The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against ra...The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against rabies. To compare the difference in RFFIT results between the laboratories of The National Institute of Infectious Disease in Japan （NIID） and the Chinese Centre for Disease Control （CCDC） as well the influence of the choice of standard serum （STD） for the detection, the two laboratories detection methods were simultaneously manipulated by RFFIT. The reference serums used in NIID and the WHO standard serum used in CCDC were compared in the same RFFIT detection to determine the titer of four sera samples C1, Sl, S2 and S4 in parallel, and the titers of the detected sera samples were calculated using the standard formula for neutralizing antibody titer. No significant difference was found in RFFIT methods from the two laboratories and the RFFIT testing procedures of the two laboratories have good consistency. However, different titers were obtained with the tentative internal standard serum （TI-STD） produced by adjusting to 2.0 IU of WHO standard serum in NIID and the WHO STD. The titer determined with the TI-STD was higher than that determined with WHO STD, This difference appears to be significant and requires further investigation展开更多
Thoron （Rn-220） is an invisible, odorless radioactive gas and nine times heavier than air. Purpose of project is to set up procedure to determine Rn-220 concentration which has been carried out in laboratory using S...Thoron （Rn-220） is an invisible, odorless radioactive gas and nine times heavier than air. Purpose of project is to set up procedure to determine Rn-220 concentration which has been carried out in laboratory using Solid State Nuclear Track Detector （SSNTD） based passive detector technique. In this study, technical procedure has been applied in Karlsruhe diffusion chamber and LR-115, Type II strippable （Kodak Pathe, France） detector. The results have investigated how LR-115 work for Rn-220 by using Monazite ore to simultaneously measure Rn-222 and Rn-220. To carry out experiment, Karlsruhe diffusion chamber is used to with and without Poly-Ethylene （PE） membrane. Karlsruhe diffusion chamber with PE membrane only detect Rn-222, without PE membrane detect total Rn-222 and Rn-220. Precision evaluation by duplicate measure at 8 cm detector-source distance with relative standard deviation is less than 2.54%. Testing technical procedure, detectors have been sent to National Institute of Radiological Science （NIRS） for Rn-220 calibration exposure. After detectors have been calibration exposure at NIRS, it carried out all the following steps of procedure which set up at laboratory in 1NST, Vietnam. Finally, calibration factor calculated is 0.21 （tracks-cm2/Bq·m3·h） and constructed curve between integrated Tn-220 concentration and tracks density with factor R2 = 0.975.展开更多
By considering the identification problem of unknown but fixed Hamiltonian H = S0σ0 ＋∑i=x,y,z Siσi where σi （i = x, y, z） are pauli matrices and σ0=I, we explore the feasibility and limitation of empirically d...By considering the identification problem of unknown but fixed Hamiltonian H = S0σ0 ＋∑i=x,y,z Siσi where σi （i = x, y, z） are pauli matrices and σ0=I, we explore the feasibility and limitation of empirically determining the Hamiltonian parameters for quantum systems under experimental conditions imposed by projective measurements and initialization procedures. It may be unsurprising to physicists that one can not obtain the knowledge of So no matter what kind of projective measurements and initialization are permitted, but the observation draws our attention to the importance of the parameter identifiability under different experimental condition. It has also been revealed that one can obtain the knowledge of ｜Sz｜ and Sx^2＋Sy^2 at most when only the projective measurement {｜0/（0｜, ｜1/（1｜} is permitted to perform on and initialize the qubit. Further more, we demonstrated that it is feasible to distinguish ｜Sx｜, ｜Sy｜, and ｜Sz｜ even without any a priori information about Hamiltonian if at least two kinds of projective measurement or initialization procedures are permitted. It should be emphasized that both projective measurements and initialization procedures play an important role in quantum system identification.展开更多
The nuclear disaster at Fukushima has raised questions about the nature of democratic policymaking in Japan. Focusing on nuclear policymaking post-Fukushima, this paper considers ways in which the diversity of public ...The nuclear disaster at Fukushima has raised questions about the nature of democratic policymaking in Japan. Focusing on nuclear policymaking post-Fukushima, this paper considers ways in which the diversity of public opinion can be connected with legislative processes. The disaster forced the government to rethink existing nuclear policies. To infuse public voices into government policy, the Democratic Party of Japan （DPJ） government introduced a new method of public participation called ＂national debates＂, comprising a series of public hearings, mass public comments, and deliberative polling. The government also attached importance to anti-nuclear rallies and opinion polls conducted by the media. The national debates highlighted that the majority of Japanese people supported a nuclear-free society; as a result, the government drafted a new energy plan to phase out nuclear power by 2039. Owing to both domestic and international opposition, the plan failed to become law. Progress was also impeded by the public＇s contradictory demands. However, this paper posits that inefficient legislative deliberation was the main factor behind the policy failure. The Japanese case suggests that effective legislative deliberation is crucial to assessing and coordinating numerous divergent public voices.展开更多
