Drug delivery systems able to deliver the required dose of the drug to the target level use active or passive nano metric designed systems. In the earlier researches, carbon nanocones are used for transferring the ser...Drug delivery systems able to deliver the required dose of the drug to the target level use active or passive nano metric designed systems. In the earlier researches, carbon nanocones are used for transferring the serum to damaged proteins and damaged cancer cellules. In this lecture, stability analysis of drug delivery to damaged cancer cellutes is studied in the shape of single-walled carbon nanocone. In this method, each atom is considered as node and interactions between them are supposed as 3D-beam elements. By supposing that potential energy in macro relations is equal to the nano relations, nano-drug characteristics can be calculated. Then shape functions can be extracted to use in blood＇s FEM model and using reduced-order method, divergence velocities of carbon nanocone can be found. In this lecture, carbon nanocones are modeled with different dimensions and boundary conditions and stability of them in blood flow is studied and optimized carbon nanocone is selected in blood flow. Results show that conical nano-drug structures have more efficiency in blood flow rather than tube nano-drug structures and by increasing length of carbon nanocones, dimensionless stability parameter decreased and by increasing declination angle of carbon nanocones, dimensionless stability parameter increased.展开更多
A computational framework for parachute inflation is developed based on the immersed boundary/finite element approach within the open-source IBAMR library.The fluid motion is solved by Peskin's diffuse-interface i...A computational framework for parachute inflation is developed based on the immersed boundary/finite element approach within the open-source IBAMR library.The fluid motion is solved by Peskin's diffuse-interface immersed boundary(IB)method,which is attractive for simulating moving-boundary flows with large deformations.The adaptive mesh refinement technique is employed to reduce the computational cost while retain the desired resolution.The dynamic response of the parachute is solved with the finite element approach.The canopy and cables of the parachute system are modeled with the hyperelastic material.A tether force is introduced to impose rigidity constraints for the parachute system.The accuracy and reliability of the present framework is validated by simulating inflation of a constrained square plate.Application of the present framework on several canonical cases further demonstrates its versatility for simulation of parachute inflation.展开更多
The data information transfer and time marching strategies between computational fluid dynamics （CFD） and computational structural dynamics （CSD） play crucial roles on the aeroelastic analysis in a time domain. An...The data information transfer and time marching strategies between computational fluid dynamics （CFD） and computational structural dynamics （CSD） play crucial roles on the aeroelastic analysis in a time domain. An improved CFD/CSD coupled system is designed, including an interpolation method and an improved loosely coupled algorithm. The interpolation method based on boundary element method （BEM） is developed to transfer aerodynamic loads and structural displacements between CFD and CSD grid systems, it can be universally used in fluid structural interaction solution by keeping energy conservation. The improved loosely coupled algo-rithm is designed, thus it improves the computational accuracy and efficiency. The new interface is performed on the two-dimensional （2-D） extrapolation and the aeroelastie response of AGARD445.6 wing. Results show that the improved interface has a superior accuracy.展开更多
A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both co...A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both coupling computation of para- chute FSI and flow field analysis. Both fiat circular parachute and conical parachute are modeled and simulated by this new method. Flow field characteristics at various angles of attack are further simulated for the conical parachute model. Compari- son with the space-time FSI technique shows that this method also provides similar and reasonable results.展开更多
文摘Drug delivery systems able to deliver the required dose of the drug to the target level use active or passive nano metric designed systems. In the earlier researches, carbon nanocones are used for transferring the serum to damaged proteins and damaged cancer cellules. In this lecture, stability analysis of drug delivery to damaged cancer cellutes is studied in the shape of single-walled carbon nanocone. In this method, each atom is considered as node and interactions between them are supposed as 3D-beam elements. By supposing that potential energy in macro relations is equal to the nano relations, nano-drug characteristics can be calculated. Then shape functions can be extracted to use in blood＇s FEM model and using reduced-order method, divergence velocities of carbon nanocone can be found. In this lecture, carbon nanocones are modeled with different dimensions and boundary conditions and stability of them in blood flow is studied and optimized carbon nanocone is selected in blood flow. Results show that conical nano-drug structures have more efficiency in blood flow rather than tube nano-drug structures and by increasing length of carbon nanocones, dimensionless stability parameter decreased and by increasing declination angle of carbon nanocones, dimensionless stability parameter increased.
基金supported by the Open Project of Key Laboratory of Aerospace EDLA,CASC(No.EDL19092208)。
文摘A computational framework for parachute inflation is developed based on the immersed boundary/finite element approach within the open-source IBAMR library.The fluid motion is solved by Peskin's diffuse-interface immersed boundary(IB)method,which is attractive for simulating moving-boundary flows with large deformations.The adaptive mesh refinement technique is employed to reduce the computational cost while retain the desired resolution.The dynamic response of the parachute is solved with the finite element approach.The canopy and cables of the parachute system are modeled with the hyperelastic material.A tether force is introduced to impose rigidity constraints for the parachute system.The accuracy and reliability of the present framework is validated by simulating inflation of a constrained square plate.Application of the present framework on several canonical cases further demonstrates its versatility for simulation of parachute inflation.
基金Supported by the Ph.D.Program Foundation of Ministry of Education of China (20070699054)~~
文摘The data information transfer and time marching strategies between computational fluid dynamics （CFD） and computational structural dynamics （CSD） play crucial roles on the aeroelastic analysis in a time domain. An improved CFD/CSD coupled system is designed, including an interpolation method and an improved loosely coupled algorithm. The interpolation method based on boundary element method （BEM） is developed to transfer aerodynamic loads and structural displacements between CFD and CSD grid systems, it can be universally used in fluid structural interaction solution by keeping energy conservation. The improved loosely coupled algo-rithm is designed, thus it improves the computational accuracy and efficiency. The new interface is performed on the two-dimensional （2-D） extrapolation and the aeroelastie response of AGARD445.6 wing. Results show that the improved interface has a superior accuracy.
基金supported by the National Natural Science Foundation of China (Grant No. 10577003)Monash University of Australia
文摘A numerical simulation method for parachute Fluid-Structure Interaction （FSI） problem using Semi-Implicit Method for Pres- sure-Linked Equations （SIMPLE） algorithm is proposed. This method could be used in both coupling computation of para- chute FSI and flow field analysis. Both fiat circular parachute and conical parachute are modeled and simulated by this new method. Flow field characteristics at various angles of attack are further simulated for the conical parachute model. Compari- son with the space-time FSI technique shows that this method also provides similar and reasonable results.
