Background Increased red blood cell distribution width (RDW) is associated with adverse outcomes in patients with heart failure (HF). The objective of this study was to compare the differences in the predictive va...Background Increased red blood cell distribution width (RDW) is associated with adverse outcomes in patients with heart failure (HF). The objective of this study was to compare the differences in the predictive value of RDW in patients with HF due to different causes. Methods We retrospectively investigated 1,021 HF patients from October 2009 to December 2011 at Fuwai Hospital (Beijing, China). HF in these patients was caused by three diseases; coronary heart disease (CHD), dilated cardiomyopathy (DCM) and valvular heart disease (VHD). Patients were followed-up for 21 ~ 9 months. Results The RDW, mortality and survival duration were significantly different among the three groups. Kaplan-Meier analysis showed that the cumulative survival decreased significantly with increased RDW in patients with HF caused by CHD and DCM, but not in those with HF patients caused by VHD. In a multivariable model, RDW was identified as an independent predictor for the mortality of HF patients with CHD (P 〈 0.001, HR 1.315, 95% CI 1.122-1.543). The group with higher N-terminal pro-brain natriuretic peptide (NT-proBNP) and higher RDW than median had the lowest cumulative survival in patients with HF due to CHD, but not in patients with HF due to DCM. Conclusions RDW is a prognostic indicator for patients with HF caused by CHD and DCM; thus, RDW adds important information to NT-proBNP in CHD caused HF patients.展开更多
Current health monitoring systems often do not concern about the needs of the elderly,leading to inaccurate health status monitoring and delayed treatment for emergency health conditions.Similarly,they do not consider...Current health monitoring systems often do not concern about the needs of the elderly,leading to inaccurate health status monitoring and delayed treatment for emergency health conditions.Similarly,they do not consider the variable factors affecting each patient,resulting in discrepancies between the measured values and real health status.To solve the problems,we propose a new health monitoring system with physiological parameter measurement,correction,and feedback.The study collects clinical samples of the elderly to formulate regression equations and statistical models for analyzing the relationship between gender,age,measurement time,and physical signs.After multiple adjustments to measurements of physical signs,the correction algorithm compares the data with a standard value.The process significantly reduces the risk of misjudgment while matching users’health status more accurately.The application case of this paper proves the validity of the method for measuring and correcting heart rate results in the elderly and presents a specific correction procedure.Additionally,the correction algorithm provides a scientific basis for eliminating or modifying other influencing factors in future health monitoring studies.展开更多
Objective To construct a model of Seasonal Autoregressive Integrated Moving Average (SARIMA) for forecasting the epidemic of Japanese encephalitis (JE) in Xianyang, Shaanxi, China, and provide valuable reference ...Objective To construct a model of Seasonal Autoregressive Integrated Moving Average (SARIMA) for forecasting the epidemic of Japanese encephalitis (JE) in Xianyang, Shaanxi, China, and provide valuable reference information for JE control and prevention. Methods Theoretically epidemiologic study was employed in the research process. Monthly incidence data on JE for the period from Jan 2005 to Sep 2014 were obtained from a passive surveillance system at the Center for Diseases Prevention and Control in Xianyang, Shaanxi province. An optimal SARIMA model was developed for JE incidence from 2005 to 2013 with the Box and Jenkins approach. This SARIMA model could predict JE incidence for the year 2014 and 2015. Results SARIMA (1, 1, 1) (2, 1, 1)12 was considered to be the best model with the lowest Bayesian information criterion, Akaike information criterion, Mean Absolute Error values, the highest R2, and a lower Mean Absolute Percent Error. SARIMA (1, 1, 1) (2, 1, 1)12 was stationary and accurate for predicting JE incidence in Xianyang. The predicted incidence, around 0.3/100 000 from June to August in 2014 with low errors, was higher compared with the actual incidence. Therefore, SARIMA (1, 1, 1) (2, 1, 1)12 appeared to be reliable and accurate and could be applied to incidence prediction. Conclusions The proposed prediction model could provide clues to early identification of the JE incidence that is increased abnormally (≥0.4/100 000). According to the predicted results in 2014, the JE incidence in Xianyang will decline slightly and reach its peak from June to August.The authors wish to thank the staff from the CDCs from 13 counties of Xianyang, Shaanxi province, China, for their contribution to Japanese encephalitis cases reporting.展开更多
