扎根农村市场的青岛海诺药业连锁公司

青岛海诺药业连锁有限公司成立于2002年，公司总部“扎根”在“农村”——青岛莱西市姜山镇。公司成立之初，就把目光投向广阔的农村药品市场，并尝试借用邮政部门投递网络向公司所属药品零售连锁网点进行物流配送，以节省配送费用、降低成本。青岛海诺药业连锁有限公司在短短不到两年的时间里。

电梯工程技术专业与行业企业协同发展的实证研究

电梯行业的特种性要求作业人员具备职业资格证,由于正规培训机构的缺乏,导致电梯作业人员的严重紧缺。在此背景下,湖南职业技术学院顺应电梯产业需求,成立"海诺电梯学院",与电梯企业、电梯行业协同互动,共同培育电梯工程技术人才。

在上海看樱花

在繁华忙碌的上海，进入春天时会有一种静静的期待：看樱花，感受那种“花开如霞落似雪”的美妙。

Seasonal distribution and relationship of water mass and suspended load in North Yellow Sea

The concentration of suspended load can be determined by its linear relationship to turbidity. Our results present the basic distribution of suspended load in North Yellow Sea. In summer, the suspended load concentration is high along the coast and low in the center of the sea. There are four regions of high concentration in the surface layer： Penglai and Chengshantou along the north of the Shandong Peninsula, and the coastal areas of Ltishun and Changshan Islands. There is a 2 mg/L contour at 124°E that separates the North Yellow Sea from regions of lower concentrations in the open sea to the west. And there is a 2 mg/L contour at 124°E that separates the North Yellow Sea from regions of lower concentrations in the open sea to the west. The distribution features in the 10 m and bottom layer are similar to the surface layer, however, the suspended load concentration declines in the 10 m layer while it increases in the bottom layer. And in the bottom layer there is a low suspended load concentration water mass at the region south of 38°N and east of 123°E extending to the southeast. In general, the lowest suspended load concentration in a vertical profile is at a depth of 10 to 20 m, the highest suspended load concentration is in the bottom near Chengshantou area. In winter, the distribution of suspended load is similar to summer, but the average concentrations are three times higher. There are two tongue-shaped high suspended load concentration belt, one occurring from surface to seafloor, extends to the north near Chengshantou and the other invades north to south along the east margin of Dalian Bay. They separate the low suspended load concentration water masses in the center of North Yellow Sea into east and west parts, Vertical distribution is quite uniform in the whole North Yellow Sea because of the cooling effect and strong northeast winds. The distribution of suspended load has a very close relationship to the current circulation and wind-induced waves in the North Yellow Sea. Because of this, we have been able to show for the first time that the distribution of suspended load can be used to identify water masses.

Asymmetric Response of the South China Sea SST to El Nio and La Nia

The interannual variability of the sea surface temperature （SST） in the South China Sea （SCS） is investigated according to its relationship with E1 Nifio/La Nifia （EN/LN） using monthly products from ICOADS. The SCS SST bears two peaks associated with EN/LN and shows the asymmetric features. Coinciding with the mature phase of EN/LN, the first SST warming/cooling peaks in December（0）-February（1） （DJF（1）） and centers in the southern part. The major difference is in the amplitude associated with the strength of EN/LN. However, the SCS SST anomaly shows distinct difference after the mature phase of EN/LN. The EN SST warm- ing develops a mid-summer peak in June-August（1） （JJA（1）） and persists up to September-October（l）, with the same amplitude of the first warming peak. Whereas the LN SST cooling peaks in May（l）, it decays slowly until the end of the year, with amplitude much weaker. Comparing with SST and atmospheric circulations, the weak response and early termination of the second cooling is due to the failure of the cyclonic wind anomalies to develop in the northwest Pacific during JJA（1）.

Pedestrian environment prediction with different types of on-shore building distribution

The aim of this work is to evaluate how the building distribution influences the cooling effect of water bodies. Different turbulence models, including the S-A, SKE, RNG, Realizable, Low-KE and RSM model, were evaluated, and the CFD results were compared with wind tunnel experiment. The effects of the water body were detected by analyzing the water vapor distribution around it. It is found that the RNG model is the most effective model in terms of accuracy and computational economy. Next, the RNG model was used to simulate four waterfront planning cases to predict the wind, thermal and moisture environment in urban areas around urban water bodies. The results indicate that the building distribution, especially the height of the frontal building, has a larger effect on the water vapor dispersion, and indicate that the column-type distribution has a better performance than the enclosed-type distribution.