Though TES （thermal energy storage） is developed hugely in most of the solar power generation plants, it is less growth in implementing a modular type of TES in a solar plant, e.g., solar dish/stifling engine applic...Though TES （thermal energy storage） is developed hugely in most of the solar power generation plants, it is less growth in implementing a modular type of TES in a solar plant, e.g., solar dish/stifling engine application. The main issue in designing the TES system is its thermal capacity of storage materials, e.g., insulator. This study is focusing on the potential waste material as an insulator for thermal energy storage applications. The insulator usage is to reduce the heat transfer between two mediums and the capability is measured by its resistance to heat flow. It is needed to obtain optimal materials to energy conversion at the same time reduce the waste generation. Therefore, a small-scale experimental testing of natural cooling process of an insulated tank within a confined room without any forced cooling system, e.g., fan. The testing is repeated by changing the insulator using the potential waste material from natural and industrial waste and also by changing the HTF （heat transfer fluid）. The analysis is performed on the relationship between heat loss and the reserved period by the insulator. The results indicate the percentage of period of the insulated tank withstands the heat compared to non-insulated tank, e.g., cotton reserved the period of 14% more than non-insulated tank to withstand the heat transfer of cooking oil to the surrounding. The paper finally justifies the most potential waste material as an insulator in different heat transfer fluids.展开更多
Linear mixed-effects models are widely used in analysis of longitudinal data. However, testing for zero-variance components of random effects has not been well-resolved in statistical literature, although some likelih...Linear mixed-effects models are widely used in analysis of longitudinal data. However, testing for zero-variance components of random effects has not been well-resolved in statistical literature, although some likelihood-based procedures have been proposed and studied. In this article, we propose a generalized p-value based method in coupling with fiducial inference to tackle this problem. The proposed method is also applied to test linearity of the nonparametric functions in additive models. We provide theoretical justifications and develop an implementation algorithm for the proposed method. We evaluate its finite-sample performance and compare it with that of the restricted likelihood ratio test via simulation experiments. We illustrate the proposed approach using an application from a nutritional study.展开更多
Ordinary differential equation(ODE) are widely used for quantifying HIV viral dynamics.It is interesting but challenging to estimate ODE parameters from noisy data, especially when the data have some outliers. In this...Ordinary differential equation(ODE) are widely used for quantifying HIV viral dynamics.It is interesting but challenging to estimate ODE parameters from noisy data, especially when the data have some outliers. In this study, the authors use the Mean Shift Outlier Model(MSOM) to detect outliers in HIV model based on the two-step estimation of ODE. Approximate formula for shift parameter is derived. Furthermore, a score test statistic is constructed and its approximating distribution is established. The simulation results show that: 1) The boundary points have more impact on the parameter estimation relative to interior points. 2) The proposed procedure can detect the outliers effectively. The authors illustrate the proposed approach using an application example from an HIV clinical trial and find similar pattern to the simulation studies.展开更多
基金Grant from National Institute of Infectious Diseases(NIID)National Department Public Benefit Research Foundation (201103032)
文摘The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against rabies. To compare the difference in RFFIT results between the laboratories of The National Institute of Infectious Disease in Japan （NIID） and the Chinese Centre for Disease Control （CCDC） as well the influence of the choice of standard serum （STD） for the detection, the two laboratories detection methods were simultaneously manipulated by RFFIT. The reference serums used in NIID and the WHO standard serum used in CCDC were compared in the same RFFIT detection to determine the titer of four sera samples C1, Sl, S2 and S4 in parallel, and the titers of the detected sera samples were calculated using the standard formula for neutralizing antibody titer. No significant difference was found in RFFIT methods from the two laboratories and the RFFIT testing procedures of the two laboratories have good consistency. However, different titers were obtained with the tentative internal standard serum （TI-STD） produced by adjusting to 2.0 IU of WHO standard serum in NIID and the WHO STD. The titer determined with the TI-STD was higher than that determined with WHO STD, This difference appears to be significant and requires further investigation
文摘Thoron （Rn-220） is an invisible, odorless radioactive gas and nine times heavier than air. Purpose of project is to set up procedure to determine Rn-220 concentration which has been carried out in laboratory using Solid State Nuclear Track Detector （SSNTD） based passive detector technique. In this study, technical procedure has been applied in Karlsruhe diffusion chamber and LR-115, Type II strippable （Kodak Pathe, France） detector. The results have investigated how LR-115 work for Rn-220 by using Monazite ore to simultaneously measure Rn-222 and Rn-220. To carry out experiment, Karlsruhe diffusion chamber is used to with and without Poly-Ethylene （PE） membrane. Karlsruhe diffusion chamber with PE membrane only detect Rn-222, without PE membrane detect total Rn-222 and Rn-220. Precision evaluation by duplicate measure at 8 cm detector-source distance with relative standard deviation is less than 2.54%. Testing technical procedure, detectors have been sent to National Institute of Radiological Science （NIRS） for Rn-220 calibration exposure. After detectors have been calibration exposure at NIRS, it carried out all the following steps of procedure which set up at laboratory in 1NST, Vietnam. Finally, calibration factor calculated is 0.21 （tracks-cm2/Bq·m3·h） and constructed curve between integrated Tn-220 concentration and tracks density with factor R2 = 0.975.
