Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid (GABA) in the hippocampal ventral sub...Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid (GABA) in the hippocampal ventral subiculum, which play a critical role in the reinstatement of drug-seeking behavior induced by environmental cues. Methods Conditioning place preference (CPP) and conditioning place aversion (CPA) models were used to establish environment associated with rewarding and aversive properties of morphine respectively. Microdialysis and high performance liquid chromatography were used to measure the extracelluar level of glutamate and GABA in the ventral subiculum under these environmental cues. Results Exposure to the environmental cues associated with rewarding properties of morphine resulted in a decrease (approximately 11%) of extracellular level of GABA in ventral subiculum, and exposure to the environmental cues associated with aversive properties of morphine resulted in an increase (approximately 230%) of extracellular level of glutamate in ventral subiculum. Conclusion Environmental cues associated with different properties of morphine modulate the release of distinct neurotransmitters in the hippocampal ventral subiculum possibly through different neural circuit.展开更多
This study aims to quantify the influence of the amount of cement and chloride salt on the unconfined compression strength (UCS) of Lianyungang marine clay. The clays with various sodium chloride salt concentrations...This study aims to quantify the influence of the amount of cement and chloride salt on the unconfined compression strength (UCS) of Lianyungang marine clay. The clays with various sodium chloride salt concentrations were prepared artificially and stabilized by ordinary Portland cement with various contents. A series of UCS tests of cement stabilized clay specimen after 28 d curing were carried out. The results indicate that the increase of salt concentration results in the decrease in the UCS of cement-treated soil. The negative effect of salt concentration on the strength of cement stabilized clay directly relates to the cement content and salt concentration. The porosity-salt concentration/cement content ratio is a fundamental parameter for assessing the UCS of cement-treated salt-rich clay. An empirical prediction model of UCS is also proposed to take into account the effect of salt concentration. The findings of this study can be referenced for the stabilization improvement of chloride slat- rich soft clay.展开更多
Multi-beam Sonar and Side-scan Sonar compensate each other. In order to fully utilize all information, it is necessary to fuse two kinds of image and data. And the image co-registration is an important and complicated...Multi-beam Sonar and Side-scan Sonar compensate each other. In order to fully utilize all information, it is necessary to fuse two kinds of image and data. And the image co-registration is an important and complicated job before fusion. This paper suggests combining bathymetric data with intensity image, obtaining the characteristic points through the minimal angles of lines, and then deciding the corresponding image points by the maximal correlate coefficient in searching space. Finally, the second order polynomial is applied to the deformation model. After the images have been co-registered, Wavelet is used to fuse the images. It is shown that this algorithm can be used in the flat seafloor or the isotropic seabed. Verification is made in the paper with the observed data.展开更多
In order to avoid the curing effects of paraffin on the transport process and reduce the transport difficulty,usually high temperature and high pressure are used in the transportation of oil and gas.The differences of...In order to avoid the curing effects of paraffin on the transport process and reduce the transport difficulty,usually high temperature and high pressure are used in the transportation of oil and gas.The differences of temperature and pressure cause additional stress along the pipeline,due to the constraint of the foundation soil,the additional stress can not release freely,when the additional stress is large enough to motivate the submarine pipelines buckle.In this work,the energy method is introduced to deduce the analytical solution which is suitable for the global buckling modes of idealized subsea pipeline and analyze the relationship between the critical buckling temperature,buckling length and amplitude under different high-order global lateral buckling modes.To obtain a consistent formulation of the problem,the principles of virtual displacements and the variation calculus for variable matching points are applied.The finite element method based on elasto-plastic theory is used to simulate the lateral global buckling of the pipelines under high temperature and pressure.The factors influencing the lateral buckling of pipelines are further studied.Based upon some actual engineering projects,the finite element results are compared with the analytical ones,and then the influence of thermal stress,the section rigidity of pipeline,the soil properties and the trigging force to the high order lateral buckling are discussed.The method of applying the small trigging force on pipeline is reliable in global buckling numerical analysis.In practice,increasing the section rigidity of a pipeline is an effective measure to improve the ability to resist the global buckling.展开更多