Movements of the Western Pacific Warm Pool Centroid and Their Relationship to Sea Surface Temperature Changes in Nino Regions

By using monthly historical sea surface temperature (SST) data for the yearsfrom 1950 to 2000, the Western Pacific Warm Pool (WPWP) climatology and anomalies are studied inthis paper. The analysis of WPWP centroid (WPWPC) movement anomalies and the Nino-3 region SSTanomalies(SSTA) seems to reveal a close, linear relation between the zonal WPWPC and Nino-3 regionSSTA, which suggests that a 9° anomaly of the zonal displacement from the climatological positionof the WPWPC corresponds to about a 1℃ anomaly in the Nino-3 region area-mean SST. This studyconnects the WPWPC zonal displacement with the Nino-3 SSTA, and it may be helpful in betterunderstanding the fact that the WPWP eastward extension is conducive to the Nino-3 region SSTincrease during an El Nino-Southern Oscillation (ENSO) event.

Revisiting Asymmetry for the Decaying Phases of El Ni?o and La Ni?a

This study investigated the relationship be- tween the asymmetry in the duration of El Nifio and La Nina and the length of their decaying phases. The results suggested that the duration asymmetry comes from the long decaying ENSO cases rather than the short decaying ones. The evolutions of short decaying El Nino and La Nina are approximately a mirror image with a rapid decline in the following summer for the warm and cold events. However, a robust asymmetry was found in long decaying cases, with a prolonged and re-intensified La Nina in the following winter. The asymmetry for long decaying cases starts from the westward extension of the zonal wind anomalies in a mature winter, and is further contributed to by the air-sea interaction over the tropical Pacific in the following seasons.

Numerical simulation of calm water entry of flatted-bottom seafloor mining tool

The hydrodynamic problem of a two-dimensional model of seafloor mining tool entering still water vertically at constant speed was analyzed based on the velocity potential theory. For the assumption that the water entry occurs with very short time interval, the viscosity and gravity of fluid were neglected. Considering the characteristic shape of it, the seafloor mining tool was simplified as a flat-bottom body. The governing equations were the Reynolds time-averaged equations and the k-e model. Finite element analysis was undertaken using the CFD software, Fluent. The impact pressures on the bottom of the mining tool were computed based on the improved volume of fuid method （VOF）. The pressure distribution, the maximum impact pressure, and the impact duration time during the water entry of mining tool are presented at various deploying velocities, the two peak pressures in the impact process are observed, and the relationship between the maximum impact pressure and the deploying velocity is obtained. The results are compared with those based on other prediction theories and methods.

A novel derivative of xanomeline improved memory function in aged mice

Objective To characterize the function of a new xanomeline-derived M 1 agonist, 3-[3-（3-florophenyl-2-propyn- 1- ylthio）-1,2,5-thiadiazol-4-yl]-1,2,5,6- tetrahydro-1-methylpyridine Oxalate （EUK1001）, the acute toxicity and the effects on synaptic plasticity and cognition of EUK1001 were evaluated. Methods To examine the median lethal dose （LD50） of EUK1001, a wide dose range of EUK1001 was administered by p.o. and i.p. in aged mice. Furthermore, novel object recognition task and in vitro electrophysiological technique were utilized to investigate the effects of EUK1001 on recognition memory and hippocampal synaptic plasticity in aged mice. Results EUK1001 exhibited lower toxicity than xanomeline, and improved the performance of aged mice in the novel object recognition test. In addition, bath application of 1 μmol/L EUK1001 directly induced long-term potentiation in the hippocampus slices. Conclusion We conclude that EUK1001 can improve the agerelated cognitive deficits.

The Role of the Equatorial Currents on the Evolution of SSTA in the Eastern Pacific during Two Different Kinds of El Nio Events

Based on the Simple Ocean Data Assimilation （SODA） from 1970 to 2001, equatorial currents and their association with the warm water propagation mechanism during two patterns of El Nifio events are studied. In this study, the middle-pattern of E1 Nifio （ME） and the eastern-pattern of E1 Nifio （EE） events are defined as anomalous warm water originating first to the west and the east of 120°W, respectively. It is pointed out that the westerly and eastward anomalous currents in the western Pacific are stronger during the ME event than the EE event, which is conducive to the eastward migration of warm water from western Pacific by zon＇al advection of temperature. In contrast, the weaker westerly and the west- ward anomalous currents east of the dateline would be unfavorable for the eastward migration of warm water during EE events. More importantly, another propagation mechanism of the warm water is attributed to the anomalous convergence of the surface currents, as well as the anomalous divergence of the subsurface currents, which obstruct the upwelling of colder water from the deep ocean. Meanwhile, the anomalous convergence of the surface currents and the anomalous divergence of the subsurface currents maintain eastward migration, which plays an important role in the eastward migration of the warm water during ME events. Although there is anomalous convergence in the upper ocean and anomalous divergence in the subsurface ocean during EE events, they appear quasi-stationary in the western Pacific. The warm water over the eastern Pacific during EE events is caused by the local anomalous convergence of surface currents and the anomalous divergence of subsurface currents.