In this study,six intensity forecast guidance techniques from the East China Regional Meteorological Center are verified for the 2008 and 2009 typhoon seasons through an alternative forecast verification technique.Thi...In this study,six intensity forecast guidance techniques from the East China Regional Meteorological Center are verified for the 2008 and 2009 typhoon seasons through an alternative forecast verification technique.This technique is used to verify intensity forecasts if those forecasts call for a typhoon to dissipate or if the real typhoon dissipates.Using a contingency table,skill scores,chance,and probabilities are computed.It is shown that the skill of the six tropical cyclone intensity guidance techniques was highest for the 12-h forecasts,while the lowest skill of all the six models did not occur in 72-h forecasting.For both the 2008 and 2009 seasons,the average probabilities of the forecast intensity having a small error(6 m s-1) tended to decrease steadily.Some of the intensity forecasts had small skill scores,but the associated probabilities of the forecast intensity errors > 15 m s-1 were not the highest.展开更多
Two-dimensional physical models of low crested breakwaters were tested to establish the effect of water depth, crest width, slope, stone size, core permeability and incident wave characteristics on the wave transforma...Two-dimensional physical models of low crested breakwaters were tested to establish the effect of water depth, crest width, slope, stone size, core permeability and incident wave characteristics on the wave transformation processes. The structure of the breakwaters can be used as coastal protection system by reducing the amount of incoming wave energy. Effect of slope, core permeability, water depth and incident wave characteristics on the stability was also studied. The breakwater model consisted of a core and two armour layers attacked by irregular waves. This paper discusses and compares the test results with the existing design equations. In general, the existing design equations do not seem to predict the wave transmission and reflection accurately for the range of test data. In the range of variable tested, it was observed that the water depth, crest width and wave period have a significant influence on wave transmission process. Further, results show strong influence of the water depth and wave period on the wave reflection process. The structural stability of low crested breakwaters is very much affected by the water depth and wave period.展开更多
Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the po...Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the possibilities of ubiquitous respiratory monitoring,however,relatively little attention is paid to accuracy and reliability.In previous study,a wearable respiration biofeedback system was designed.In this work,three kinds of signals were mixed to extract respiratory rate,i.e.,respiration inductive plethysmography(RIP),3D-acceleration and ECG.In-situ experiments with twelve subjects indicate that the method significantly improves the accuracy and reliability over a dynamic range of respiration rate.It is possible to derive respiration rate from three signals within mean absolute percentage error 4.37%of a reference gold standard.Similarly studies derive respiratory rate from single-lead ECG within mean absolute percentage error 17%of a reference gold standard.展开更多
The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some vo...The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some voice alarm if the HRV is abnormal.Then it is decided whether to see a doctor at a convenient time for further diagnosis.The instrument has a feature of voice guidance that can save keyboard steps,which extends the scope of use.All people,old and young,the blind and the deaf,can use it by themselves.展开更多
The local defect in rotating machine always gives rise to repetitive transients in the collected vibration signal. However, the transient signature is prone to be contaminated by strong background noises, thus it is a...The local defect in rotating machine always gives rise to repetitive transients in the collected vibration signal. However, the transient signature is prone to be contaminated by strong background noises, thus it is a challenging task to detect the weak transients for machine fault diagnosis. In this paper, a novel adaptive tunable Q-factor wavelet transform(TQWT) filter based feature extraction method is proposed to detect repetitive transients. The emerging TQWT possesses distinct advantages over the classical constant-Q wavelet transforms, whose Q-factor can be tuned to match the oscillatory behavior of different signals, but the parameter selection for TQWT heavily relies on prior knowledge. Within our adaptive TQWT filter algorithm, the automatic optimization techniques for three TQWT parameters are implemented to achieve an optimal TQWT basis that matches the transient components. Specifically, the decomposition level is selected according to a center frequency ratio based stopping criterion, and the Q-factor and redundancy are optimized based on the minimum energy-weighted normalized wavelet entropy.Then, the adaptive TQWT decomposition can be achieved in a sparse way and result in subband signals at various wavelet scales.Further, the optimum subband signal which carries transient feature information, is identified using a normalized energy to bandwidth ratio index. Finally, the single branch reconstruction signal from the optimum subband is obtained with transient signatures via inverse TQWT, and the frequency of repetitive transients is detected using Hilbert envelope demodulation. It has been verified via numerical simulation that the proposed adaptive TQWT filter based feature extraction method can adaptively select TQWT parameters and the optimum subband for repetitive transient detection without prior knowledge. The proposed method is also applied to faulty bearing vibration signals and its effectiveness is validated.展开更多
