,it does not satisfy a conventional maximum princi- ple.Certain hypotheses are placed on the coupling matrices B and A that ensure exis- tence and uniqueness of a solution to the system and also permit boundary layers in the components of this solution at only one endpoint of the domain;these hypotheses can be regarded as a strong form of diagonal dominance of B.This solution is decomposed into a sum of regular and layer components.Bounds are established on these compo- nents and their derivatives to show explicitly their dependence on the small parameterε.Finally,numerical methods consisting of upwinding on piecewise-uniform Shishkin meshes are proved to yield numerical solutions that are essentially first-order conver- gent,uniformly inε,to the true solution in the discrete maximum norm.Numerical results on Shishkin meshes are presented to support these theoretical bounds.展开更多
Due to the increasing global demand for industrial gas, the development of large-scale cryogenic air separation systems has attracted considerable attention in recent years. Increasing the height of the adsorption bed...Due to the increasing global demand for industrial gas, the development of large-scale cryogenic air separation systems has attracted considerable attention in recent years. Increasing the height of the adsorption bed in a vertical radial flow adsorber used in cryogenic air separation systems may efficiently increase the treatment capacity of the air in the adsorber. However, uniformity of the flow distribution of the air inside the adsorber would be deteriorated using the height-increasing method. In order to reduce the non-uniformity of the flow distribution caused by the excessive height of adsorption bed in a vertical radial flow adsorber, a novel parallel connection method is proposed in the present work. The experimental apparatus is designed and constructed; the Computational Fluid Dynamics(CFD) technique is used to develop a CFD-based model, which is used to analyze the flow distribution, the static pressure drop and the radial velocity in the newly designed adsorber. In addition, the geometric parameters of annular flow channels and the adsorption bed thickness of the upper unit in the parallelconnected vertical radial flow adsorber are optimized, so that the upper and lower adsorption units could be penetrated by air simultaneously. Comparisons are made between the height-increasing method and the parallel connection method with the same adsorber height. It is shown that using the parallel connection method could reduce the difference between the maximum and minimum radial static pressure drop by 86.2% and improve the uniformity by 80% compared with those of using the height-increasing method. The optimal thickness ratio of the upper and lower adsorption units is obtained as 0.966, in which case the upper and lower adsorption units could be penetrated by air simultaneously, so that the adsorbents in adsorption space could be used more efficiently.展开更多
Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Th...Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Then,parameters of PI controller were calculated on the basis of an equivalent controlled object.Finally,Norton equivalent circuit for the current control loop of grid-connected system was derived by integrating one control equation,which connected the PWM inverter output voltage and the LCL inverter-side current,with two circuit equations,separately using the LCL inverter-side current and the injected current as loop currents.With the induced Norton equivalent circuit,system-level resonant and unstable issues on real grid-connected system applied in weak distributed power systems can be easily analyzed.The validity of substituting Norton equivalent circuit for grid-connected system is verified by simulation and experiment.展开更多
AIM:To investigate the effect of side-stream smoking on gut microflora composition,intestinal inflammation and expression of tight junction proteins.METHODS:C57BL/6 mice were exposed to side-stream cigarette smoking f...AIM:To investigate the effect of side-stream smoking on gut microflora composition,intestinal inflammation and expression of tight junction proteins.METHODS:C57BL/6 mice were exposed to side-stream cigarette smoking for one hour daily over eight weeks.Cecal contents were collected for microbial composition analysis.Large intestine was collected for immunoblotting and quantitative reverse transcriptase polymerase chain reaction analyses of the inflammatory pathway and tight junction proteins.RESULTS:Side-stream smoking induced significant changes in the gut microbiota with increased mouse intestinal bacteria,Clostridium but decreased Fermicutes(Lactoccoci and Ruminococcus),Enterobacteriaceae family and Segmented filamentous baceteria compared to the control mice.Meanwhile,side-stream smoking inhibited the nuclear factor-κB pathway with reduced phosphorylation of p65 and IκBα,accompanied with unchanged mRNA expression of tumor necrosis factor-α or interleukin-6.The contents of tight junction proteins,claudin3 and ZO2 were up-regulated in the large intestine of mice exposed side-stream smoking.In addition,side-stream smoking increased c-Jun N-terminal kinase and p38 MAPK kinase signaling,while inhibiting AMPactivated protein kinase in the large intestine.CONCLUSION:Side-stream smoking altered gut microflora composition and reduced the inflammatory response,which was associated with increased expression of tight junction proteins.展开更多
