To achieve full-surface strain measurement of variable curvature objects,a 360°3D digital image correlation(DIC)system is proposed.The measurement system consists of four double-camera systems,which capture the o...To achieve full-surface strain measurement of variable curvature objects,a 360°3D digital image correlation(DIC)system is proposed.The measurement system consists of four double-camera systems,which capture the object’s entire surface from multiple angles,enabling comprehensive full-surface measurement.To increase the stitching quality,a hierarchical coordinate matching method is proposed.Initially,a 3D rigid body calibration auxiliary block is employed to track motion trajectory,which enables preliminary matching of four 3D-DIC sub-systems.Subsequently,secondary precise matching is performed based on feature points on the test specimen’s surface.Through the hierarchical coordinate matching method,the local 3D coordinate systems of each double-camera system are unified into a global coordinate system,achieving 3D surface reconstruction of the variable curvature cylindrical shell,and error analysis is conducted on the results.Furthermore,axial compression buckling experiment is conducted to measure the displacement and strain fields on the cylindrical shell’s surface.The experimental results are compared with the finite element analysis,validating the accuracy and effectiveness of the proposed multi-camera 3D-DIC measuring system.展开更多
According to the actual conditions in Sanshandao Gold Mine, the cancelling ore pillars mining method was researched. Firstly, a series of tests for the physical and mechanical characteristics of rock mass were carried...According to the actual conditions in Sanshandao Gold Mine, the cancelling ore pillars mining method was researched. Firstly, a series of tests for the physical and mechanical characteristics of rock mass were carried out and a quality classification system of rock mass applied in coastal metal deposit was established. Secondly, the reasonable demarcation depth of cancelling ore pillars was simulated using the finite element method, and the simulation results show that the ore pillars can be cancelled below the level of-555 m. Thirdly, a novel layer-backfill mining method of room-pillar alternation was designed to reduce the disturbance and settlement of terrain in mining area. Engineering practice shows that the new mining method enhanced the mining output and relieved rock disturbance. Furthermore, the settlement of the roof strata was small and no disaster occurred. The new mining technology effectively controlled the deformation of the terrain, indicating that the mining of the large-scale gold coastal deposit in Sanshandao Gold Mine was achieved safely, efficiently, and with a low loss rate.展开更多
The principle and process of parallel seismic (PS) testing for the integrity testing of cemented soil columns are in- troduced in this paper. A three-dimensional (3D) finite element model (FEM) for the pile-soil syste...The principle and process of parallel seismic (PS) testing for the integrity testing of cemented soil columns are in- troduced in this paper. A three-dimensional (3D) finite element model (FEM) for the pile-soil system is established for impulse responses. Under saturated soil or unsaturated soil condition, several vibrating velocity-time histories at different depths in parallel hole are obtained based on the numerical simulation. It shows that the length of the pile and the one-dimensional (1D) P-wave velocity in the pile can be determined easily from the features of the mentioned velocity-time histories. By examining the slopes of the first arrival time plotted versus depth or the depth where the amplitude of the first arrival significantly decreases, the length of the pile can be determined. The effects of the 3D P-wave propagation through the saturated soil and the defect of the cemented soil column on the velocity-time histories are also investigated.展开更多
The adsorption behavior of multiwalled carbon nanotubes (MWNTs) toward heavy elements has been investigated systemically, and a new method has been developed for the determination of trace elements in water samples ...The adsorption behavior of multiwalled carbon nanotubes (MWNTs) toward heavy elements has been investigated systemically, and a new method has been developed for the determination of trace elements in water samples based on preconcentration with mini-column packed with MWNTs prior to its determination by flame atomic absorption spectrometry (FAAS) The recommended parameters of proposed method influencing the preconcentration of the analytes, such as pH of the sample, sample flow rate and volume, elute solution and interfering ions, have been used. Under the optimized conditions, the calibration graphs were linear with the correlation coefficient range 0.9981-0.9995. According to the results, the metals were found 0.019-0.051, 0.011-0.031, 0.00-0.081, 0.00-0.0002, 0.007-0.0925, 0.00-0.0104 μg/L in water samples for Pb, Mn, Zn, Cd, Fe, Cu respectively. The percentage relative standard deviation (%RSD) for five replicate samples were 〈 5% in all cases. The method has been successfully applied to the determination of trace elements in some environmental samples with satisfactory results.展开更多
