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海力特治疗慢性乙型肝炎临床观察 被引量:7
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作者 潘兆随 李志娟 +6 位作者 唐保禄 陈淑慎 李宗欣 代兆举 李梅 王杰刚 郭常同 《中国海洋药物》 CAS CSCD 1996年第1期36-38,共3页
采用海洋药物海力特治疗慢性乙型肝炎25例,并与猪苓多糖加乙肝疫苗治疗作为对照。结果表明,海力特治疗慢性乙型肝炎总有效率为88.0%,ALT复常率86.96%,HBeAg转阴率40.91%,与猪苓多糖加乙肝疫苗的疗效无显著性差异(P>0.05)。
关键词 海力特 乙型肝炎 药物疗法
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海力特抗肿瘤作用及其对免疫功能的影响 被引量:4
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作者 朱媛媛 李桂玲 +2 位作者 王菊英 袁玮 管华诗 《中国海洋药物》 CAS CSCD 2003年第5期41-44,共4页
观察海力特(Hailite)的抗肿瘤作用及对机体免疫功能的影响。结果表明,海力特60,120mg·kg^(-1)对小鼠S_(180)实体瘤及小鼠肝癌H_(22)均有明显抑制作用(P<0.01);海力特10,20,40,80mg·kg^(-1)能明显促进小鼠腹腔巨噬细胞吞噬... 观察海力特(Hailite)的抗肿瘤作用及对机体免疫功能的影响。结果表明,海力特60,120mg·kg^(-1)对小鼠S_(180)实体瘤及小鼠肝癌H_(22)均有明显抑制作用(P<0.01);海力特10,20,40,80mg·kg^(-1)能明显促进小鼠腹腔巨噬细胞吞噬功能及提高血清溶血素含量,并能显著增强T淋巴细胞增殖活性及NK细胞杀伤靶细胞的活性,明显增加脾脏T细胞产生IL-2的能力。 展开更多
关键词 海力特 抗肿瘤作用 溶血素 NK细胞 IL-2
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海力特联合病毒唑治疗慢性乙型肝炎临床疗效观察 被引量:1
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作者 李志娟 潘兆随 +2 位作者 李 梅 闫爱国 熊 玲 《潍坊医学院学报》 1999年第3期177-178,共2页
目的 探讨海力特联合病毒唑治疗慢性乙型肝炎的临床疗效。方法 用海力特联合大剂量病毒唑治疗慢性乙型肝炎60例,并与60例用一般保肝药物治疗的慢性乙型肝炎进行了观察对比。结果 治疗组总有效率为88.33%,明显优于对照组... 目的 探讨海力特联合病毒唑治疗慢性乙型肝炎的临床疗效。方法 用海力特联合大剂量病毒唑治疗慢性乙型肝炎60例,并与60例用一般保肝药物治疗的慢性乙型肝炎进行了观察对比。结果 治疗组总有效率为88.33%,明显优于对照组(71.62%),(P<0.05)。其ALT,γGT,A/G复常率分别为90%,95.25%,68.42%,均明显优于对照组。另外对HBV也有一定的抑制作用。HBeAg和HBVDNA阴转率分别为38.00%和38.46%,均高于对照组。结论 海力特联合病毒唑对改善慢性乙型肝炎患者临床症状、肝功均有较好疗效,且具有一定的HBeAg,HBVDNA转阴作用。 展开更多
关键词 海力特 病毒唑 慢性 乙型肝炎 治疗
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干扰素-α_1b联合海力特治疗慢性乙型肝炎32例
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作者 潘兆随 李曾欣 +1 位作者 杨振芳 张庆 《中国临床药理学与治疗学》 CAS CSCD 2001年第4期370-370,共1页
关键词 干扰素-Α1B 海力特 慢性乙型肝炎 治疗方法
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高效液相色谱法测定海力特胶囊含量及体外溶出度
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作者 吕志华 赵峡 《青岛海洋大学学报(自然科学版)》 CSCD 北大核心 2002年第2期241-244,共4页
本文建立了测定海力特胶囊含量和体外溶出度的高效液相色谱方法。采用 Aminex HPX-87H(30 0 mm× 7.8mm)柱 ,以 0 .0 0 2 5 mol· L-1H2 SO4 为流动相 ,柱温为 6 5℃ ,流速为 0 .5 m L·min-1,以示差检测器检测 ,外标法峰... 本文建立了测定海力特胶囊含量和体外溶出度的高效液相色谱方法。采用 Aminex HPX-87H(30 0 mm× 7.8mm)柱 ,以 0 .0 0 2 5 mol· L-1H2 SO4 为流动相 ,柱温为 6 5℃ ,流速为 0 .5 m L·min-1,以示差检测器检测 ,外标法峰面积定量。本法测定线性范围为 1μg~ 4 0μg,方法平均回收率为96 .1% ,RSD为 0 .83% (n=5 ) ,体外溶出度测定结果为 96 %~ 99%。本法测定海力特胶囊含量和溶出度 ,具有方法简便、快捷 ,重复性好的特点 ,可作为制剂质量控制方法。 展开更多
关键词 海力特胶囊 高效液相色谱法 溶出度 海洋生物 海洋药物
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单磷酸阿糖腺苷联合海力特治疗慢性乙型肝炎30例观察 被引量:1
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作者 朱维亮 赵龙翠 《临沂医学专科学校学报》 2000年第4期275-276,共2页
关键词 乙型肝炎 单磷酸阿糖腺苷 海力特 治疗
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海力特治疗慢性乙型肝炎30例初步观察
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作者 陈淑慎 李宗欣 潘兆随 《临沂医学专科学校学报》 1996年第2期145-146,共2页
海力特治疗慢性乙型肝炎30例初步观察陈淑慎,李宗欣,潘兆随(日照市石臼医院,日照市人民医院)关键词慢性乙型肝炎,海力特,药物治疗慢性乙型肝炎的治疗,国内、外虽有很多研究,但无突破性进展,因而加强对治疗病毒性肝炎药物的... 海力特治疗慢性乙型肝炎30例初步观察陈淑慎,李宗欣,潘兆随(日照市石臼医院,日照市人民医院)关键词慢性乙型肝炎,海力特,药物治疗慢性乙型肝炎的治疗,国内、外虽有很多研究,但无突破性进展,因而加强对治疗病毒性肝炎药物的研究有非常重要的意义。青岛海洋大学... 展开更多
关键词 慢性 乙型肝炎 海力特 药物治疗
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海力特治疗慢乙肝疗效观察
