AIM： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this popul...AIM： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient＇s life.urease test, 13C urea breath test （UBT）, and immunoglobulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESULTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatment for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and male gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological examination （RR = 4.4）. CONCLUSION： The 13C-UBT outperformed the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to document treatment outcome or when monitoring for reinfection.展开更多
为实现对彩色摄像机颜色分辨力测试,设计了通过双离散颜色源、反射式准直光学系统和四杆靶靶标模块组成的测试装置。双离散颜色源分别产生经过标定的前景和背景颜色光束,经过准直光学系统,最终合成四杆靶测试靶标图像。该系统在测量过...为实现对彩色摄像机颜色分辨力测试,设计了通过双离散颜色源、反射式准直光学系统和四杆靶靶标模块组成的测试装置。双离散颜色源分别产生经过标定的前景和背景颜色光束,经过准直光学系统,最终合成四杆靶测试靶标图像。该系统在测量过程分别获取各频率下从靶标图像中提取的目标靶标并对其进行色差计算,通过图像算法对测试靶标进行判断和识别,获得彩色摄像机的最小可分辨色差(minimum resolvable E difference,MRED)和最小可探测色差(minimum detectable E difference,MDED),实现对彩色摄像机颜色分辨力的客观检测。展开更多
Split Hopkinson pressure bar（SHPB） apparatus, usually used for testing behavior of material in median and high strain-rate, is now widely used in the study of rock dynamic constitutive relation, damage evolvement me...Split Hopkinson pressure bar（SHPB） apparatus, usually used for testing behavior of material in median and high strain-rate, is now widely used in the study of rock dynamic constitutive relation, damage evolvement mechanism and energy consumption. However, the possible reasons of sampling disturbance, machining error and so on often lead to the scattering of test results, and bring ultimate difficulty for forming general test conclusion. Based on the stochastic finite element method, the uncertain parameters of specimen density ps, specimen radius Rs, specimen elastic modulus Es and specimen length Ls in the data processing of SHPB test were considered, and the correlation between the parameters and the test results was analyzed. The results show that the specimen radius Rs has direct correlation with the test result, improving the accuracy in preparing and measuring of specimen is an effective way to improve the accuracy of test and minish the scattering of results for SHPB test.展开更多
We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibito...We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.展开更多
基金Supported by The Centers for Disease Control and Prevention13C urea breath tests were provided by Meretek Diagnostics Inc.,Lafayette,CO,United States
文摘AIM： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient＇s life.urease test, 13C urea breath test （UBT）, and immunoglobulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESULTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatment for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and male gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological examination （RR = 4.4）. CONCLUSION： The 13C-UBT outperformed the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to document treatment outcome or when monitoring for reinfection.
文摘为实现对彩色摄像机颜色分辨力测试,设计了通过双离散颜色源、反射式准直光学系统和四杆靶靶标模块组成的测试装置。双离散颜色源分别产生经过标定的前景和背景颜色光束,经过准直光学系统,最终合成四杆靶测试靶标图像。该系统在测量过程分别获取各频率下从靶标图像中提取的目标靶标并对其进行色差计算,通过图像算法对测试靶标进行判断和识别,获得彩色摄像机的最小可分辨色差(minimum resolvable E difference,MRED)和最小可探测色差(minimum detectable E difference,MDED),实现对彩色摄像机颜色分辨力的客观检测。
基金Projects(50490274, 50534030) supported by the National Natural Science Foundation of ChinaProject supported by the Natural Science Foundatin of Hunan Province, China
文摘Split Hopkinson pressure bar（SHPB） apparatus, usually used for testing behavior of material in median and high strain-rate, is now widely used in the study of rock dynamic constitutive relation, damage evolvement mechanism and energy consumption. However, the possible reasons of sampling disturbance, machining error and so on often lead to the scattering of test results, and bring ultimate difficulty for forming general test conclusion. Based on the stochastic finite element method, the uncertain parameters of specimen density ps, specimen radius Rs, specimen elastic modulus Es and specimen length Ls in the data processing of SHPB test were considered, and the correlation between the parameters and the test results was analyzed. The results show that the specimen radius Rs has direct correlation with the test result, improving the accuracy in preparing and measuring of specimen is an effective way to improve the accuracy of test and minish the scattering of results for SHPB test.
基金Supported by A grant from the National Hospital Organization,No. H21-NHO-01
文摘We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.