基金Supported by the National Nature Science Foundation of China under Grant No.60674040
文摘By considering the identification problem of unknown but fixed Hamiltonian H = S0σ0 ＋∑i=x,y,z Siσi where σi （i = x, y, z） are pauli matrices and σ0=I, we explore the feasibility and limitation of empirically determining the Hamiltonian parameters for quantum systems under experimental conditions imposed by projective measurements and initialization procedures. It may be unsurprising to physicists that one can not obtain the knowledge of So no matter what kind of projective measurements and initialization are permitted, but the observation draws our attention to the importance of the parameter identifiability under different experimental condition. It has also been revealed that one can obtain the knowledge of ｜Sz｜ and Sx^2＋Sy^2 at most when only the projective measurement {｜0/（0｜, ｜1/（1｜} is permitted to perform on and initialize the qubit. Further more, we demonstrated that it is feasible to distinguish ｜Sx｜, ｜Sy｜, and ｜Sz｜ even without any a priori information about Hamiltonian if at least two kinds of projective measurement or initialization procedures are permitted. It should be emphasized that both projective measurements and initialization procedures play an important role in quantum system identification.
文摘The nuclear disaster at Fukushima has raised questions about the nature of democratic policymaking in Japan. Focusing on nuclear policymaking post-Fukushima, this paper considers ways in which the diversity of public opinion can be connected with legislative processes. The disaster forced the government to rethink existing nuclear policies. To infuse public voices into government policy, the Democratic Party of Japan （DPJ） government introduced a new method of public participation called ＂national debates＂, comprising a series of public hearings, mass public comments, and deliberative polling. The government also attached importance to anti-nuclear rallies and opinion polls conducted by the media. The national debates highlighted that the majority of Japanese people supported a nuclear-free society; as a result, the government drafted a new energy plan to phase out nuclear power by 2039. Owing to both domestic and international opposition, the plan failed to become law. Progress was also impeded by the public＇s contradictory demands. However, this paper posits that inefficient legislative deliberation was the main factor behind the policy failure. The Japanese case suggests that effective legislative deliberation is crucial to assessing and coordinating numerous divergent public voices.
文摘Though TES （thermal energy storage） is developed hugely in most of the solar power generation plants, it is less growth in implementing a modular type of TES in a solar plant, e.g., solar dish/stifling engine application. The main issue in designing the TES system is its thermal capacity of storage materials, e.g., insulator. This study is focusing on the potential waste material as an insulator for thermal energy storage applications. The insulator usage is to reduce the heat transfer between two mediums and the capability is measured by its resistance to heat flow. It is needed to obtain optimal materials to energy conversion at the same time reduce the waste generation. Therefore, a small-scale experimental testing of natural cooling process of an insulated tank within a confined room without any forced cooling system, e.g., fan. The testing is repeated by changing the insulator using the potential waste material from natural and industrial waste and also by changing the HTF （heat transfer fluid）. The analysis is performed on the relationship between heat loss and the reserved period by the insulator. The results indicate the percentage of period of the insulated tank withstands the heat compared to non-insulated tank, e.g., cotton reserved the period of 14% more than non-insulated tank to withstand the heat transfer of cooking oil to the surrounding. The paper finally justifies the most potential waste material as an insulator in different heat transfer fluids.
基金supported by Shandong Provincial Natural Science Foundation of China(Grant No.ZR2014AM019)National Natural Science Foundation of China(Grant Nos.11171188 and 11529101)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry of China,and National Science Foundation of USA(Grant Nos.DMS-1418042 and DMS-1620898)
文摘Linear mixed-effects models are widely used in analysis of longitudinal data. However, testing for zero-variance components of random effects has not been well-resolved in statistical literature, although some likelihood-based procedures have been proposed and studied. In this article, we propose a generalized p-value based method in coupling with fiducial inference to tackle this problem. The proposed method is also applied to test linearity of the nonparametric functions in additive models. We provide theoretical justifications and develop an implementation algorithm for the proposed method. We evaluate its finite-sample performance and compare it with that of the restricted likelihood ratio test via simulation experiments. We illustrate the proposed approach using an application from a nutritional study.
基金supported by the Fundamental Research Funds for the Cental Universities under Grant No.JB140706the National Funds of China for Young Scientists under Grant Nos.11302157 and 11301409
文摘Ordinary differential equation(ODE) are widely used for quantifying HIV viral dynamics.It is interesting but challenging to estimate ODE parameters from noisy data, especially when the data have some outliers. In this study, the authors use the Mean Shift Outlier Model(MSOM) to detect outliers in HIV model based on the two-step estimation of ODE. Approximate formula for shift parameter is derived. Furthermore, a score test statistic is constructed and its approximating distribution is established. The simulation results show that: 1) The boundary points have more impact on the parameter estimation relative to interior points. 2) The proposed procedure can detect the outliers effectively. The authors illustrate the proposed approach using an application example from an HIV clinical trial and find similar pattern to the simulation studies.