In order to predict acoustic radiation from a structure in waveguide, a method based on wave superposition is proposed, in which the free-space Green's function is used to match the strength of equivalent sources. In...In order to predict acoustic radiation from a structure in waveguide, a method based on wave superposition is proposed, in which the free-space Green's function is used to match the strength of equivalent sources. In addition, in order to neglect the effect of sound reflection from boundaries, necessary treatment is conducted, which makes the method more efficient. Moreover, this method is combined with the sound propagation algorithms to predict the sound radiated from a cylindrical shell in waveguide. Numerical simulations show the effect of how reflections can be neglected if the distance between the structure and the boundary exceeds the maximum linear dimension of the structure. It also shows that the reflection from the bottom of the waveguide can be approximated by plane wave conditionally. The proposed method is more robust and efficient in computation, which can be used to predict the acoustic radiation in waveguide.展开更多
Evaluation of grade and recovery plays an important role in process control and plant profitability in mineral processing operations, especially flotation. The accurate measurement or estimation of these two parameter...Evaluation of grade and recovery plays an important role in process control and plant profitability in mineral processing operations, especially flotation. The accurate measurement or estimation of these two parameters, based on the secondary variables, is a critical issue. Data-driven modeling techniques, which entail comprehensive data analysis and implementation of machine learning methods for system forecast, provide an attractive alternative. In this paper, two types of artificial neural networks(ANNs),namely radial basis function neural network(RBFNN) and layer recurrent neural network(RNN), and also a multivariate nonlinear regression(MNLR) model were employed to predict metallurgical performance of the flotation column. The training capacity and the accuracy of these three above mentioned types of models were compared. In order to acquire data for the simulation, a case study was conducted at Sarcheshmeh copper complex pilot plant. Based on the root mean squared error and correlation coefficient values, at training and testing stages, the RNN forecasted the metallurgical performance of the flotation column better than RBF and MNLR models. The RNN could predict Cu grade and recovery with correlation coefficients of 0.92 and 0.9, respectively in testing process.展开更多
Deformation prediction and the analysis of underground goaf are important to the safe and efficient recovery of residual ore when shifting from open-pit mining to underground mining.To address the comprehensive proble...Deformation prediction and the analysis of underground goaf are important to the safe and efficient recovery of residual ore when shifting from open-pit mining to underground mining.To address the comprehensive problem of stability in the double mined-out area of the Tong-Lv-Shan(TLS)mine,which employed the dry stacked gangue technology,this paper applies the function fitting theory and a regression analysis method to screen the sensitive interval of four influencing factors based on single-factor experiments and the numerical simulation software FLAC3D.The influencing factors of the TLS mine consist of the column thickness(d),gob area span(D),boundary pillar thickness(h)and height of tailing gangue(H).The fitting degree between the four factors and the displacement of the gob roof(W)is reasonable because the correlation coefficient(R2)is greater than0.9701.After establishing29groups that satisfy the principles of Box-Behnken design(BBD),the dry gangue tailings process was re-simulated for the selected sensitive interval.Using a combination of an analysis of variance(ANOVA),regression equations and a significance analysis,the prediction results of the response surface methodology(RSM)show that the significant degree for the stability of the mined-out area for the factors satisfies the relationship of h>D>d>H.The importance of the four factors cannot be disregarded in a comparison of the prediction results of the engineering test stope in the TLS mine.By comparing the data of monitoring points and function prediction,the proposed method has shown promising results,and the prediction accuracy of RSM model is acceptable.The relative errors of the two test stopes are1.67%and3.85%,respectively,which yield satisfactory reliability and reference values for the mines.展开更多