For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the com...For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the compressor characteristics at small or negative flow rate. In this paper, measurement and numerical simulation of the characteristics at small or negative flow rate are carried out. In the measurement, an experimental facility with a valve immediately downstream of the compressor is used to suppress the surge. In the numerical work, a new boundary condition that specifies mass flow rate at the outlet boundary is used to simulate the characteristics around the zero flow rate region. Furthermore, flow field analyses at small or negative flow rate are performed with the numerical results. The separated and re-circulated flow fields are investigated by visualization to identify the origin of losses.展开更多
OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this mult...OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma.展开更多
The aspect sensitivity is the main problem in radar automatic target recognition using high resolution range profile (HRRP). In the traditional viewpoint,HRRPs are assumed to be highly similar if the aspect variation ...The aspect sensitivity is the main problem in radar automatic target recognition using high resolution range profile (HRRP). In the traditional viewpoint,HRRPs are assumed to be highly similar if the aspect variation is not enough to cause range migration. However,some experiments in anechoic chambers don’t agree with the assumption. Particularly,some abnormal HRRPs often occur in the measured data. Based on the scattering center model,this paper focuses on the reason of abnormal HRRP,which is named as the speckle. The theoretical model of speckle is established and the "spurious dual peaks" feature of the speckled HRRP is analyzed. Then the occurrence condition of speckle is concluded,and so is the relationship between the speckle probability in HRRP and radar carrier frequency. At last,the experiment in an anechoic chamber is used to verify all the analyses about the speckle.展开更多
文摘Background Increased red blood cell distribution width (RDW) is associated with adverse outcomes in patients with heart failure (HF). The objective of this study was to compare the differences in the predictive value of RDW in patients with HF due to different causes. Methods We retrospectively investigated 1,021 HF patients from October 2009 to December 2011 at Fuwai Hospital (Beijing, China). HF in these patients was caused by three diseases; coronary heart disease (CHD), dilated cardiomyopathy (DCM) and valvular heart disease (VHD). Patients were followed-up for 21 ~ 9 months. Results The RDW, mortality and survival duration were significantly different among the three groups. Kaplan-Meier analysis showed that the cumulative survival decreased significantly with increased RDW in patients with HF caused by CHD and DCM, but not in those with HF patients caused by VHD. In a multivariable model, RDW was identified as an independent predictor for the mortality of HF patients with CHD (P 〈 0.001, HR 1.315, 95% CI 1.122-1.543). The group with higher N-terminal pro-brain natriuretic peptide (NT-proBNP) and higher RDW than median had the lowest cumulative survival in patients with HF due to CHD, but not in patients with HF due to DCM. Conclusions RDW is a prognostic indicator for patients with HF caused by CHD and DCM; thus, RDW adds important information to NT-proBNP in CHD caused HF patients.
基金This work was supported by the National Natural Science Foundation of China(No.51804014).
文摘Current health monitoring systems often do not concern about the needs of the elderly,leading to inaccurate health status monitoring and delayed treatment for emergency health conditions.Similarly,they do not consider the variable factors affecting each patient,resulting in discrepancies between the measured values and real health status.To solve the problems,we propose a new health monitoring system with physiological parameter measurement,correction,and feedback.The study collects clinical samples of the elderly to formulate regression equations and statistical models for analyzing the relationship between gender,age,measurement time,and physical signs.After multiple adjustments to measurements of physical signs,the correction algorithm compares the data with a standard value.The process significantly reduces the risk of misjudgment while matching users’health status more accurately.The application case of this paper proves the validity of the method for measuring and correcting heart rate results in the elderly and presents a specific correction procedure.Additionally,the correction algorithm provides a scientific basis for eliminating or modifying other influencing factors in future health monitoring studies.