Due to the various performance requirements and data access restrictions of different types of real-time transactions, concurrency control protocols which had been designed for the systems with single type of transact...Due to the various performance requirements and data access restrictions of different types of real-time transactions, concurrency control protocols which had been designed for the systems with single type of transactions are not sufficient for mixed real-time database systems (MRTDBS), where different types of real-time transactions coexist in the systems concurrently. In this paper, a new concurrency control protocol MRTT_CC for mixed real-time transactions is proposed. The new strategy integrates with different concurrency control protocols to meet the deadline requirements of different types of real-time transactions. The data similarity concept is also explored in the new protocol to reduce the blocking time of soft real-time transactions, which increases their chances to meet the deadlines. Simulation experiments show that the new protocol has gained good performance.展开更多
文摘针对电力设备载流故障与接触电阻、设备载流、外部环境温度及其结构尺寸之间的关系,研究建立了高压电气设备载流连接板温升故障的有限元计算方法,借助传热学理论,建立温升模型。并针对一起35 k V电流互感器载流连接板仿真发热故障进行了ANSYS计算分析,重点研究了载流连接板通过的电流大小、外部环境温度及连接板尺寸对其温度升高的影响。该分析结果可以用于对红外测温过程中电气设备电流型致热故障进行参考分析,并对实际设计中生产厂家选用高压电气设备一次电流连接板尺寸大小有一定的指导意义。
基金the financial supports from Prince of Songkla University (Contract number AGR530031M)
文摘An aluminum extrusion process is mainly used to fabricate long tubes, beams and rods for various applications. However, this process has a high production cost due to the need for investment of high-pressure machinery. The objective of this work is to develop a new semi-solid extrusion process using semi-solid slurry at low solid fractions. A laboratory extrusion system was used to fabricate aluminum rods with the diameter of 12 ram. The semi-solid metal process used in this study was the gas induced semi-solid (GISS) technique. To study the feasibility of the GISS extrusion process, the effects of extrusion parameters such as plunger speed and solid fi-action on the extrudability, microstructure, and mechanical properties of extruded samples were investigated. The results show that the plunger speed and solid fraction of the semi-solid metal need to be carefully controlled to produce complete extruded parts.
基金China National 111 Project Under Grant No. B07019.
文摘Underwater cylindrical shell structures have been found a wide of application in many engineering fields, such as the element of marine, oil platforms, etc. The coupled vibration analysis is a hot issue for these underwater structures. The vibration characteristics of underwater structures are influenced not only by hydrodynamic pressure but also by hydrostatic pressure corresponding to different water depths. In this study, an acoustic finite element method was used to evaluate the underwater structures. Taken the hydrostatic pressure into account in terms of initial stress stiffness, an acoustical fluid-structure coupled analysis of underwater cylindrical shells has been made to study the effect of hydrodynamic pressures on natural frequency and sound radiation. By comparing with the frequencies obtained by the acoustic finite element method and by the added mass method based on the Bessel function, the validity of present analysis was checked. Finally, test samples of the sound radiation of stiffened cylindrical shells were acquired by a harmonic acoustic analysis. The results showed that hydrostatic pressure plays an important role in determining a large submerged body motion, and the characteristics of sound radiation change with water depth. Furthermore, the analysis methods and the results are of significant reference value for studies of other complicated submarine structures.
文摘A kind of low power connector used e.g. in household appliances was partly burned in routine experiment. The heat sources were four paralleled contacts constructed by springs (Sn/CuSn-alloy) in socket and a plug sheet (Ni/Steel) while mating. The contact interfaces were detected by scanning electronic microscope (SEM) and X-ray energy dispersive spectros- copy (XEDS), obvious wear tracks and various contaminants, including element Si, Al, Na, K, S, Cl, O, etc., were found. The contamination degrees on the four paralleled contacts were different, so that the ratio of average contact resistance on the four contacts was about 5:8:3:1. The maximum contact resistance on contacts of the plug sheet reached 28 ?. The main failure rea- sons were fretting and contamination between the contact interfaces. Fretting simulation showed that connection resistance of connectors was raised up, even to ohms level. When the current increased to 5 A, the socket housing was heated and decom- posed. By the thermal analysis, it was estimated that the connector would be burned under the lower current if the current was not evenly distributed on the four paralleled contacts caused by uneven contamination. Improvement methods for connector failure are also discussed.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41421004 and 41130103)the Special Fund for Public Welfare Industry (Mete orology) (Grant No. GYHY201306026)
文摘This study investigated the connection between the Australian summer monsoon(ASM) and summer precipitation over central China. It was found that,following a weaker-than-normal ASM, the East Asian summer monsoon and western North Pacific subtropical high tend to be stronger, yielding anomalous northward moisture to be transported from the western Pacific to central China. Besides, anomalous upwelling motion emerges over 30–37.5°N, along 110°E. Consequently,significant positive summer precipitation anomalies are located over central China. Further analysis indicated that the boreal winter sea surface temperature(SST) in the Indian Ocean and South China Sea shows positive anomalies in association with a weaker-than-normal ASM. The Indian Ocean warming in boreal winter could persist into the following summer because of its own long memory, emanating a baroclinic Kelvin wave into the Pacific that triggers suppressed convection and an anomalous anticyclone. Besides, the abnormal SST signal in the South China Sea develops eastward with time because of local air-sea interaction, causing summer SST warming in the western Pacific. The SST warming can further affect East Asian atmospheric circulation and precipitation through its impact on convection.