This work aims to understand the relationship between the member angle limit and the energy ratio for 24 test samples of composite beams and CFT square steel tube columns. This work also compares the formula applicabi...This work aims to understand the relationship between the member angle limit and the energy ratio for 24 test samples of composite beams and CFT square steel tube columns. This work also compares the formula applicability for member angle limit with the previous test result to provide the basic data for the design of composite beam-CFT column. The evaluation of the member angle limit was performed with concrete compressive strength (fC =22.16 MPa, 30.49 MPa), breadth-to-thickness ratio (B/t=25.0, 33.3, 43.5), and axial capacity ratio (N/N0=0, 0.3, 0.4, 0.5) as the main variables of the test samples. For the relationship between the member angle limit (Ru) and the energy ratio (ES/EC ), the test result shows that the energy ratio becomes lower as the axial capacity ratio and the breadth-to-thickness ratio increase. The energy ratio is lower for the Type B test sample compared with that of Types A and C. For the formula suggested by SATO, the test samples are distributed evenly for comparison between test values and the member angle limit; however, other formulas indicate a deviation. Specifically, for the comparison between R u,cal and R u (Test), Maeda's formula shows severe deviation.展开更多
A cylindrical coordinate measuring machine for the detection of large-size rotational parts is introduced. The measuring machine can simultaneously measure the geometrical dimensions, form and position errors of the i...A cylindrical coordinate measuring machine for the detection of large-size rotational parts is introduced. The measuring machine can simultaneously measure the geometrical dimensions, form and position errors of the inner and outer surfaces. Since the maximum length of the workpiece can reach 2 000 mm , it is difficult to be clamped and adjusted and easy to produce clamping error. The eccentricity can be up to 1.5 mm, which has an interaction effect with the probe mounting offset. We mainly study the probe offset of the measuring machine and the influence of the workpiece clamping error on the measurement. A method of controlling the offset of the measuring probe is proposed. The effect of the clamping error is eliminated through the space coordinate transformation of the workpiece axis, and the axis is fitted by the least square method. Finally, a common fixture can be realized to meet the clamping requirements of the workpiece.展开更多
The goaf may face a series of deformation and settlement problems when the room-pillar mining method is used to excavate ore and pillars in the deep strata.To this end,a deep room-pillar model with two levels was made...The goaf may face a series of deformation and settlement problems when the room-pillar mining method is used to excavate ore and pillars in the deep strata.To this end,a deep room-pillar model with two levels was made,and the pillar recovery was carried out.The instantaneous deformation responses during the pillars recovery and the long-term settlements after the pillar recovery were analyzed.During the pillar recovery,different regions of surrounding rocks suffer from different dynamic disturbances which can be divided into three types,including(I)the combined action of blasting disturbance and unloading disturbance,(II)the sequential action of blasting disturbance and unloading disturbance,and(III)the action of unloading disturbance.After the pillar recovery,the settlement above the first recovering pillar is the largest,which has a traction effect on the settlement in other areas.The settlement process can be divided into two stages,stable displacement stage and unstable displacement stage.When the pillar-room system undergoes the unstable displacement stage,rock spalling and further cascading collapse will occur.展开更多
A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods: After SPE column purification and liquid-l...A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods: After SPE column purification and liquid-liquid extraction, the sample test solutions were analyzed with RPLC using a C18 analytical column. This improved analytical method has been validated for linearity, accuracy (recovery from urine), repeatability (within-day and between-day precision), specificity, sensitivity, and stability. This SPE-liquid/liquid extraction-RPLC is rapid, simple, accurate and reproducible. The technique is particularly useful for monitoring the CYP3A activity of cancer patients in clinical settings. The results are expressed as the ratio of 6β-hydroxycortisol to cortisol. Results: The CYP3A activity from a total of 153 samples was measured using this improved method. Considerable variation in the CYP3A activity of different cancer patients has been documented. Thus, personalized medical treatment based on the individual metabolic enzyme activity level is necessary. Conclusion: This new analytical method facilitates such individualized medical treatments.展开更多
