药品流通监管重点与科学监管方法探讨

针对药品批发企业对医疗机构的药品配送,即对医疗机构使用药品的数据加以分析,研究药品的流通特性与医疗机构的关系、药品与使用者的关系、药品成本与质量的关系,从中找出药品流通领域应监管的重点药品品种、品规及重点单位,提高监管的针对性和决策的科学性,为在药品流通市场建立预防性和针对性相结合的监督管理体系提供科学依据。

定点药流通迷航

在定点药流通开始重返计划时代的背景下。

大气边界层相似性理论及其应用

系统总结了大气边界层相似性理论及其在湍流通量观测应用方面的研究进展，指出了该领域目前所遇到的一系列难题及未来发展方向，介绍了最近在这方面所取得的一些新的研究成果。

上市公司存量非流通股流通改造方法研究

1999年开始的国有股减持市场化实践 ,实际上已涉及到非流通股流通问题 ,2 0 0 2年 1月 2 7日在中国证监会网站公布的国有股减持方案阶段性成果 ,更是将国有股减持扩展到实现非流通股的流通这一关系股票市场全局的问题上。在开放与持续健康发展的要求下 ,上市公司股份分割缺陷是目前中国股票亟待解决的问题。本文在归纳已有的非流通股流通问题研究思路的基础上 ,着重分析了出售与缩股思路的出发点及存在的问题 ,提出了尊重历史、兼顾发起人对股份公司贡献的指导思想 ,引入发起人资本公积贡献杠杆作为调节系数 ,通过对非流通股的历史追溯调整来解决其流通问题。

Lattice Boltzmann simulation of a laminar square jet in cross flows

A three-dimensional, nineteen-velocity(D3Q19) Lattice Boltzmann Method(LBM) model was developed to simulate the fluid flow of a laminar square jet in cross flows based on the single relaxation time algorithm. The code was validated by the mathematic solution of the Poiseuille flow in a square channel, and was further validated with a previous well studied empirical correlation for the central trajectory of a jet in cross flows. The developed LBM model was found to be able to capture the dominant vortex, i.e. the Counter-rotating Vortex Pair(CVP) and the upright wake vortex. Results show that the incoming fluid in the cross flow channel was entrained into the leeside of the jet fluid, which contributes to the blending of the jet. That the spread width of the transverse jet decreases with the velocity ratio. A layer-organized entrainment pattern was found indicating that the incoming fluid at the lower position is firstly entrained into the leeside of the jet, and followed by the incoming fluid at the upper position.

A Stream Pattern Matching Method for Traffic Analysis

In order to identify any traces of suspicious activities for the networks security, Network Traffic Analysis has been the basis of network security and network management. With the continued emergence of new applications and encrypted traffic, the currently available approaches can not perform well for all kinds of network data. In this paper, we propose a novel stream pattern matching technique which is not only easily deployed but also includes the advantages of different methods. The main idea is： first, defining a formal description specification, by which any series of data stream can be unambiguously descrbed by a special stream pattern; then a tree representation is constructed by parsing the stream pattern; at last, a stream pattern engine is constructed with the Non-t-mite automata （S-CG-NFA） and Bit-parallel searching algorithms. Our stream pattern analysis system has been fully prototyped on C programming language and Xilinx Vn-tex2 FPGA. The experimental results show the method could provides a high level of recognition efficiency and accuracy.

Study on the Influence of Structural Parameters of Multi-channel Cylinder Dryer on Heat Transfer Performance

An approach to design multi-channel cylinder dryer was proposed. The heat transfer performance and flow characteristic under various structural parameters were analyzed. First, an experiment was designed and set up to measure the condensing heat transfer coefficient and the pressure drop in order to ,~erify the applicability of the Cavallini＇s correlation. Then, the relationship among the count of channels, aspect ratio, spacing ratio, width, height and hydraulic diameter of a channel was given. Finally, the correlation of condensing heat transfer and the homogeneous model was introduced in order to observe the heat transfer performance and flow characteristic of the multi-channel cylinder dryer affected by different structures. The study reveals that the structural parameters including count of channels, aspect ratio, spacing ratio of a channel dramatically influence the condensation heat transfer coefficient and frictional resistance of the steam. Based on the selected paper machine, it is suggested that the overall performance of the multi-channel cylinder dryer is best if the count of channels is 150-200, the aspect ratio is 1 ： 3 and the spacing ratio is 1 ： 1-1 ： 3.