基金Supported by A grant from the Doctoral Program of China Medical University
文摘AIM: To investigate the correlation between the expression levels of interleukin (IL)-6 and proteins in tight junctions (TJs) in the esophageal mucosa of rats modeling different types of reflux esophagitis (RE), and the ability of aluminum phosphate to protect against RE-induced mucosal damage via these proteins. METHODS: Male SPF Wistar rats aged 56 d were divided randomly into acid RE, alkaline RE, mixed RE, and control groups. Various surgical procedures were performed to establish rat models of acid RE. At 14 d after the procedure, some of the rats started aluminum phosphate treatment. Transmission electron microscopy (TEM) was used to observe the morphological features of TJs and desmosomes in the esophageal epithelium. Immunohistochemical methods and Western blotting were used to measure expression of claudin 1, occludin, ZO-1, JAM-l, DSG-1 and IL-6; reverse transcription polymerase chain reaction (RT- PCR) was used to measure expression of mRNA of claudin 1, occludin, ZO-1, JAM-1, DSG-1 and IL-6. RESULTS: At day 14 alter the procedures, an RE model was established in all subsequently sacrificed rats of groups A, B and C. By both gross and microscopic observation, the mucosa was damaged and thickened as the disease progressed. With TEM observation, a widened intercellular space was noticed, with significantly fewer desmosomes. Immunohistochemistry showed significantly higher levels of all proteins in all RE models compared to control rats at 3 d after operation (65.5% ± 25.6% vs 20.5% ± 2.1%, P 〈 0.05, respectively). At 14 d after operation, along with continuing hyperplasia in the basal layer, the expression of TJ proteins in individual cells gradually decreased (12.4% ± 2.1% vs 20.5% ± 2.1%, P 〈 0.05, respectively). Western blottings and RT-PCR showed a directly proportional increase in IL-6 levels in relation to TJ proteins, as compared to controls (0.878 ± 0.024 vs 0.205 ± 0.021 and 0.898±0.022 vs 0.205 ± 0.021, P 〈 0.05, respectively). Upon treatment with aluminum phosphate, however, these protein levels were restored to normal gradually over 30-60 d in rats with acid RE (30.4% ± 2.1% vs 20.5% ± 2.1%, P 〉 0.05, treated vs untreated, respectively). These levels increased in the rat with alkaline RE, and this increase was accompanied by continued hyperplasia in comparison with controls (85.5% ± 25.6% vs 20.5% ± 2.1%, P 〈 0.05, respectively). Furthermore, the expression of TJ proteins was not correlated significantly with that of IL-6 in this group. CONCLUSION: These findings indicate that TJ proteins are highly expressed as an early molecular event involved in RE development, and that IL-6 is an inflammatory factor in this process,
文摘A system of m (≥2) linear convection-diffusion two-point boundary value problems is examined,where the diffusion term in each equation is multiplied by a small parameterεand the equations are coupled through their convective and reactive terms via matrices B and A respectively.This system is in general singularly perturbed. Unlike the case of a single equation,it does not satisfy a conventional maximum princi- ple.Certain hypotheses are placed on the coupling matrices B and A that ensure exis- tence and uniqueness of a solution to the system and also permit boundary layers in the components of this solution at only one endpoint of the domain;these hypotheses can be regarded as a strong form of diagonal dominance of B.This solution is decomposed into a sum of regular and layer components.Bounds are established on these compo- nents and their derivatives to show explicitly their dependence on the small parameterε.Finally,numerical methods consisting of upwinding on piecewise-uniform Shishkin meshes are proved to yield numerical solutions that are essentially first-order conver- gent,uniformly inε,to the true solution in the discrete maximum norm.Numerical results on Shishkin meshes are presented to support these theoretical bounds.