Using experimental data from a number of pulsed disc and doughnut solvent extraction columns, a unified correla- tion for the prediction of dispersed phase holdup that considers the effects of mass transfer is present...Using experimental data from a number of pulsed disc and doughnut solvent extraction columns, a unified correla- tion for the prediction of dispersed phase holdup that considers the effects of mass transfer is presented. Pulsed disc and doughnut solvent extraction columns (PDDC) have been used for a range of important applications such as ura- nium extraction and nuclear fuel recycling. Although the dispersed phase holdup in a PDDC has been presented by some researchers, there is still the need to develop a robust correlation that can predict the experimental dispersed phase holdup over a range of operating conditions including the effects of mass transfer direction. In this study, dis- persed phase holdup data from different literature sources for a PDDC were used to refit constants for the correlation presented by Kumar and Hartland lind. Eng. Chem. Res.,27 (1988),131-138] which did not consider the effect of col- umn geometry. In order to incorporate the characteristic length of the PDDC (i.e. the plate spacing), the unified cor- relation for holdup proposed by Kumar and Hartland based on data from eight different types of columns [Ind. Eng. Chem. Res.,34 (1995) 3925-3940] was refitted to the PDDC data. New constants have been presented for each hold- up correlation for a PDDC based on regression analysis using published holdup data from PDDCs that cover a range of onerating conditions and nhwical nronerties and consider the direction of mass transfer.展开更多
AIM: To characterize the gastric myoelectric activity (GMA) and intra-abdominal pressure changes induced by emetic stimuli (apomorphine and cisplatin) in the ferret. METHODS: GMA and intra-abdominal pressure wer...AIM: To characterize the gastric myoelectric activity (GMA) and intra-abdominal pressure changes induced by emetic stimuli (apomorphine and cisplatin) in the ferret. METHODS: GMA and intra-abdominal pressure were recorded in conscious, unrestrained ferrets surgically implanted with radiotelemetry transmitters. Animals were challenged with apomorphine (0.25 mg/kg sc) and cisplatin (10 mg/kg ip), and the emetic response was quantified via direct observation and intra-abdominal pressure recording for 1 and 4 h, respectively. The GMA was analyzed by spectral analysis; the parameters used to characterize the GMA were the dominant frequency (DF) and the repartition of spectral power in the bradygastric, normogastric and tachygastric frequency ranges. RESULTS: Retches were identified on the intraabdominal pressure trace as peaks 0.30 ± 1.01 s in duration and 59.57 ± 2.74 mmHg in amplitude, vomit peaks were longer (0.82 ± 0.06 s, P 〈 0.01) and reached a higher pressure (87.73 ± 8.12 mmHg, P 〈 0.001). The number of retches and vomits quantified via direct observation [apomorphine: 65.5 ± 11.8 retches ± vomits (R+V), cisplatin: 202.6 ± 64.1 R+V] and intra-abdominal pressure (apomorphine: 68.3± 13.7 R+V, n = 8; cisplatin: 219.0 ± 69.2 R+V, n = 8) were correlated (r = 0.97, P 〈 0.0001) and the timing of emesis was consistent between the 2 methods. Apomorphine induced a decrease in normogastria from 45.48% ± 4.35% to 36.70 ± 4.34% (n = 8, P 〈 0.05) but the DF of the slow waves was not changed [8.95 ± 0.25 counts/rain (cpm) vs 8.68 ± 0.35 cpm, n = 8, P 〉 0.05]. Cisplatin induced a decrease in normogastria from 55.83% ± 4.30% to 29.22% ± 5.16% and an increase in bradygastria from 14.28% ± 2.32% to 31.19% ± 8.33% (n = 8, P 〈 0.001) but the DF (9.14 ± 0.13 cpm) remained unchanged (P 〉 0.05). The GMA changes induced by cisplatin preceded the emetic response as normogastria was reduced for 1 h before the onset of emesis (57.61% ± 5.66% to 39.91% ± 5.74%, n = 6, P 〈 0.05). Peri-emesis analysis revealed that the GMA was significantly disturbed during and immediately after, but not immediately before, the emetic episodes. CONCLUSION: The induction of emesis is reliably associated with a disrupted GMA, but changes may also occur prior to and following the emetic response.展开更多
基金funded by the National Natural Science Foundations of China(Nos.12272176,U2037603).
