艾博混合疟/恶性疟快速诊断试剂效果评价

目的评价艾博混合疟/恶性疟(Malaria Pan./p.f..)快速诊断试剂的检测效果。方法采集疟疾、疑似疟疾、不明原因发热及感冒"四热"患者血样,以显微镜镜检方法为金标准,比较艾博混合疟/恶性疟试剂检测效果结果共采集584份血样,艾博试剂检测恶性疟原虫277份,灵敏度为98.9%,特异性为97.7%,与显微镜符合率为98.3%。艾博试剂检测混合疟377份的灵敏度为99.5%,特异性为99.0%,与显微镜符合率为99.3%,总符合率为98.8%,上述2方面的检测结果经Kappa一致性检验,Kappa值均大于0.97。结论艾博混合疟/恶性疟试剂盒实验室检测敏感性和特异性高,能检测混合疟并区分恶性疟,结果与血涂片吉氏染色镜检结果高度一致,适用于疟疾流行的基层使用。

抗氯喹恶性疟混合卵形疟1例报告

抗氯喹恶性疟混合卵形疟１例报告许国君，康杨，肖宁，代玉茹四川省寄生虫病防治研究所（成都６１００４１）患者，男，３４岁，广汉市第一建筑公司职工，１９９１年３月２６日随建筑队赴非洲乌干达的坎帕拉（ｋａｍ－ｐａｌａ）和卡巴勒（Ｋａｂａｌｅ）工作，于１９９２...

Antimalarial Activity of an Alkaloid Mixture Isolated from the Tender Leaves of the Nectandra membranacea （Laureaceae）

Despite the breadth of knowledge about malaria, its transmission, preventive measures and available treatments and its difficulty in controlling the vector and the rapid spread of resistance to current drugs, there is a stimulus to develop new research looking for active molecules. The phytochemical studies of the active extract confirmed the presence of alkaloids, flavonoids, coumarins, tannins, reducing compounds, anthocyanins, terpenes, triterpenes and steroids. In the present work, it was possible to isolate a mixture of isoquinolinic alkaloids from the tender leaves of Nectandra membranacea （Laureaceae） with antimalarial activity. The mixture composed of （-） - gliazovine and （＋） - aplogliazovine showed an IC50 value of 32.18 μg/mL against the P. berghei NK65 strain. It is important to continue with these studies and their chemical components isolated from N. membranacea that could be used as an alternative the treatment of malaria.