Purpose: Physical activity (PA) and sedentary behavior (SB) are increasingly considered independent health behaviors. Additionally, current research suggests that both controlled and automatic determinants accoun...Purpose: Physical activity (PA) and sedentary behavior (SB) are increasingly considered independent health behaviors. Additionally, current research suggests that both controlled and automatic determinants account for their adoption. The purpose of this article was to identify intention-automaticity profiles toward PA and screen-based SB and to examine how those profiles are associated with different behavioral patterns. Method: Two cross-sectional studies based on self-report questionnaires were conducted with French high school students (Study 1: n = 198; Study 2: n = 185). Results: In all, 4 distinct motivational profiles appeared. The first 3 clusters emerged in both studies: "PA" (high levels of automaticity and intention for PA, low levels of automaticity and intention for screen-based SB); "screen" (high levels of automaticity and intention for screen-based SB, low levels of automatieity and intention for PA), and "mixed" (high levels of all variables), whereas the fourth cluster was observed only in Study 2: "high control" (below-mean levels of automaticity, high levels of intention toward both PA and screen-based SB). Adolescents with a screen profile displayed the least healthy behavioral pattern, whereas those in the PA profile demonstrated the most favorable behaviors. Conclusion: Future research is needed to extend these results to other populations using complementary assessment methods of automatic psychological processes and PA and SB behaviors.2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).展开更多
Dysregulated GABAergic inhibition in the amygdala has long been implicated in stress-related neuropsychiatric disorders.However,the molecular and circuit mechanisms underlying the dysregulation remain elusive.Here,by ...Dysregulated GABAergic inhibition in the amygdala has long been implicated in stress-related neuropsychiatric disorders.However,the molecular and circuit mechanisms underlying the dysregulation remain elusive.Here,by using a mouse model of chronic social defeat stress(CSDS),we observed that the dysregulation varied drastically across individual projection neurons(PNs)in the basolateral amygdala(BLA),one of the kernel amygdala subregions critical for stress coping.While persistently reducing the extrasynaptic GABAAreceptor(GABA_(A)R)-mediated tonic current in the BLA PNs projecting to the ventral hippocampus(BLA→v HPC PNs),CSDS increased the current in those projecting to the anterodorsal bed nucleus of stria terminalis(BLA→adBNST PNs),suggesting projection-based dysregulation of tonic inhibition in BLA PNs by CSDS.Transcriptional and electrophysiological analysis revealed that the opposite CSDS influences were mediated by loss-and gain-of-function ofδ-containing GABA_(A)Rs(GABA_(A)(δ)Rs)in BLA→vHPC and BLA→adBNST PNs,respectively.Importantly,it was the lost inhibition in the former population but not the augmentation in the latter population that correlated with the increased anxiety-like behavior in CSDS mice.Virally mediated maintenance of GABA_(A)(δ)R currents in BLA→vHPC PNs occluded CSDS-induced anxiety-like behavior.These findings clarify the molecular substrate for the dysregulated GABAergic inhibition in amygdala circuits for stress-associated psychopathology.展开更多
This study used a 1.5-layer reduced-gravity numerical model to investigate the nonlinear dynamics of Kuroshio intrusion into the Luzon Strait.The model results suggested that both basin-scale wind curl and lateral fri...This study used a 1.5-layer reduced-gravity numerical model to investigate the nonlinear dynamics of Kuroshio intrusion into the Luzon Strait.The model results suggested that both basin-scale wind curl and lateral friction are the primary factors that control the transformation of the flow,although inertia also plays an important role.Using an idealized model,both the mechanism via which the flow pattern changes depending on the two primary factors and the occurrence of hysteresis were investigated.It was established that the transformation of the Kuroshio flow field between the four previously reported flow patterns(i.e.,leaping across,current looping,eddy shedding,and branch intruding) can be explained under a unified theoretical framework.A diagram is proposed to explain how the flow field transforms between the four patterns from a certain prior state when varying the values of the controlling factors.展开更多
基金supported by the National Natural Science Foundation of China(No.30230130 and No.30400129)the Ministry of Science and Technology of China(No.2003CB515405,No.2005CB522406)+1 种基金the Program for Changjiang Scholars and Innovative Research Team of Ministry of Education of ChinaShanghai Municipal Commission for Science and Technology(No.06JC14008).