文摘To achieve full-surface strain measurement of variable curvature objects,a 360°3D digital image correlation(DIC)system is proposed.The measurement system consists of four double-camera systems,which capture the object’s entire surface from multiple angles,enabling comprehensive full-surface measurement.To increase the stitching quality,a hierarchical coordinate matching method is proposed.Initially,a 3D rigid body calibration auxiliary block is employed to track motion trajectory,which enables preliminary matching of four 3D-DIC sub-systems.Subsequently,secondary precise matching is performed based on feature points on the test specimen’s surface.Through the hierarchical coordinate matching method,the local 3D coordinate systems of each double-camera system are unified into a global coordinate system,achieving 3D surface reconstruction of the variable curvature cylindrical shell,and error analysis is conducted on the results.Furthermore,axial compression buckling experiment is conducted to measure the displacement and strain fields on the cylindrical shell’s surface.The experimental results are compared with the finite element analysis,validating the accuracy and effectiveness of the proposed multi-camera 3D-DIC measuring system.
基金Projects(2013BAB02B03,2012BAB08B00)supported by the National Science and Technology Support Program of ChinaProject(51074177)supported by the Joint Funding of National Natural Science Foundation and Shanghai Baosteel Group CorporationProjects(51274254,51322403)supported by the National Natural Science Foundation of China
文摘According to the actual conditions in Sanshandao Gold Mine, the cancelling ore pillars mining method was researched. Firstly, a series of tests for the physical and mechanical characteristics of rock mass were carried out and a quality classification system of rock mass applied in coastal metal deposit was established. Secondly, the reasonable demarcation depth of cancelling ore pillars was simulated using the finite element method, and the simulation results show that the ore pillars can be cancelled below the level of-555 m. Thirdly, a novel layer-backfill mining method of room-pillar alternation was designed to reduce the disturbance and settlement of terrain in mining area. Engineering practice shows that the new mining method enhanced the mining output and relieved rock disturbance. Furthermore, the settlement of the roof strata was small and no disaster occurred. The new mining technology effectively controlled the deformation of the terrain, indicating that the mining of the large-scale gold coastal deposit in Sanshandao Gold Mine was achieved safely, efficiently, and with a low loss rate.
基金Project (No. 50478022) supported by the National Natural Science Foundation of China
文摘The principle and process of parallel seismic (PS) testing for the integrity testing of cemented soil columns are in- troduced in this paper. A three-dimensional (3D) finite element model (FEM) for the pile-soil system is established for impulse responses. Under saturated soil or unsaturated soil condition, several vibrating velocity-time histories at different depths in parallel hole are obtained based on the numerical simulation. It shows that the length of the pile and the one-dimensional (1D) P-wave velocity in the pile can be determined easily from the features of the mentioned velocity-time histories. By examining the slopes of the first arrival time plotted versus depth or the depth where the amplitude of the first arrival significantly decreases, the length of the pile can be determined. The effects of the 3D P-wave propagation through the saturated soil and the defect of the cemented soil column on the velocity-time histories are also investigated.
文摘The adsorption behavior of multiwalled carbon nanotubes (MWNTs) toward heavy elements has been investigated systemically, and a new method has been developed for the determination of trace elements in water samples based on preconcentration with mini-column packed with MWNTs prior to its determination by flame atomic absorption spectrometry (FAAS) The recommended parameters of proposed method influencing the preconcentration of the analytes, such as pH of the sample, sample flow rate and volume, elute solution and interfering ions, have been used. Under the optimized conditions, the calibration graphs were linear with the correlation coefficient range 0.9981-0.9995. According to the results, the metals were found 0.019-0.051, 0.011-0.031, 0.00-0.081, 0.00-0.0002, 0.007-0.0925, 0.00-0.0104 μg/L in water samples for Pb, Mn, Zn, Cd, Fe, Cu respectively. The percentage relative standard deviation (%RSD) for five replicate samples were 〈 5% in all cases. The method has been successfully applied to the determination of trace elements in some environmental samples with satisfactory results.