MRT-LBM-based numerical simulation of seepage flow through fractal fracture networks

The study on seepage flow passing through single fractures is essential and critical for understanding of the law of seepage flow passing through fracture networks and the coupling mechanisms of seepage field and stress field in rock masses.By using the fractal interpolation to reconstruct a natural coarse fracture,as well as taking into account the microstructure of the fracture,the numerical simulation of seepage flow passing through the coarse fractures with two distinct vertical scaling factors is conducted based on the MRT-LBM model of the lattice Boltzmann method.Then,after obtaining the length of the preferential flow pathway,the permeability of the two kinds of fractures is estimated respectively.In view of difficulties in locating the preferential flow pathway of natural fracture networks,by numerical tests a transect permeability weighted algorithm for estimating the fracture network permeability is proposed.The algorithm is not specific to one or more particular preferential flow pathways,but considers the contribution of each section to hinder the fluid passing through the medium.In order to apply the new algorithm,by capturing the structure of fracture networks based on the image-processing technique,the numerical simulations of seepage flow passing through two groups of natural fracture networks is carried out,the permeability is forecasted and the partial flows are reproduced for both cases.It is found that the preferential flow pathway emerges at the beginning of evolution,then is strengthened subsequently,and finally reaches a steady status.Furthermore,by using the proposed method some details on local flow can be clearly observed such as backflows and vortices at local branches can exist simultaneously and so forth,suggesting the validness of the proposed method for multiscale simulations of seepage flow.

DYNAMIC VALUATION OF OPTIONS ON NON-TRADED ASSETS AND TRADING STRATEGIES

This paper investigates the pricing of options written on non-traded assets and trading strategies for the stock and option in an exponential utility maximization framework.Under the assumption that the option can be continuously traded without friction just as the stock,a dynamic relationship between their optimal positions is derived by using the stochastic dynamic programming techniques.The dynamic option pricing equations are also established.In particular,the properties of the associated solutions are discussed and their explicit representations are demonstrated via the Feynman-Kac formula.This paper further compares the dynamic option price to the existing price notions,such as the marginal price and indifference price.

Numerical simulation of immiscible liquid-liquid flow in microchannels using lattice Boltzmann method

Immiscible kerosene-water two-phase flows in microchannels connected by a T-junction were numerically studied by a Lattice Boltzmann (LB) method based on field mediators.The two-phase flow lattice Boltzmann model was first validated and improved by several test cases of a still droplet.The five distinct flow regimes of the kerosene-water system,previously identified in the experiments from Zhao et al.,were reproduced.The quantitative and qualitative agreement between the simulations and the experimental data show the effectiveness of the numerical method.The roles of the interfacial tension and contact angle on the flow patterns and shapes of droplets were discussed and highlighted according to the numerical results based on the improved two-phase LB model.This work demonstrated that the developed LBM simulator is a viable tool to study immiscible two-phase flows in microchannels,and such a tool could provide tangible guidance for the design of various microfluidic devices that involve immiscible multi-phase flows.

Development and application of a throughflow method for high-loaded axial flow compressors

In this paper, a novel engineering platform for throughflow analysis based on streamline curvature approach is developed for the research of a 5-stage compressor. The method includes several types of improved loss and deviation angle models, which are combined with the authors' adjustments for the purpose of reflecting the influences of three-dimensional internal flow in high-loaded multistage compressors with higher accuracy. In order to validate the reliability and robustness of the method, a series of test cases, including a subsonic compressor P&W 3S1, a transonic rotor NASA Rotor 1B and especially an advanced high pressure core compressor GE E^3 HPC, are conducted. Then the computation procedure is applied to the research of a 5-stage compressor which is designed for developing an industrial gas turbine. The overall performance and aerodynamic configuration predicted by the procedure, both at design- and part-speed conditions, are analyzed and compared with experimental results, which show a good agreement. Further discussion regarding the universality of the method compared with CFD is made afterwards. The throughflow method is verified as a reliable and convenient tool for aerodynamic design and performance prediction of modern high-loaded compressors. This method is also qualified for use in the further optimization of the 5-stage compressor.