文摘Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid (GABA) in the hippocampal ventral subiculum, which play a critical role in the reinstatement of drug-seeking behavior induced by environmental cues. Methods Conditioning place preference (CPP) and conditioning place aversion (CPA) models were used to establish environment associated with rewarding and aversive properties of morphine respectively. Microdialysis and high performance liquid chromatography were used to measure the extracelluar level of glutamate and GABA in the ventral subiculum under these environmental cues. Results Exposure to the environmental cues associated with rewarding properties of morphine resulted in a decrease (approximately 11%) of extracellular level of GABA in ventral subiculum, and exposure to the environmental cues associated with aversive properties of morphine resulted in an increase (approximately 230%) of extracellular level of glutamate in ventral subiculum. Conclusion Environmental cues associated with different properties of morphine modulate the release of distinct neurotransmitters in the hippocampal ventral subiculum possibly through different neural circuit.
基金The Natural Science Foundation of Jiangsu Province(No.BK2011618)the National Key Technology R&D Program of China during the12th Five-Year Plan Period(No.2012BAJ01B02)
文摘This study aims to quantify the influence of the amount of cement and chloride salt on the unconfined compression strength (UCS) of Lianyungang marine clay. The clays with various sodium chloride salt concentrations were prepared artificially and stabilized by ordinary Portland cement with various contents. A series of UCS tests of cement stabilized clay specimen after 28 d curing were carried out. The results indicate that the increase of salt concentration results in the decrease in the UCS of cement-treated soil. The negative effect of salt concentration on the strength of cement stabilized clay directly relates to the cement content and salt concentration. The porosity-salt concentration/cement content ratio is a fundamental parameter for assessing the UCS of cement-treated salt-rich clay. An empirical prediction model of UCS is also proposed to take into account the effect of salt concentration. The findings of this study can be referenced for the stabilization improvement of chloride slat- rich soft clay.
文摘Multi-beam Sonar and Side-scan Sonar compensate each other. In order to fully utilize all information, it is necessary to fuse two kinds of image and data. And the image co-registration is an important and complicated job before fusion. This paper suggests combining bathymetric data with intensity image, obtaining the characteristic points through the minimal angles of lines, and then deciding the corresponding image points by the maximal correlate coefficient in searching space. Finally, the second order polynomial is applied to the deformation model. After the images have been co-registered, Wavelet is used to fuse the images. It is shown that this algorithm can be used in the flat seafloor or the isotropic seabed. Verification is made in the paper with the observed data.
基金Project(51021004)supported by Innovative Research Groups of the National Natural Science Foundation of ChinaProject(NCET-11-0370)supported by Program for New Century Excellent Talents in Universities of China+1 种基金Project(40776055)supported by the National Natural Science Foundation of ChinaProject(1002)supported by State Key Laboratory of Ocean Engineering Foundation,China
文摘In order to avoid the curing effects of paraffin on the transport process and reduce the transport difficulty,usually high temperature and high pressure are used in the transportation of oil and gas.The differences of temperature and pressure cause additional stress along the pipeline,due to the constraint of the foundation soil,the additional stress can not release freely,when the additional stress is large enough to motivate the submarine pipelines buckle.In this work,the energy method is introduced to deduce the analytical solution which is suitable for the global buckling modes of idealized subsea pipeline and analyze the relationship between the critical buckling temperature,buckling length and amplitude under different high-order global lateral buckling modes.To obtain a consistent formulation of the problem,the principles of virtual displacements and the variation calculus for variable matching points are applied.The finite element method based on elasto-plastic theory is used to simulate the lateral global buckling of the pipelines under high temperature and pressure.The factors influencing the lateral buckling of pipelines are further studied.Based upon some actual engineering projects,the finite element results are compared with the analytical ones,and then the influence of thermal stress,the section rigidity of pipeline,the soil properties and the trigging force to the high order lateral buckling are discussed.The method of applying the small trigging force on pipeline is reliable in global buckling numerical analysis.In practice,increasing the section rigidity of a pipeline is an effective measure to improve the ability to resist the global buckling.