基金Foundation item: Supported by the National Natural Science Foundation of China under Grant No. 11274080, and the Young Scientists Fund of the National Natural Science Foundation of China under Grant No. 11404313.
文摘In order to predict acoustic radiation from a structure in waveguide, a method based on wave superposition is proposed, in which the free-space Green's function is used to match the strength of equivalent sources. In addition, in order to neglect the effect of sound reflection from boundaries, necessary treatment is conducted, which makes the method more efficient. Moreover, this method is combined with the sound propagation algorithms to predict the sound radiated from a cylindrical shell in waveguide. Numerical simulations show the effect of how reflections can be neglected if the distance between the structure and the boundary exceeds the maximum linear dimension of the structure. It also shows that the reflection from the bottom of the waveguide can be approximated by plane wave conditionally. The proposed method is more robust and efficient in computation, which can be used to predict the acoustic radiation in waveguide.
基金the support of the Department of Research and Development of Sarcheshmeh Copper Plants for this research
文摘Evaluation of grade and recovery plays an important role in process control and plant profitability in mineral processing operations, especially flotation. The accurate measurement or estimation of these two parameters, based on the secondary variables, is a critical issue. Data-driven modeling techniques, which entail comprehensive data analysis and implementation of machine learning methods for system forecast, provide an attractive alternative. In this paper, two types of artificial neural networks(ANNs),namely radial basis function neural network(RBFNN) and layer recurrent neural network(RNN), and also a multivariate nonlinear regression(MNLR) model were employed to predict metallurgical performance of the flotation column. The training capacity and the accuracy of these three above mentioned types of models were compared. In order to acquire data for the simulation, a case study was conducted at Sarcheshmeh copper complex pilot plant. Based on the root mean squared error and correlation coefficient values, at training and testing stages, the RNN forecasted the metallurgical performance of the flotation column better than RBF and MNLR models. The RNN could predict Cu grade and recovery with correlation coefficients of 0.92 and 0.9, respectively in testing process.
基金Project(2017YFC0602902) supported by the National Science and Technology Pillar Program during the 13th Five-Year Plan Period,ChinaProject(2015CX005) supported by the Innovation Driven Plan of Central South University,ChinaProject(2016zzts445) supported by the Fundamental Research Funds for the Central Universities,China
文摘Deformation prediction and the analysis of underground goaf are important to the safe and efficient recovery of residual ore when shifting from open-pit mining to underground mining.To address the comprehensive problem of stability in the double mined-out area of the Tong-Lv-Shan(TLS)mine,which employed the dry stacked gangue technology,this paper applies the function fitting theory and a regression analysis method to screen the sensitive interval of four influencing factors based on single-factor experiments and the numerical simulation software FLAC3D.The influencing factors of the TLS mine consist of the column thickness(d),gob area span(D),boundary pillar thickness(h)and height of tailing gangue(H).The fitting degree between the four factors and the displacement of the gob roof(W)is reasonable because the correlation coefficient(R2)is greater than0.9701.After establishing29groups that satisfy the principles of Box-Behnken design(BBD),the dry gangue tailings process was re-simulated for the selected sensitive interval.Using a combination of an analysis of variance(ANOVA),regression equations and a significance analysis,the prediction results of the response surface methodology(RSM)show that the significant degree for the stability of the mined-out area for the factors satisfies the relationship of h>D>d>H.The importance of the four factors cannot be disregarded in a comparison of the prediction results of the engineering test stope in the TLS mine.By comparing the data of monitoring points and function prediction,the proposed method has shown promising results,and the prediction accuracy of RSM model is acceptable.The relative errors of the two test stopes are1.67%and3.85%,respectively,which yield satisfactory reliability and reference values for the mines.