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作者 王跃民 张娴 +1 位作者 李美玉 于秋兰 《青岛医药卫生》 1996年第3期40-41,共2页
使用海洋天然药物——海力特治疗慢乙肝37例,并与一般保肝药物治疗的慢乙肝15例对照。海力特治疗组总有效率100%,对照组总有效率73%。治疗组病人在症状、体征改善、肝功恢复方面优于对照组,有显著差异(P<0.05)。且治疗组血清HBeAg... 使用海洋天然药物——海力特治疗慢乙肝37例,并与一般保肝药物治疗的慢乙肝15例对照。海力特治疗组总有效率100%,对照组总有效率73%。治疗组病人在症状、体征改善、肝功恢复方面优于对照组,有显著差异(P<0.05)。且治疗组血清HBeAg阴转率为26.9%,对照组仅为15.4%。说明海力特对乙肝病毒复制有抑制作用,且无毒副作用。 展开更多
关键词 海力特 慢性肝炎 HBEAG
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我国第1个海洋药物中试基地建设取得重大突破
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作者 波影 《海洋信息》 1995年第4期28-28,共1页
经国家经贸委批准,由青岛第三制药厂承担的我国第1个,也是目前唯一一个国家海洋药物中试基地建设取得重大突破。 这个中试基地是按中国医药企业最高标准—GMP设计施工,建成的一座占地3万多平方米,建筑面积2.5万平方米,采用国内一流先进... 经国家经贸委批准,由青岛第三制药厂承担的我国第1个,也是目前唯一一个国家海洋药物中试基地建设取得重大突破。 这个中试基地是按中国医药企业最高标准—GMP设计施工,建成的一座占地3万多平方米,建筑面积2.5万平方米,采用国内一流先进技术设备的现代综合性制药企业。 展开更多
关键词 中试基地 中国医药企业 海洋药物 国家经贸委 先进技术设备 海力特 海尔冰箱 制药产业 海通 药物原料
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Influence of Microstructure Change of Seafloor Sediments on the Sound Velocity in them in the Course of Stress-strain
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作者 李赶先 卢博 黄韶健 《Marine Science Bulletin》 CAS 2009年第1期62-69,共8页
Test tools and methods for synchronizing acoustic measurements in the course of stress-strain for seafloor sediment are elaborated and the test data of 45 sediment samples from the seafloor in the South China Sea are ... Test tools and methods for synchronizing acoustic measurements in the course of stress-strain for seafloor sediment are elaborated and the test data of 45 sediment samples from the seafloor in the South China Sea are analysed. The result shows that the coarser the sediment grains are, the smaller the porosity is and the larger the unconfined compression strength is, the higher the sound velocity is. In the course of stress-strain, the sediment sound velocity varies obviously with the stress. Acoustic characteristics of sediment in different strain phases and the influence of sediment microstructure change on its sound velocity are discussed. This study will be of important significance for surveying wells of petroleum geology and evaluating the base stabilization of seafloor engineering. 展开更多
关键词 seafloor sediment STRESS-STRAIN microstructure features sound velocity compression strength
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Measuring Spatio-temporal Characteristics of City Expansion and Its Driving Forces in Shanghai from 1990 to 2015 被引量:4
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作者 TIAN Li LI Yongfu +1 位作者 SHAO Lei ZHANG Yue 《Chinese Geographical Science》 SCIE CSCD 2017年第6期875-890,共16页
Urbanization has both direct and indirect impacts on land use change, and analyzing spatio-temporal characteristics of land use change is essential for understanding these impacts. By comparing Landsat TM images, this... Urbanization has both direct and indirect impacts on land use change, and analyzing spatio-temporal characteristics of land use change is essential for understanding these impacts. By comparing Landsat TM images, this paper examines the changes of land use