文摘Purpose: Physical activity (PA) and sedentary behavior (SB) are increasingly considered independent health behaviors. Additionally, current research suggests that both controlled and automatic determinants account for their adoption. The purpose of this article was to identify intention-automaticity profiles toward PA and screen-based SB and to examine how those profiles are associated with different behavioral patterns. Method: Two cross-sectional studies based on self-report questionnaires were conducted with French high school students (Study 1: n = 198; Study 2: n = 185). Results: In all, 4 distinct motivational profiles appeared. The first 3 clusters emerged in both studies: "PA" (high levels of automaticity and intention for PA, low levels of automaticity and intention for screen-based SB); "screen" (high levels of automaticity and intention for screen-based SB, low levels of automatieity and intention for PA), and "mixed" (high levels of all variables), whereas the fourth cluster was observed only in Study 2: "high control" (below-mean levels of automaticity, high levels of intention toward both PA and screen-based SB). Adolescents with a screen profile displayed the least healthy behavioral pattern, whereas those in the PA profile demonstrated the most favorable behaviors. Conclusion: Future research is needed to extend these results to other populations using complementary assessment methods of automatic psychological processes and PA and SB behaviors.2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金supported by National Natural Science Foundation of China(82125010,81930032,31970953,81741759,31700916,and 81601179)Natural Science Foundation of Jiangxi Province(20172BCB22005,20192ACB20023,and 20192ACB21024)。
文摘Dysregulated GABAergic inhibition in the amygdala has long been implicated in stress-related neuropsychiatric disorders.However,the molecular and circuit mechanisms underlying the dysregulation remain elusive.Here,by using a mouse model of chronic social defeat stress(CSDS),we observed that the dysregulation varied drastically across individual projection neurons(PNs)in the basolateral amygdala(BLA),one of the kernel amygdala subregions critical for stress coping.While persistently reducing the extrasynaptic GABAAreceptor(GABA_(A)R)-mediated tonic current in the BLA PNs projecting to the ventral hippocampus(BLA→v HPC PNs),CSDS increased the current in those projecting to the anterodorsal bed nucleus of stria terminalis(BLA→adBNST PNs),suggesting projection-based dysregulation of tonic inhibition in BLA PNs by CSDS.Transcriptional and electrophysiological analysis revealed that the opposite CSDS influences were mediated by loss-and gain-of-function ofδ-containing GABA_(A)Rs(GABA_(A)(δ)Rs)in BLA→vHPC and BLA→adBNST PNs,respectively.Importantly,it was the lost inhibition in the former population but not the augmentation in the latter population that correlated with the increased anxiety-like behavior in CSDS mice.Virally mediated maintenance of GABA_(A)(δ)R currents in BLA→vHPC PNs occluded CSDS-induced anxiety-like behavior.These findings clarify the molecular substrate for the dysregulated GABAergic inhibition in amygdala circuits for stress-associated psychopathology.
基金supported by the National Programme on Global Change and Air-Sea Interaction(Grant No.GASI-IPOVAI-01-06)the National Natural Science Foundation of China(Grant Nos. 41630967,41476018,U1406401 & 41421005)the CAS Strategic Priority Project(Grant No.XDA11020101)
文摘This study used a 1.5-layer reduced-gravity numerical model to investigate the nonlinear dynamics of Kuroshio intrusion into the Luzon Strait.The model results suggested that both basin-scale wind curl and lateral friction are the primary factors that control the transformation of the flow,although inertia also plays an important role.Using an idealized model,both the mechanism via which the flow pattern changes depending on the two primary factors and the occurrence of hysteresis were investigated.It was established that the transformation of the Kuroshio flow field between the four previously reported flow patterns(i.e.,leaping across,current looping,eddy shedding,and branch intruding) can be explained under a unified theoretical framework.A diagram is proposed to explain how the flow field transforms between the four patterns from a certain prior state when varying the values of the controlling factors.