基金supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) and funded by the Ministry of Education,Science and Technology (2011-0009227)
文摘This work aims to understand the relationship between the member angle limit and the energy ratio for 24 test samples of composite beams and CFT square steel tube columns. This work also compares the formula applicability for member angle limit with the previous test result to provide the basic data for the design of composite beam-CFT column. The evaluation of the member angle limit was performed with concrete compressive strength (fC =22.16 MPa, 30.49 MPa), breadth-to-thickness ratio (B/t=25.0, 33.3, 43.5), and axial capacity ratio (N/N0=0, 0.3, 0.4, 0.5) as the main variables of the test samples. For the relationship between the member angle limit (Ru) and the energy ratio (ES/EC ), the test result shows that the energy ratio becomes lower as the axial capacity ratio and the breadth-to-thickness ratio increase. The energy ratio is lower for the Type B test sample compared with that of Types A and C. For the formula suggested by SATO, the test samples are distributed evenly for comparison between test values and the member angle limit; however, other formulas indicate a deviation. Specifically, for the comparison between R u,cal and R u (Test), Maeda's formula shows severe deviation.
基金National Natural Science Foundation of China(No.51375338)National Key R&D Program of China(No.2017YFF0108102)
文摘A cylindrical coordinate measuring machine for the detection of large-size rotational parts is introduced. The measuring machine can simultaneously measure the geometrical dimensions, form and position errors of the inner and outer surfaces. Since the maximum length of the workpiece can reach 2 000 mm , it is difficult to be clamped and adjusted and easy to produce clamping error. The eccentricity can be up to 1.5 mm, which has an interaction effect with the probe mounting offset. We mainly study the probe offset of the measuring machine and the influence of the workpiece clamping error on the measurement. A method of controlling the offset of the measuring probe is proposed. The effect of the clamping error is eliminated through the space coordinate transformation of the workpiece axis, and the axis is fitted by the least square method. Finally, a common fixture can be realized to meet the clamping requirements of the workpiece.
基金Projects(11972378,41630642)supported by the National Natural Science Foundation of China。
文摘The goaf may face a series of deformation and settlement problems when the room-pillar mining method is used to excavate ore and pillars in the deep strata.To this end,a deep room-pillar model with two levels was made,and the pillar recovery was carried out.The instantaneous deformation responses during the pillars recovery and the long-term settlements after the pillar recovery were analyzed.During the pillar recovery,different regions of surrounding rocks suffer from different dynamic disturbances which can be divided into three types,including(I)the combined action of blasting disturbance and unloading disturbance,(II)the sequential action of blasting disturbance and unloading disturbance,and(III)the action of unloading disturbance.After the pillar recovery,the settlement above the first recovering pillar is the largest,which has a traction effect on the settlement in other areas.The settlement process can be divided into two stages,stable displacement stage and unstable displacement stage.When the pillar-room system undergoes the unstable displacement stage,rock spalling and further cascading collapse will occur.
基金supported by the Shanghai Pharmaceutical Association
文摘A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods: After SPE column purification and liquid-liquid extraction, the sample test solutions were analyzed with RPLC using a C18 analytical column. This improved analytical method has been validated for linearity, accuracy (recovery from urine), repeatability (within-day and between-day precision), specificity, sensitivity, and stability. This SPE-liquid/liquid extraction-RPLC is rapid, simple, accurate and reproducible. The technique is particularly useful for monitoring the CYP3A activity of cancer patients in clinical settings. The results are expressed as the ratio of 6β-hydroxycortisol to cortisol. Results: The CYP3A activity from a total of 153 samples was measured using this improved method. Considerable variation in the CYP3A activity of different cancer patients has been documented. Thus, personalized medical treatment based on the individual metabolic enzyme activity level is necessary. Conclusion: This new analytical method facilitates such individualized medical treatments.