structure and landscape patterns in Shanghai from 1990 to 2015. It finds that the city doubled in size, with the growth of isolated construction land being most significant among eight land use types. A land use change matrix was established and landscape indices were selected to evaluate the change of spatial structure in Shanghai. In order to identify the main driving forces of city expansion in Shanghai, this research ran partial least square regression models to assess the impact of 10 social-economic factors on land use change of Shanghai from 1990 to 2015. It then conducted bivariate correlation analysis to explore the drivers of change of various land use types: urban settlement, rural settlement and isolated construction land. Besides quantitative analysis, this paper analyzes the influence of policy-dimensional factors in land use change. It concludes with future potential research topics on land use change in a rapidly urbanizing context. 展开更多
关键词 URBANIZATION land use change partial least squares regression driving forces SHANGHAI
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Progress on Research and Construction of Marine Ranching along the Coast of Shandong Province of China 被引量:1
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作者 Jiao Li Changtao Guan +4 位作者 Yong Cui Jufa Chen Jun Wang Wei Yuan Baoqing Yang 《Journal of Shipping and Ocean Engineering》 2014年第11期338-347,共10页
As a new fishery mode of low-carbon economy, marine ranching has played an important role in promoting sustainable development of fishery and construction of ocean economic zone in China. Since the year of 2000, envir... As a new fishery mode of low-carbon economy, marine ranching has played an important role in promoting sustainable development of fishery and construction of ocean economic zone in China. Since the year of 2000, environment improvement, stock enhancement and mariculture development have been given very high degree of importance along the coast of Shandong Province of China. Studies and tests on artificial reefs and marine ranching, including effect investigation of artificial reefs set up in Jiaonan coastal areas in 1980s, hydrodynamic characteristics experiment of artificial reef, study on material and configuration of artificial reef models, algae transplantation and seaweed beds construction, stock enhancement and releasing etc., have been carried out in recent years. Furthermore, the Restoration Plan of Fishery Resources of Shandong Province has been implemented since the year of 2005, which greatly boosted the construction of artificial reefs and marine ranching along the coast of Shandong. By June of 2010, the total investment on the construction of artificial reefs and marine ranching is over $77 million USD. One hundred artificial reef districts, with total area about 33,350,000 m2 have been set up. The construction of marine ranching along the coast of Shandong Province has been in certain scale and the economic, social and ecological effects are obvious. 展开更多
关键词 Marine ranching artificial reef seaweed beds stock enhancement Shandong Province.