基金Supported by the Youth Project of Shaanxi University of Chinese Medicine(2015QN05)
文摘Objective To construct a model of Seasonal Autoregressive Integrated Moving Average (SARIMA) for forecasting the epidemic of Japanese encephalitis (JE) in Xianyang, Shaanxi, China, and provide valuable reference information for JE control and prevention. Methods Theoretically epidemiologic study was employed in the research process. Monthly incidence data on JE for the period from Jan 2005 to Sep 2014 were obtained from a passive surveillance system at the Center for Diseases Prevention and Control in Xianyang, Shaanxi province. An optimal SARIMA model was developed for JE incidence from 2005 to 2013 with the Box and Jenkins approach. This SARIMA model could predict JE incidence for the year 2014 and 2015. Results SARIMA (1, 1, 1) (2, 1, 1)12 was considered to be the best model with the lowest Bayesian information criterion, Akaike information criterion, Mean Absolute Error values, the highest R2, and a lower Mean Absolute Percent Error. SARIMA (1, 1, 1) (2, 1, 1)12 was stationary and accurate for predicting JE incidence in Xianyang. The predicted incidence, around 0.3/100 000 from June to August in 2014 with low errors, was higher compared with the actual incidence. Therefore, SARIMA (1, 1, 1) (2, 1, 1)12 appeared to be reliable and accurate and could be applied to incidence prediction. Conclusions The proposed prediction model could provide clues to early identification of the JE incidence that is increased abnormally (≥0.4/100 000). According to the predicted results in 2014, the JE incidence in Xianyang will decline slightly and reach its peak from June to August.The authors wish to thank the staff from the CDCs from 13 counties of Xianyang, Shaanxi province, China, for their contribution to Japanese encephalitis cases reporting.
基金supported by the National Basic Research Program of China (2009CB421505)the Shanghai Typhoon Foundation (2009ST09)+1 种基金the National Natural Science Foundation of China (40775060)the Program of China Mete-orological Administration (GYHY201006008 and GYHY200906002)
文摘In this study,six intensity forecast guidance techniques from the East China Regional Meteorological Center are verified for the 2008 and 2009 typhoon seasons through an alternative forecast verification technique.This technique is used to verify intensity forecasts if those forecasts call for a typhoon to dissipate or if the real typhoon dissipates.Using a contingency table,skill scores,chance,and probabilities are computed.It is shown that the skill of the six tropical cyclone intensity guidance techniques was highest for the 12-h forecasts,while the lowest skill of all the six models did not occur in 72-h forecasting.For both the 2008 and 2009 seasons,the average probabilities of the forecast intensity having a small error(6 m s-1) tended to decrease steadily.Some of the intensity forecasts had small skill scores,but the associated probabilities of the forecast intensity errors > 15 m s-1 were not the highest.
文摘Two-dimensional physical models of low crested breakwaters were tested to establish the effect of water depth, crest width, slope, stone size, core permeability and incident wave characteristics on the wave transformation processes. The structure of the breakwaters can be used as coastal protection system by reducing the amount of incoming wave energy. Effect of slope, core permeability, water depth and incident wave characteristics on the stability was also studied. The breakwater model consisted of a core and two armour layers attacked by irregular waves. This paper discusses and compares the test results with the existing design equations. In general, the existing design equations do not seem to predict the wave transmission and reflection accurately for the range of test data. In the range of variable tested, it was observed that the water depth, crest width and wave period have a significant influence on wave transmission process. Further, results show strong influence of the water depth and wave period on the wave reflection process. The structural stability of low crested breakwaters is very much affected by the water depth and wave period.
基金Project(2012M510207)supported by the China Postdoctoral Science FoundationProjects(60932001,61072031)supported by the National Natural Science Foundation of China+2 种基金Project(2012AA02A604)supported by the National High Technology Research and Development Program of ChinaProject(2013ZX03005013)supported by the Next Generation Communication Technology Major Project of National Science and Technology,ChinaProject supported by the"One-hundred Talent"and the"Low-cost Healthcare"Programs of Chinese Academy of Sciences
文摘Respiratory monitoring is increasingly used in clinical and healthcare practices to diagnose chronic cardio-pulmonary functional diseases during various routine activities.Wearable medical devices have realized the possibilities of ubiquitous respiratory monitoring,however,relatively little attention is paid to accuracy and reliability.In previous study,a wearable respiration biofeedback system was designed.In this work,three kinds of signals were mixed to extract respiratory rate,i.e.,respiration inductive plethysmography(RIP),3D-acceleration and ECG.In-situ experiments with twelve subjects indicate that the method significantly improves the accuracy and reliability over a dynamic range of respiration rate.It is possible to derive respiration rate from three signals within mean absolute percentage error 4.37%of a reference gold standard.Similarly studies derive respiratory rate from single-lead ECG within mean absolute percentage error 17%of a reference gold standard.
