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深海来源淡紫拟青霉ZBY-1的代谢产物及其抗肿瘤活性 被引量:16
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作者 崔香 李长伟 +4 位作者 吴长景 华威 崔承彬 朱天骄 顾谦群 《国际药学研究杂志》 CAS CSCD 2013年第2期177-186,共10页
目的阐明来自深海海水的淡紫拟青霉ZBY-1的代谢产物及其抗肿瘤活性。方法采用活性跟踪分离模式,利用各种色谱技术分离纯化代谢产物;根据理化和波谱数据结合部分化合物的甲醇解反应鉴定化合物结构;采用MTT法测试抗肿瘤活性。结果从淡紫... 目的阐明来自深海海水的淡紫拟青霉ZBY-1的代谢产物及其抗肿瘤活性。方法采用活性跟踪分离模式,利用各种色谱技术分离纯化代谢产物;根据理化和波谱数据结合部分化合物的甲醇解反应鉴定化合物结构;采用MTT法测试抗肿瘤活性。结果从淡紫拟青霉ZBY-1发酵产物中分离鉴定了9(11)-去氢过氧化麦角甾醇(1)、过氧化麦角甾醇(2)、(22E,24R)-5α,6α-环氧-3β-羟基麦角甾-22-烯-7-酮(3)和脑苷脂A(4)、B(5)、C(6)、D(7)等7个化合物。化合物1~3对人癌细胞K562、MCF-7、HL-60、BGC-823有较强抑制作用,IC50在9.5~59.6 mg/L之间,而4~7对上述4种癌细胞均无抑制活性。结论本文是有关深海来源淡紫拟青霉代谢产物的首篇研究报道。化合物1~7为首次从淡紫拟青霉产物中分离得到,其中1和3首次从拟青霉属、3还首次从真菌中分离报道。化合物1对K562和BGC-823细胞以及3对上述4种癌细胞的抑制活性亦属首次测试报道。 展开更多
关键词 深海海水来源真菌 淡紫拟青霉ZBY-1 次级代谢产物 抗肿瘤活性 甾类 脑苷脂
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淡紫拟青霉ZBY-1的次级代谢产物及其抗肿瘤活性 被引量:7
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作者 崔香 李长伟 +4 位作者 吴长景 华威 崔承彬 朱天骄 顾谦群 《国际药学研究杂志》 CAS CSCD 2013年第6期765-771,794,共8页
目的阐明来自深海海水的淡紫拟青霉ZBY-1的代谢产物及其抗肿瘤活性。方法采用活性跟踪模式分得活性组分,利用各种色谱技术分离纯化代谢产物。根据理化和波谱数据鉴定化合物结构。采用MTF法测试抗肿瘤活性。结果从淡紫拟青霉ZBY.1发酵... 目的阐明来自深海海水的淡紫拟青霉ZBY-1的代谢产物及其抗肿瘤活性。方法采用活性跟踪模式分得活性组分,利用各种色谱技术分离纯化代谢产物。根据理化和波谱数据鉴定化合物结构。采用MTF法测试抗肿瘤活性。结果从淡紫拟青霉ZBY.1发酵产物中分离鉴定了paecilaminol(1)、paecilaminol盐酸盐(2)、1(2)-linolyl-2(1)-palmityl—glycero—04’-(N,N,N.trimethyl)homoserine(3)、1,2-dilinolylglycero—O-4’-(N,N,N—tfimethyl)homoserine(4)、肉豆蔻酸甲酯(5)、亚油酸甲酯(6)、亚油酸(7)、油酸(8)、3-吲哚甲醛(9)、3一吲哚甲酸(10)和对羟基苯甲酸(11)等11个化合物。化合物1和2对4种人癌细胞有较强的抑制作用,IC50值为1.12~8.63μmol/L,且2对该4种人癌细胞的抑制活性是1的2.2—2.7倍。结论化合物1—11为首次从淡紫拟青霉产物中分离得到,其中3、4和9—11还系首次从拟青霉属分离报道。化合物1是菌株ZBY-1的主要抗肿瘤活性产物。本文首次报道1和2对人癌细胞的抑制活性。 展开更多
关键词 深海海水来源真菌 淡紫拟青霉ZBY-1 次级代谢产物 抗肿瘤活性
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Depth inversion in coastal water based on SAR image of waves 被引量:1
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作者 范开国 黄韦艮 +3 位作者 贺明霞 傅斌 张彪 陈小燕 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2008年第4期434-439,共6页
Wave-number spectrum technique is proposed to retrieve coastal water depths by means of Synthetic Aperture Radar (SAR) image of waves. Based on the general dispersion relation of ocean waves the wavelength changes o... Wave-number spectrum technique is proposed to retrieve coastal water depths by means of Synthetic Aperture Radar (SAR) image of waves. Based on the general dispersion relation of ocean waves the wavelength changes of a surface wave over varying water depths can be derived from SAR. Approaching the analysis of SAR images of waves and using the general dispersion relation of ocean waves, this indirect technique of remote sensing bathymetry has been applied to a coastal region of Xiapu in Fujian Province, China. Results show that this technique is suitable for the coastal waters especially for the near-shore regions with variable water depths. 展开更多
关键词 SAR coastal water depth ocean waves dispersion relation
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Design and research on a variable ballast system for deep-sea manned submersibles 被引量:7
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作者 邱中梁 《Journal of Marine Science and Application》 2008年第4期255-260,共6页
Variable ballast systems are necessary for manned submersibles to adjust their buoyancy.In this paper,the design of a variable ballast system for a manned submersible is described.The variable ballast system uses a su... Variable ballast systems are necessary for manned submersibles to adjust their buoyancy.In this paper,the design of a variable ballast system for a manned submersible is described.The variable ballast system uses a super high pressure hydraulic seawater system.A super high pressure seawater pump and a deep-sea brushless DC motor are used to pump seawater into or from the variable ballast tank,increasing or decreasing the weight of the manned submersible.A magnetostrictive linear displacement transducer can detect the seawater level in the variable ballast tank.Some seawater valves are used to control pumping direction and control on-off states.The design and testing procedure for the valves is described.Finally,the future development of variable ballast systems and seawater hydraulic systems is projected. 展开更多
关键词 DEEP-SEA manned submersible variable ballast system WEIGHT seawater pump seawater hydraulic system
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Bathymetry and bottom albedo retrieval using Hyperion:a case study of Thitu Island and reef 被引量:3