文摘Using experimental data from a number of pulsed disc and doughnut solvent extraction columns, a unified correla- tion for the prediction of dispersed phase holdup that considers the effects of mass transfer is presented. Pulsed disc and doughnut solvent extraction columns (PDDC) have been used for a range of important applications such as ura- nium extraction and nuclear fuel recycling. Although the dispersed phase holdup in a PDDC has been presented by some researchers, there is still the need to develop a robust correlation that can predict the experimental dispersed phase holdup over a range of operating conditions including the effects of mass transfer direction. In this study, dis- persed phase holdup data from different literature sources for a PDDC were used to refit constants for the correlation presented by Kumar and Hartland lind. Eng. Chem. Res.,27 (1988),131-138] which did not consider the effect of col- umn geometry. In order to incorporate the characteristic length of the PDDC (i.e. the plate spacing), the unified cor- relation for holdup proposed by Kumar and Hartland based on data from eight different types of columns [Ind. Eng. Chem. Res.,34 (1995) 3925-3940] was refitted to the PDDC data. New constants have been presented for each hold- up correlation for a PDDC based on regression analysis using published holdup data from PDDCs that cover a range of onerating conditions and nhwical nronerties and consider the direction of mass transfer.
基金Supported by A PhD studentship from Merck Research Laboratories (to Percie du Sert N)
文摘AIM: To characterize the gastric myoelectric activity (GMA) and intra-abdominal pressure changes induced by emetic stimuli (apomorphine and cisplatin) in the ferret. METHODS: GMA and intra-abdominal pressure were recorded in conscious, unrestrained ferrets surgically implanted with radiotelemetry transmitters. Animals were challenged with apomorphine (0.25 mg/kg sc) and cisplatin (10 mg/kg ip), and the emetic response was quantified via direct observation and intra-abdominal pressure recording for 1 and 4 h, respectively. The GMA was analyzed by spectral analysis; the parameters used to characterize the GMA were the dominant frequency (DF) and the repartition of spectral power in the bradygastric, normogastric and tachygastric frequency ranges. RESULTS: Retches were identified on the intraabdominal pressure trace as peaks 0.30 ± 1.01 s in duration and 59.57 ± 2.74 mmHg in amplitude, vomit peaks were longer (0.82 ± 0.06 s, P 〈 0.01) and reached a higher pressure (87.73 ± 8.12 mmHg, P 〈 0.001). The number of retches and vomits quantified via direct observation [apomorphine: 65.5 ± 11.8 retches ± vomits (R+V), cisplatin: 202.6 ± 64.1 R+V] and intra-abdominal pressure (apomorphine: 68.3± 13.7 R+V, n = 8; cisplatin: 219.0 ± 69.2 R+V, n = 8) were correlated (r = 0.97, P 〈 0.0001) and the timing of emesis was consistent between the 2 methods. Apomorphine induced a decrease in normogastria from 45.48% ± 4.35% to 36.70 ± 4.34% (n = 8, P 〈 0.05) but the DF of the slow waves was not changed [8.95 ± 0.25 counts/rain (cpm) vs 8.68 ± 0.35 cpm, n = 8, P 〉 0.05]. Cisplatin induced a decrease in normogastria from 55.83% ± 4.30% to 29.22% ± 5.16% and an increase in bradygastria from 14.28% ± 2.32% to 31.19% ± 8.33% (n = 8, P 〈 0.001) but the DF (9.14 ± 0.13 cpm) remained unchanged (P 〉 0.05). The GMA changes induced by cisplatin preceded the emetic response as normogastria was reduced for 1 h before the onset of emesis (57.61% ± 5.66% to 39.91% ± 5.74%, n = 6, P 〈 0.05). Peri-emesis analysis revealed that the GMA was significantly disturbed during and immediately after, but not immediately before, the emetic episodes. CONCLUSION: The induction of emesis is reliably associated with a disrupted GMA, but changes may also occur prior to and following the emetic response.