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Motion Characteristics of Novel Floating Foundation for Offshore Wind Turbine 被引量:1
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作者 李嘉文 唐友刚 王宾 《Transactions of Tianjin University》 EI CAS 2016年第1期57-63,共7页
A novel floating foundation to support the NREL offshore 5 MW wind turbine was designed conceptually by combining the characteristics of barge and Spar. The main focus was structural design and hydrodynamic modelling.... A novel floating foundation to support the NREL offshore 5 MW wind turbine was designed conceptually by combining the characteristics of barge and Spar. The main focus was structural design and hydrodynamic modelling. Based on this novel floating foundation, the hydrodynamic performance was investigated in the frequency domain and time domain by using the wave analysis software Hydro D and Deep C from Det Norske Veritas. The frequency domain analysis was conducted to investigate the effects of the incident wave angle and water depth. The time-domain analysis was carried out to evaluate the response of the floating foundation under a selected operational condition. The hydrodynamic performances of this floating foundation with respect to time series and response spectra were also investigated in this study. 展开更多
关键词 offshore wind turbine floating foundation frequency domain analysis time domain analysis
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Numerical Simulation of Motion Response of an Offshore Observation Platform in Waves 被引量:8
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作者 Yuanchuan Liu Decheng Wan 《Journal of Marine Science and Application》 2013年第1期89-97,共9页
Offshore observation platforms are required to have great ability to resist waves when they are operating at sea. Investigation on the motion characteristics of the platforms in the sea can provide significant referen... Offshore observation platforms are required to have great ability to resist waves when they are operating at sea. Investigation on the motion characteristics of the platforms in the sea can provide significant reference values during the platform design procedure. In this paper, a series of numerical simulation on the interaction of a triple-hulled offshore observation platform with different incident waves is carried out. All of the simulations are implemented utilizing our own solver naoe-FOAM-SJTU, which is based and developed on the open source tools of OpenFOAM. Duration curves of motion characteristics and loads acting on the platform are obtained, and a comparison between the results of the amplitude in different incident waves is presented. The results show that the solver is competent in the simulation of motion response of platforms in waves. 展开更多
关键词 offshore observation platform motion characteristics naoe-FOAM-SJTU solver finite volume method (FVM) pressure-implicit-split-operator (PISO)
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Pyrolytic characteristics and kinetics of the marine green tide macroalgae, Enteromorpha prolifera
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作者 赵辉 闫华晓 +2 位作者 刘明 张从旺 秦松 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2011年第5期996-1001,共6页
The marine macroalgae Enteromorpha prolifera was one of the main algal genera that occurred in the widespread green tides in Qingdao, China, during the summers of 2007, 2008 and 2010. It is thus a plentiful source of ... The marine macroalgae Enteromorpha prolifera was one of the main algal genera that occurred in the widespread green tides in Qingdao, China, during the summers of 2007, 2008 and 2010. It is thus a plentiful source of biomass and could be used as a biofuel. In this study, the pyrolytic characteristics and kinetics of E. prolifera were investigated using thermogravimetric analysis (TGA) method. Cornstalk and sawdust were used as comparisons. Pyrolytic characteristics were studied using TG-DTG (thermogravimetry-derivative thermogravimetry) curves. Three stages in the pyrolytic process were determined: dehydration, dramatic weight loss and slow weight loss. E. prolifera was pyrolyzed at a lower initial temperature than the two terrestrial biomass forms. The apparent activation energy values for the three types of biomass were calculated and the mechanism functions were determined using 16 different mechanism functions, frequently used in thermal kinetics analysis. Activation energy values varied with mechanism function and the range of activation energy values for E. prolifera, cornstalk, and sawdust were 25-50 kJ/mol, 60-90 kJ/mol and 120-155 kJ/mol, respectively. This indicates that E. prolifera has low thermal stability for pyrolysis and good combustion characteristics. 展开更多
关键词 MACROALGAE green tide Enteromorpha prolifera PYROLYSIS KINETICS
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On the geo-basis of river regulation in the lower reaches of the Yellow River 被引量:3
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作者 LIU GuoWei 《Science China Earth Sciences》 SCIE EI CAS 2012年第4期530-544,共15页
This paper investigates the important scientific problem of river regulation strategies in the lower reaches of the Yellow River, and discusses the "geo-basis" of river regulation. The concept of a geo-basis... This paper investigates the important scientific problem of river regulation strategies in the lower reaches of the Yellow River, and discusses the "geo-basis" of river regulation. The concept of a geo-basis to river regulation in the lower Yellow River was discussed in terms of subsidence and sedimentation features of the fiver plain; channel features, erosion characteristics of the Loess Plateau and storm-flood features of the middle and lower reaches. The geographic features of the lower Yellow River have gradually changed since the Holocene but there has been no fundamental change. Based on an analysis of the geo-attributes of the lower reaches of the Yellow River, several conclusions on its river regulation were made. The release of sediment should be the first measure of river regulation because of deposition in the lower reaches. The fiver channels should be provided with adequate space for wandering in the lower reaches. The tail river should be also provided with necessary wandering space because of weak marine dynamics in the estuary area and changes in the delta. Because the erosion environ- ment of the Loess Plateau will not fundamentally change, river harnessing of the middle reaches should focus on improving the plateau morphology, which can be done by reducing the fragmentation of terrain and building a planation surface. Eco- remediation should focus on converting farmland to grassland. There may be extreme floods in the future, as has occurred pre- viously, thus an extreme flood defense system should be considered for the lower reaches. A periodic law for regulation in the Yellow River is discussed. We also discuss how the current use of the lower reaches of the Yellow River is unsustainable and it is urgent to research artificial rechanneling and the creation of new flow paths for the lower reaches. 展开更多
关键词 RIVER geo-attributes river regulation the Yellow River floods
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