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高变异药物生物等效性评价的几种解决方法初探 被引量:3
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作者 黄亚芳 谢文杰 《中国药物评价》 2017年第5期339-344,共6页
实现生物等效是仿制药一致性评价工作中的重要结论性评判标准,近年来得到国家食品药品监督管理总局药品审评中心高度重视。然而,由于通常需要更大的样本量或更多的试验周期,高变异药物(HVD)生物等效性评价仍有难度,尤其是试验设计和统... 实现生物等效是仿制药一致性评价工作中的重要结论性评判标准,近年来得到国家食品药品监督管理总局药品审评中心高度重视。然而,由于通常需要更大的样本量或更多的试验周期,高变异药物(HVD)生物等效性评价仍有难度,尤其是试验设计和统计方法存在较多争论,困扰着众多医药工作者。为此,本文将针对这些争论焦点问题,分析总结几种目前国际上基于节省样本量和试验周期数的对高(或超高)变异药物生物等效性的评价技术和方法,旨在为降低我国HVD的仿制风险提供借鉴与参考。 展开更多
关键词 高变异药物 生物等效性 的平均生物等效性 混合标化模型
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Multi-objective coordination optimal model for new power intelligence center based on hybrid algorithm 被引量:1
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作者 刘吉成 牛东晓 乞建勋 《Journal of Central South University》 SCIE EI CAS 2009年第4期683-689,共7页
In order to resolve the coordination and optimization of the power network planning effectively, on the basis of introducing the concept of power intelligence center (PIC), the key factor power flow, line investment a... In order to resolve the coordination and optimization of the power network planning effectively, on the basis of introducing the concept of power intelligence center (PIC), the key factor power flow, line investment and load that impact generation sector, transmission sector and dispatching center in PIC were analyzed and a multi-objective coordination optimal model for new power intelligence center (NPIC) was established. To ensure the reliability and coordination of power grid and reduce investment cost, two aspects were optimized. The evolutionary algorithm was introduced to solve optimal power flow problem and the fitness function was improved to ensure the minimum cost of power generation. The gray particle swarm optimization (GPSO) algorithm was used to forecast load accurately, which can ensure the network with high reliability. On this basis, the multi-objective coordination optimal model which was more practical and in line with the need of the electricity market was proposed, then the coordination model was effectively solved through the improved particle swarm optimization algorithm, and the corresponding algorithm was obtained. The optimization of IEEE30 node system shows that the evolutionary algorithm can effectively solve the problem of optimal power flow. The average load forecasting of GPSO is 26.97 MW, which has an error of 0.34 MW compared with the actual load. The algorithm has higher forecasting accuracy. The multi-objective coordination optimal model for NPIC can effectively process the coordination and optimization problem of power network. 展开更多
关键词 power intelligence center (PIC) coordination optimal model power network planning hybrid algorithm
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Modeling and Multi-objective Optimization of Refinery Hydrogen Network 被引量:12
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作者 焦云强 苏宏业 +1 位作者 廖祖维 侯卫锋 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2011年第6期990-998,共9页
The demand of hydrogen in oil refinery is increasing as market forces and environmental legislation, so hydrogen network management is becoming increasingly important in refineries. Most studies focused on single-obje... The demand of hydrogen in oil refinery is increasing as market forces and environmental legislation, so hydrogen network management is becoming increasingly important in refineries. Most studies focused on single-objective optimization problem for the hydrogen network, but few account for the multi-objective optimization problem. This paper presents a novel approach for modeling and multi-objective optimization for hydrogen network in refineries. An improved multi-objective optimization model is proposed based on the concept of superstructure. The optimization includes minimization of operating cost and minimization of investment cost of equipment. The proposed methodology for the multi-objective optimization of hydrogen network takes into account flow rate constraints, pressure constraints, purity constraints, impurity constraints, payback period, etc. The method considers all the feasible connections and subjects this to mixed-integer nonlinear programming (MINLP). A deterministic optimization method is applied to solve this multi-objective optimization problem. Finally, a real case study is intro-duced to illustrate the applicability of the approach. 展开更多
关键词 REFINERY multi-objective optimization hydrogen network mixed integer nonlinear programming
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