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作者 刘振 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2013年第6期1338-1343,共6页
The Spratly(Nansha) Islands in the South China Sea have considerable economic and important militarily strategic status.Ocean color remote sensing is an effective mean of surveying and research and especially it is us... The Spratly(Nansha) Islands in the South China Sea have considerable economic and important militarily strategic status.Ocean color remote sensing is an effective mean of surveying and research and especially it is useful for areas that are difficult to access,such as Thitu Island and its reef in the Spratly Islands.The Hyper-spectral Optimization Process Exemplar(HOPE) model,developed by Lee et al.(1999) is a rapid and robust bathymetry method that uses hyper-spectral remote sensing.In this study,using Hyperion hyper-spectral sensor data and HOPE,we derive bathymetry and bottom albedo measurements around Thitu Island and its reef.We compare the distribution of bottom depths from C-MAP with that derived from the Hyperion data.The retrieved bathymetry results correlate well with the distribution obtained from the bathymetry contour from 2.0 to 20 m.The average difference between Hyperion and C-MAP for two selected transects was 17.1%(n=59,R=0.848,RMSE=2.342) and 10.9%(n=59,R2=0.834,RMSE=0.463).The retrieved bottom albedo is homogeneous in the lagoon and significantly non-homogeneous around the lagoon.These results indicate that HOPE could be very useful for bathymetry studies for the islands of the South China Sea. 展开更多
关键词 HYPER-SPECTRAL BATHYMETRY SEMI-ANALYTICAL HOPE bottom albedo
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Three new records of deep-water goniasterids (Echinodermata:Asteroidea:Goniasteridae) from China seas
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作者 肖宁 廖玉麟 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2013年第5期1036-1044,共9页
In this paper,three deep-water species of the family Goniasteridae,Ceramaster misakiensis(Goto,1914),Nymphaster arthrocnemis Fisher,1913 and Pontioceramus grandis Fisher,1911,are recorded for the first time from Chine... In this paper,three deep-water species of the family Goniasteridae,Ceramaster misakiensis(Goto,1914),Nymphaster arthrocnemis Fisher,1913 and Pontioceramus grandis Fisher,1911,are recorded for the first time from Chinese waters based on collections deposited in the Marine Biological Museum,Chinese Academy of Sciences.The specimens examined were collected during the period 1956 to 1978 from the East China and South China Seas at depths of 184 to 472 m.Diagnosis,detailed figures,and the geographic distributions are provided.A revised list of Goniasteridae recorded from Chinese waters is proposed. 展开更多
关键词 ECHINODERMATA ASTEROIDEA Valvatida deep-water goniasterids new records China seas
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Characteristics of water exchange in the Luzon Strait during September 2006 被引量:9
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作者 周慧 南峰 +2 位作者 侍茂崇 周良明 郭佩芳 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2009年第3期650-657,共8页
The Luzon Strait is the only deep channel that connects the South China Sea(SCS) with the Pacific.The transport through the Luzon Strait is an important process influencing the circulation,heat and water budgets of th... The Luzon Strait is the only deep channel that connects the South China Sea(SCS) with the Pacific.The transport through the Luzon Strait is an important process influencing the circulation,heat and water budgets of the SCS.Early observations have suggested that water enters the SCS in winter but water inflow or outflow in summer is quite controversial.On the basis of hydrographic measurements from CTD along 120° E in the Luzon Strait during the period from September 18 to 20 in 2006,the characteristics of temperature,salinity and density distributions are analyzed.The velocity and volume transport through the Luzon Strait are calculated using the method of dynamic calculation.The major observed results show that water exchanges are mainly from the Pacific to the South China Sea in the upper layer,and the flow is relatively weak and eastward in the deeper layer.The net volume transport of the Luzon Strait during the observation period is westward,amounts to about 3.25 Sv.This result is consistent with historical observations. 展开更多
关键词 Luzon Strait water exchange dynamic calculation volume transport
