新型温度敏感性液体栓塞材料的实验研究

目的探讨一种新型温度敏感性液体栓塞材料的合成及其栓塞脑动静脉畸形(AVM)的可行性。方法应用氮异丙基丙烯酰胺(N isoprophlacrylamide ,NIPAM)和氮正丙基丙烯酰胺(N n propylacrylamide ,NNPAM)合成共聚物,进行物理性质分析和体外AVM模型栓塞试验。结果共聚物具有低临界溶解温度及水溶性和非粘附性的特点,能成功栓塞体外AVM模型。结论共聚物为一种新型液体栓塞材料。

温度敏感型液体栓塞材料的实验研究

目的:合成一种新型温度敏感性液体栓塞材料并探讨用于栓塞脑动静脉畸形(AVM)的可能性。方法:应用氮-异丙基丙烯酰胺(NIPAM)、氮-正丙基丙烯酰胺(NNPAM)和乙烯基己内酰胺(VC)合成共聚物,进行物理性质测定和体外AVM模型栓塞试验。结果:共聚物具有低临界溶解温度(LCST),具有水溶性和非粘附性特点,能成功栓塞体外AVM模型。结论:共聚物为一种脑AVM血管内栓塞治疗的新型液体栓塞材料,可用于进一步动物实验。

Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers

In this study, double-hydrophilic hydroxylpropyl cellulose （HPC） based copolymers with poly（N- isopropylacrylamide） （PNIPAM） and poly（acrylic acid） （PAA） as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process.