OBJECTIVE To identify clinicopathological characteristics as predictive factors for recurrence in early gastric cancer （EGC）, and to determine which lesions should be removed by gastrectomy by means other than endos...OBJECTIVE To identify clinicopathological characteristics as predictive factors for recurrence in early gastric cancer （EGC）, and to determine which lesions should be removed by gastrectomy by means other than endoscopic mucosal resection （EMR）. METHODS Data from 249 patients with EGC were collected and the relationship between their clinicopathological characteristics and postoperative recurrence was retrospectively analyzed by univariate analysis. RESULTS Of the 249 patients after gastrectomy, 19 cases （7.6%） experienced a recurrence. The postoperative recurrence rate was 18.9% （7/37） in patients with lymph node metastasis, and 5.7% （12/212） in those without. Lymph node metastases were found to be significantly related to recurrence in EGC （P = 0.005）. CONCLUSION Lymph node metastases were the only predictive factor for recurrence in EGC. However, this was not the determining factor for performing gastrectomy rather than EMR. Although after gastrectomy with lymphadenectomy of EGC, patients with lymph node metastasis should be considered as candidates for adjuvant treatment. For lymph-node metastatic EGCs, adjuvant therapy is recommended following gastrectomy with lymphadenectomy.展开更多
Lymphatic vessels are essential for tissue fluid homeostasis,immune cell trafficking,and intestinal lipid absorption.The lymphatics have long been recognized to serve as conduits for distant tumor dissemination.Howeve...Lymphatic vessels are essential for tissue fluid homeostasis,immune cell trafficking,and intestinal lipid absorption.The lymphatics have long been recognized to serve as conduits for distant tumor dissemination.However,recent findings suggest that the regional lymphatic vasculature also shapes the immune microenvironment of the tumor mass and potentiates immunotherapy.This review discusses the role of lymphatic vessels in tumor metastasis and tumor immunity.展开更多
基金This work was supported by a grant from the Nature Science Foundation of Liaoning province(No.20042071)
文摘OBJECTIVE To identify clinicopathological characteristics as predictive factors for recurrence in early gastric cancer （EGC）, and to determine which lesions should be removed by gastrectomy by means other than endoscopic mucosal resection （EMR）. METHODS Data from 249 patients with EGC were collected and the relationship between their clinicopathological characteristics and postoperative recurrence was retrospectively analyzed by univariate analysis. RESULTS Of the 249 patients after gastrectomy, 19 cases （7.6%） experienced a recurrence. The postoperative recurrence rate was 18.9% （7/37） in patients with lymph node metastasis, and 5.7% （12/212） in those without. Lymph node metastases were found to be significantly related to recurrence in EGC （P = 0.005）. CONCLUSION Lymph node metastases were the only predictive factor for recurrence in EGC. However, this was not the determining factor for performing gastrectomy rather than EMR. Although after gastrectomy with lymphadenectomy of EGC, patients with lymph node metastasis should be considered as candidates for adjuvant treatment. For lymph-node metastatic EGCs, adjuvant therapy is recommended following gastrectomy with lymphadenectomy.
基金Project supported by the National Institutes of Health(NIH),USA(No.K12 HL120001-05)
文摘Lymphatic vessels are essential for tissue fluid homeostasis,immune cell trafficking,and intestinal lipid absorption.The lymphatics have long been recognized to serve as conduits for distant tumor dissemination.However,recent findings suggest that the regional lymphatic vasculature also shapes the immune microenvironment of the tumor mass and potentiates immunotherapy.This review discusses the role of lymphatic vessels in tumor metastasis and tumor immunity.