The Formation of Precipitation Anomaly Patterns during the Developing and Decaying Phases of ENSO

This study proposes a new explanation for the formation of precipitation anomaly patterns in the boreal summer during the E1 Nifio-Southem Oscillation （ENSO） developing and decaying phases. During the boreal sum- mer June-July-August （JJA） （0） of the E1 Nino （La Nina） developing phase, the upper level （300-100 hPa） positive potential temperature anomalies resemble a Ma- tsuno-Gill-type response to central Pacific heating （cool- ing）, and the lower level （1000-850 hPa） potential tem- perature anomalies are consistent with local SST anoma- lies. During the boreal summer JJA（1） of the E1 Nifio （La Nifia） decaying phase, the upper level potential tempera- ture warms over the entire tropical zone and resembles a Matsuno-Gill-type response to Indian Ocean heating （cooling）, and the lower level potential temperature anomalies follow local SST anomalies. The vertical heterogeneity of potential temperature anomalies influences the atmospheric stability, which in turn influences the precipitation anomaly pattern. The results of numerical experiments confirm our observations.

The first meteorological observations at a tropical high elevation site:Antisana,1846

Antisana is a stratovolcano with an associated glacier located in the Ecuadorian Andes. Dr Aguirre made meteorological readings every day, at every hour from sunrise to sunset, from December 1845 to December 1846, at Antisana using a meteorological station at 4060 mamsl （meters above mean sea level）. Unfortunately, only the monthly average data have been preserved. These meteorological data are here studied and compared with the closest modern stations for monthly values of temperature, rainfall, and pressure. According to these comparisons, the year 1846 was rainy and cold in comparison with the current climate. Moreover, these observations have been useful to help resolve a debate about a possible E1Nifio event in 1846 with the high precipitation in Antisana and Quito in 1846 discarding the occurrence of an E1 Nifio event. The probable occurrence of a La Nifia event is discussed. These data are the earliest known systematic instrumental meteorological observations taken at above 4000 mamsl.

Interannual variability of latent and sensible heat fluxes in the South China Sea

The South China Sea （SCS） is significantly influenced by El Nino and the Southern Oscillation （ENSO） through ENSO-driven atmospheric and oceanic changes. We analyzed measurements made from 1960 to 2004 to investigate the interannual variability of the latent and sensible heat fluxes over the SCS. Both the interannual variations of latent and sensible heat fluxes are closely related to ENSO events. The low-pass mean heat flux anomalies vary in a coherent manner with the low-pass mean Southern Oscillation Index （SOI）. Time lags between the heat flux anomalies and the SST anomalies were also studied. We found that latent heat flux anomalies have a minimum value around January of the year following El Nino events. During and after the mature phase of E1 Nino, a change of atmospheric circulation alters the local SCS near-surface humidity and the monsoon winds. During the mature phase of E1 Nino, the wind speed decreases over the entire sea, and the air-sea specific humidity difference anomalies decreases in the northern SCS and increases in the southern SCS. Thus, a combined effect of wind speed anomalies and air-sea specific humidity difference anomalies results in the latent heat flux anomalies attaining minimum levels around January of the year following an E1 Nino year.

Enhanced correlation between ENSO and western North Pacific monsoon during boreal summer around the 1990s

The correlation between summertime Nino3.4 index and western North Pacific(WNP)summer monsoon index has strikingly enhanced since the early 1990 s,with nonsignificant correlation before the early1990 s but significant correlation afterward.This observed interdecadal change around the 1990 s may be associated with more frequent occurrences of central Pacific(CP)El Nino and the interdecadal changes in ENSO-associated SST anomalies.During the post-1990 s period(the pre-1990 s period),highly noticeable tropical Atlantic(Indian)Ocean SST anomalies tend to co-occur with the summertime Nino3.4 SST anomalies.The concurrent tropical Atlantic(Indian)Ocean SST anomalies could constructively reinforce(destructively mitigate)the WNP monsoon circulation anomalies induced by the summertime Nino3.4 SST,thus boosting(muting)the correlation between summertime Nino3.4 SST and WNP monsoon.In addition,the faster decaying pace of preceding-winter El Nino after the 1990 s,which may have been mainly induced by the influences from the spring tropical North Atlantic SST anomalies,could also have contributed to the enhanced correlation between the summertime Nino3.4 index and WNP monsoon.These results suggest that the enhanced influences from the tropical Atlantic SST may have triggered the intensified correlation between summertime ENSO and WNP monsoon since the early 1990 s.

