With the development of GPS carrier wave phase technology, it becomes possible that the height accuracy of centimeter level is got by GPS RTK technology. Vessel attitudes are very important parameters in marine survey...With the development of GPS carrier wave phase technology, it becomes possible that the height accuracy of centimeter level is got by GPS RTK technology. Vessel attitudes are very important parameters in marine survey. In this paper, they were determined by 4 GPS receivers. At the same time, the arithmetic and procedure of vessel attitude determining were given. Based on an experiment, some useful conclusions were obtained and the corresponding methods were put forward to improve the accuracy.展开更多
In view of the importance of the hotel segment for the tourism and for the economy of countries such as Portugal, the objective of this study was to measure the level of orientation for the market of the largest hotel...In view of the importance of the hotel segment for the tourism and for the economy of countries such as Portugal, the objective of this study was to measure the level of orientation for the market of the largest hotel groups of Portugal. This investigation initially emphasized the importance of the marketing for the organizations, mainly the orientation for the market. After a brief explanation on the hotel segment in Portugal, an empirical study was presented, of quantitative, exploratory and traversal character, performed with the largest groups of 20 hotels of Portugal, using as an instrument of collection data, the traditional Markor scale （market orientation） adapted to the hotel sector. After analyzing the data, it was found in the investigated organizations that a good capacity to generate market information and response to the market, which formed two of the three constructs of Markor scale. However the results obtained with the construct of the dissemination of market information were below the expectations. It was possible to conclude that marketing professionals of the large hotel groups in Portugal are well oriented to the market, something not shared by other investigated departments of the hotels. So the current challenge for the main networks of hotels in Portugal is to improve the internal dissemination of information that marketing professionals gathered at the market.展开更多
We perform the updated constraints on the Hubble constant H_0 by using the model-independent method, Gaussian processes.Utilizing the latest 30 cosmic chronometer measurements, we obtain H_0= 67.38 ± 4.72 km s^(-...We perform the updated constraints on the Hubble constant H_0 by using the model-independent method, Gaussian processes.Utilizing the latest 30 cosmic chronometer measurements, we obtain H_0= 67.38 ± 4.72 km s^(-1)Mpc^(-1), which is consistent with the Planck 2015 and Riess et al. analysis at 1σ confidence level. Different from the results of Busti et al. by only using 19 H(z) measurements, our reconstruction results of H(z) and the derived values of H_0 are insensitive to the concrete choice of covariance functions of Matern family.展开更多
OBJECTIVE: To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47 D breast cancer cell line.METHODS: In this experimental study, T47 D cells were cultured...OBJECTIVE: To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47 D breast cancer cell line.METHODS: In this experimental study, T47 D cells were cultured in monolayers in RPMI 1640. IC50 was determined by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay after 24 h treatment at different concentrations of quercetin.The levels of leptin gene expression were measured by reverse-transcription real-time polymerase chain reaction(PCR). Secreted leptin was measured in the supernatant of cells by an enzyme-linked immuno sorbent assay.RESULTS: Analysis of MTT assay data showed that quercetin has a cytotoxic effect on T47 D breast cancer cells with 40 μM IC50 after 24 h exposure. Dataanalysis of real-time PCR showed that with increases in quercetin concentration, a decreasing trend was seen in m RNA levels of leptin of treated cells compared with the control cells(P < 0.05). Also,measurement of secreted leptin in the culture media showed a similar decreasing trend in the amount of leptin protein in the treated cells compared with the control cells(P < 0.05).CONCLUSION: Quercetin significantly inhibits the growth of T47 D cells through inhibition of leptin secretion and gene expression in T47 D breast cancer cells. Therefore, it might be an alternative approach to breast cancer therapy through leptin targeting.展开更多
文摘With the development of GPS carrier wave phase technology, it becomes possible that the height accuracy of centimeter level is got by GPS RTK technology. Vessel attitudes are very important parameters in marine survey. In this paper, they were determined by 4 GPS receivers. At the same time, the arithmetic and procedure of vessel attitude determining were given. Based on an experiment, some useful conclusions were obtained and the corresponding methods were put forward to improve the accuracy.
文摘In view of the importance of the hotel segment for the tourism and for the economy of countries such as Portugal, the objective of this study was to measure the level of orientation for the market of the largest hotel groups of Portugal. This investigation initially emphasized the importance of the marketing for the organizations, mainly the orientation for the market. After a brief explanation on the hotel segment in Portugal, an empirical study was presented, of quantitative, exploratory and traversal character, performed with the largest groups of 20 hotels of Portugal, using as an instrument of collection data, the traditional Markor scale （market orientation） adapted to the hotel sector. After analyzing the data, it was found in the investigated organizations that a good capacity to generate market information and response to the market, which formed two of the three constructs of Markor scale. However the results obtained with the construct of the dissemination of market information were below the expectations. It was possible to conclude that marketing professionals of the large hotel groups in Portugal are well oriented to the market, something not shared by other investigated departments of the hotels. So the current challenge for the main networks of hotels in Portugal is to improve the internal dissemination of information that marketing professionals gathered at the market.
文摘We perform the updated constraints on the Hubble constant H_0 by using the model-independent method, Gaussian processes.Utilizing the latest 30 cosmic chronometer measurements, we obtain H_0= 67.38 ± 4.72 km s^(-1)Mpc^(-1), which is consistent with the Planck 2015 and Riess et al. analysis at 1σ confidence level. Different from the results of Busti et al. by only using 19 H(z) measurements, our reconstruction results of H(z) and the derived values of H_0 are insensitive to the concrete choice of covariance functions of Matern family.
基金Tabriz University of Medical SciencesAhar Islamic Azad University for all of the support they provided
文摘OBJECTIVE: To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47 D breast cancer cell line.METHODS: In this experimental study, T47 D cells were cultured in monolayers in RPMI 1640. IC50 was determined by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay after 24 h treatment at different concentrations of quercetin.The levels of leptin gene expression were measured by reverse-transcription real-time polymerase chain reaction(PCR). Secreted leptin was measured in the supernatant of cells by an enzyme-linked immuno sorbent assay.RESULTS: Analysis of MTT assay data showed that quercetin has a cytotoxic effect on T47 D breast cancer cells with 40 μM IC50 after 24 h exposure. Dataanalysis of real-time PCR showed that with increases in quercetin concentration, a decreasing trend was seen in m RNA levels of leptin of treated cells compared with the control cells(P < 0.05). Also,measurement of secreted leptin in the culture media showed a similar decreasing trend in the amount of leptin protein in the treated cells compared with the control cells(P < 0.05).CONCLUSION: Quercetin significantly inhibits the growth of T47 D cells through inhibition of leptin secretion and gene expression in T47 D breast cancer cells. Therefore, it might be an alternative approach to breast cancer therapy through leptin targeting.