基金supported by the National Nature Science Foundation of China(60804034)Nature Science Foundation of Shandong Province(ZR2009GQ006)+3 种基金the Project of Science and Technology of Qingdao Economic and Technological Development Area(2009-2-39)"Taishan Scholarship"Construction Engineering,Innovation Project Special Fund for PostDoctors of Shandong Province(201002028)SDUST Research Fund(2010KYJQ105)the Project of Shandong Province Higher Educational Science and Technology Program(J11LG53)
文摘The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some voice alarm if the HRV is abnormal.Then it is decided whether to see a doctor at a convenient time for further diagnosis.The instrument has a feature of voice guidance that can save keyboard steps,which extends the scope of use.All people,old and young,the blind and the deaf,can use it by themselves.
基金supported by the National Natural Science Foundation of China (Grant Nos. 51335006 & 51605244)
文摘The local defect in rotating machine always gives rise to repetitive transients in the collected vibration signal. However, the transient signature is prone to be contaminated by strong background noises, thus it is a challenging task to detect the weak transients for machine fault diagnosis. In this paper, a novel adaptive tunable Q-factor wavelet transform(TQWT) filter based feature extraction method is proposed to detect repetitive transients. The emerging TQWT possesses distinct advantages over the classical constant-Q wavelet transforms, whose Q-factor can be tuned to match the oscillatory behavior of different signals, but the parameter selection for TQWT heavily relies on prior knowledge. Within our adaptive TQWT filter algorithm, the automatic optimization techniques for three TQWT parameters are implemented to achieve an optimal TQWT basis that matches the transient components. Specifically, the decomposition level is selected according to a center frequency ratio based stopping criterion, and the Q-factor and redundancy are optimized based on the minimum energy-weighted normalized wavelet entropy.Then, the adaptive TQWT decomposition can be achieved in a sparse way and result in subband signals at various wavelet scales.Further, the optimum subband signal which carries transient feature information, is identified using a normalized energy to bandwidth ratio index. Finally, the single branch reconstruction signal from the optimum subband is obtained with transient signatures via inverse TQWT, and the frequency of repetitive transients is detected using Hilbert envelope demodulation. It has been verified via numerical simulation that the proposed adaptive TQWT filter based feature extraction method can adaptively select TQWT parameters and the optimum subband for repetitive transient detection without prior knowledge. The proposed method is also applied to faulty bearing vibration signals and its effectiveness is validated.
文摘For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the compressor characteristics at small or negative flow rate. In this paper, measurement and numerical simulation of the characteristics at small or negative flow rate are carried out. In the measurement, an experimental facility with a valve immediately downstream of the compressor is used to suppress the surge. In the numerical work, a new boundary condition that specifies mass flow rate at the outlet boundary is used to simulate the characteristics around the zero flow rate region. Furthermore, flow field analyses at small or negative flow rate are performed with the numerical results. The separated and re-circulated flow fields are investigated by visualization to identify the origin of losses.
基金Supported by the Major State Basic Research and Development Program of People's Republic of China(No.2009CB522902)National Key Technology R&D Program(No.2006BAI12B04-2)+2 种基金National Natural Science Foundation of China(No.81160453)National Natural Science Foundation of China(No.81202854)Jiangxi Key R&D Project
文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma.
文摘The aspect sensitivity is the main problem in radar automatic target recognition using high resolution range profile (HRRP). In the traditional viewpoint,HRRPs are assumed to be highly similar if the aspect variation is not enough to cause range migration. However,some experiments in anechoic chambers don’t agree with the assumption. Particularly,some abnormal HRRPs often occur in the measured data. Based on the scattering center model,this paper focuses on the reason of abnormal HRRP,which is named as the speckle. The theoretical model of speckle is established and the "spurious dual peaks" feature of the speckled HRRP is analyzed. Then the occurrence condition of speckle is concluded,and so is the relationship between the speckle probability in HRRP and radar carrier frequency. At last,the experiment in an anechoic chamber is used to verify all the analyses about the speckle.