Combined effect of the QBO and ENSO on the MJO

This study investigates the combined effect of the El Nino–Southern Oscillation(ENSO) and stratospheric quasi-biennial oscillation(QBO) on the Madden Julian Oscillation(MJO). The results show that the western Pacific MJO originating from the Indian Ocean during La Nina/QBO easterly years is stronger than that during El Nino years. This relation, however, disappears during La Nina/QBO westerly years. The reason is that ENSO and the QBO have different effects on each MJO event. For an El Nino year, there is only about one MJO event, and the QBO effect is small. During a La Nina/QBO easterly year, there are 1.7 MJO events, while during a La Nina/QBO westerly year, there are only 0.6 MJO events. El Nino can reinforce the MJO over the western Pacific because of the positive moisture advection of the El Nino mean state by MJO easterly wind anomalies. The QBO mainly affects the MJO over the Maritime Continent region by changing the high-cloud-controlled diurnal cycle;and the Maritime Continent barrier effect is enhanced during the QBO westerly phase because of the strong diurnal cycle. During El Nino years, even the MJO over the Maritime Continent is suppressed by the QBO westerly phase;the MJO can be reinforced over the western Pacific. During La Nina/QBO westerly years,the MJO over the Maritime Continent is suppressed because of the strong Maritime Continent diurnal cycle, and it is further suppressed over the western Pacific because of the lack of a reinforcement process.

Estimates of Reynolds Stress and TKE Production in the Seasonally Stratified East China Sea

During the two cruises in March and July of 2011, the tidal cycling of turbulent properties and the T/S profiles at the same location in seasonally stratified East China Sea （ECS） were measured synchronously by a bottom-mounted fast sampling ADCP （acoustic Doppler current profiler） and a RBR CTD （RBR-620） profiler. While focusing on the tide-induced and stratification＇s impact on mixing, the Reynolds stress and the turbulent kinetic energy （TKE） production rate were calculated using the ‘variance method＇. In spring, the features of mixing mainly induced by tides were clear when the water column was well-mixed. Velocity shear and turbulent parameters intensified towards the seabed due to the bottom friction. The components of the velocity shear and the Reynolds stress displayed a dominant semi-diurnal variation related to velocity changes caused by the flood and ebb of M2 tide. Stratification occurred in summer, and the water column showed a strongly stratified pycnocline with a characteristic squared buoy- ancy frequency of N2~ （1-6）x 10 3 S-2 The components of the velocity shear and the Reynolds stress penetrated upwards very fast from the bottom boundary layer to the whole water column in spring, while in summer they only penetrated to the bottom of the pycnocline with a relatively slow propagation speed. In summer, the TKE production within the pycnocline was comparable with and sometimes larger than that in the well-mixed bottom layer under the pycnocline. Considering the associated high velocity shear, it is speculated that the mixing in the pycnocline is a result of the local velocity shear.

Traditional El Nio and El Ni o Modoki Revisited:Is El Nio Modoki Linearly Independent of Traditional El Nio?

The present study revisited the first two leading modes of tropical Pacific sea surface temperature anomalies （SSTA） during the period of 1979-2008. It is suggested that the so-called El Nino Modoki, which is captured by the second mode, exists objectively and exhibits obvious differences from traditional El Nifio, which is captured by the first mode, in terms of its spatial characteristics. Furthermore, the authors found that El Nino Modoki is linearly independent of traditional El Nino; hence, it cannot be described as part of the traditional El Nino evolution, and vice versa.

RELATIONSHIP BETWEEN INTERANNUAL VARIATION OF MERIDIONAL WIND ANOMALIES IN TROPICAL PACIFIC AND SSTA

The Singular Spectrum Analysis (SSA) method is used to conduct studies of periodicity of the SST and meridional winds in tropical Pacific Ocean. The results show that the air-sea system for the Pacific varies on quasi-4-year, quasi-2-year and interannual scales, with the quasi-4-year scale having the highest variability. Depending on the scale, the wind field has a varying degree of association with the SST anomalies. Difference is also found in the evolution of phase. In addition, the work discusses the difference in SSTA resulted from wind fields for quasi-4-year and quasi-2-year components.