AIM： To analyze the incidence of digestive system cancer in Changle of China over a 15-year period. METHODS： The datasets were presented as timeseries of China-standardized annual incidence during 1988-2002. Linear ...AIM： To analyze the incidence of digestive system cancer in Changle of China over a 15-year period. METHODS： The datasets were presented as timeseries of China-standardized annual incidence during 1988-2002. Linear regression model was used to analyze the incidence of stomach, liver, esophagus and colorectal cancers. RESULTS： Linear regression models for the time-series of stomach and esophagus cancer incidences for both men and women were statistically significant （P 〈 0.05）; Regression models for liver cancer and for colorectal cancer were statistically significant for men （P 〈 0.05）. CONCLUSION： The incidence rates of stomach and esophagus cancers for both men and women had down tendencies. For men, liver cancer had a down trend of the incidence and colorectal cancer had an upward trend of the incidence rate.展开更多
To review the implication of CXCR4 for gastrointestinal cancer, a ＂Pubmed＂ analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were ...To review the implication of CXCR4 for gastrointestinal cancer, a ＂Pubmed＂ analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were ＂cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF- 1α, and SDF-1β＂. CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1α might act as ＂chemorepellent＂ while SDF-1β might act as ＂chemorepellent＂ for CTLs, inducing tumor rejection. The paracrine expression of SDF-1α was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of CXCR4 might be an interesting therapeutic option.展开更多
基金Supported by the Natural Science Foundation of Fujian Province, No.Z0516023
文摘AIM： To analyze the incidence of digestive system cancer in Changle of China over a 15-year period. METHODS： The datasets were presented as timeseries of China-standardized annual incidence during 1988-2002. Linear regression model was used to analyze the incidence of stomach, liver, esophagus and colorectal cancers. RESULTS： Linear regression models for the time-series of stomach and esophagus cancer incidences for both men and women were statistically significant （P 〈 0.05）; Regression models for liver cancer and for colorectal cancer were statistically significant for men （P 〈 0.05）. CONCLUSION： The incidence rates of stomach and esophagus cancers for both men and women had down tendencies. For men, liver cancer had a down trend of the incidence and colorectal cancer had an upward trend of the incidence rate.
文摘To review the implication of CXCR4 for gastrointestinal cancer, a ＂Pubmed＂ analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were ＂cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF- 1α, and SDF-1β＂. CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1α might act as ＂chemorepellent＂ while SDF-1β might act as ＂chemorepellent＂ for CTLs, inducing tumor rejection. The paracrine expression of SDF-1α was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of CXCR4 might be an interesting therapeutic option.
