Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neuro...Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies.Biomarkers are generally classified into three groups:biomarkers of exposure,effect,and susceptibility.The main body compartments that store lead are the blood,soft tissues,and bone;the half-life of lead in these tissues is measured in weeks for blood,months for soft tissues,and years for bone.Within the brain,lead-induced damage in the prefrontal cerebral cortex,hippocampus,and cerebellum can lead to a variety of neurological disorders,such as brain damage,mental retardation,behavioral problems,nerve damage,and possibly Alzheimer’s disease,Parkinson’s disease,and schizophrenia.This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.展开更多
Objective： To observe the clinical efficacy of electroacupuncture（EA） on Alzheimer＇s disease（AD）.Methods： A total of 50 AD patients were randomly allocated into a Western medication（WM） group（n=25） and an a...Objective： To observe the clinical efficacy of electroacupuncture（EA） on Alzheimer＇s disease（AD）.Methods： A total of 50 AD patients were randomly allocated into a Western medication（WM） group（n=25） and an acupuncture plus medication（APM） group（n=25）. Patients in the WM group took oral huperzine A capsules. In addition to huperzine A capsules, patients in the APM group also received EA at Shenting（GV 24）, Baihui（GV 20）, Dazhui（GV 14）,Fengfu（GV 16）, Mingmen（GV 4） and Yongquan（KI 1）. The needles on the above points were connected to G6805-Ⅱelectric stimulator [3 pairs： Shenting（GV 24） and Baihui（GV 20）; Dazhui（GV 14） and Fengfu（GV 16）; and bilateral Yongquan（KI 1）]. The needles were retained 25 min. The treatment was done once a day, and 10 times made up a course of treatment.The patients received a total of 3 treatment courses. There was a 3-day interval between two courses. The mini-mental state examination（MMSE） and Hasegawa dementia scale revised（HDS-R） were conducted before and after treatment. The clinical efficacies were evaluated when the treatment was completed.Results： Before treatment, there were no between-group statistical differences in MMSE and HDS-R scores（both P〈0.05）.After treatment, the MMSE and HDS-R scores in the APM group were significantly higher than those in the WM group（both P〈0.05）. The total effective rate in the APM group was 88.0%, versus 76.0% in the WM group, showing a statistical difference（P〈0.05）.Conclusion： EA is effective for AD and can improve clinical symptoms in AD patients.展开更多
文摘Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies.Biomarkers are generally classified into three groups:biomarkers of exposure,effect,and susceptibility.The main body compartments that store lead are the blood,soft tissues,and bone;the half-life of lead in these tissues is measured in weeks for blood,months for soft tissues,and years for bone.Within the brain,lead-induced damage in the prefrontal cerebral cortex,hippocampus,and cerebellum can lead to a variety of neurological disorders,such as brain damage,mental retardation,behavioral problems,nerve damage,and possibly Alzheimer’s disease,Parkinson’s disease,and schizophrenia.This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.
基金supported by Key Research Project of Science and Technology Bureau of Leshan Town,No.15ZDYJ0150~~
文摘Objective： To observe the clinical efficacy of electroacupuncture（EA） on Alzheimer＇s disease（AD）.Methods： A total of 50 AD patients were randomly allocated into a Western medication（WM） group（n=25） and an acupuncture plus medication（APM） group（n=25）. Patients in the WM group took oral huperzine A capsules. In addition to huperzine A capsules, patients in the APM group also received EA at Shenting（GV 24）, Baihui（GV 20）, Dazhui（GV 14）,Fengfu（GV 16）, Mingmen（GV 4） and Yongquan（KI 1）. The needles on the above points were connected to G6805-Ⅱelectric stimulator [3 pairs： Shenting（GV 24） and Baihui（GV 20）; Dazhui（GV 14） and Fengfu（GV 16）; and bilateral Yongquan（KI 1）]. The needles were retained 25 min. The treatment was done once a day, and 10 times made up a course of treatment.The patients received a total of 3 treatment courses. There was a 3-day interval between two courses. The mini-mental state examination（MMSE） and Hasegawa dementia scale revised（HDS-R） were conducted before and after treatment. The clinical efficacies were evaluated when the treatment was completed.Results： Before treatment, there were no between-group statistical differences in MMSE and HDS-R scores（both P〈0.05）.After treatment, the MMSE and HDS-R scores in the APM group were significantly higher than those in the WM group（both P〈0.05）. The total effective rate in the APM group was 88.0%, versus 76.0% in the WM group, showing a statistical difference（P〈0.05）.Conclusion： EA is effective for AD and can improve clinical symptoms in AD patients.