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Accumulation and exploration of gas hydrate in deep-sea sediments of northern South China Sea 被引量:4
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作者 张光学 陈芳 +5 位作者 杨胜雄 苏新 沙志彬 王宏斌 梁金强 周洋 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2012年第5期876-888,共13页
The large deep-sea area from the southwestern Qiongdongnan Basin to the eastern Dongsha Islands,within the continental margin of northern South China Sea,is a frontier of natural gas hydrate exploration in China.Multi... The large deep-sea area from the southwestern Qiongdongnan Basin to the eastern Dongsha Islands,within the continental margin of northern South China Sea,is a frontier of natural gas hydrate exploration in China.Multiform of deep-sea sedimentations have been occurred since late Miocene,and sediment waves as a potential quality reservoir of natural gas hydrate is an most important style of them.Based on abundant available data of seismic,gravity sampling and drilling core,we analyzed the characteristics of seismic reflection and sedimentation of sediment waves and the occurrence of natural gas hydrate hosted in it,and discussed the control factors on natural gas hydrate accumulation.The former findings revealed the deep sea of the northern South China Sea have superior geological conditions on natural gas hydrate accumulation.Therefore,it will be of great significance in deep-sea natural gas hydrate exploration with the study on the relationship between deep-sea sedimentation and natural gas hydrate accumulation. 展开更多
关键词 northern South China Sea deep-sea sedimentation sediment wave natural gas hydrate
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3-D reconstruction of coastal bathymetry from AIRSAR/POLSAR data 被引量:1
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作者 Maged MARGHANY Mazlan HASHIM Arthur P. CRACKNELL 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2009年第1期117-123,共7页
This paper introduces a new method for reconstructing three-dimensional (3D) coastal bathymetry changes from Airborne AIRSAR/POLSAR synthetic aperture data. The new method is based on integration between fuzzy B-spl... This paper introduces a new method for reconstructing three-dimensional (3D) coastal bathymetry changes from Airborne AIRSAR/POLSAR synthetic aperture data. The new method is based on integration between fuzzy B-spline and Volterra algorithm. Volterra algorithm is used to simulate the ocean surface current from AIRSAR/POLSAR data. Then, the ocean surface current information used as input for continuity equation to estimate the water depths from AIRSAR/POLSAR data. This study shows that 3D ocean bathymetry can be reconstructed from AIRSAR/POLSAR data with root mean square error of ±0.03 m. 展开更多
关键词 AIRSAR/POLSAR data Volterra algorithm Fuzzy B-spline 3D bathymetry
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What Depth Should Deep-Sea Water be Pumped up from in the South China Sea for Medicinal Research? 被引量:1
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作者 HE Shan LIU Hongbing +2 位作者 YANG Xue LI Chunxia GUAN Huashi 《Journal of Ocean University of China》 SCIE CAS 2013年第1期134-138,共5页
In this study, seawater was pumped up from 150, 200, 300, 500 and 1000 m in the South China Sea and analyzed to make certain what depth should deep-sea water (DSW) be pumped up for medicinal usage. The pumping depth o... In this study, seawater was pumped up from 150, 200, 300, 500 and 1000 m in the South China Sea and analyzed to make certain what depth should deep-sea water (DSW) be pumped up for medicinal usage. The pumping depth of DSW was determined on the basis of chemical ingredients. The analyses of inorganic elements and dissolved organic matter (DOM) were performed by inductively coupled plasma mass spectrometry (ICP-MS) and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) respectively. The raw data were used for hierarchical cluster analysis (HCA) and principal component analysis (PCA). The results showed that seawater pumped up from 500 m and 1000 m was similar in their chemical ingredients, and was different from the seawater pumped up from other depths. These results indicated that seawater from more than 500 m depth had relatively stable chemical ingredients and could be used as DSW in the South China Sea. 展开更多
关键词 Deep-sea water (DSW) depth chemical ingredients hierarchical cluster analysis (HCA) principal component analysis (PCA)
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Numerical simulation of deepwater deployment for offshore structures with deploying cables 被引量:1
