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心磷脂蓝莓类结构的形成和演化 被引量:2
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作者 陈燕 李莉 邱枫 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2012年第1期188-192,共5页
用共聚焦显微镜和光学显微镜研究了NaCl溶液中心磷脂蓝莓类结构的形成和演化过程.研究发现,在NaCl溶液(浓度0.005~0.25 mol/L)中,心磷脂海绵相的表面首先生成半球形的层状相微结构元胞,并逐渐呈蜂窝状六角密堆积排列.溶液中NaCl浓度的... 用共聚焦显微镜和光学显微镜研究了NaCl溶液中心磷脂蓝莓类结构的形成和演化过程.研究发现,在NaCl溶液(浓度0.005~0.25 mol/L)中,心磷脂海绵相的表面首先生成半球形的层状相微结构元胞,并逐渐呈蜂窝状六角密堆积排列.溶液中NaCl浓度的轻微增加驱使层状相与海绵相的界面由表面向海绵相内部扩散,溶液中微弱流场的存在也会影响微结构元胞的形貌,最终形成蜂窝样网状结构、蓝莓样包状结构和蓝莓样球状结构,统称蓝莓类结构.由于心磷脂在线粒体内膜的拓扑结构转变中具有重要作用,因此相转变及微结构形态演化的研究有助于进一步理解其在线粒体功能发挥中的作用机理. 展开更多
关键词 心磷脂 蜂窝样结构 蓝莓样结构 海绵相 层状
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多模态影像融合在颅底肿瘤的诊断、治疗中的应用价值 被引量:9
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作者 李成才 姚国杰 +6 位作者 杜威 胡亮平 韦可 伍杰 秦汉 王再贵 马廉亭 《中国临床神经外科杂志》 2018年第3期145-148,共4页
目的探讨多模态影像融合在颅底肿瘤的诊断、治疗中的应用价值。方法 9例颅底肿瘤术前均行DynaCTA检查及MRI薄层(2 mm)增强扫描检查,将多组影像数据输入工作站,采用"双容积重建"技术进行脑血管及MRI的影像融合,通过静态及动态... 目的探讨多模态影像融合在颅底肿瘤的诊断、治疗中的应用价值。方法 9例颅底肿瘤术前均行DynaCTA检查及MRI薄层(2 mm)增强扫描检查,将多组影像数据输入工作站,采用"双容积重建"技术进行脑血管及MRI的影像融合,通过静态及动态融合影像观察肿瘤与脑结构、血管及颅骨的毗邻关系,并对肿瘤的诊断、手术治疗及预防血管并发症进行分析。结果 9例均获得满意的影像融合、具有很好的空间一致性,在一张影像上可以清晰显示病变及其周围脑结构、血管及颅骨解剖关系,提高精准性诊断,并应用于指导治疗策略、设计手术划及预防并发症。9例均恢复满意出院。结论多模态影像融合对提高颅底肿瘤的诊断精准性、提高肿瘤全切除率、降低病死率和残疾率效果肯定,对血管损伤并发症治疗疗效肯定。 展开更多
关键词 颅底肿瘤 多模态影像融合 诊断 治疗 并发症
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基于聚乙二醇双硬脂酸酯的注射用载多西他赛液晶纳米粒的研制
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作者 王熙临 许欣媛 +2 位作者 陈黎明 潘颋 翁伟宇 《中国医药工业杂志》 EI CAS CSCD 北大核心 2023年第12期1731-1737,1744,共8页
本研究旨在考察将聚乙二醇双硬脂酸酯作为液晶材料制备载药液晶纳米粒(LCNPs)的可行性。分别合成了2种液晶材料,甲氧基聚乙二醇(m PEG)双硬脂酸酯(m PEG350-DS)和聚乙二醇(PEG)双硬脂酸酯(S-PEG400-S)。所得的2种材料遇水均可形成溶致液... 本研究旨在考察将聚乙二醇双硬脂酸酯作为液晶材料制备载药液晶纳米粒(LCNPs)的可行性。分别合成了2种液晶材料,甲氧基聚乙二醇(m PEG)双硬脂酸酯(m PEG350-DS)和聚乙二醇(PEG)双硬脂酸酯(S-PEG400-S)。所得的2种材料遇水均可形成溶致液晶,其中S-PEG400-S液晶可被稳定地分散而得到LCNPs。以多西他赛为模型药,添加适量卵磷脂后可获得具有良好负载能力的LCNPs,其粒径为137.9 nm、ζ电位为–19.7 m V、包封率96.5%、载药量为3.4%、含量为标示量(2 mg/m L)的98.2%。载药LCNPs在体外抑瘤试验和体内药动学研究中显示出优于市售注射液(泰索帝)的抑瘤效果和显著的长循环特征。根据偏光显微镜、小角X射线散射和冷冻透射电镜的观察结果,推测该LCNPs中的液晶相态为海绵(L3)相。上述试验结果表明,S-PEG400-S具备成为载药LCNPs材料的良好潜力。 展开更多
关键词 聚乙二醇衍生物 硬脂酸酯 液晶纳米粒 海绵相 多西他赛 注射剂 药物动力学
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Isolation of metabolic products from the fungus Nectria sp.HLS206 that is associated with the marine sponge Gelliodes carnosa collected from the South China Sea
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作者 王瑞杉 巩婷 +1 位作者 朱平 程克棣 《Journal of Chinese Pharmaceutical Sciences》 CAS 2012年第2期183-186,共4页
The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus... The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus were isolated.From the solid cultures,five compounds were purified,which are chalmicrin(1),hypocrealesate(2),fucosterol(3),stigmasterol(4) and β-sitosterol(5).The structures of the 5 compounds were elucidated by ESI-MS,1D and 2D NMR spectra(COSY,HMQC and HMBC).To the best of our knowledge,it is the first time compound 1 was isolated from the order of Hypocreales,and the spectral data of compound 2 are also firstly reported. 展开更多
关键词 Sponge-associated fungus Nectria sp. Secondary metabolites Spectral data
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A new strategy for integrated urban water management in China:Sponge city 被引量:30
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作者 WANG Hao MEI Chao +1 位作者 LIU JiaHong SHAO WeiWei 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2018年第3期317-329,共13页
Urban water-related problems associated with rapid urbanization, including waterlogging, water pollution, the ecological degradation of water, and water shortages, have caused global concerns in recent years. In 2013,... Urban water-related problems associated with rapid urbanization, including waterlogging, water pollution, the ecological degradation of water, and water shortages, have caused global concerns in recent years. In 2013, in order to mitigate increasingly severe urban water-related problems, China set forth a new strategy for integrated urban water management(IUWM) called the "Sponge City". This is the first holistic IUWM strategy implemented in a developing country that is still undergoing rapid urbanization, and holds promise for application in other developing countries. This paper aims to comprehensively summarize the sponge city. First, this paper reviews prior studies and policies on urban water management in China as important background for the sponge city proposal. Then, the connotations, goals, and features of the sponge city are summarized and discussed.Finally, the challenges, research needs, and development directions pertinent to the sponge city are discussed based on investigations and studies conducted by the authors. The sponge city in China has a short history—given this, there are many issues that should be examined with regard to the stepwise implementation of the Sponge City Programme(SCP). Accordingly, the authors perceive this study as only the beginning of abundant studies on the sponge city. 展开更多
关键词 flexible adaptation urban hydrological cycle low impact development green infrastructure
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