基金Supported by the National Key R&D Program of China(2017YFB0603702)the Natural Science Foundation of Zhejiang Province(Y15E060014)+1 种基金the National Natural Science Foundation of China(51636007)Shanghai Young Teachers Development Program(10-16-301-801)
文摘Due to the increasing global demand for industrial gas, the development of large-scale cryogenic air separation systems has attracted considerable attention in recent years. Increasing the height of the adsorption bed in a vertical radial flow adsorber used in cryogenic air separation systems may efficiently increase the treatment capacity of the air in the adsorber. However, uniformity of the flow distribution of the air inside the adsorber would be deteriorated using the height-increasing method. In order to reduce the non-uniformity of the flow distribution caused by the excessive height of adsorption bed in a vertical radial flow adsorber, a novel parallel connection method is proposed in the present work. The experimental apparatus is designed and constructed; the Computational Fluid Dynamics(CFD) technique is used to develop a CFD-based model, which is used to analyze the flow distribution, the static pressure drop and the radial velocity in the newly designed adsorber. In addition, the geometric parameters of annular flow channels and the adsorption bed thickness of the upper unit in the parallelconnected vertical radial flow adsorber are optimized, so that the upper and lower adsorption units could be penetrated by air simultaneously. Comparisons are made between the height-increasing method and the parallel connection method with the same adsorber height. It is shown that using the parallel connection method could reduce the difference between the maximum and minimum radial static pressure drop by 86.2% and improve the uniformity by 80% compared with those of using the height-increasing method. The optimal thickness ratio of the upper and lower adsorption units is obtained as 0.966, in which case the upper and lower adsorption units could be penetrated by air simultaneously, so that the adsorbents in adsorption space could be used more efficiently.
基金Project(51307009)supported by the National Natural Science Foundation of ChinaProject(12JJ4045)supported by Hunan Provincial Natural Science Foundation,China+2 种基金Project(2011KFJJ003)supported by the Key Laboratory for Power Technology of Renewable Energy Sources of Hunan Province,ChinaProject(2011kfj14)supported by the Fund of Key Laboratory of Hunan Province about Power System Operation and Control,ChinaProject(454.13S-20)supported by the Enterprises’Postdoctoral Funds of Pudong Area of Shanghai,China
文摘Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Then,parameters of PI controller were calculated on the basis of an equivalent controlled object.Finally,Norton equivalent circuit for the current control loop of grid-connected system was derived by integrating one control equation,which connected the PWM inverter output voltage and the LCL inverter-side current,with two circuit equations,separately using the LCL inverter-side current and the injected current as loop currents.With the induced Norton equivalent circuit,system-level resonant and unstable issues on real grid-connected system applied in weak distributed power systems can be easily analyzed.The validity of substituting Norton equivalent circuit for grid-connected system is verified by simulation and experiment.
基金Supported by INBRE P20RR016474USDA-NRI 200835203-19084USDA-AFRI 2009-65203-05716
文摘AIM:To investigate the effect of side-stream smoking on gut microflora composition,intestinal inflammation and expression of tight junction proteins.METHODS:C57BL/6 mice were exposed to side-stream cigarette smoking for one hour daily over eight weeks.Cecal contents were collected for microbial composition analysis.Large intestine was collected for immunoblotting and quantitative reverse transcriptase polymerase chain reaction analyses of the inflammatory pathway and tight junction proteins.RESULTS:Side-stream smoking induced significant changes in the gut microbiota with increased mouse intestinal bacteria,Clostridium but decreased Fermicutes(Lactoccoci and Ruminococcus),Enterobacteriaceae family and Segmented filamentous baceteria compared to the control mice.Meanwhile,side-stream smoking inhibited the nuclear factor-κB pathway with reduced phosphorylation of p65 and IκBα,accompanied with unchanged mRNA expression of tumor necrosis factor-α or interleukin-6.The contents of tight junction proteins,claudin3 and ZO2 were up-regulated in the large intestine of mice exposed side-stream smoking.In addition,side-stream smoking increased c-Jun N-terminal kinase and p38 MAPK kinase signaling,while inhibiting AMPactivated protein kinase in the large intestine.CONCLUSION:Side-stream smoking altered gut microflora composition and reduced the inflammatory response,which was associated with increased expression of tight junction proteins.
文摘Due to the various performance requirements and data access restrictions of different types of real-time transactions, concurrency control protocols which had been designed for the systems with single type of transactions are not sufficient for mixed real-time database systems (MRTDBS), where different types of real-time transactions coexist in the systems concurrently. In this paper, a new concurrency control protocol MRTT_CC for mixed real-time transactions is proposed. The new strategy integrates with different concurrency control protocols to meet the deadline requirements of different types of real-time transactions. The data similarity concept is also explored in the new protocol to reduce the blocking time of soft real-time transactions, which increases their chances to meet the deadlines. Simulation experiments show that the new protocol has gained good performance.