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作者 胡小舟 刘少军 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第3期922-930,共9页
Deepwater deployment of offshore structures in different sea states was investigated. The whole deployment system was modeled as a lumped mass model, and discretization scheme for cable geometry and methodology for ca... Deepwater deployment of offshore structures in different sea states was investigated. The whole deployment system was modeled as a lumped mass model, and discretization scheme for cable geometry and methodology for calculating the internal and external force acting on deploying cable were presented. The deployment model suitable for the time-varying length of deploying cable was specified. The free-surface flow fields together with the ship motions were used to calculate dynamic tension in the deploying cable during deployment of the structure. The deployment of deep sea mining system which was a typical subsea working system was employed. Based on lumped mass analysis model and parameters of deep sea mining system, numerical simulations were performed, and dynamic load and dynamic amplification factor(DAF) with different cable parameters, deploying velocities and sea states were obtained. It is shown that cable parameters and amplitudes of ocean waves can significantly influence the dynamic load and DAF, and the time-varying natural period of deploying system is a dominant factor, while the effect of deploying velocity is not obvious. 展开更多
关键词 deployment cable dynamic load dynamic amplification factor
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全氟/多氟烷基化合物在全球海洋水体中的污染演变趋势研究进展 被引量:5
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作者 向前 单国强 +1 位作者 邬畏 祝凌燕 《科学通报》 EI CAS CSCD 北大核心 2019年第9期911-922,共12页
全氟/多氟烷基化合物(PFASs)的环境污染及危害愈来愈受到全球关注.目前,部分传统PFASs的生产使用受到限制或管控,一些新型PFASs替代品不断进入市场,使得PFASs的环境污染状况变得更为复杂.PFASs不仅在人口密集地区的陆地环境中高频检出,... 全氟/多氟烷基化合物(PFASs)的环境污染及危害愈来愈受到全球关注.目前,部分传统PFASs的生产使用受到限制或管控,一些新型PFASs替代品不断进入市场,使得PFASs的环境污染状况变得更为复杂.PFASs不仅在人口密集地区的陆地环境中高频检出,还在各大海洋甚至人迹罕见的两极地区普遍检出.海洋已经成为PFASs污染最重要的"汇"之一,并对全球生态环境以及两极地区产生重要的影响.关于海洋中PFASs污染的报道也日趋增多,本文旨在对近年来海洋PFASs污染的研究数据进行剖析,以期阐明PFASs在全球洋流尺度上的污染时空分布情况,为PFASs的环境风险评估和环境政策的制定提供科学依据. 展开更多
关键词 全氟/多氟烷基化合物 大洋 表层海水 深海海水 洋流
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Tracking shallow marine red beds through geological time as exemplified by the lower Telychian (Silurian) in the Upper Yangtze Region,South China 被引量:28
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作者 RONG JiaYu WANG Yi ZHANG XiaoLe 《Science China Earth Sciences》 SCIE EI CAS 2012年第5期699-713,共15页
Marine red beds occur frequently in China through geological time.Despite their complex environments,the red beds are found in three depositional settings:1) oceanic,deep water,as in the Upper Cretaceous of southern T... Marine red beds occur frequently in China through geological time.Despite their complex environments,the red beds are found in three depositional settings:1) oceanic,deep water,as in the Upper Cretaceous of southern Tibet;2) outer shelf,deeper water,as in the Lower-Middle Ordovician of South China;and 3) inner shelf,shallow water,as in the Silurian and Triassic in South China.The Silurian marine red beds are recurrent in the lower Telychian,upper Telychian,and upper Ludlow.This paper is to document the marine nature of the lower Telychian red beds (LRBs) in the Upper Yangtze Region and to discuss the spatial and temporal distribution of the LRBs and their depositional environments.The LRBs are best developed on the north side of the Cathaysian Oldland,which can be interpreted as the source area.It is inferred that they were deposited during a marine regression,characterized by the lack of upwelling,low nutrition and organic productivity with a decrease of biodiversity and a high rate of sedimentation.The iron-rich sediments may have been transported by rivers on the oldland into the Upper Yangtze Sea,as rates of deposition were rapid enough to counteract normal reducing effect around sediment-water interface.The LRBs are different from the off-shore,deeper water red beds of lower Telychian in Avalonia and Baltica and further from the oceanic,deep water red beds of Upper Cretaceous in southern Tibet chiefly in palaeogeographic settings,biotic assemblages and marine environments. 展开更多
关键词 shallow marine red beds lower Telychian of Lower Silurian South China DISTRIBUTION environments
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